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John E Edwards, M.D.

Contact Information:

Fax Number:

(310) 782-2016

Work Phone Number:

(310) 222-3813
(310) 828-8566
(310)-222-1867

Mailing Address:

1124 West Carson Street RB-2, Room 223
Torrance, CA 90502
UNITED STATES

Office Address:

Harbor-UCLA Medl Cntr-Inf Dis
1000 W Carson St, Box 466
Torrance, CA 90502
UNITED STATES

Email Address:

edwards@humc.edu

Work Email Address:

jedwards@labiomed.org

Websites:

  

Home Page:

     Home Page
     Web-Profile


Chief, Division of Infectious Diseases

Professor in Residence, Infectious Diseases

Department of Medicine


A Short Biography:

Dr. Edwards has devoted the majority of his career to studying the pathogenesis and therapy of fungal infectious diseases, principally those caused by Candida albicans. He has been committed to research on both cellular and sub-cellular mechanisms of antimicrobial host defense for over twenty years. Recently, Dr. Edwards and his group have focused their research efforts on determining the specific ligands which mediate Candida interactions with host cells. The ultimate goals of this line of investigation are to delineate the interaction among C. albicans, endothelial cells, and neutrophils. These interactions determine how Candida penetrates the vascular compartment to invade deeper parenchymal tissues. For instance, his group has established a C. albicans DNA library in Saccharomyces cerevisae, an organism which does not normally adhere well to host cells. This work is being conducted in part through a Mycology Research Unit (NIH P01) entitled Candida adherence, that involves the laboratories of Dr. Tom Kozel, University of Nevada, Reno, Dr. John Cutler, University of Montana, Dr. William Fonzi, Georgetown University. Dr. Edwards and Dr. Filler (below) are also coordinating activities of the Candida subproject of the NIAID Mycoses Study Group (MSG). This group facilitates national cooperative clinical studies with the aim of improving prevention and treatment of life-threatening candidal infections. Dr. Edwards also chairs the NIAID advisory panel on chronic Lyme Disease.

Awards and Honors:

Kaiser Permanente - Los Angeles Medical Cente
UC Irvine Medical Center

Publications:

