Stephan R Targan

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of TL1A-driven Paneth Cell dysfunction in IBD
    NIH R01DK123511Jan 1, 2020 - Dec 31, 2023
    Role: Principal Investigator
    Molecular characterization of the role of RNASET2 in Severe Crohn's Disease
    NIH R01DK117893Sep 19, 2019 - Jul 31, 2022
    Role: Principal Investigator
    A genetic model of inflammatory bowel disease using human intestinal organoids.
    NIH R56DK106202Sep 5, 2015 - Aug 31, 2017
    Role: Principal Investigator
    Role of TRIF-Dependent TLR Signaling in Intestinal Mucosa
    NIH R01AI095255Jul 1, 2012 - Jun 30, 2022
    Role: Principal Investigator
    The Cedars-Sinai Immunobiology Training Program
    NIH T32AI089553Sep 1, 2010 - Mar 5, 2018
    Role: Co-Principal Investigator
    Role of TL1A in Severity of Crohn's Disease
    NIH R01DK056328Aug 15, 1999 - Jul 31, 2020
    Role: Principal Investigator
    IBD: Role of Genetic and Immunopathologic Mechanisms
    NIH P01DK046763Sep 30, 1992 - Jul 31, 2021
    Role: Principal Investigator
    IBD: Mucosa Specific Regulation of IFN-gamma Production
    NIH R37DK043211Sep 20, 1991 - Feb 28, 2017
    Role: Principal Investigator
    IBD--MUCOSA-SPECIFIC REGULATION OF IFN-GAMMA PRODUCTION
    NIH R01DK043211Sep 20, 1991 - Dec 31, 2005
    Role: Principal Investigator
    IBD: ROLE OF ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES
    NIH R01DK043026Jun 15, 1991 - May 31, 1995
    Role: Principal Investigator
    MECHANISM OF THE NK LETHAL HIT IN PROGRAMMED TUMOR CELLS
    NIH R01CA037205Mar 15, 1984 - Mar 31, 1991
    Role: Principal Investigator
    INFLAMMATORY BOWEL DISEASE: NK ACTIVITY IN GUT MUCOSA
    NIH R01AM027806Aug 1, 1981 - Jul 31, 1988
    Role: Principal Investigator
    INFLAMMATORY BOWEL DISEASE: NK ACTIVITY IN GUT MUCOSA
    NIH R01DK027806Aug 1, 1981 - Jul 31, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn's disease. World J Gastrointest Surg. 2024 Mar 27; 16(3):740-750. Gu P, Dube S, Gellada N, Choi SY, Win S, Lee YJ, Yang S, Haritunians T, Melmed GY, Vasiliauskas EA, Bonthala N, Syal G, Yarur AJ, Ziring D, Rabizadeh S, Fleshner P, Kallman C, Devkota S, Targan SR, Li D, McGovern DP. PMID: 38577075; PMCID: PMC10989343.
      View in: PubMed   Mentions:
    2. Comprehensive association analyses of extraintestinal manifestations in inflammatory bowel disease. Gastroenterology. 2024 Feb 27. Khrom M, Long M, Dube S, Robbins L, Botwin GJ, Yang S, Mengesha E, Li D, Naito T, Bonthala NN, Ha C, Melmed G, Rabizadeh S, Syal G, Vasiliauskas E, Ziring D, Brant SR, Cho J, Duerr RH, Rioux J, Schumm P, Silverberg M, Ananthakrishnan AN, Faubion WA, Jabri B, Lira SA, Newberry RD, Sandler RS, Xavier RJ, Kugathasan S, Hercules D, Targan SR, Sartor RB, Haritunians T, McGovern DPB. PMID: 38490347.
      View in: PubMed   Mentions:    Fields:    
    3. Comparative Persistence of Non-tumor Necrosis Factor (TNF) vs. TNF Antagonists for Post-operative Prophylaxis in Crohn's Disease (CD). Dig Dis Sci. 2024 Jan; 69(1):235-245. Gu P, Dube S, Lee Y, Yang S, Li D, Haritunians T, Vasiliauskas E, Bonthala N, Syal G, Yarur A, Ziring D, Targan S, Rabizadeh S, Melmed GY, Fleshner P, McGovern DPB. PMID: 38015321; PMCID: PMC10787872.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Higher Intra-Abdominal Visceral Adipose Tissue Mass Is Associated With Lower Rates of Clinical and Endoscopic Remission in Patients With Inflammatory Bowel Diseases Initiating Biologic Therapy: Results of the Constellation Study. Gastroenterology. 2023 10; 165(4):963-975.e5. Yarur AJ, Bruss A, Moosreiner A, Beniwal-Patel P, Nunez L, Berens B, Colombel JF, Targan SR, Fox C, Melmed GY, Abreu MT, Deepak P. PMID: 37499955; PMCID: PMC10589067.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Evolution of Symptoms After Ustekinumab Induction Therapy in Patients With Crohn's Disease. Clin Gastroenterol Hepatol. 2024 01; 22(1):144-153.e2. Colombel JF, Sands BE, Gasink C, Yeager B, Adedokun OJ, Izanec J, Ma T, Gao LL, Lee SD, Targan SR, Ghosh S, Hanauer SB, Sandborn WJ. PMID: 37391056.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    6. Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis. Gut. 2023 11; 72(11):2068-2080. Akhlaghpour M, Haritunians T, More SK, Thomas LS, Stamps DT, Dube S, Li D, Yang S, Landers CJ, Mengesha E, Hamade H, Murali R, Potdar AA, Wolf AJ, Botwin GJ, Khrom M, International IBD Genetics Consortium, Ananthakrishnan AN, Faubion WA, Jabri B, Lira SA, Newberry RD, Sandler RS, Sartor RB, Xavier RJ, Brant SR, Cho JH, Duerr RH, Lazarev MG, Rioux JD, Schumm LP, Silverberg MS, Zaghiyan K, Fleshner P, Melmed GY, Vasiliauskas EA, Ha C, Rabizadeh S, Syal G, Bonthala NN, Ziring DA, Targan SR, Long MD, McGovern DPB, Michelsen KS. PMID: 37080587.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. DR3 Regulates Intestinal Epithelial Homeostasis and Regeneration After Intestinal Barrier Injury. Cell Mol Gastroenterol Hepatol. 2023; 16(1):83-105. Shimodaira Y, More SK, Hamade H, Blackwood AY, Abraham JP, Thomas LS, Miller JH, Stamps DT, Castanon SL, Jacob N, Ha CWY, Devkota S, Shih DQ, Targan SR, Michelsen KS. PMID: 37011811; PMCID: PMC10213104.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    8. Diagnostic and therapeutic potential of RNASET2 in Crohn's disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion. Front Immunol. 2022; 13:999155. Biener-Ramanujan E, Rosier F, Coetzee SG, McGovern DDP, Hazelett D, Targan SR, Gonsky R. PMID: 36466822; PMCID: PMC9709281.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Combination Therapy With Immunomodulators Improves the Pharmacokinetics of Infliximab But Not Vedolizumab or Ustekinumab. Clin Gastroenterol Hepatol. 2023 10; 21(11):2908-2917.e10. Yarur AJ, McGovern D, Abreu MT, Cheifetz A, Papamichail K, Deepak P, Bruss A, Beniwal-Patel P, Dubinsky M, Targan SR, Melmed GY. PMID: 36280102.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    10. Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility. Nat Genet. 2022 09; 54(9):1275-1283. Sazonovs A, Stevens CR, Venkataraman GR, Yuan K, Avila B, Abreu MT, Ahmad T, Allez M, Ananthakrishnan AN, Atzmon G, Baras A, Barrett JC, Barzilai N, Beaugerie L, Beecham A, Bernstein CN, Bitton A, Bokemeyer B, Chan A, Chung D, Cleynen I, Cosnes J, Cutler DJ, Daly A, Damas OM, Datta LW, Dawany N, Devoto M, Dodge S, Ellinghaus E, Fachal L, Farkkila M, Faubion W, Ferreira M, Franchimont D, Gabriel SB, Ge T, Georges M, Gettler K, Giri M, Glaser B, Goerg S, Goyette P, Graham D, Hämäläinen E, Haritunians T, Heap GA, Hiltunen M, Hoeppner M, Horowitz JE, Irving P, Iyer V, Jalas C, Kelsen J, Khalili H, Kirschner BS, Kontula K, Koskela JT, Kugathasan S, Kupcinskas J, Lamb CA, Laudes M, Lévesque C, Levine AP, Lewis JD, Liefferinckx C, Loescher BS, Louis E, Mansfield J, May S, McCauley JL, Mengesha E, Mni M, Moayyedi P, Moran CJ, Newberry RD, O'Charoen S, Okou DT, Oldenburg B, Ostrer H, Palotie A, Paquette J, Pekow J, Peter I, Pierik MJ, Ponsioen CY, Pontikos N, Prescott N, Pulver AE, Rahmouni S, Rice DL, Saavalainen P, Sands B, Sartor RB, Schiff ER, Schreiber S, Schumm LP, Segal AW, Seksik P, Shawky R, Sheikh SZ, Silverberg MS, Simmons A, Skeiceviciene J, Sokol H, Solomonson M, Somineni H, Sun D, Targan S, Turner D, Uhlig HH, van der Meulen AE, Vermeire S, Verstockt S, Voskuil MD, Winter HS, Young J, Belgium IBD Consortium, Cedars-Sinai IBD, International IBD Genetics Consortium, NIDDK IBD Genetics Consortium, NIHR IBD BioResource, Regeneron Genetics Center, SHARE Consortium, SPARC IBD Network, UK IBD Genetics Consortium, Duerr RH, Franke A, Brant SR, Cho J, Weersma RK, Parkes M, Xavier RJ, Rivas MA, Rioux JD, McGovern DPB, Huang H, Anderson CA, Daly MJ. PMID: 36038634; PMCID: PMC9700438.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    11. Crohn's disease in endoscopic remission, obesity, and cases of high genetic risk demonstrates overlapping shifts in the colonic mucosal-luminal interface microbiome. Genome Med. 2022 08 15; 14(1):91. Jacobs JP, Goudarzi M, Lagishetty V, Li D, Mak T, Tong M, Ruegger P, Haritunians T, Landers C, Fleshner P, Vasiliauskas E, Ippoliti A, Melmed G, Shih D, Targan S, Borneman J, Fornace AJ, McGovern DPB, Braun J. PMID: 35971134; PMCID: PMC9377146.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    12. BATF3 Protects Against Metabolic Syndrome and Maintains Intestinal Epithelial Homeostasis. Front Immunol. 2022; 13:841065. Hamade H, Stamps JT, Stamps DT, More SK, Thomas LS, Blackwood AY, Lahcene NL, Castanon SL, Salumbides BC, Shimodaira Y, Goodridge HS, Targan SR, Michelsen KS. PMID: 35812447; PMCID: PMC9257242.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    13. Development of a Personalized Intestinal Fibrosis Model Using Human Intestinal Organoids Derived From Induced Pluripotent Stem Cells. Inflamm Bowel Dis. 2022 05 04; 28(5):667-679. Estrada HQ, Patel S, Rabizadeh S, Casero D, Targan SR, Barrett RJ. PMID: 34918082; PMCID: PMC9074870.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    14. TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization. Oxid Med Cell Longev. 2021; 2021:3877617. Luo Y, Guo J, Jia W, Wu M, Yin F, Niu G, Shih DQ, Targan SR, Zhang X. PMID: 35003513; PMCID: PMC8741351.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    15. Performance Characteristics of a Clinical Decision Support Tool for Disease Complications in Crohn's Disease. Crohns Colitis 360. 2021 Oct; 3(4):otab074. Siegel CA, Siegel LS, Dubinsky MC, Targan S, Braun J, Landers C, Bilsborough J, Princen F, Lasch K, Candela N, McGovern DPB, Dervieux T. PMID: 36777269; PMCID: PMC9802159.
