Shlomo K Melmed, M.B., Ch.B

Work Titles and Affiliation
Cedar-Sinai Medical Center Director, Clinical Research Institute Vice President, Academic Affairs
UCLA Professor, Associate Dean, Medicine
Ch.B, University of Cape Town, South Africa, 1970
M.B., University of Cape Town, Cape Town, South Africa, 1970

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Cedars-Sinai Medl Cntr, Endo
8700 Beverly Bl, Rm. 2015 NT
Los Angeles, CA 90048

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Los Angeles, CA 90095

Detailed Biography:

World-renowned endocrinologist Shlomo Melmed, (MBChB 1970) currently Director of Cedars-Sinai Medical Centre's Burns 5 Allen Research Institute and Director of the Division of Endocrinology and Metabolism, has been named its Senior Vice-President for Academic Affairs. Dr Melmed has been associated with Cedars-Sinai since 1980, and with UCLA – where he is a professor of medicine – since 1979. He was appointed associate director of Cedars' Division of Endocrinology in 1983 and its director in 1986. He became the first director of Cedars' Burns K Allen Research Institute shortly after its founding in 1991. Dr Melmed is the author of over 150 peer-reviewed manuscripts and more than 50 book chapters, monographs and reviews. He has received many honours and awards in recognition of his clinical and scientific leadership in the field of pituitary disease, including the Clinical Endocrinology Trust Medal of the Royal Society of Medicine (1994), the Neuro-endocrinology Award of McGill University (1995), and the Pituitary Society's Award for Contributions to Understanding Pituitary Disease (1997). He was elected a Fellow of the American College of Physicians in 1981, and has been listed in Best Doctors of America every year since 1984. Dr. Melmed received his medical degree from the University of Cape Town in 1970, and was also awarded the Gold Medal in Medicine and Paediatrics for that year.


Petersenn Stephan, Farrall Andrew J, Block Christophe, Melmed Shlomo, Schopohl Jochen, Caron Philippe, Cuneo Ross, Kleinberg David, Colao Annamaria, Ruffin Matthieu, Hermosillo Reséndiz Karina, Hughes Gareth, Hu Ke, Barkan Ariel   Long-term efficacy and safety of subcutaneous pasireotide in acromegaly: results from an open-ended, multicenter, Phase II extension study Pituitary, 2013; 43(2): .
Hartman Mark L, Xu Rong, Crowe Brenda J, Robison Leslie L, Erfurth Eva Marie, Kleinberg David L, Zimmermann Alan G, Woodmansee Whitney W, Cutler Gordon B, Chipman John J, Melmed Shlomo, Melmed Shlomo   Prospective safety surveillance of GH-deficient adults: comparison of GH-treated vs untreated patients The Journal of clinical endocrinology and metabolism, 2013; 98(3): 980-8.
Melmed Shlomo   Update: Idiopathic Adult Growth Hormone Deficiency The Journal of clinical endocrinology and metabolism, 2013; 43(2): .
Thakker Rajesh V, Newey Paul J, Walls Gerard V, Bilezikian John, Dralle Henning, Ebeling Peter R, Melmed Shlomo, Sakurai Akihiro, Tonelli Francesco, Brandi Maria Luisa, Brandi Maria Luisa   Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1) The Journal of clinical endocrinology and metabolism, 2012; 97(9): 2990-3011.
Chesnokova Vera, Zonis Svetlana, Wawrowsky Kolja, Tani Yuji, Ben-Shlomo Anat, Ljubimov Vladimir, Mamelak Adam, Bannykh Serguei, Melmed Shlomo   Clusterin and FOXL2 act concordantly to regulate pituitary gonadotroph adenoma growth Molecular endocrinology (Baltimore, Md.), 2012; 26(12): 2092-103.
Toledano Yoel, Zonis Svetlana, Ren Song-Guang, Wawrowsky Kolja, Chesnokova Vera, Melmed Shlomo   Estradiol partially recapitulates murine pituitary cell cycle response to pregnancy Endocrinology, 2012; 153(10): 5011-22.
Tong Yunguang, Zheng Yun, Zhou Jin, Oyesiku Nelson M, Koeffler H Phillip, Melmed Shlomo   Genomic characterization of human and rat prolactinomas Endocrinology, 2012; 153(8): 3679-91.