Fu Yue, Phan Quynh T, Luo Guanpingsheng, Solis Norma V, Liu Yaoping, Cormack Brendan P, Edwards John E, Ibrahim Ashraf S, Filler Scott G   Investigation of the Function of Candida albicans Als3 by Heterologous Expression in Candida glabrata Infection and immunity, 2013; .
Edwards John E   Fungal Cell Wall Vaccines: An Update Journal of medical microbiology, 2012; .
Schmidt Clint S, White C Jo, Ibrahim Ashraf S, Filler Scott G, Fu Yue, Yeaman Michael R, Edwards John E, Hennessey John P   NDV-3, a recombinant alum-adjuvanted vaccine for Candida and Staphylococcus aureus, is safe and immunogenic in healthy adults Vaccine, 2012; 30(52): 7594-600.
Luo Guanpingsheng, Ibrahim Ashraf S, French Samuel W, Edwards John E, Fu Yue   Active and passive immunization with rHyr1p-N protects mice against hematogenously disseminated candidiasis PloS one, 2011; 6(10): e25909.
Ibrahim Ashraf S, Gebremariam Teclegiorgis, Luo Guanpingsheng, Fu Yue, French Samuel W, Edwards John E, Spellberg Brad   Combination therapy of murine mucormycosis or aspergillosis with iron chelation, polyenes, and echinocandins Antimicrobial agents and chemotherapy, 2011; 55(4): 1768-70.
Brass Eric P, Edwards John E   Should the guidelines for management of central venous catheters in patients with candidemia be changed now? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2010; 51(3): 304-6.
Liu Mingfu, Spellberg Brad, Phan Quynh T, Fu Yue, Fu Yong, Lee Amy S, Edwards John E, Filler Scott G, Ibrahim Ashraf S   The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice The Journal of clinical investigation, 2010; 120(6): 1914-24.
Ibrahim Ashraf S, Gebremariam Teclegiorgis, Lin Lin, Luo Guanpingsheng, Husseiny Mohamed I, Skory Christopher D, Fu Yue, French Samuel W, Edwards John E, Spellberg Brad   The high affinity iron permease is a key virulence factor required for Rhizopus oryzae pathogenesis Molecular microbiology, 2010; 77(3): 587-604.
Ibrahim Ashraf S, Gebremariam Teclegiorgis, French Samuel W, Edwards John E, Spellberg Brad   The iron chelator deferasirox enhances liposomal amphotericin B efficacy in treating murine invasive pulmonary aspergillosis The Journal of antimicrobial chemotherapy, 2010; 65(2): 289-92.
Boucher Helen W, Talbot George H, Bradley John S, Edwards John E, Gilbert David, Rice Louis B, Scheld Michael, Spellberg Brad, Bartlett John   Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009; 48(1): 1-12.
Pappas Peter G, Kauffman Carol A, Andes David, Benjamin Daniel K, Calandra Thierry F, Edwards John E, Filler Scott G, Fisher John F, Kullberg Bart-Jan, Ostrosky-Zeichner Luis, Reboli Annette C, Rex John H, Walsh Thomas J, Sobel Jack D, Sobel Jack D   Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009; 48(5): 503-35.
Ibrahim Ashraf S, Edwards John E, Bryant Richard, Spellberg Brad   Economic burden of mucormycosis in the United States: can a vaccine be cost-effective? Medical mycology : official publication of the International Society for Human and Animal Mycology, 2009; 47(6): 592-600.
Ibrahim Ashraf S, Gebremariam Teclegiorgis, Schwartz Julie A, Edwards John E, Spellberg Brad   Posaconazole mono- or combination therapy for treatment of murine zygomycosis Antimicrobial agents and chemotherapy, 2009; 53(2): 772-5.
Lin Lin, Ibrahim Ashraf S, Xu Xin, Farber Joshua M, Avanesian Valentina, Baquir Beverlie, Fu Yue, French Samuel W, Edwards John E, Spellberg Brad   Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice PLoS pathogens, 2009; 5(12): e1000703.
Spellberg Brad, Ibrahim Ashraf S, Lin Lin, Avanesian Valentina, Fu Yue, Lipke Peter, Otoo Henry, Ho Tiffany, Edwards John E   Antibody titer threshold predicts anti-candidal vaccine efficacy even though the mechanism of protection is induction of cell-mediated immunity The Journal of infectious diseases, 2008; 197(7): 967-71.
Ibrahim Ashraf S, Gebremariam Teclegiorgis, Liu Mingfu, Chamilos Georgios, Kontoyiannis Dimitrios, Mink Richard, Kwon-Chung Kyung J, Fu Yue, Skory Christopher D, Edwards John E, Spellberg Brad   Bacterial endosymbiosis is widely present among zygomycetes but does not contribute to the pathogenesis of mucormycosis The Journal of infectious diseases, 2008; 198(7): 1083-90.