      View in: PubMed   Mentions: 3  
    16. Preoperative Serum Vedolizumab Levels Do Not Impact Postoperative Outcomes in Inflammatory Bowel Disease. Dis Colon Rectum. 2021 10 01; 64(10):1259-1266. Parrish AB, Lopez NE, Truong A, Zaghiyan K, Melmed GY, McGovern DPB, Ha C, Syal G, Bonthala N, Jain A, Landers CJ, Targan SR, Fleshner P. PMID: 34516445.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    17. Decreased Antibody Responses to Ad26.COV2.S Relative to SARS-CoV-2 mRNA Vaccines in Patients With Inflammatory Bowel Disease. Gastroenterology. 2021 12; 161(6):2041-2043.e1. Pozdnyakova V, Botwin GJ, Sobhani K, Prostko J, Braun J, Mcgovern DPB, Melmed GY, Appel K, Banty A, Feldman E, Ha C, Kumar R, Lee S, Rabizadeh S, Stein T, Syal G, Targan S, Vasiliauskas E, Ziring D, Debbas P, Hampton M, Mengesha E, Stewart JL, Frias EC, Cheng S, Ebinger J, Figueiredo JC, Boland B, Charabaty A, Chiorean M, Cohen E, Flynn A, Valentine J, Fudman D, Horizon A, Hou J, Hwang C, Lazarev M, Lum D, Fausel R, Reddy S, Mattar M, Metwally M, Ostrov A, Parekh N, Raffals L, Sheibani S, Siegel C, Wolf D, Younes Z. PMID: 34391771; PMCID: PMC8359492.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    18. Double-Balloon Endoscopy in Crohn Disease: A Tertiary Referral Center Experience. Inflamm Bowel Dis. 2021 07 27; 27(8):1248-1255. Halloran BP, Jamil LH, Lo SK, Reeson M, Vasiliauskas EA, Targan S, Ippoliti A, Mann NK, Melmed GY. PMID: 33155643.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Antitumour necrosis factor therapy is associated with de novo Crohn's disease after ileal pouch-anal anastomosis. Colorectal Dis. 2021 Sep; 23(9):2416-2424. Truong A, Zaghiyan KN, Mirocha J, Melmed GY, McGovern DPB, Syal G, Ha CY, Targan SR, Fleshner PR. PMID: 34157179; PMCID: PMC8440372.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis. Mediators Inflamm. 2021; 2021:5927064. Wenxiu J, Mingyue Y, Fei H, Yuxin L, Mengyao W, Chenyang L, Jia S, Hong Z, Shih DQ, Targan SR, Xiaolan Z. PMID: 34257516; PMCID: PMC8253633.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    21. Pre-pouch Ileitis is Associated with Development of Crohn's Disease-like Complications and Pouch Failure. J Crohns Colitis. 2021 Jun 22; 15(6):960-968. Syal G, Shemtov R, Bonthala N, Vasiliauskas EA, Feldman EJ, Zaghiyan K, Ha CY, McGovern DPB, Targan SR, Melmed GY, Fleshner PR. PMID: 33300546; PMCID: PMC8218713.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Five-Year Efficacy and Safety of Ustekinumab Treatment in Crohn's Disease: The IM-UNITI Trial. Clin Gastroenterol Hepatol. 2022 03; 20(3):578-590.e4. Sandborn WJ, Rebuck R, Wang Y, Zou B, Adedokun OJ, Gasink C, Sands BE, Hanauer SB, Targan S, Ghosh S, de Villiers WJS, Colombel JF, Feagan BG, Lynch JP. PMID: 33618023; PMCID: PMC8374005.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    23. Modeling Intestinal Epithelial Response to Interferon-γ in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids. Int J Mol Sci. 2020 Dec 30; 22(1). Workman MJ, Troisi E, Targan SR, Svendsen CN, Barrett RJ. PMID: 33396621; PMCID: PMC7794932.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    24. Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease. Gastroenterology. 2021 02; 160(3):809-822.e7. Potdar AA, Dube S, Naito T, Li K, Botwin G, Haritunians T, Li D, Casero D, Yang S, Bilsborough J, Perrigoue JG, Denson LA, Daly M, Targan SR, Fleshner P, Braun J, Kugathasan S, Stappenbeck TS, McGovern DPB. PMID: 33160965; PMCID: PMC9671555.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    25. Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo. Sci Rep. 2020 10 23; 10(1):18189. Jacob N, Kumagai K, Abraham JP, Shimodaira Y, Ye Y, Luu J, Blackwood AY, Castanon SL, Stamps DT, Thomas LS, Gonsky R, Shih DQ, Michelsen KS, Targan SR. PMID: 33097818; PMCID: PMC7584589.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    26. Ustekinumab is effective and safe for ulcerative colitis through 2 years of maintenance therapy. Aliment Pharmacol Ther. 2020 12; 52(11-12):1658-1675. Panaccione R, Danese S, Sandborn WJ, O'Brien CD, Zhou Y, Zhang H, Adedokun OJ, Tikhonov I, Targan S, Abreu MT, Hisamatsu T, Scherl EJ, Leong RW, Rowbotham DS, Arasaradnam RP, Sands BE, Marano C. PMID: 33086438; PMCID: PMC8776399.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    27. TL1A primed dendritic cells activation exacerbated chronic murine colitis. Life Sci. 2020 Dec 01; 262:118220. Han F, Song J, Jia W, Yang M, Wang D, Zhang H, Shih DQ, Targan SR, Zhang X. PMID: 32781075.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    28. Reduced expression of COVID-19 host receptor, ACE2 is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy in Crohn's disease. medRxiv. 2020 Apr 23. Potdar AA, Dube S, Naito T, Botwin G, Haritunians T, Li D, Yang S, Bilsborough J, Denson LA, Daly M, Targan SR, Fleshner P, Braun J, Kugathasan S, Stappenbeck TS, McGovern DPB. PMID: 32511625; PMCID: PMC7276052.
      View in: PubMed   Mentions: 2  
    29. Hypoalbuminemia and Bandemia Predict Failure of Infliximab Rescue Therapy in Acute Severe Ulcerative Colitis. Dig Dis Sci. 2021 01; 66(1):199-205. Syal G, Robbins L, Kashani A, Bonthala N, Feldman E, Fleshner P, Vasiliauskas E, McGovern D, Ha C, Targan S, Melmed GY. PMID: 32170473.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    30. Development of Physiologically Responsive Human iPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD. Int J Mol Sci. 2020 Feb 20; 21(4). Gleeson JP, Estrada HQ, Yamashita M, Svendsen CN, Targan SR, Barrett RJ. PMID: 32093254; PMCID: PMC7073090.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    31. Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis. N Engl J Med. 2019 09 26; 381(13):1201-1214. Sands BE, Sandborn WJ, Panaccione R, O'Brien CD, Zhang H, Johanns J, Adedokun OJ, Li K, Peyrin-Biroulet L, Van Assche G, Danese S, Targan S, Abreu MT, Hisamatsu T, Szapary P, Marano C, UNIFI Study Group. PMID: 31553833.