Mamelak Adam N, Carmichael John, Bonert Vivien H, Cooper Odelia, Melmed Shlomo   Single-surgeon fully endoscopic endonasal transsphenoidal surgery: outcomes in three-hundred consecutive cases Pituitary, 2012; 153(10): .
Gruszka Anna, Culler Michael D, Melmed Shlomo   Somatostatin analogs and chimeric somatostatin-dopamine molecules differentially regulate human growth hormone and prolactin gene expression and secretion in vitro Molecular and cellular endocrinology, 2012; 362(1-2): 104-9.
Cooper Odelia, Melmed Shlomo   Subclinical hyperfunctioning pituitary adenomas: the silent tumors Best practice & research. Clinical endocrinology & metabolism, 2012; 26(4): 447-60.
Tong Yunguang, Zhou Jin, Mizutani Jun, Fukuoka Hidenori, Ren Song-Guang, Gutierrez-Hartmann Arthur, Koeffler H Phillip, Melmed Shlomo   CEBPD suppresses prolactin expression and prolactinoma cell proliferation Molecular endocrinology (Baltimore, Md.), 2011; 25(11): 1880-91.
Melmed Shlomo, Casanueva Felipe F, Hoffman Andrew R, Kleinberg David L, Montori Victor M, Schlechte Janet A, Wass John A H, Wass John A H   Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline The Journal of clinical endocrinology and metabolism, 2011; 96(2): 273-88.
Fukuoka Hidenori, Cooper Odelia, Ben-Shlomo Anat, Mamelak Adam, Ren Song-Guang, Bruyette Dave, Melmed Shlomo   EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas The Journal of clinical investigation, 2011; 121(12): 4712-21.
Cooper Odelia, Vlotides George, Fukuoka Hidenori, Greene Mark I, Melmed Shlomo   Expression and function of ErbB receptors and ligands in the pituitary Endocrine-related cancer, 2011; 18(6): R197-211.
Fukuoka Hidenori, Cooper Odelia, Mizutani Jun, Tong Yunguang, Ren Song-Guang, Bannykh Serguei, Melmed Shlomo   HER2/ErbB2 receptor signaling in rat and human prolactinoma cells: strategy for targeted prolactinoma therapy Molecular endocrinology (Baltimore, Md.), 2011; 25(1): 92-103.
Chesnokova Vera, Zonis Svetlana, Zhou Cuiqi, Ben-Shlomo Anat, Wawrowsky Kolja, Toledano Yoel, Tong Yunguang, Kovacs Kalman, Scheithauer Bernd, Melmed Shlomo   Lineage-specific restraint of pituitary gonadotroph cell adenoma growth PloS one, 2011; 6(3): e17924.
Tong Yunguang, Zhao Weijiang, Zhou Cuiqi, Wawrowsky Kolja, Melmed Shlomo   PTTG1 attenuates drug-induced cellular senescence PloS one, 2011; 6(8): e23754.
Melmed Shlomo   Pathogenesis of pituitary tumors Nature reviews. Endocrinology, 2011; 7(5): 257-66.
Hoffman Andrew R, Melmed Shlomo, Schlechte Janet   Patient guide to hyperprolactinemia diagnosis and treatment The Journal of clinical endocrinology and metabolism, 2011; 96(2): 35A-6A.
Famini Pouyan, Maya Marcel M, Melmed Shlomo   Pituitary magnetic resonance imaging for sellar and parasellar masses: ten-year experience in 2598 patients The Journal of clinical endocrinology and metabolism, 2011; 96(6): 1633-41.
Liu Ning-Ai, Jiang Hong, Ben-Shlomo Anat, Wawrowsky Kolja, Fan Xue-Mo, Lin Shuo, Melmed Shlomo   Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(20): 8414-9.
Ríos Yesenia, Melmed Shlomo, Lin Shuo, Liu Ning-Ai   Zebrafish usp39 mutation leads to rb1 mRNA splicing defect and pituitary lineage expansion PLoS genetics, 2011; 7(1): e1001271.
Ben-Shlomo Anat, Wawrowsky Kolja, Melmed Shlomo   Constitutive activity of somatostatin receptor subtypes Methods in enzymology, 2010; 484(2): 149-64.