Ibrahim Ashraf S, Gebremariam Teclegiorgis, Fu Yue, Edwards John E, Spellberg Brad   Combination echinocandin-polyene treatment of murine mucormycosis Antimicrobial agents and chemotherapy, 2008; 52(4): 1556-8.
Ibrahim Ashraf S, Gebremariam Teclegiorgis, Husseiny Mohamed I, Stevens David A, Fu Yue, Edwards John E, Spellberg Brad   Comparison of lipid amphotericin B preparations in treating murine zygomycosis Antimicrobial agents and chemotherapy, 2008; 52(4): 1573-6.
Lin Lin, Ibrahim Ashraf S, Avanesian Valentina, Edwards John E, Fu Yue, Baquir Beverlie, Taub Rebecca, Spellberg Brad   Considerable differences in vaccine immunogenicities and efficacies related to the diluent used for aluminum hydroxide adjuvant Clinical and vaccine immunology : CVI, 2008; 15(3): 582-4.
Fu Yue, Luo Guanpingsheng, Spellberg Brad J, Edwards John E, Ibrahim Ashraf S   Gene overexpression/suppression analysis of candidate virulence factors of Candida albicans Eukaryotic cell, 2008; 7(3): 483-92.
De Pauw Ben, Walsh Thomas J, Donnelly J Peter, Stevens David A, Edwards John E, Calandra Thierry, Pappas Peter G, Maertens Johan, Lortholary Olivier, Kauffman Carol A, Denning David W, Patterson Thomas F, Maschmeyer Georg, Bille Jacques, Dismukes William E, Herbrecht Raoul, Hope William W, Kibbler Christopher C, Kullberg Bart Jan, Marr Kieren A, Muñoz Patricia, Odds Frank C, Perfect John R, Restrepo Angela, Ruhnke Markus, Segal Brahm H, Sobel Jack D, Sorrell Tania C, Viscoli Claudio, Wingard John R, Zaoutis Theoklis, Bennett John E, Bennett John E, Bennett John E   Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008; 46(12): 1813-21.
Gank Kimberly D, Yeaman Michael R, Kojima Satoshi, Yount Nannette Y, Park Hyunsook, Edwards John E, Filler Scott G, Fu Yue   SSD1 is integral to host defense peptide resistance in Candida albicans Eukaryotic cell, 2008; 7(8): 1318-27.
Spellberg Brad, Ibrahim Ashraf S, Yeaman Michael R, Lin Lin, Fu Yue, Avanesian Valentina, Bayer Arnold S, Filler Scott G, Lipke Peter, Otoo Henry, Edwards John E   The antifungal vaccine derived from the recombinant N terminus of Als3p protects mice against the bacterium Staphylococcus aureus Infection and immunity, 2008; 76(10): 4574-80.
Almeida Ricardo S, Brunke Sascha, Albrecht Antje, Thewes Sascha, Laue Michael, Edwards John E, Filler Scott G, Hube Bernhard   the hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin PLoS pathogens, 2008; 4(11): e1000217.
Phan Quynh T, Myers Carter L, Fu Yue, Sheppard Donald C, Yeaman Michael R, Welch William H, Ibrahim Ashraf S, Edwards John E, Filler Scott G   Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells PLoS biology, 2007; 5(3): e64.
Chiang Lisa Y, Sheppard Donald C, Bruno Vincent M, Mitchell Aaron P, Edwards John E, Filler Scott G   Candida albicans protein kinase CK2 governs virulence during oropharyngeal candidiasis Cellular microbiology, 2007; 9(1): 233-45.
Spellberg Brad J, Collins Mary, Avanesian Valentina, Gomez Mayela, Edwards John E, Cogle Christopher, Applebaum David, Fu Yue, Ibrahim Ashraf S   Optimization of a myeloid cell transfusion strategy for infected neutropenic hosts Journal of leukocyte biology, 2007; 81(3): 632-41.
Ibrahim Ashraf S, Gebermariam Teclegiorgis, Fu Yue, Lin Lin, Husseiny Mohamed I, French Samuel W, Schwartz Julie, Skory Christopher D, Edwards John E, Spellberg Brad J   The iron chelator deferasirox protects mice from mucormycosis through iron starvation The Journal of clinical investigation, 2007; 117(9): 2649-57.
Rieg Gunter, Spellberg Brad, Schwartz Julie, Fu Yue, Edwards John E, Sheppard Donald C, Ibrahim Ashraf S   Antifungal prophylaxis is effective against murine invasive pulmonary aspergillosis Antimicrobial agents and chemotherapy, 2006; 50(8): 2895-6.
Spellberg Brad, Schwartz Julie, Fu Yue, Avanesian Valentina, Adler-Moore Jill, Edwards John E, Ibrahim Ashraf S   Comparison of antifungal treatments for murine fusariosis The Journal of antimicrobial chemotherapy, 2006; 58(5): 973-9.