      View in: PubMed   Mentions: 316     Fields:    Translation:HumansCTClinical Trials
    32. Ileal Gene Expression Data from Crohn's Disease Small Bowel Resections Indicate Distinct Clinical Subgroups. J Crohns Colitis. 2019 Aug 14; 13(8):1055-1066. Potdar AA, Li D, Haritunians T, VanDussen KL, Fiorino MF, Liu TC, Stappenbeck TS, Fleshner P, Targan SR, McGovern DPB, Bilsborough J. PMID: 30877309; PMCID: PMC6939877.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    33. Correction: Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population. PLoS Genet. 2019 May; 15(5):e1008190. Rivas MA, Avila BE, Koskela J, Huang H, Stevens C, Pirinen M, Haritunians T, Neale BM, Kurki M, Ganna A, Graham D, Glaser B, Peter I, Atzmon G, Barzilai N, Levine AP, Schiff E, Pontikos N, Weisburd B, Lek M, Karczewski KJ, Bloom J, Minikel EV, Petersen BS, Beaugerie L, Seksik P, Cosnes J, Schreiber S, Bokemeyer B, Bethge J, International IBD Genetics Consortium, NIDDK IBD Genetics Consortium, T2D-GENES Consortium, Heap G, Ahmad T, Plagnol V, Segal AW, Targan S, Turner D, Saavalainen P, Farkkila M, Kontula K, Palotie A, Brant SR, Duerr RH, Silverberg MS, Rioux JD, Weersma RK, Franke A, Jostins L, Anderson CA, Barrett JC, MacArthur DG, Jalas C, Sokol H, Xavier RJ, Pulver A, Cho JH, McGovern DPB, Daly MJ. PMID: 31145742; PMCID: PMC6542503.
      View in: PubMed   Mentions: 6     Fields:    
    34. Malassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models. Cell Host Microbe. 2019 Mar 13; 25(3):377-388.e6. Limon JJ, Tang J, Li D, Wolf AJ, Michelsen KS, Funari V, Gargus M, Nguyen C, Sharma P, Maymi VI, Iliev ID, Skalski JH, Brown J, Landers C, Borneman J, Braun J, Targan SR, McGovern DPB, Underhill DM. PMID: 30850233; PMCID: PMC6417942.
      View in: PubMed   Mentions: 172     Fields:    Translation:Animals
    35. Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science. 2019 03 01; 363(6430):993-998. Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, Shih DQ, Conner ME, Glickman JN, Fuhler GM, Palm NW, de Zoete MR, van der Woude CJ, Yuan GC, Wucherpfennig KW, Targan SR, Rosenstiel P, Flavell RA, McCoy KD, Macpherson AJ, Kaser A, Blumberg RS. PMID: 30819965; PMCID: PMC6637967.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    36. A role for BATF3 in TH9 differentiation and T-cell-driven mucosal pathologies. Mucosal Immunol. 2019 05; 12(3):644-655. Tsuda M, Hamade H, Thomas LS, Salumbides BC, Potdar AA, Wong MH, Nunnelee JS, Stamps JT, Neutzsky-Wulff AV, Barrett RJ, Wang Y, Tang J, Funari VA, Targan SR, Michelsen KS. PMID: 30617301; PMCID: PMC6462229.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    37. Prevalence and Associations of Avascular Necrosis of the Hip in a Large Well-characterized Cohort of Patients With Inflammatory Bowel Disease. J Clin Rheumatol. 2019 Jan; 25(1):45-49. Rolston VS, Patel AV, Learch TJ, Li D, Karayev D, Williams C, Siddanthi ML, Targan SR, Weisman MH, McGovern DPB. PMID: 29794876; PMCID: PMC6252167.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    38. Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis. Immunity. 2018 12 18; 49(6):1077-1089.e5. Castellanos JG, Woo V, Viladomiu M, Putzel G, Lima S, Diehl GE, Marderstein AR, Gandara J, Perez AR, Withers DR, Targan SR, Shih DQ, Scherl EJ, Longman RS. PMID: 30552020; PMCID: PMC6301104.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    39. A Multidisciplinary Approach to Biopsychosocial Care for Adults With Inflammatory Bowel Disease: A Pilot Study. Inflamm Bowel Dis. 2018 11 29; 24(12):2550-2554. Lee CK, Melmed GY, Mann A, Danovitch I, Hedrick R, McGovern DPB, Targan S, Shih D, Vasiliauskas E, IsHak WW, Feldman E. PMID: 29920581.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    40. Late-Onset Crohn's Disease Is A Subgroup Distinct in Genetic and Behavioral Risk Factors With UC-Like Characteristics. Inflamm Bowel Dis. 2018 10 12; 24(11):2413-2422. Li D, Haritunians T, Landers C, Potdar AA, Yang S, Huang H, Schumm LP, Daly M, Targan SR, McGovern DPB. PMID: 29860388; PMCID: PMC6195175.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    41. The Effects of Ustekinumab on Health-related Quality of Life in Patients With Moderate to Severe Crohn's Disease. J Crohns Colitis. 2018 Jul 30; 12(8):883-895. Sands BE, Han C, Gasink C, Jacobstein D, Szapary P, Gao LL, Lang Y, Targan S, Sandborn WJ, Feagan BG. PMID: 29726939.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    42. Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome. Mucosal Immunol. 2018 09; 11(5):1466-1476. Jacob N, Jacobs JP, Kumagai K, Ha CWY, Kanazawa Y, Lagishetty V, Altmayer K, Hamill AM, Von Arx A, Sartor RB, Devkota S, Braun J, Michelsen KS, Targan SR, Shih DQ. PMID: 29988118; PMCID: PMC6162160.
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    44. Plasma N-Glycan Signatures Are Associated With Features of Inflammatory Bowel Diseases. Gastroenterology. 2018 09; 155(3):829-843. Clerc F, Novokmet M, Dotz V, Reiding KR, de Haan N, Kammeijer GSM, Dalebout H, Bladergroen MR, Vukovic F, Rapp E, IBD-BIOM Consortium, Targan SR, Barron G, Manetti N, Latiano A, McGovern DPB, Annese V, Lauc G, Wuhrer M. PMID: 29792883.
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    46. Serological, genetic and clinical associations with increased health-care resource utilization in inflammatory bowel disease. J Dig Dis. 2018 Jan; 19(1):15-23. Gu P, Kapur A, Li D, Haritunians T, Vasiliauskas E, Shih DQ, Targan SR, Spiegel BM, Mcgovern DP, Black JT, Melmed GY. PMID: 29251413; PMCID: PMC6023617.
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    47. Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Cell Mol Gastroenterol Hepatol. 2018; 5(4):669-677.e2. Workman MJ, Gleeson JP, Troisi EJ, Estrada HQ, Kerns SJ, Hinojosa CD, Hamilton GA, Targan SR, Svendsen CN, Barrett RJ. PMID: 29930984; PMCID: PMC6009013.
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    48. TL1A blocking ameliorates intestinal fibrosis in the T cell transfer model of chronic colitis in mice. Pathol Res Pract. 2018 Feb; 214(2):217-227. Li H, Song J, Niu G, Zhang H, Guo J, Shih DQ, Targan SR, Zhang X. PMID: 29254800.
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    49. Colonic Phenotypes Are Associated with Poorer Response to Anti-TNF Therapies in Patients with IBD. Inflamm Bowel Dis. 2017 08; 23(8):1382-1393. Yoon SM, Haritunians T, Chhina S, Liu Z, Yang S, Landers C, Li D, Ye BD, Shih D, Vasiliauskas EA, Ippoliti A, Rabizadeh S, Targan SR, Melmed GY, McGovern DPB. PMID: 28590340; PMCID: PMC6510223.
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    50. Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity in Crohn's Disease. Gastroenterology. 2017 07; 153(1):219-232. Gonsky R, Fleshner P, Deem RL, Biener-Ramanujan E, Li D, Potdar AA, Bilsborough J, Yang S, McGovern DPB, Targan SR. PMID: 28400196; PMCID: PMC5484733.
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    51. Myeloid ATG16L1 Facilitates Host-Bacteria Interactions in Maintaining Intestinal Homeostasis. J Immunol. 2017 03 01; 198(5):2133-2146. Zhang H, Zheng L, McGovern DP, Hamill AM, Ichikawa R, Kanazawa Y, Luu J, Kumagai K, Cilluffo M, Fukata M, Targan SR, Underhill DM, Zhang X, Shih DQ. PMID: 28130498; PMCID: PMC5322190.
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    52. Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis. J Exp Med. 2017 02; 214(2):401-422. Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A. PMID: 28082357; PMCID: PMC5294857.
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    53. Ustekinumab as Induction and Maintenance Therapy for Crohn's Disease. N Engl J Med. 2016 11 17; 375(20):1946-1960. Feagan BG, Sandborn WJ, Gasink C, Jacobstein D, Lang Y, Friedman JR, Blank MA, Johanns J, Gao LL, Miao Y, Adedokun OJ, Sands BE, Hanauer SB, Vermeire S, Targan S, Ghosh S, de Villiers WJ, Colombel JF, Tulassay Z, Seidler U, Salzberg BA, Desreumaux P, Lee SD, Loftus EV, Dieleman LA, Katz S, Rutgeerts P, UNITI–IM-UNITI Study Group. PMID: 27959607.
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    54. The TNF family member TL1A induces IL-22 secretion in committed human Th17 cells via IL-9 induction. J Leukoc Biol. 2017 03; 101(3):727-737. Thomas LS, Targan SR, Tsuda M, Yu QT, Salumbides BC, Haritunians T, Mengesha E, McGovern DP, Michelsen KS. PMID: 27733581; PMCID: PMC6608031.