Webb Susan M, Mo Daojun, Lamberts Steven W J, Melmed Shlomo, Cavagnini Francesco, Pecori Giraldi Francesca, Strasburger Christian J, Zimmermann Alan G, Woodmansee Whitney W, Woodmansee Whitney W   Metabolic, cardiovascular, and cerebrovascular outcomes in growth hormone-deficient subjects with previous cushing's disease or non-functioning pituitary adenoma The Journal of clinical endocrinology and metabolism, 2010; 95(2): 630-8.
Chesnokova Vera, Zonis Svetlana, Ben-Shlomo Anat, Wawrowsky Kolja, Melmed Shlomo   Molecular mechanisms of pituitary adenoma senescence Frontiers of hormone research, 2010; 38(2): 7-14.
Yu Run, Melmed Shlomo   Pathogenesis of pituitary tumors Progress in brain research, 2010; 182(1): 207-27.
Chesnokova Vera, Melmed Shlomo   Pituitary senescence: the evolving role of Pttg Molecular and cellular endocrinology, 2010; 326(1-2): 55-9.
Ben-Shlomo Anat, Melmed Shlomo   Pituitary somatostatin receptor signaling Trends in endocrinology and metabolism: TEM, 2010; 21(3): 123-33.
Cooper Odelia, Ben-Shlomo Anat, Bonert Vivien, Bannykh Serguei, Mirocha James, Melmed Shlomo   Silent corticogonadotroph adenomas: clinical and cellular characteristics and long-term outcomes Hormones & cancer, 2010; 1(2): 80-92.
Klibanski Anne, Melmed Shlomo, Clemmons David R, Colao Annamaria, Cunningham Regina S, Molitch Mark E, Vinik Aaron I, Adelman Daphne T, Liebert Karen J P   The endocrine tumor summit 2008: appraising therapeutic approaches for acromegaly and carcinoid syndrome Pituitary, 2010; 13(3): 266-86.
Melmed Shlomo   Acromegaly pathogenesis and treatment The Journal of clinical investigation, 2009; 119(11): 3189-202.
Webb Susan M, Strasburger Christian J, Mo Daojun, Hartman Mark L, Melmed Shlomo, Jung Heike, Blum Werner F, Attanasio Andrea F, Attanasio Andrea F   Changing patterns of the adult growth hormone deficiency diagnosis documented in a decade-long global surveillance database The Journal of clinical endocrinology and metabolism, 2009; 94(2): 392-9.
Ben-Shlomo Anat, Zhou Cuiqi, Pichurin Oxana, Chesnokova Vera, Liu Ning-Ai, Culler Michael D, Melmed Shlomo   Constitutive somatostatin receptor activity determines tonic pituitary cell response Molecular endocrinology (Baltimore, Md.), 2009; 23(3): 337-48.
Ben-Shlomo Anat, Schmid Herbert, Wawrowsky Kolja, Pichurin Oxana, Hubina Erika, Chesnokova Vera, Liu Ning-Ai, Culler Michael, Melmed Shlomo   Differential ligand-mediated pituitary somatostatin receptor subtype signaling: implications for corticotroph tumor therapy The Journal of clinical endocrinology and metabolism, 2009; 94(11): 4342-50.
Zhou Cuiqi, Wawrowsky Kolja, Bannykh Serguei, Gutman Shiri, Melmed Shlomo   E2F1 induces pituitary tumor transforming gene (PTTG1) expression in human pituitary tumors Molecular endocrinology (Baltimore, Md.), 2009; 23(12): 2000-12.
Vlotides George, Chen Yen-Hao, Eigler Tamar, Ren Song-Guang, Melmed Shlomo   Fibroblast growth factor-2 autofeedback regulation in pituitary folliculostellate TtT/GF cells Endocrinology, 2009; 150(7): 3252-8.
Vlotides George, Cooper Odelia, Chen Yen-Hao, Ren Song-Guang, Greenman Yona, Melmed Shlomo   Heregulin regulates prolactinoma gene expression Cancer research, 2009; 69(10): 4209-16.
Arzt Eduardo, Chesnokova Vera, Stalla Günter K, Melmed Shlomo   Pituitary adenoma growth: a model for cellular senescence and cytokine action Cell cycle (Georgetown, Tex.), 2009; 8(5): 677-8.
Chesnokova Vera, Melmed Shlomo   Pituitary tumour-transforming gene (PTTG) and pituitary senescence Hormone research, 2009; 71 Suppl 2(10): 82-7.
Carmichael John D, Bonert Vivien S, Mirocha James M, Melmed Shlomo   The utility of oral glucose tolerance testing for diagnosis and assessment of treatment outcomes in 166 patients with acromegaly The Journal of clinical endocrinology and metabolism, 2009; 94(2): 523-7.