Spellberg Brad J, Filler Scott G, Edwards John E   Current treatment strategies for disseminated candidiasis Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006; 42(2): 244-51.
Reed Caitlin, Ibrahim Ashraf, Edwards John E, Walot Irwin, Spellberg Brad   Deferasirox, an iron-chelating agent, as salvage therapy for rhinocerebral mucormycosis Antimicrobial agents and chemotherapy, 2006; 50(11): 3968-9.
Ibrahim Ashraf S, Edwards John E, Fu Yue, Spellberg Brad   Deferiprone iron chelation as a novel therapy for experimental mucormycosis The Journal of antimicrobial chemotherapy, 2006; 58(5): 1070-3.
Spellberg Brad J, Ibrahim Ashraf S, Avanesian Valentina, Fu Yue, Myers Carter, Phan Quynh T, Filler Scott G, Yeaman Michael R, Edwards John E   Efficacy of the anti-Candida rAls3p-N or rAls1p-N vaccines against disseminated and mucosal candidiasis The Journal of infectious diseases, 2006; 194(2): 256-60.
Ibrahim Ashraf S, Spellberg Brad J, Avanesian Valentina, Fu Yue, Edwards John E   The anti-Candida vaccine based on the recombinant N-terminal domain of Als1p is broadly active against disseminated candidiasis Infection and immunity, 2006; 74(5): 3039-41.
Spellberg Brad J, Collins Mary, French Samuel W, Edwards John E, Fu Yue, Ibrahim Ashraf S   A phagocytic cell line markedly improves survival of infected neutropenic mice Journal of leukocyte biology, 2005; 78(2): 338-44.
Ibrahim Ashraf S, Bowman Joel C, Avanessian Valentina, Brown Keturah, Spellberg Brad, Edwards John E, Douglas Cameron M   Caspofungin inhibits Rhizopus oryzae 1,3-beta-D-glucan synthase, lowers burden in brain measured by quantitative PCR, and improves survival at a low but not a high dose during murine disseminated zygomycosis Antimicrobial agents and chemotherapy, 2005; 49(2): 721-7.
Spellberg Brad, Fu Yue, Edwards John E, Ibrahim Ashraf S   Combination therapy with amphotericin B lipid complex and caspofungin acetate of disseminated zygomycosis in diabetic ketoacidotic mice Antimicrobial agents and chemotherapy, 2005; 49(2): 830-2.
Ibrahim Ashraf S, Magee B B, Sheppard D C, Yang Molly, Kauffman Sarah, Becker Jeff, Edwards John E, Magee P T   Effects of ploidy and mating type on virulence of Candida albicans Infection and immunity, 2005; 73(11): 7366-74.
Spellberg Brad, Ibrahim Ashraf S, Edwards John E, Filler Scott G   Mice with disseminated candidiasis die of progressive sepsis The Journal of infectious diseases, 2005; 192(2): 336-43.
Phan Quynh T, Fratti Rutillio A, Prasadarao Nemani V, Edwards John E, Filler Scott G   N-cadherin mediates endocytosis of Candida albicans by endothelial cells The Journal of biological chemistry, 2005; 280(11): 10455-61.
Ibrahim Ashraf S, Spellberg Brad, Avanessian Valentina, Fu Yue, Edwards John E   Rhizopus oryzae adheres to, is phagocytosed by, and damages endothelial cells in vitro Infection and immunity, 2005; 73(2): 778-83.
Park Hyunsook, Myers Carter L, Sheppard Donald C, Phan Quynh T, Sanchez Angela A, E Edwards John, Filler Scott G   Role of the fungal Ras-protein kinase A pathway in governing epithelial cell interactions during oropharyngeal candidiasis Cellular microbiology, 2005; 7(4): 499-510.
Toenjes Kurt A, Munsee Suzanne M, Ibrahim Ashraf S, Jeffrey Rachel, Edwards John E, Johnson Douglas I   Small-molecule inhibitors of the budded-to-hyphal-form transition in the pathogenic yeast Candida albicans Antimicrobial agents and chemotherapy, 2005; 49(3): 963-72.
Spellberg Brad J, Ibrahim Ashraf S, Avenissian Valentina, Filler Scott G, Myers Carter L, Fu Yue, Edwards John E   The anti-Candida albicans vaccine composed of the recombinant N terminus of Als1p reduces fungal burden and improves survival in both immunocompetent and immunocompromised mice Infection and immunity, 2005; 73(9): 6191-3.
Ibrahim Ashraf S, Spellberg Brad J, Avenissian Valentina, Fu Yue, Filler Scott G, Edwards John E   Vaccination with recombinant N-terminal domain of Als1p improves survival during murine disseminated candidiasis by enhancing cell-mediated, not humoral, immunity Infection and immunity, 2005; 73(2): 999-1005.