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    55. Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease. Gastroenterology. 2017 01; 152(1):206-217.e2. Brant SR, Okou DT, Simpson CL, Cutler DJ, Haritunians T, Bradfield JP, Chopra P, Prince J, Begum F, Kumar A, Huang C, Venkateswaran S, Datta LW, Wei Z, Thomas K, Herrinton LJ, Klapproth JA, Quiros AJ, Seminerio J, Liu Z, Alexander JS, Baldassano RN, Dudley-Brown S, Cross RK, Dassopoulos T, Denson LA, Dhere TA, Dryden GW, Hanson JS, Hou JK, Hussain SZ, Hyams JS, Isaacs KL, Kader H, Kappelman MD, Katz J, Kellermayer R, Kirschner BS, Kuemmerle JF, Kwon JH, Lazarev M, Li E, Mack D, Mannon P, Moulton DE, Newberry RD, Osuntokun BO, Patel AS, Saeed SA, Targan SR, Valentine JF, Wang MH, Zonca M, Rioux JD, Duerr RH, Silverberg MS, Cho JH, Hakonarson H, Zwick ME, McGovern DP, Kugathasan S. PMID: 27693347; PMCID: PMC5164948.
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    56. A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Brodalumab in Patients With Moderate-to-Severe Crohn's Disease. Am J Gastroenterol. 2016 Nov; 111(11):1599-1607. Targan SR, Feagan B, Vermeire S, Panaccione R, Melmed GY, Landers C, Li D, Russell C, Newmark R, Zhang N, Chon Y, Hsu YH, Lin SL, Klekotka P. PMID: 27481309.
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    57. A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition. Gastroenterology. 2016 10; 151(4):724-32. Li D, Achkar JP, Haritunians T, Jacobs JP, Hui KY, D'Amato M, Brand S, Radford-Smith G, Halfvarson J, Niess JH, Kugathasan S, Büning C, Schumm LP, Klei L, Ananthakrishnan A, Aumais G, Baidoo L, Dubinsky M, Fiocchi C, Glas J, Milgrom R, Proctor DD, Regueiro M, Simms LA, Stempak JM, Targan SR, Törkvist L, Sharma Y, Devlin B, Borneman J, Hakonarson H, Xavier RJ, Daly M, Brant SR, Rioux JD, Silverberg MS, Cho JH, Braun J, McGovern DP, Duerr RH. PMID: 27492617; PMCID: PMC5037008.
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    58. Outcomes with Anti-Tumour Necrosis Factor-Alpha Therapy and Serology in Patients with Denovo Crohn's Disease After Ileal Pouch Anal Anastomosis. J Crohns Colitis. 2017 Jan; 11(1):77-83. Robbins L, Zaghiyan K, Melmed G, Vasiliauskas E, Ahmed S, McGovern D, Rabizadeh S, Singh N, Landers C, Ippoliti A, Shih D, Targan S, Fleshner P. PMID: 27466172.
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    59. A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF. Gastroenterology. 2016 10; 151(4):710-723.e2. Chuang LS, Villaverde N, Hui KY, Mortha A, Rahman A, Levine AP, Haritunians T, Evelyn Ng SM, Zhang W, Hsu NY, Facey JA, Luong T, Fernandez-Hernandez H, Li D, Rivas M, Schiff ER, Gusev A, Schumm LP, Bowen BM, Sharma Y, Ning K, Remark R, Gnjatic S, Legnani P, George J, Sands BE, Stempak JM, Datta LW, Lipka S, Katz S, Cheifetz AS, Barzilai N, Pontikos N, Abraham C, Dubinsky MJ, Targan S, Taylor K, Rotter JI, Scherl EJ, Desnick RJ, Abreu MT, Zhao H, Atzmon G, Pe'er I, Kugathasan S, Hakonarson H, McCauley JL, Lencz T, Darvasi A, Plagnol V, Silverberg MS, Muise AM, Brant SR, Daly MJ, Segal AW, Duerr RH, Merad M, McGovern DP, Peter I, Cho JH. PMID: 27377463; PMCID: PMC5037012.
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    60. Clinical Factors Associated with the Development of Crohn's Disease in Inflammatory Bowel Disease-unclassified Patients Undergoing Ileal Pouch-anal Anastomosis. Inflamm Bowel Dis. 2016 06; 22(6):1397-402. Koh SZ, Zaghiyan KN, Li Q, Rabizadeh S, Melmed GY, Targan SR, Fleshner PR. PMID: 26978722.
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    61. TNFRSF1B Is Associated with ANCA in IBD. Inflamm Bowel Dis. 2016 06; 22(6):1346-52. Li D, Silverberg MS, Haritunians T, Dubinsky MC, Landers C, Stempak JM, Milgrom R, Guo X, Chen YD, Rotter JI, Taylor KD, McGovern DP, Targan SR. PMID: 27104820; PMCID: PMC7288902.
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    62. Cytokine and anti-cytokine therapies in prevention or treatment of fibrosis in IBD. United European Gastroenterol J. 2016 Aug; 4(4):531-40. Jacob N, Targan SR, Shih DQ. PMID: 27536363; PMCID: PMC4971798.
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    63. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science. 2016 May 27; 352(6289):1116-20. Chu H, Khosravi A, Kusumawardhani IP, Kwon AH, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, Targan SR, Xavier RJ, Ernst PB, Green DR, McGovern DP, Virgin HW, Mazmanian SK. PMID: 27230380; PMCID: PMC4996125.
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    65. Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis. Inflamm Bowel Dis. 2016 Mar; 22(3):548-59. Sidhu-Varma M, Shih DQ, Targan SR. PMID: 26818423; PMCID: PMC4752386.
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    66. Nonbloody Diarrhea but Not Significant Weight Loss at Diagnosis Is Associated with the Development of Denovo Crohn's Disease After Ileal Pouch-anal Anastomosis for Ulcerative Colitis. Inflamm Bowel Dis. 2016 Mar; 22(3):654-61. Ahmed S, Melmed G, McGovern D, Robbins LA, Shih D, Vasiliauskas E, Singh N, Rabidzadeh S, Ippoliti A, Targan S, Fleshner P. PMID: 26595552.
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    67. Ocular Manifestations in Inflammatory Bowel Disease Are Associated with Other Extra-intestinal Manifestations, Gender, and Genes Implicated in Other Immune-related Traits. J Crohns Colitis. 2016 Jan; 10(1):43-9. Taleban S, Li D, Targan SR, Ippoliti A, Brant SR, Cho JH, Duerr RH, Rioux JD, Silverberg MS, Vasiliauskas EA, Rotter JI, Haritunians T, Shih DQ, Dubinsky M, Melmed GY, McGovern DP. PMID: 26449790; PMCID: PMC6082592.
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    68. Colectomy with Permanent End Ileostomy Is More Cost-Effective than Ileal Pouch-Anal Anastomosis for Crohn's Colitis. Dig Dis Sci. 2016 Feb; 61(2):550-9. Taleban S, Van Oijen MG, Vasiliauskas EA, Fleshner PR, Shen B, Ippoliti AF, Targan SR, Melmed GY. PMID: 26434930.
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    70. Combined Immunosuppression Impairs Immunogenicity to Tetanus and Pertussis Vaccination Among Patients with Inflammatory Bowel Disease. Inflamm Bowel Dis. 2015 Aug; 21(8):1754-60. Dezfoli S, Horton HA, Thepyasuwan N, Berel D, Targan SR, Vasiliauskas EA, Dubinsky M, Shih DQ, Kaur M, McGovern DP, Ippoliti A, Feldman EJ, Melmed GY. PMID: 25985242.
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    71. Pyoderma Gangrenosum among Patients with Inflammatory Bowel Disease: A Descriptive Cohort Study. J Cutan Med Surg. 2015 Mar-Apr; 19(2):125-31. Weizman AV, Huang B, Targan S, Dubinsky M, Fleshner P, Kaur M, Ippoliti A, Panikkath D, Vasiliauskas E, Shih D, McGovern DP, Melmed GY. PMID: 25775631.
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    72. The impact of preoperative serum anti-TNFα therapy levels on early postoperative outcomes in inflammatory bowel disease surgery. Ann Surg. 2015 Mar; 261(3):487-96. Lau C, Dubinsky M, Melmed G, Vasiliauskas E, Berel D, McGovern D, Ippoliti A, Shih D, Targan S, Fleshner P. PMID: 24950263; PMCID: PMC4994811.
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    73. Molecular patterns in human ulcerative colitis and correlation with response to infliximab. Inflamm Bowel Dis. 2014 Dec; 20(12):2353-63. Halloran B, Chang J, Shih DQ, McGovern D, Famulski K, Evaschesen C, Fedorak RN, Thiesen A, Targan S, Halloran PF. PMID: 25397893; PMCID: PMC4985265.
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    74. Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines. Stem Cells Transl Med. 2014 Dec; 3(12):1429-34. Barrett R, Ornelas L, Yeager N, Mandefro B, Sahabian A, Lenaeus L, Targan SR, Svendsen CN, Sareen D. PMID: 25298370; PMCID: PMC4250214.
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    78. Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk. J Innate Immun. 2015; 7(1):87-101. Hyun J, Romero L, Riveron R, Flores C, Kanagavelu S, Chung KD, Alonso A, Sotolongo J, Ruiz J, Manukyan A, Chun S, Singh G, Salas P, Targan SR, Fukata M. PMID: 25171731; PMCID: PMC4409129.
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    79. Human NK cells licensed by killer Ig receptor genes have an altered cytokine program that modifies CD4+ T cell function. J Immunol. 2014 Jul 15; 193(2):940-9. Lin L, Ma C, Wei B, Aziz N, Rajalingam R, Yusung S, Erlich HA, Trachtenberg EA, Targan SR, McGovern DP, Heath JR, Braun J. PMID: 24935928; PMCID: PMC4096688.
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    83. Elevated serum anti-flagellin antibodies implicate subclinical bowel inflammation in ankylosing spondylitis: an observational study. Arthritis Res Ther. 2013 Oct 26; 15(5):R166. Wallis D, Asaduzzaman A, Weisman M, Haroon N, Anton A, McGovern D, Targan S, Inman R. PMID: 24286190; PMCID: PMC3978579.