Murray Robert D, Melmed Shlomo   A critical analysis of clinically available somatostatin analog formulations for therapy of acromegaly The Journal of clinical endocrinology and metabolism, 2008; 93(8): 2957-68.
Ben-Shlomo Anat, Melmed Shlomo   Acromegaly Endocrinology and metabolism clinics of North America, 2008; 37(1): 101-22, viii.
Melmed Gil Y, Devlin Shane M, Vlotides George, Dhall Deepti, Ross Soraya, Yu Run, Melmed Shlomo   Anti-aging therapy with human growth hormone associated with metastatic colon cancer in a patient with Crohn's colitis Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2008; 6(3): 360-3.
Liu Ning-Ai, Ren Meina, Song Jianbo, Ríos Yesenia, Wawrowsky Kolja, Ben-Shlomo Anat, Lin Shuo, Melmed Shlomo   In vivo time-lapse imaging delineates the zebrafish pituitary proopiomelanocortin lineage boundary regulated by FGF3 signal Developmental biology, 2008; 319(2): 192-200.
Bonert Vivien S, Kennedy Laurence, Petersenn Stephan, Barkan Ariel, Carmichael John, Melmed Shlomo   Lipodystrophy in patients with acromegaly receiving pegvisomant The Journal of clinical endocrinology and metabolism, 2008; 93(9): 3515-8.
Zhou Cuiqi, Tong Yunguang, Wawrowsky Kolja, Bannykh Serguei, Donangelo Ines, Melmed Shlomo   Oct-1 induces pituitary tumor transforming gene expression in endocrine tumors Endocrine-related cancer, 2008; 15(3): 817-31.
Cooper Odelia, Geller Jordan L, Melmed Shlomo   Ovarian hyperstimulation syndrome caused by an FSH-secreting pituitary adenoma Nature clinical practice. Endocrinology & metabolism, 2008; 4(4): 234-8.
Vlotides George, Siegel Emily, Donangelo Ines, Gutman Shiri, Ren Song-Guang, Melmed Shlomo   Rat prolactinoma cell growth regulation by epidermal growth factor receptor ligands Cancer research, 2008; 68(15): 6377-86.
Ben-Shlomo Anat, Melmed Shlomo   Somatostatin agonists for treatment of acromegaly Molecular and cellular endocrinology, 2008; 286(1-2): 192-8.
Melmed Shlomo   Update in pituitary disease The Journal of clinical endocrinology and metabolism, 2008; 93(2): 331-8.
Chesnokova Vera, Zonis Svetlana, Kovacs Kalman, Ben-Shlomo Anat, Wawrowsky Kolja, Bannykh Serguei, Melmed Shlomo   p21(Cip1) restrains pituitary tumor growth Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(45): 17498-503.
Melmed Shlomo   Aryl hydrocarbon receptor interacting protein and pituitary tumorigenesis: another interesting protein The Journal of clinical endocrinology and metabolism, 2007; 92(5): 1617-9.
Rubinek Tami, Chesnokova Vera, Wolf Ido, Wawrowsky Kolja, Vlotides George, Melmed Shlomo   Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells American journal of physiology. Cell physiology, 2007; 293(3): C1082-92.
Ben-Shlomo Anat, Melmed Shlomo   Pasireotide--a somatostatin analog for the potential treatment of acromegaly, neuroendocrine tumors and Cushing's disease IDrugs : the investigational drugs journal, 2007; 10(12): 885-95.
Vlotides George, Eigler Tamar, Melmed Shlomo   Pituitary tumor-transforming gene: physiology and implications for tumorigenesis Endocrine reviews, 2007; 28(2): 165-86.
Gruszka Anna, Ren Song-Guang, Dong Jesse, Culler Michael D, Melmed Shlomo   Regulation of growth hormone and prolactin gene expression and secretion by chimeric somatostatin-dopamine molecules Endocrinology, 2007; 148(12): 6107-14.
Ben-Shlomo Anat, Pichurin Oxana, Barshop Nicole J, Wawrowsky Kolja A, Taylor John, Culler Michael D, Chesnokova Vera, Liu Ning-Ai, Melmed Shlomo   Selective regulation of somatostatin receptor subtype signaling: evidence for constitutive receptor activation Molecular endocrinology (Baltimore, Md.), 2007; 21(10): 2565-78.