VandenBerg Alysia L, Ibrahim Ashraf S, Edwards John E, Toenjes Kurt A, Johnson Douglas I   Cdc42p GTPase regulates the budded-to-hyphal-form transition and expression of hypha-specific transcripts in Candida albicans Eukaryotic cell, 2004; 3(3): 724-34.
Fu Yue, Lee Helen, Collins Mary, Tsai Huei-Fung, Spellberg Brad, Edwards John E, Kwon-Chung Kyung J, Ibrahim Ashraf S   Cloning and functional characterization of the Rhizopus oryzae high affinity iron permease (rFTR1) gene FEMS microbiology letters, 2004; 235(1): 169-76.
Sheppard Donald C, Edwards John E   Development of a vaccine for invasive aspergillosis Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2004; 38(8): 1137-8.
Loza Lucio, Fu Yue, Ibrahim Ashraf S, Sheppard Donald C, Filler Scott G, Edwards John E   Functional analysis of the Candida albicans ALS1 gene product Yeast (Chichester, England), 2004; 21(6): 473-82.
Sheppard Donald C, Yeaman Michael R, Welch William H, Phan Quynh T, Fu Yue, Ibrahim Ashraf S, Filler Scott G, Zhang Mason, Waring Alan J, Edwards John E   Functional and structural diversity in the Als protein family of Candida albicans The Journal of biological chemistry, 2004; 279(29): 30480-9.
Rauceo Jason M, Gaur Nand K, Lee Kyeng-Gea, Edwards John E, Klotz Stephen A, Lipke Peter N   Global cell surface conformational shift mediated by a Candida albicans adhesin Infection and immunity, 2004; 72(9): 4948-55.
Sheppard Donald C, Rieg Gunter, Chiang Lisa Y, Filler Scott G, Edwards John E, Ibrahim Ashraf S   Novel inhalational murine model of invasive pulmonary aspergillosis Antimicrobial agents and chemotherapy, 2004; 48(5): 1908-11.
Sanchez Angela A, Johnston Douglas A, Myers Carter, Edwards John E, Mitchell Aaron P, Filler Scott G   Relationship between Candida albicans virulence during experimental hematogenously disseminated infection and endothelial cell damage in vitro Infection and immunity, 2004; 72(1): 598-601.
Yeaman Michael R, Cheng Darwin, Desai Bhavesh, Kupferwasser Leon I, Xiong Yan-Qiong, Gank Kimberly D, Edwards John E, Bayer Arnold S   Susceptibility to thrombin-induced platelet microbicidal protein is associated with increased fluconazole efficacy against experimental endocarditis due to Candida albicans Antimicrobial agents and chemotherapy, 2004; 48(8): 3051-6.
Spellberg Brad, Powers John H, Brass Eric P, Miller Loren G, Edwards John E   Trends in antimicrobial drug development: implications for the future Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2004; 38(9): 1279-86.
Spellberg Brad, Rieg Gunter, Bayer Arnold, Edwards John E   Lack of cross-hepatotoxicity between fluconazole and voriconazole Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2003; 36(8): 1091-3.
Ibrahim Ashraf S, Avanessian Valentina, Spellberg Brad, Edwards John E   Liposomal amphotericin B, and not amphotericin B deoxycholate, improves survival of diabetic mice infected with Rhizopus oryzae Antimicrobial agents and chemotherapy, 2003; 47(10): 3343-4.
Spellberg Brad, Johnston Douglas, Phan Quynh Trang, Edwards John E, French Samuel W, Ibrahim Ashraf S, Filler Scott G   Parenchymal organ, and not splenic, immunity correlates with host survival during disseminated candidiasis Infection and immunity, 2003; 71(10): 5756-64.
Fu Yue, Ibrahim Ashraf S, Sheppard Donald C, Chen Yee-Chun, French Samuel W, Cutler Jim E, Filler Scott G, Edwards John E   Candida albicans Als1p: an adhesin that is a downstream effector of the EFG1 filamentation pathway Molecular microbiology, 2002; 44(1): 61-72.
Gilbert David N, Edwards John E   Is there hope for the prevention of future antimicrobial shortages? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2002; 35(2): 215-6; author reply 216-7.
Spellberg Brad, Edwards John E.   The Pathophysiology and Treatment of Candida Sepsis Current infectious disease reports, 2002; 4(5): 387-399.
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