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    91. Surgical outcome of ileal pouch-anal anastomosis when used intentionally for well-defined Crohn's disease. Inflamm Bowel Dis. 2013 Jan; 19(1):30-6. Le Q, Melmed G, Dubinsky M, McGovern D, Vasiliauskas EA, Murrell Z, Ippoliti A, Shih D, Kaur M, Targan S, Fleshner P. PMID: 22467562; PMCID: PMC4457327.
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    92. Assessing health status in inflammatory bowel disease using a novel single-item numeric rating scale. Dig Dis Sci. 2013 May; 58(5):1313-21. Surti B, Spiegel B, Ippoliti A, Vasiliauskas EA, Simpson P, Shih DQ, Targan SR, McGovern DP, Melmed GY. PMID: 23250673; PMCID: PMC4161217.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    93. Markers of intestinal inflammation in patients with ankylosing spondylitis: a pilot study. Arthritis Res Ther. 2012 Nov 29; 14(6):R261. Matzkies FG, Targan SR, Berel D, Landers CJ, Reveille JD, McGovern DP, Weisman MH. PMID: 23194008; PMCID: PMC3674603.
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    94. B lymphocyte-induced maturation protein-1 contributes to intestinal mucosa homeostasis by limiting the number of IL-17-producing CD4+ T cells. J Immunol. 2012 Dec 15; 189(12):5682-93. Salehi S, Bankoti R, Benevides L, Willen J, Couse M, Silva JS, Dhall D, Meffre E, Targan S, Martins GA. PMID: 23162130; PMCID: PMC3529138.
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    95. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 2012 Nov 01; 491(7422):119-24. Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A, Boucher G, Brand S, Büning C, Cohain A, Cichon S, D'Amato M, De Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH, Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W, Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M, Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M, Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier RJ, Zeissig S, Zhang B, Zhang CK, Zhao H, International IBD Genetics Consortium (IIBDGC), Silverberg MS, Annese V, Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD, Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC, Cho JH. PMID: 23128233; PMCID: PMC3491803.
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    96. Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med. 2012 Oct 18; 367(16):1519-28. Sandborn WJ, Gasink C, Gao LL, Blank MA, Johanns J, Guzzo C, Sands BE, Hanauer SB, Targan S, Rutgeerts P, Ghosh S, de Villiers WJ, Panaccione R, Greenberg G, Schreiber S, Lichtiger S, Feagan BG, CERTIFI Study Group. PMID: 23075178.
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    97. Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. Am J Gastroenterol. 2013 Jan; 108(1):90-8. Sandborn WJ, Targan SR, Byers VS, Rutty DA, Mu H, Zhang X, Tang T. PMID: 23044768; PMCID: PMC3538174.
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    98. The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice. Gut. 2013 Sep; 62(9):1295-305. Hing TC, Ho S, Shih DQ, Ichikawa R, Cheng M, Chen J, Chen X, Law I, Najarian R, Kelly CP, Gallo RL, Targan SR, Pothoulakis C, Koon HW. PMID: 22760006; PMCID: PMC3737259.
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    99. Does preoperative immunosuppression influence unplanned hospital readmission after surgery in patients with Crohn's disease? Dis Colon Rectum. 2012 May; 55(5):563-8. White EC, Melmed GY, Vasiliauskas E, Dubinsky M, Ippoliti A, McGovern D, Targan S, Fleshner P. PMID: 22513435.
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    100. Abatacept for Crohn's disease and ulcerative colitis. Gastroenterology. 2012 Jul; 143(1):62-69.e4. Sandborn WJ, Colombel JF, Sands BE, Rutgeerts P, Targan SR, Panaccione R, Bressler B, Geboes K, Schreiber S, Aranda R, Gujrathi S, Luo A, Peng Y, Salter-Cid L, Hanauer SB. PMID: 22504093.
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    101. Colorectal cancer screening and surveillance in Crohn's colitis. J Crohns Colitis. 2012 Sep; 6(8):824-9. Basseri RJ, Basseri B, Vassilaki ME, Melmed GY, Ippoliti A, Vasiliauskas EA, Fleshner PR, Lechago J, Hu B, Berel D, Targan SR, Papadakis KA. PMID: 22398087.
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    102. Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohn's disease. Inflamm Bowel Dis. 2012 Sep; 18(9):1743-8. Murdoch TB, Xu W, Stempak JM, Landers C, Targan SR, Rotter JI, Silverberg MS. PMID: 22275320; PMCID: PMC3418471.
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    103. Current concepts on the immunopathogenesis of inflammatory bowel disease. Front Biosci (Elite Ed). 2012 01 01; 4(4):1451-77. Vora P, Shih DQ, McGovern DP, Targan SR. PMID: 22201968.
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    104. Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis. Am J Pathol. 2012 Feb; 180(2):636-49. Barrett R, Zhang X, Koon HW, Vu M, Chang JY, Yeager N, Nguyen MA, Michelsen KS, Berel D, Pothoulakis C, Targan SR, Shih DQ. PMID: 22138299; PMCID: PMC3349869.
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    105. Substance P induces CCN1 expression via histone deacetylase activity in human colonic epithelial cells. Am J Pathol. 2011 Nov; 179(5):2315-26. Koon HW, Shih DQ, Hing TC, Chen J, Ho S, Zhao D, Targan SR, Pothoulakis C. PMID: 21945803; PMCID: PMC3204086.
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    106. Cathelicidin signaling via the Toll-like receptor protects against colitis in mice. Gastroenterology. 2011 Nov; 141(5):1852-63.e1-3. Koon HW, Shih DQ, Chen J, Bakirtzi K, Hing TC, Law I, Ho S, Ichikawa R, Zhao D, Xu H, Gallo R, Dempsey P, Cheng G, Targan SR, Pothoulakis C. PMID: 21762664; PMCID: PMC3199285.
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    107. A case of steroid-dependent myeloid granulocytic sarcoma masquerading as Crohn's disease. World J Gastroenterol. 2011 May 21; 17(19):2446-9. Kwan LY, Targan SR, Shih DQ. PMID: 21633646; PMCID: PMC3103799.
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    108. Assessing inflammatory bowel disease-associated antibodies in Caucasian and First Nations cohorts. Can J Gastroenterol. 2011 May; 25(5):269-73. Bernstein CN, El-Gabalawy H, Sargent M, Landers C, Rawsthorne P, Elias B, Targan SR. PMID: 21647462; PMCID: PMC3115008.
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    109. Future therapeutic approaches for inflammatory bowel diseases. Gastroenterology. 2011 May; 140(6):1838-46. Plevy SE, Targan SR. PMID: 21530750; PMCID: PMC5076881.
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    110. Combination of genetic and quantitative serological immune markers are associated with complicated Crohn's disease behavior. Inflamm Bowel Dis. 2011 Dec; 17(12):2488-96. Lichtenstein GR, Targan SR, Dubinsky MC, Rotter JI, Barken DM, Princen F, Carroll S, Brown M, Stachelski J, Chuang E, Landers CJ, Stempak JM, Singh S, Silverberg MS. PMID: 21391291; PMCID: PMC4203682.
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    111. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet. 2011 Mar; 43(3):246-52. Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lémann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panés J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK, Rioux JD. PMID: 21297633; PMCID: PMC3084597.
      View in: PubMed   Mentions: 652     Fields:    Translation:Humans
    112. Variants in ZNF365 isoform D are associated with Crohn's disease. Gut. 2011 Aug; 60(8):1060-7. Haritunians T, Jones MR, McGovern DP, Shih DQ, Barrett RJ, Derkowski C, Dubinsky MC, Dutridge D, Fleshner PR, Ippoliti A, King L, Leshinsky-Silver E, Levine A, Melmed GY, Mengesha E, Vasilauskas EA, Ziaee S, Rotter JI, Targan SR, Taylor KD. PMID: 21257989; PMCID: PMC3250380.
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    113. Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis. PLoS One. 2011 Jan 11; 6(1):e16090. Shih DQ, Barrett R, Zhang X, Yeager N, Koon HW, Phaosawasdi P, Song Y, Ko B, Wong MH, Michelsen KS, Martins G, Pothoulakis C, Targan SR. PMID: 21264313; PMCID: PMC3019214.
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    114. Insights into TL1A and IBD pathogenesis. Adv Exp Med Biol. 2011; 691:279-88. Shih DQ, Michelsen KS, Barrett RJ, Biener-Ramanujan E, Gonsky R, Zhang X, Targan SR. PMID: 21153332.
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    115. Introductory words about TL1A/DR3. Adv Exp Med Biol. 2011; 691:271-4. Targan SR. PMID: 21153330.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    116. Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens. Inflamm Bowel Dis. 2011 Jan; 17(1):171-8. Gonsky R, Deem RL, Landers CJ, Derkowski CA, Berel D, McGovern DP, Targan SR. PMID: 20848535; PMCID: PMC3400263.
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    117. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet. 2010 Dec; 42(12):1118-25. Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De Vos M, D'Inca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van Gossum A, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panés J, Phillips A, Proctor DD, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, D'Amato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes M. PMID: 21102463; PMCID: PMC3299551.
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    118. Anti-CD3 antibody visilizumab is not effective in patients with intravenous corticosteroid-refractory ulcerative colitis. Gut. 2010 Nov; 59(11):1485-92. Sandborn WJ, Colombel JF, Frankel M, Hommes D, Lowder JN, Mayer L, Plevy S, Stokkers P, Travis S, Van Assche G, Baumgart DC, Targan SR. PMID: 20947884.