Chesnokova Vera, Zonis Svetlana, Rubinek Tami, Yu Run, Ben-Shlomo Anat, Kovacs Kalman, Wawrowsky Kolja, Melmed Shlomo   Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth Cancer research, 2007; 67(21): 10564-72.
Melmed Shlomo   2004 World Health Organization classification of pituitary tumors: what is new? Acta neuropathologica, 2006; 111(1): 78-9.
Bonert Vivien S, Melmed Shlomo   Acromegaly with moderate hyperprolactinemia caused by an intrasellar macroadenoma Nature clinical practice. Endocrinology & metabolism, 2006; 2(7): 408-12; quiz following 412.
Yu Run, Bonert Vivien, Saporta Inbar, Raffel Leslie J, Melmed Shlomo   Aryl hydrocarbon receptor interacting protein variants in sporadic pituitary adenomas The Journal of clinical endocrinology and metabolism, 2006; 91(12): 5126-9.
Yu Run, Bonert Vivien, Cruz-Soto Martha, Melmed Shlomo   Cyclin-dependent kinase inhibitor gene polymorphisms in pituitary gigantism Endocrine, 2006; 29(1): 119-20.
Donangelo Ines, Melmed Shlomo   Implication of pituitary tropic status on tumor development Frontiers of hormone research, 2006; 35(1): 1-8.
Melmed Shlomo   Medical progress: Acromegaly The New England journal of medicine, 2006; 355(24): 2558-73.
Yu Run, Cruz-Soto Martha, Li Calzi Sergio, Hui Hongxiang, Melmed Shlomo   Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells The Journal of endocrinology, 2006; 191(1): 45-53.
Donangelo Ines, Gutman Shiri, Horvath Eva, Kovacs Kalman, Wawrowsky Kolja, Mount Michael, Melmed Shlomo   Pituitary tumor transforming gene overexpression facilitates pituitary tumor development Endocrinology, 2006; 147(10): 4781-91.
Liu Ning-Ai, Liu Qian, Wawrowsky Kolja, Yang Zhongan, Lin Shuo, Melmed Shlomo   Prolactin receptor signaling mediates the osmotic response of embryonic zebrafish lactotrophs Molecular endocrinology (Baltimore, Md.), 2006; 20(4): 871-80.
Ren Song-Guang, Melmed Shlomo   Pyridoxal phosphate inhibits pituitary cell proliferation and hormone secretion Endocrinology, 2006; 147(8): 3936-42.
Ben-Shlomo Anat, Melmed Shlomo   Skin manifestations in acromegaly Clinics in dermatology, 2006; 24(4): 256-9.
Melmed Shlomo   Supplemental growth hormone in healthy adults: the endocrinologist's responsibility Nature clinical practice. Endocrinology & metabolism, 2006; 2(3): 119.
Melmed Shlomo, Sternberg Richard, Cook David, Klibanski Anne, Chanson Philippe, Bonert Vivien, Vance Mary Lee, Rhew David, Kleinberg David, Barkan Ariel   A critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly The Journal of clinical endocrinology and metabolism, 2005; 90(7): 4405-10.
Akino Kozo, Akita Sadanori, Mizuguchi Toru, Takumi Ichiro, Yu Run, Wang Xhi-yong, Rozga Jacek, Demetriou Achilles A, Melmed Shlomo, Ohtsuru Akira, Yamashita Shunichi   A novel molecular marker of pituitary tumor transforming gene involves in a rat liver regeneration The Journal of surgical research, 2005; 129(1): 142-6.
Abbud Rula A, Takumi Ichiro, Barker Erin M, Ren Song-Guang, Chen Dar-Yong, Wawrowsky Kolja, Melmed Shlomo   Early multipotential pituitary focal hyperplasia in the alpha-subunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice Molecular endocrinology (Baltimore, Md.), 2005; 19(5): 1383-91.
Chesnokova Vera, Kovacs Kalman, Castro Anna-Valeria, Zonis Svetlana, Melmed Shlomo   Pituitary hypoplasia in Pttg-/- mice is protective for Rb+/- pituitary tumorigenesis Molecular endocrinology (Baltimore, Md.), 2005; 19(9): 2371-9.
