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John E Edwards, M.D.
Contact Information:
Fax Number:
(310) 782-2016
Work Phone Number:
(310) 222-3813
(310) 828-8566
(310)-222-1867
Mailing Address:
1124 West Carson Street RB-2, Room 223 Torrance, CA 90502 UNITED STATES
Office Address:
Harbor-UCLA Medl Cntr-Inf Dis 1000 W Carson St, Box 466 Torrance, CA 90502 UNITED STATES
Professor,
Division of Infectious Diseases
Infectious Diseases
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Professor in Residence,
Medicine
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Member,
CTSI
Research Education, Training, and Career Development Program (CTSI-ED)
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A Short Biography:
Dr. Edwards has devoted the majority of his career to studying the pathogenesis and therapy of fungal infectious diseases, principally those caused by Candida albicans. He has been committed to research on both cellular and sub-cellular mechanisms of antimicrobial host defense for over twenty years. Recently, Dr. Edwards and his group have focused their research efforts on determining the specific ligands which mediate Candida interactions with host cells. The ultimate goals of this line of investigation are to delineate the interaction among C. albicans, endothelial cells, and neutrophils. These interactions determine how Candida penetrates the vascular compartment to invade deeper parenchymal tissues. For instance, his group has established a C. albicans DNA library in Saccharomyces cerevisae, an organism which does not normally adhere well to host cells. This work is being conducted in part through a Mycology Research Unit (NIH P01) entitled Candida adherence, that involves the laboratories of Dr. Tom Kozel, University of Nevada, Reno, Dr. John Cutler, University of Montana, Dr. William Fonzi, Georgetown University. Dr. Edwards and Dr. Filler (below) are also coordinating activities of the Candida subproject of the NIAID Mycoses Study Group (MSG). This group facilitates national cooperative clinical studies with the aim of improving prevention and treatment of life-threatening candidal infections. Dr. Edwards also chairs the NIAID advisory panel on chronic Lyme Disease.
Awards and Honors:
Kaiser Permanente - Los Angeles Medical Cente
UC Irvine Medical Center
Publications:
Schmidt Clint S, White C Jo, Ibrahim Ashraf S, Filler Scott G, Fu Yue, Yeaman Michael R, Edwards John E, Hennessey John P
NDV-3, a recombinant alum-adjuvanted vaccine for Candida and
Staphylococcus aureus, is safe and immunogenic in healthy adults.
Vaccine,
2012; 30(52):
7594-600.
Ibrahim Ashraf S, Gebremariam Teclegiorgis, Lin Lin, Luo Guanpingsheng, Husseiny Mohamed I, Skory Christopher D, Fu Yue, French Samuel W, Edwards John E, Spellberg Brad
The high affinity iron permease is a key virulence factor required for
Rhizopus oryzae pathogenesis.
Molecular microbiology,
2010; 77(3):
587-604.
Boucher Helen W, Talbot George H, Bradley John S, Edwards John E, Gilbert David, Rice Louis B, Scheld Michael, Spellberg Brad, Bartlett John
Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases
Society of America.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
2009; 48(1):
1-12.
Pappas Peter G, Kauffman Carol A, Andes David, Benjamin Daniel K, Calandra Thierry F, Edwards John E, Filler Scott G, Fisher John F, Kullberg Bart-Jan, Ostrosky-Zeichner Luis, Reboli Annette C, Rex John H, Walsh Thomas J, Sobel Jack D, Sobel Jack D
Clinical practice guidelines for the management of candidiasis: 2009
update by the Infectious Diseases Society of America.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
2009; 48(5):
503-35.
Lin Lin, Ibrahim Ashraf S, Xu Xin, Farber Joshua M, Avanesian Valentina, Baquir Beverlie, Fu Yue, French Samuel W, Edwards John E, Spellberg Brad
Th1-Th17 cells mediate protective adaptive immunity against
Staphylococcus aureus and Candida albicans infection in mice.
PLoS pathogens,
2009; 5(12):
e1000703.
Ibrahim Ashraf S, Gebremariam Teclegiorgis, Liu Mingfu, Chamilos Georgios, Kontoyiannis Dimitrios, Mink Richard, Kwon-Chung Kyung J, Fu Yue, Skory Christopher D, Edwards John E, Spellberg Brad
Bacterial endosymbiosis is widely present among zygomycetes but does
not contribute to the pathogenesis of mucormycosis.
The Journal of infectious diseases,
2008; 198(7):
1083-90.
De Pauw Ben, Walsh Thomas J, Donnelly J Peter, Stevens David A, Edwards John E, Calandra Thierry, Pappas Peter G, Maertens Johan, Lortholary Olivier, Kauffman Carol A, Denning David W, Patterson Thomas F, Maschmeyer Georg, Bille Jacques, Dismukes William E, Herbrecht Raoul, Hope William W, Kibbler Christopher C, Kullberg Bart Jan, Marr Kieren A, Muñoz Patricia, Odds Frank C, Perfect John R, Restrepo Angela, Ruhnke Markus, Segal Brahm H, Sobel Jack D, Sorrell Tania C, Viscoli Claudio, Wingard John R, Zaoutis Theoklis, Bennett John E, Bennett John E, Bennett John E
Revised definitions of invasive fungal disease from the European
Organization for Research and Treatment of Cancer/Invasive Fungal
Infections Cooperative Group and the National Institute of Allergy and
Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
2008; 46(12):
1813-21.
Spellberg Brad, Ibrahim Ashraf S, Yeaman Michael R, Lin Lin, Fu Yue, Avanesian Valentina, Bayer Arnold S, Filler Scott G, Lipke Peter, Otoo Henry, Edwards John E
The antifungal vaccine derived from the recombinant N terminus of
Als3p protects mice against the bacterium Staphylococcus aureus.
Infection and immunity,
2008; 76(10):
4574-80.
Ibrahim Ashraf S, Gebermariam Teclegiorgis, Fu Yue, Lin Lin, Husseiny Mohamed I, French Samuel W, Schwartz Julie, Skory Christopher D, Edwards John E, Spellberg Brad J
The iron chelator deferasirox protects mice from mucormycosis through
iron starvation.
The Journal of clinical investigation,
2007; 117(9):
2649-57.
Ibrahim Ashraf S, Bowman Joel C, Avanessian Valentina, Brown Keturah, Spellberg Brad, Edwards John E, Douglas Cameron M
Caspofungin inhibits Rhizopus oryzae 1,3-beta-D-glucan synthase,
lowers burden in brain measured by quantitative PCR, and improves
survival at a low but not a high dose during murine disseminated
zygomycosis.
Antimicrobial agents and chemotherapy,
2005; 49(2):
721-7.
Sheppard Donald C, Yeaman Michael R, Welch William H, Phan Quynh T, Fu Yue, Ibrahim Ashraf S, Filler Scott G, Zhang Mason, Waring Alan J, Edwards John E
Functional and structural diversity in the Als protein family of
Candida albicans.
The Journal of biological chemistry,
2004; 279(29):
30480-9.
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