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    119. Genetic predictors of medically refractory ulcerative colitis. Inflamm Bowel Dis. 2010 Nov; 16(11):1830-40. Haritunians T, Taylor KD, Targan SR, Dubinsky M, Ippoliti A, Kwon S, Guo X, Melmed GY, Berel D, Mengesha E, Psaty BM, Glazer NL, Vasiliauskas EA, Rotter JI, Fleshner PR, McGovern DP. PMID: 20848476; PMCID: PMC2959149.
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    120. High levels of Crohn's disease-associated anti-microbial antibodies are present and independent of colitis in chronic granulomatous disease. Clin Immunol. 2011 Jan; 138(1):14-22. Yu JE, De Ravin SS, Uzel G, Landers C, Targan S, Malech HL, Holland SM, Cao W, Harpaz N, Mayer L, Cunningham-Rundles C. PMID: 20956091; PMCID: PMC3061829.
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    121. Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2010 Aug; 16(8):1357-66. Dubinsky MC, Mei L, Friedman M, Dhere T, Haritunians T, Hakonarson H, Kim C, Glessner J, Targan SR, McGovern DP, Taylor KD, Rotter JI. PMID: 20014019; PMCID: PMC2889173.
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    122. Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's disease. Inflamm Bowel Dis. 2010 Aug; 16(8):1279-85. Ippoliti A, Devlin S, Mei L, Yang H, Papadakis KA, Vasiliauskas EA, McGovern DP, Abreu MT, Melmed G, Shaye O, Enayati P, Chen G, Choi J, Taylor K, Landers CJ, Rotter JI, Targan SR. PMID: 20027650; PMCID: PMC3875376.
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    123. A prospective analysis of clinical variables, serologic factors, and outcome of ileal pouch-anal anastomosis in patients with backwash ileitis. Dis Colon Rectum. 2010 Jul; 53(7):987-94. White E, Melmed GY, Vasiliauskas EA, Dubinsky M, Berel D, Targan SR, Fleshner PR. PMID: 20551749; PMCID: PMC5002988.
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    124. Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. Hum Mol Genet. 2010 Sep 01; 19(17):3468-76. McGovern DP, Jones MR, Taylor KD, Marciante K, Yan X, Dubinsky M, Ippoliti A, Vasiliauskas E, Berel D, Derkowski C, Dutridge D, Fleshner P, Shih DQ, Melmed G, Mengesha E, King L, Pressman S, Haritunians T, Guo X, Targan SR, Rotter JI, International IBD Genetics Consortium. PMID: 20570966; PMCID: PMC2916706.
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    125. Functional signaling of membrane-bound TL1A induces IFN-gamma expression. FEBS Lett. 2010 Jun 03; 584(11):2376-80. Biener-Ramanujan E, Gonsky R, Ko B, Targan SR. PMID: 20403353.
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    126. Prospective randomized open-label multicenter phase I/II dose escalation trial of visilizumab (HuM291) in severe steroid-refractory ulcerative colitis. Inflamm Bowel Dis. 2010 Apr; 16(4):620-9. Baumgart DC, Targan SR, Dignass AU, Mayer L, van Assche G, Hommes DW, Hanauer SB, Mahadevan U, Reinisch W, Plevy SE, Salzberg BA, Buchman AL, Mechkov GM, Krastev ZA, Lowder JN, Frankel MB, Sandborn WJ. PMID: 19714757.
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    127. TL1A selectively enhances IL-12/IL-18-induced NK cell cytotoxicity against NK-resistant tumor targets. J Clin Immunol. 2010 Jul; 30(4):531-8. Heidemann SC, Chavez V, Landers CJ, Kucharzik T, Prehn JL, Targan SR. PMID: 20349123; PMCID: PMC2900590.
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    128. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet. 2010 Apr; 42(4):332-7. McGovern DP, Gardet A, Törkvist L, Goyette P, Essers J, Taylor KD, Neale BM, Ong RT, Lagacé C, Li C, Green T, Stevens CR, Beauchamp C, Fleshner PR, Carlson M, D'Amato M, Halfvarson J, Hibberd ML, Lördal M, Padyukov L, Andriulli A, Colombo E, Latiano A, Palmieri O, Bernard EJ, Deslandres C, Hommes DW, de Jong DJ, Stokkers PC, Weersma RK, NIDDK IBD Genetics Consortium, Sharma Y, Silverberg MS, Cho JH, Wu J, Roeder K, Brant SR, Schumm LP, Duerr RH, Dubinsky MC, Glazer NL, Haritunians T, Ippoliti A, Melmed GY, Siscovick DS, Vasiliauskas EA, Targan SR, Annese V, Wijmenga C, Pettersson S, Rotter JI, Xavier RJ, Daly MJ, Rioux JD, Seielstad M. PMID: 20228799; PMCID: PMC3087600.
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    129. Preoperative wireless capsule endoscopy does not predict outcome after ileal pouch-anal anastomosis. Dis Colon Rectum. 2010 Mar; 53(3):293-300. Murrell Z, Vasiliauskas E, Melmed G, Lo S, Targan S, Fleshner P. PMID: 20173476.
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    130. Future biologic targets for IBD: potentials and pitfalls. Nat Rev Gastroenterol Hepatol. 2010 Feb; 7(2):110-7. Melmed GY, Targan SR. PMID: 20134493.
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    131. Insights into IBD Pathogenesis. Curr Gastroenterol Rep. 2009 Dec; 11(6):473-80. Shih DQ, Targan SR. PMID: 19903423; PMCID: PMC2895981.
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    132. Inflammatory bowel disease serologies in ankylosing spondylitis patients: a pilot study. Arthritis Res Ther. 2009; 11(6):R177. Mundwiler ML, Mei L, Landers CJ, Reveille JD, Targan S, Weisman MH. PMID: 19930665; PMCID: PMC3003540.
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    133. Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells. Eur J Immunol. 2009 Nov; 39(11):3239-50. Shih DQ, Kwan LY, Chavez V, Cohavy O, Gonsky R, Chang EY, Chang C, Elson CO, Targan SR. PMID: 19839006; PMCID: PMC2839414.
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    134. Immunosuppression impairs response to pneumococcal polysaccharide vaccination in patients with inflammatory bowel disease. Am J Gastroenterol. 2010 Jan; 105(1):148-54. Melmed GY, Agarwal N, Frenck RW, Ippoliti AF, Ibanez P, Papadakis KA, Simpson P, Barolet-Garcia C, Ward J, Targan SR, Vasiliauskas EA. PMID: 19755964.
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    135. Rigorous histopathological assessment of the colectomy specimen in patients with inflammatory bowel disease unclassified does not predict outcome after ileal pouch-anal anastomosis. Am J Gastroenterol. 2010 Jan; 105(1):155-61. Nasseri Y, Melmed G, Wang HL, Targan S, Fleshner P. PMID: 19755970.
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    136. TLR8-mediated activation of human monocytes inhibits TL1A expression. Eur J Immunol. 2009 Aug; 39(8):2195-202. Saruta M, Michelsen KS, Thomas LS, Yu QT, Landers CJ, Targan SR. PMID: 19637197; PMCID: PMC2839407.
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    137. Distinct Methylation of IFNG in the Gut. J Interferon Cytokine Res. 2009 Jul; 29(7):407-14. Gonsky R, Deem RL, Targan SR. PMID: 19450149; PMCID: PMC2956574.
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    138. Therapeutic Targets for Emerging Biologic Therapies in IBD. Gastroenterol Hepatol (N Y). 2009 Jul; 5(7 Suppl 16):4-16. Hanauer SB, Plevy SE, Sands BE, Targan SR. PMID: 37967429; PMCID: PMC2886434.
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    139. Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease. Inflamm Bowel Dis. 2009 Jun; 15(6):883-9. McGovern DP, Rotter JI, Mei L, Haritunians T, Landers C, Derkowski C, Dutridge D, Dubinsky M, Ippoliti A, Vasiliauskas E, Mengesha E, King L, Pressman S, Targan SR, Taylor KD. PMID: 19235914; PMCID: PMC2916929.
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    140. A prospective evaluation of the long-term outcome of ileal pouch-anal anastomosis in patients with inflammatory bowel disease-unclassified and indeterminate colitis. Dis Colon Rectum. 2009 May; 52(5):872-8. Murrell ZA, Melmed GY, Ippoliti A, Vasiliauskas EA, Dubinsky M, Targan SR, Fleshner PR. PMID: 19502850.
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    141. Age of diagnosis influences serologic responses in children with Crohn's disease: a possible clue to etiology? Inflamm Bowel Dis. 2009 May; 15(5):714-9. Markowitz J, Kugathasan S, Dubinsky M, Mei L, Crandall W, LeLeiko N, Oliva-Hemker M, Rosh J, Evans J, Mack D, Otley A, Pfefferkorn M, Bahar R, Vasiliauskas E, Wahbeh G, Silber G, Quiros JA, Wrobel I, Nebel J, Landers C, Picornell Y, Targan S, Lerer T, Hyams J. PMID: 19107777; PMCID: PMC2726983.
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    142. IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein. PLoS One. 2009; 4(3):e4719. Michelsen KS, Thomas LS, Taylor KD, Yu QT, Mei L, Landers CJ, Derkowski C, McGovern DP, Rotter JI, Targan SR. PMID: 19262684; PMCID: PMC2648040.
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    143. High-frequency haplotypes in the X chromosome locus TLR8 are associated with both CD and UC in females. Inflamm Bowel Dis. 2009 Mar; 15(3):321-7. Saruta M, Targan SR, Mei L, Ippoliti AF, Taylor KD, Rotter JI. PMID: 18942751; PMCID: PMC2643315.