Ben-Shlomo Anat, Wawrowsky Kolja A, Proekt Irina, Wolkenfeld Nathaniel M, Ren Song-Guang, Taylor John, Culler Michael D, Melmed Shlomo   Somatostatin receptor type 5 modulates somatostatin receptor type 2 regulation of adrenocorticotropin secretion The Journal of biological chemistry, 2005; 280(25): 24011-21.
Donangelo Ines, Melmed Shlomo   Treatment of acromegaly: future Endocrine, 2005; 28(1): 123-8.
Bronstein Marcello D, Melmed Shlomo   [Pituitary tumorigenesis] Arquivos brasileiros de endocrinologia e metabologia, 2005; 49(5): 615-25.
Bonert Vivien S, Elashoff Janet D, Barnett Philip, Melmed Shlomo   Body mass index determines evoked growth hormone (GH) responsiveness in normal healthy male subjects: diagnostic caveat for adult GH deficiency The Journal of clinical endocrinology and metabolism, 2004; 89(7): 3397-401.
Murray Robert D, Kim Kiwon, Ren Song-Guang, Chelly Marjorie, Umehara Yutaka, Melmed Shlomo   Central and peripheral actions of somatostatin on the growth hormone-IGF-I axis The Journal of clinical investigation, 2004; 114(3): 349-56.
Heaney Anthony P, Melmed Shlomo   Molecular targets in pituitary tumours Nature reviews. Cancer, 2004; 4(4): 285-95.
Yu Run, Melmed Shlomo   Pituitary tumor transforming gene: an update Frontiers of hormone research, 2004; 32(2): 175-85.
Murray Robert D, Kim Kiwon, Ren Song-Guang, Lewis Ian, Weckbecker Gisbert, Bruns Christian, Melmed Shlomo   The novel somatostatin ligand (SOM230) regulates human and rat anterior pituitary hormone secretion The Journal of clinical endocrinology and metabolism, 2004; 89(6): 3027-32.
Giustina Andrea, Melmed Shlomo   Acromegaly consensus: the next steps The Journal of clinical endocrinology and metabolism, 2003; 88(4): 1913-4.
Turner Helen E, Harris Adrian L, Melmed Shlomo, Wass John A H   Angiogenesis in endocrine tumors Endocrine reviews, 2003; 24(5): 600-32.
Ren Song-Guang, Taylor John, Dong Jesse, Yu Run, Culler Michael D, Melmed Shlomo   Functional association of somatostatin receptor subtypes 2 and 5 in inhibiting human growth hormone secretion The Journal of clinical endocrinology and metabolism, 2003; 88(9): 4239-45.
Melmed Shlomo   Mechanisms for pituitary tumorigenesis: the plastic pituitary The Journal of clinical investigation, 2003; 112(11): 1603-18.
Clemmons David R, Chihara Kazuo, Freda Pamela U, Ho Ken K Y, Klibanski Anne, Melmed Shlomo, Shalet Stephen M, Strasburger Christian J, Trainer Peter J, Thorner Michael O   Optimizing control of acromegaly: integrating a growth hormone receptor antagonist into the treatment algorithm The Journal of clinical endocrinology and metabolism, 2003; 88(10): 4759-67.
Yu Run, Lu Wenge, Chen Jiandong, McCabe Chris J, Melmed Shlomo   Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells Endocrinology, 2003; 144(11): 4991-8.
Heaney Anthony P, Fernando Manory, Melmed Shlomo   PPAR-gamma receptor ligands: novel therapy for pituitary adenomas The Journal of clinical investigation, 2003; 111(9): 1381-8.
Liu Ning-Ai, Huang Haigen, Yang Zhongan, Herzog Wiebke, Hammerschmidt Matthias, Lin Shuo, Melmed Shlomo   Pituitary corticotroph ontogeny and regulation in transgenic zebrafish Molecular endocrinology (Baltimore, Md.), 2003; 17(5): 959-66.
Ren Song-Guang, Kim Sun, Taylor John, Dong Josse, Moreau Jacques-Pierre, Culler Michael D, Melmed Shlomo   Suppression of rat and human growth hormone and prolactin secretion by a novel somatostatin/dopaminergic chimeric ligand The Journal of clinical endocrinology and metabolism, 2003; 88(11): 5414-21.
Heaney Anthony P, Fernando Manory, Yong William H, Melmed Shlomo   Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas Nature medicine, 2002; 8(11): 1281-7.

