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Shaping the Future

Moshe Arditi, M.D.

Contact Information:

Fax Number:

310-423-8284

Work Phone Number:

310-423-4471

Mailing Address:

Cedars-Sinai Medl Cntr-Peds/ID
8700 Beverly Blvd, Rm 4211 N Twr
Los Angeles, CA 90048
UNITED STATES

Work Address:

Office
MDCC/CSMC
Los Angeles, CA 90095
UNITED STATES

Work Email Address:

moshe.arditi@cshs.org

Website:

  

Home Page:

     Web-Profile


Vice-Chair, Research, Pediatrics

Vice President, Pediatrics for Research

Editor, Pediatrics

Member, CTSI

Child Health Research


A Short Biography:

I am Vice-Chair of Pediatrics for Research at Cedars-Sinai Medical Center and Director of the Division of Pediatric Infectious Diseases and Immunology at Cedars-Sinai Medical Center. In addition, I am a Professor of Pediatrics at the David Geffen School of Medicine at UCLA. I am also a member of the Immunobiology Institute at Cedars-Sinai Medical Center and my major scientific contributions have been in the area of host-pathogen interactions, molecular pathogenesis of bacterial infections, role of innate immunity and Toll-Like Receptors in various infections and infection-induced acute and chronic inflammatory diseases, such as Allergic Asthma, Atherosclerosis. My research program has been at the cutting edge of advancing our knowledge on the pathogenesis of Pulmonary bacterial infections and inflammation; Chlamydia Pneumoniae-induced allergic sensitization and asthma and acceleration of atherosclerosis, mouse models of immune-mediated Coronary arteritis models (Mouse model for Kawasaki Disease). Each of these research projects is supported by relevant mouse models and NIH grants. My laboratory was the first to link TLRs and Atherosclerosis and published the seminal observations that high-fat diet-induced atherosclerosis is significantly diminished in ApoE-MyD88 double KO mice. I have has successfully mentored a number of clinical and research fellows, post-docs and junior faculty and guided them into independently funded scientists or clinician-scientist careers. I am the PI of a Training Grant (T32) in Immunobiology that was funded in Sep 2010. I will serve as a member of The Committee on Child Health Research and as an Ad Hoc reviewer for the CTSI.

Publications:

Sorrentino Rosalinda, Gray Pearl, Chen Shuang, Shimada Kenichi, Crother Timothy R, Arditi Moshe   Plasmacytoid dendritic cells prevent cigarette smoke and Chlamydophila pneumoniae-induced Th2 inflammatory responses American journal of respiratory cell and molecular biology, 2010; 43(4): 422-31.
Gray Pearl, Michelsen Kathrin S, Sirois Cherilyn M, Lowe Emily, Shimada Kenichi, Crother Timothy R, Chen Shuang, Brikos Constantinos, Bulut Yonca, Latz Eicke, Underhill David, Arditi Moshe   Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling Journal of immunology (Baltimore, Md. : 1950), 2010; 184(11): 6359-66.
Schulte Danica J, Yilmaz Atilla, Shimada Kenichi, Fishbein Michael C, Lowe Emily L, Chen Shuang, Wong Michelle, Doherty Terence M, Lehman Thomas, Crother Timothy R, Sorrentino Rosalinda, Arditi Moshe   Involvement of innate and adaptive immunity in a murine model of coronary arteritis mimicking Kawasaki disease Journal of immunology (Baltimore, Md. : 1950), 2009; 183(8): 5311-8.
Bulut Yonca, Shimada Kenichi, Wong Michelle H, Chen Shuang, Gray Pearl, Alsabeh Randa, Doherty Terence M, Crother Timothy R, Arditi Moshe   Chlamydial heat shock protein 60 induces acute pulmonary inflammation in mice via the Toll-like receptor 4- and MyD88-dependent pathway Infection and immunity, 2009; 77(7): 2683-90.
Karahashi Hisae, Michelsen Kathrin S, Arditi Moshe   Lipopolysaccharide-induced apoptosis in transformed bovine brain endothelial cells and human dermal microvessel endothelial cells: the role of JNK Journal of immunology (Baltimore, Md. : 1950), 2009; 182(11): 7280-6.
Shimada Kenichi, Chen Shuang, Dempsey Paul W, Sorrentino Rosalinda, Alsabeh Randa, Slepenkin Anatoly V, Peterson Ellena, Doherty Terence M, Underhill David, Crother Timothy R, Arditi Moshe   The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection PLoS pathogens, 2009; 5(4): e1000379.
Yilmaz Atilla, Arditi Moshe   Giant cell arteritis: dendritic cells take two T's to tango Circulation research, 2009; 104(4): 425-7.
Curtin James F, Liu Naiyou, Candolfi Marianela, Xiong Weidong, Assi Hikmat, Yagiz Kader, Edwards Matthew R, Michelsen Kathrin S, Kroeger Kurt M, Liu Chunyan, Muhammad A K M Ghulam, Clark Mary C, Arditi Moshe, Comin-Anduix Begonya, Ribas Antoni, Lowenstein Pedro R, Castro Maria G   HMGB1 mediates endogenous TLR2 activation and brain tumor regression PLoS medicine, 2009; 6(1): e10.
Wei Bo, Su Thomas T, Dalwadi Harnisha, Stephan Robert P, Fujiwara Daisuke, Huang Tiffany T, Brewer Sarah, Chen Lindy, Arditi Moshe, Borneman James, Rawlings David J, Braun Jonathan   Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells European journal of immunology, 2008; 38(12): 3411-25.
Chen Shuang, Sorrentino Rosalinda, Shimada Kenichi, Bulut Yonca, Doherty Terence M, Crother Timothy R, Arditi Moshe   Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation Journal of immunology (Baltimore, Md. : 1950), 2008; 181(10): 7186-93.
Naiki Yoshikazu, Sorrentino Rosalinda, Wong Michelle H, Michelsen Kathrin S, Shimada Kenichi, Chen Shuang, Yilmaz Atilla, Slepenkin Anatoly, Schröder Nicolas W J, Crother Timothy R, Bulut Yonca, Doherty Terence M, Bradley Michelle, Shaposhnik Zory, Peterson Ellena M, Tontonoz Peter, Shah Prediman K, Arditi Moshe   TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis Journal of immunology (Baltimore, Md. : 1950), 2008; 181(10): 7176-85.
Schröder Nicolas W J, Crother Timothy R, Naiki Yoshikazu, Chen Shuang, Wong Michelle H, Yilmaz Atilla, Slepenkin Anatoly, Schulte Danica, Alsabeh Randa, Doherty Terence M, Peterson Ellena, Nel Andre E, Arditi Moshe   Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitization The Journal of allergy and clinical immunology, 2008; 122(3): 595-602.e5.
Velázquez Peter, Wei Bo, McPherson Michael, Mendoza Lesley Marie A, Nguyen Sandra L, Turovskaya Olga, Kronenberg Mitchell, Huang Tiffany T, Schrage Matthew, Lobato Lynn N, Fujiwara Daisuke, Brewer Sarah, Arditi Moshe, Cheng Genhong, Sartor R Balfour, Newberry Rodney D, Braun Jonathan   Villous B cells of the small intestine are specialized for invariant NK T cell dependence Journal of immunology (Baltimore, Md. : 1950), 2008; 180(7): 4629-38.
Shuang Chen Moshe, Wong Michelle H, Schulte Danica J, Arditi Moshe, Michelsen Kathrin S   Differential expression of Toll-like receptor 2 (TLR2) and responses to TLR2 ligands between human and murine vascular endothelial cells Journal of endotoxin research, 2007; 13(5): 281-96.
Schröder Nicolas W J, Arditi Moshe   The role of innate immunity in the pathogenesis of asthma: evidence for the involvement of Toll-like receptor signaling Journal of endotoxin research, 2007; 13(5): 305-12.
Michelsen Kathrin S, Doherty Terence M, Shah Prediman K, Arditi Moshe   Role of Toll-like receptors in atherosclerosis Circulation research, 2004; 95(12): e96-7.
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