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    144. Transient cytokine-induced liver injury following administration of the humanized anti-CD3 antibody visilizumab (HuM291) in Crohn's disease. Am J Gastroenterol. 2009 Apr; 104(4):868-76. Baumgart DC, Lowder JN, Targan SR, Sandborn WJ, Frankel MB. PMID: 19240707.
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    145. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nat Genet. 2009 Feb; 41(2):216-20. Silverberg MS, Cho JH, Rioux JD, McGovern DP, Wu J, Annese V, Achkar JP, Goyette P, Scott R, Xu W, Barmada MM, Klei L, Daly MJ, Abraham C, Bayless TM, Bossa F, Griffiths AM, Ippoliti AF, Lahaie RG, Latiano A, Paré P, Proctor DD, Regueiro MD, Steinhart AH, Targan SR, Schumm LP, Kistner EO, Lee AT, Gregersen PK, Rotter JI, Brant SR, Taylor KD, Roeder K, Duerr RH. PMID: 19122664; PMCID: PMC2652837.
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    146. MAGI2 genetic variation and inflammatory bowel disease. Inflamm Bowel Dis. 2009 Jan; 15(1):75-83. McGovern DP, Taylor KD, Landers C, Derkowski C, Dutridge D, Dubinsky M, Ippoliti A, Vasiliauskas E, Mei L, Mengesha E, King L, Pressman S, Targan SR, Rotter JI. PMID: 18720471; PMCID: PMC2614310.
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    147. Enhanced CBir1-specific innate and adaptive immune responses in Crohn's disease. Inflamm Bowel Dis. 2008 Dec; 14(12):1641-51. Shen C, Landers CJ, Derkowski C, Elson CO, Targan SR. PMID: 18825772; PMCID: PMC3346963.
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    148. Recent advances in IBD pathogenesis: genetics and immunobiology. Curr Gastroenterol Rep. 2008 Dec; 10(6):568-75. Shih DQ, Targan SR, McGovern D. PMID: 19006613; PMCID: PMC2734390.
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    149. Controversies in ulcerative colitis: a survey comparing decision making of experts versus community gastroenterologists. Clin Gastroenterol Hepatol. 2009 Feb; 7(2):168-74, 174.e1. Spiegel BM, Ho W, Esrailian E, Targan S, Higgins PD, Siegel CA, Dubinsky M, Melmed GY. PMID: 18952199; PMCID: PMC3804428.
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    150. IL23R haplotypes provide a large population attributable risk for Crohn's disease. Inflamm Bowel Dis. 2008 Sep; 14(9):1185-91. Taylor KD, Targan SR, Mei L, Ippoliti AF, McGovern D, Mengesha E, King L, Rotter JI. PMID: 18470928; PMCID: PMC2574614.
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    151. Ex vivo simulation of IgG Fc and T-cell receptor functions: an application to inflammatory bowel disease. Inflamm Bowel Dis. 2008 Aug; 14(8):1061-7. Mitsuhashi M, Targan SR. PMID: 18340639.
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    152. Certolizumab pegol. Nat Rev Drug Discov. 2008 Aug; 7(8):641-2. Melmed GY, Targan SR, Yasothan U, Hanicq D, Kirkpatrick P. PMID: 18670430.
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    153. Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-D-glucose and positron emission tomography. Gastroenterology. 2008 Sep; 135(3):744-55. Brewer S, McPherson M, Fujiwara D, Turovskaya O, Ziring D, Chen L, Takedatsu H, Targan SR, Wei B, Braun J. PMID: 18639553; PMCID: PMC3752978.
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    154. Increased immune reactivity predicts aggressive complicating Crohn's disease in children. Clin Gastroenterol Hepatol. 2008 Oct; 6(10):1105-11. Dubinsky MC, Kugathasan S, Mei L, Picornell Y, Nebel J, Wrobel I, Quiros A, Silber G, Wahbeh G, Katzir L, Vasiliauskas E, Bahar R, Otley A, Mack D, Evans J, Rosh J, Hemker MO, Leleiko N, Crandall W, Langton C, Landers C, Taylor KD, Targan SR, Rotter JI, Markowitz J, Hyams J, Western Regional Pediatric IBD Research Alliance, Pediatric IBD Collaborative Research Group, Wisconsin Pediatric IBD Alliance. PMID: 18619921; PMCID: PMC3745777.
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    155. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet. 2008 Aug; 40(8):955-62. Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, NIDDK IBD Genetics Consortium, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, Belgian-French IBD Consortium, Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ. PMID: 18587394; PMCID: PMC2574810.
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    156. TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology. 2008 Aug; 135(2):552-67. Takedatsu H, Michelsen KS, Wei B, Landers CJ, Thomas LS, Dhall D, Braun J, Targan SR. PMID: 18598698; PMCID: PMC2605110.
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    157. Both preoperative perinuclear antineutrophil cytoplasmic antibody and anti-CBir1 expression in ulcerative colitis patients influence pouchitis development after ileal pouch-anal anastomosis. Clin Gastroenterol Hepatol. 2008 May; 6(5):561-8. Fleshner P, Ippoliti A, Dubinsky M, Vasiliauskas E, Mei L, Papadakis KA, Rotter JI, Landers C, Targan S. PMID: 18378498; PMCID: PMC2742560.
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    158. Immunopathogenesis of inflammatory bowel disease. World J Gastroenterol. 2008 Jan 21; 14(3):390-400. Shih DQ, Targan SR. PMID: 18200661; PMCID: PMC2679127.
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    159. Ex vivo induction of mRNA in human whole blood as a new platform of drug and dietary supplement development. Pharm Res. 2008 May; 25(5):1116-24. Mitsuhashi M, Ogura M, Endo K, Obara K, Izutsu H, Targan SR, Maemura M, Tachikawa D, Shinagawa A. PMID: 18183479; PMCID: PMC2292497.
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    160. Family history and serology predict Crohn's disease after ileal pouch-anal anastomosis for ulcerative colitis. Dis Colon Rectum. 2008 Jan; 51(1):100-8. Melmed GY, Fleshner PR, Bardakcioglu O, Ippoliti A, Vasiliauskas EA, Papadakis KA, Dubinsky M, Landers C, Rotter JI, Targan SR. PMID: 18085333; PMCID: PMC2442922.
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    161. Detection of antisynthetic mannoside antibodies (ASigmaMA) reveals heterogeneity in the ASCA response of Crohn's disease patients and contributes to differential diagnosis, stratification, and prediction. Am J Gastroenterol. 2008 Apr; 103(4):949-57. Vandewalle-El Khoury P, Colombel JF, Joossens S, Standaert-Vitse A, Collot M, Halfvarson J, Ayadi A, Landers CJ, Vermeire S, Rutgeerts P, Targan SR, Chamaillard M, Mallet JM, Sendid B, Poulain D. PMID: 18047546.
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    162. Does infliximab influence surgical morbidity of ileal pouch-anal anastomosis in patients with ulcerative colitis? Dis Colon Rectum. 2007 Nov; 50(11):1747-53. Schluender SJ, Ippoliti A, Dubinsky M, Vasiliauskas EA, Papadakis KA, Mei L, Targan SR, Fleshner PR. PMID: 17704969.
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    163. TNFSF15 is an ethnic-specific IBD gene. Inflamm Bowel Dis. 2007 Nov; 13(11):1333-8. Picornell Y, Mei L, Taylor K, Yang H, Targan SR, Rotter JI. PMID: 17663424; PMCID: PMC2552994.
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    164. A phase I study of visilizumab, a humanized anti-CD3 monoclonal antibody, in severe steroid-refractory ulcerative colitis. Gastroenterology. 2007 Nov; 133(5):1414-22. Plevy S, Salzberg B, Van Assche G, Regueiro M, Hommes D, Sandborn W, Hanauer S, Targan S, Mayer L, Mahadevan U, Frankel M, Lowder J. PMID: 17920064.
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    165. Inflammatory bowel disease diagnosis, evaluation and classification: state-of-the art approach. Curr Opin Gastroenterol. 2007 Jul; 23(4):390-4. Targan SR, Karp LC. PMID: 17545774.
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    166. American gastroenterological association consensus development conference on the use of biologics in the treatment of inflammatory bowel disease, June 21-23, 2006. Gastroenterology. 2007 Jul; 133(1):312-39. Clark M, Colombel JF, Feagan BC, Fedorak RN, Hanauer SB, Kamm MA, Mayer L, Regueiro C, Rutgeerts P, Sandborn WJ, Sands BE, Schreiber S, Targan S, Travis S, Vermeire S. PMID: 17631151.
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    167. A prospective multivariate analysis of clinical factors associated with pouchitis after ileal pouch-anal anastomosis. Clin Gastroenterol Hepatol. 2007 Aug; 5(8):952-8; quiz 887. Fleshner P, Ippoliti A, Dubinsky M, Ognibene S, Vasiliauskas E, Chelly M, Mei L, Papadakis KA, Landers C, Targan S. PMID: 17544871.
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    168. IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease. Inflamm Bowel Dis. 2007 May; 13(5):511-5. Dubinsky MC, Wang D, Picornell Y, Wrobel I, Katzir L, Quiros A, Dutridge D, Wahbeh G, Silber G, Bahar R, Mengesha E, Targan SR, Taylor KD, Rotter JI, Western Regional Research Alliance for Pediatric IBD. PMID: 17309073; PMCID: PMC2169293.
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    169. Predicting a change in diagnosis from ulcerative colitis to Crohn's disease: a nested, case-control study. Clin Gastroenterol Hepatol. 2007 May; 5(5):602-8; quiz 525. Melmed GY, Elashoff R, Chen GC, Nastaskin I, Papadakis KA, Vasiliauskas EA, Liu W, Landers C, Ippoliti AF, Targan SR. PMID: 17478347.