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ACTH-Secreting Pituitary Adenoma Accounting Acromegaly Adenoma Adolescent Adrenal Glands Adrenocorticotropic Hormone Adult Aged Aged, 80 and over Aging Amino Acid Sequence Aneuploidy Animals Animals, Genetically Modified Antineoplastic Agents Antineoplastic Agents, Hormonal Apoptosis Arginine Autoradiography Bacterial Secretion Systems Base Sequence Blotting, Western Bodily Secretions Bromodeoxyuridine CCAAT-Enhancer-Binding Protein-beta Cardiovascular Diseases Cell Aging Cell Culture Techniques Cell Cycle Cell Cycle Proteins Cell Differentiation Cell Division Cell Line Cell Line, Tumor Cell Lineage Cell Proliferation Cell Transformation, Neoplastic Cell Transformation, Viral Cells Cells, Cultured Child Chloramphenicol Chromatin Immunoprecipitation Chromosomal Instability Chromosome Walking Clone Cells Clusterin Colonic Neoplasms Comorbidity Corticosterone Cyclic AMP Cyclin D1 Cyclin E Cyclin-Dependent Kinase Inhibitor p21 Cycloheximide DNA DNA Damage DNA Primers DNA-Binding Proteins Diabetes Mellitus Diagnostic Techniques, Endocrine Disease Disease Progression Dopamine Dopamine Agonists Dose-Response Relationship, Drug Endocrine Gland Neoplasms Endocrinology Endopeptidases Estrogens Fertility Flow Cytometry Fluids and Secretions Fluorescent Antibody Technique Follicle Stimulating Hormone Follow-Up Studies Forkhead Transcription Factors G1 Phase Gene Deletion Gene Expression Gene Expression Regulation Gene Expression Regulation, Developmental Gene Expression Regulation, Neoplastic Genes Genotype Germ-Line Mutation Gonadotrophs Gonadotropins Green Fluorescent Proteins Growth Growth Disorders Growth Hormone Growth Hormone-Releasing Hormone Growth Hormone-Secreting Pituitary Adenoma Health Hepatocytes Heterozygote Hormones Human Growth Hormone Humans Hybrid Cells Hydrocortisone Hyperglycemia Hyperplasia Hyperprolactinemia Hypothalamus Immunohistochemistry Immunoprecipitation In Situ Hybridization Infertility Insulin Insulin-Like Growth Factor I Interleukin-6 Internet Intestinal Secretions Laboratories Leukemia Inhibitory Factor Ligands Luminescent Proteins Magnetic Resonance Imaging Metabolism Methylation Mice Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains Mice, Nude Mice, Transgenic Microscopy, Confocal Microscopy, Fluorescence Middle Aged Mitosis Models, Biological Molecular Sequence Data Molecular Targeted Therapy Mutation Neoplasm Proteins Neoplasm Transplantation Neoplasms Neuregulin-1 Neuroendocrine Tumors Neurosecretion Nuclear Proteins Nucleic Acid Hybridization Nucleic Acid Probes Octreotide Oligonucleotide Array Sequence Analysis Oncogenes Organ Size Osteoporosis Pathologic Processes Patients Penetrance Peptides Peptides, Cyclic Phosphorylation Pituitary ACTH Hypersecretion Pituitary Diseases Pituitary Gland Pituitary Gland, Anterior Pituitary Hormones Pituitary Neoplasms Point Mutation Polymerase Chain Reaction Population Surveillance Pregnancy Pro-Opiomelanocortin Prognosis Prolactin Prolactinoma Promoter Regions, Genetic Protein Binding Protein-Serine-Threonine Kinases Proteins Puromycin Quinazolines RNA Interference RNA, Messenger RNA, Small Interfering Radioimmunoassay Rats Rats, Sprague-Dawley Receptor, Epidermal Growth Factor Receptor, erbB-2 Receptors, Dopamine Receptors, Dopamine D2 Receptors, Somatostatin Receptors, Somatotropin Recombinant Fusion Proteins Retinoblastoma Protein Retrospective Studies Role S Phase Sella Turcica Sex Chromosomes Signal Transduction Somatostatin Sp1 Transcription Factor Thyroid Gland Tissues Trans-Activators Transcription Factor Pit-1 Transcription Factors Transcription, Genetic Transfection Travel Tumor Cells, Cultured Tumor Suppressor Protein p53 Tumor Suppressor Proteins Up-Regulation Zebrafish Zebrafish Proteins

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