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    170. Anti-flagellin (CBir1) phenotypic and genetic Crohn's disease associations. Inflamm Bowel Dis. 2007 May; 13(5):524-30. Papadakis KA, Yang H, Ippoliti A, Mei L, Elson CO, Hershberg RM, Vasiliauskas EA, Fleshner PR, Abreu MT, Taylor K, Landers CJ, Rotter JI, Targan SR. PMID: 17260364.
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    171. CD56 marks an effector T cell subset in the human intestine. J Immunol. 2007 May 01; 178(9):5524-32. Cohavy O, Targan SR. PMID: 17442934.
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    172. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet. 2007 May; 39(5):596-604. Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, Huett A, Green T, Kuballa P, Barmada MM, Datta LW, Shugart YY, Griffiths AM, Targan SR, Ippoliti AF, Bernard EJ, Mei L, Nicolae DL, Regueiro M, Schumm LP, Steinhart AH, Rotter JI, Duerr RH, Cho JH, Daly MJ, Brant SR. PMID: 17435756; PMCID: PMC2757939.
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    173. The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells. J Immunol. 2007 Apr 01; 178(7):4033-8. Prehn JL, Thomas LS, Landers CJ, Yu QT, Michelsen KS, Targan SR. PMID: 17371957.
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    174. Natalizumab for the treatment of active Crohn's disease: results of the ENCORE Trial. Gastroenterology. 2007 May; 132(5):1672-83. Targan SR, Feagan BG, Fedorak RN, Lashner BA, Panaccione R, Present DH, Spehlmann ME, Rutgeerts PJ, Tulassay Z, Volfova M, Wolf DC, Hernandez C, Bornstein J, Sandborn WJ, International Efficacy of Natalizumab in Crohn's Disease Response and Remission (ENCORE) Trial Group. PMID: 17484865.
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    175. Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease. J Immunol. 2007 Mar 01; 178(5):3293-300. Saruta M, Yu QT, Avanesyan A, Fleshner PR, Targan SR, Papadakis KA. PMID: 17312180.
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    176. Antibodies to I2 predict clinical response to fecal diversion in Crohn's disease. Inflamm Bowel Dis. 2006 Dec; 12(12):1122-30. Spivak J, Landers CJ, Vasiliauskas EA, Abreu MT, Dubinsky MC, Papadakis KA, Ippoliti A, Targan SR, Fleshner PR. PMID: 17119386.
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    177. NOD2 variants and antibody response to microbial antigens in Crohn's disease patients and their unaffected relatives. Gastroenterology. 2007 Feb; 132(2):576-86. Devlin SM, Yang H, Ippoliti A, Taylor KD, Landers CJ, Su X, Abreu MT, Papadakis KA, Vasiliauskas EA, Melmed GY, Fleshner PR, Mei L, Rotter JI, Targan SR. PMID: 17258734.
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    178. Recent understanding of IBD pathogenesis: implications for future therapies. Inflamm Bowel Dis. 2006 Nov; 12(11):1068-83. Kucharzik T, Maaser C, Lügering A, Kagnoff M, Mayer L, Targan S, Domschke W. PMID: 17075348.
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    179. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 2006 Dec 01; 314(5804):1461-3. Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH. PMID: 17068223; PMCID: PMC4410764.
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    180. Case report: evidence for transplacental transfer of maternally administered infliximab to the newborn. Clin Gastroenterol Hepatol. 2006 Oct; 4(10):1255-8. Vasiliauskas EA, Church JA, Silverman N, Barry M, Targan SR, Dubinsky MC. PMID: 17045211.
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    181. Molecular approaches to the role of the microbiota in inflammatory bowel disease. Ann N Y Acad Sci. 2006 Aug; 1072:39-51. Elson CO, Cong Y, Qi F, Hershberg RM, Targan SR. PMID: 17057189.
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    182. Current limitations of IBD treatment: where do we go from here? Ann N Y Acad Sci. 2006 Aug; 1072:1-8. Targan SR. PMID: 17057185.
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    183. Patients with inflammatory bowel disease are at risk for vaccine-preventable illnesses. Am J Gastroenterol. 2006 Aug; 101(8):1834-40. Melmed GY, Ippoliti AF, Papadakis KA, Tran TT, Birt JL, Lee SK, Frenck RW, Targan SR, Vasiliauskas EA. PMID: 16817843.
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    184. Immunogenetic phenotypes in inflammatory bowel disease. World J Gastroenterol. 2006 Jun 21; 12(23):3645-50. Dubinsky MC, Taylor K, Targan SR, Rotter JI. PMID: 16773679; PMCID: PMC4087455.
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    185. Familial expression of anti-Escherichia coli outer membrane porin C in relatives of patients with Crohn's disease. Gastroenterology. 2006 Apr; 130(4):1078-85. Mei L, Targan SR, Landers CJ, Dutridge D, Ippoliti A, Vasiliauskas EA, Papadakis KA, Fleshner PR, Rotter JI, Yang H. PMID: 16618402.
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    186. Serum immune responses predict rapid disease progression among children with Crohn's disease: immune responses predict disease progression. Am J Gastroenterol. 2006 Feb; 101(2):360-7. Dubinsky MC, Lin YC, Dutridge D, Picornell Y, Landers CJ, Farrior S, Wrobel I, Quiros A, Vasiliauskas EA, Grill B, Israel D, Bahar R, Christie D, Wahbeh G, Silber G, Dallazadeh S, Shah P, Thomas D, Kelts D, Hershberg RM, Elson CO, Targan SR, Taylor KD, Rotter JI, Yang H, Western Regional Pediatric IBD Research Alliance. PMID: 16454844; PMCID: PMC2259248.
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    187. Treatment with infliximab is associated with increased markers of bone formation in patients with Crohn's disease. J Clin Gastroenterol. 2006 Jan; 40(1):55-63. Abreu MT, Geller JL, Vasiliauskas EA, Kam LY, Vora P, Martyak LA, Yang H, Hu B, Lin YC, Keenan G, Price J, Landers CJ, Adams JS, Targan SR. PMID: 16340635.
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    188. Multiparameter analysis of immunogenetic mechanisms in clinical diagnosis and management of inflammatory bowel disease. Adv Exp Med Biol. 2006; 579:209-18. Braun J, Targan SR. PMID: 16620020.
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    189. Natalizumab induction and maintenance therapy for Crohn's disease. N Engl J Med. 2005 Nov 03; 353(18):1912-25. Sandborn WJ, Colombel JF, Enns R, Feagan BG, Hanauer SB, Lawrance IC, Panaccione R, Sanders M, Schreiber S, Targan S, van Deventer S, Goldblum R, Despain D, Hogge GS, Rutgeerts P, International Efficacy of Natalizumab as Active Crohn's Therapy (ENACT-1) Trial Group, Evaluation of Natalizumab as Continuous Therapy (ENACT-2) Trial Group. PMID: 16267322.
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    190. State of the art: IBD therapy and clinical trials in IBD. Inflamm Bowel Dis. 2005 Nov; 11 Suppl 1:S3-12. Isaacs KL, Lewis JD, Sandborn WJ, Sands BE, Targan SR. PMID: 16254481.
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    191. Elevated platelet count before ileal pouch-anal anastomosis for ulcerative colitis is associated with the development of chronic pouchitis. Am Surg. 2005 Oct; 71(10):821-6. Okon A, Dubinsky M, Vasiliauskas EA, Papadakis KA, Ippoliti A, Targan SR, Fleshner PR. PMID: 16468527.
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    192. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol. 2005 Sep; 19 Suppl A:5A-36A. Silverberg MS, Satsangi J, Ahmad T, Arnott ID, Bernstein CN, Brant SR, Caprilli R, Colombel JF, Gasche C, Geboes K, Jewell DP, Karban A, Loftus EV, Peña AS, Riddell RH, Sachar DB, Schreiber S, Steinhart AH, Targan SR, Vermeire S, Warren BF. PMID: 16151544.
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    193. Defects in mucosal immunity leading to ulcerative colitis. Immunol Rev. 2005 Aug; 206:296-305. Targan SR, Karp LC. PMID: 16048556.
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    194. Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology. 2005 Jun; 128(7):2020-8. Targan SR, Landers CJ, Yang H, Lodes MJ, Cong Y, Papadakis KA, Vasiliauskas E, Elson CO, Hershberg RM. PMID: 15940634.
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    195. Serologic responses in indeterminate colitis patients before ileal pouch-anal anastomosis may determine those at risk for continuous pouch inflammation. Dis Colon Rectum. 2005 Jun; 48(6):1254-62. Hui T, Landers C, Vasiliauskas E, Abreu M, Dubinsky M, Papadakis KA, Price J, Lin YC, Huiying Y, Targan S, Fleshner P. PMID: 15868228.
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    196. Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes. J Immunol. 2005 Apr 15; 174(8):4985-90. Papadakis KA, Zhu D, Prehn JL, Landers C, Avanesyan A, Lafkas G, Targan SR. PMID: 15814728.
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    197. LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling. J Immunol. 2005 Jan 15; 174(2):646-53. Cohavy O, Zhou J, Ware CF, Targan SR. PMID: 15634882.
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    198. Safety and efficacy of adalimumab (D2E7) in Crohn's disease patients with an attenuated response to infliximab. Am J Gastroenterol. 2005 Jan; 100(1):75-9. Papadakis KA, Shaye OA, Vasiliauskas EA, Ippoliti A, Dubinsky MC, Birt J, Paavola J, Lee SK, Price J, Targan SR, Abreu MT. PMID: 15654784.
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    199. Sero-reactivity to microbial components in Crohn's disease is associated with disease severity and progression, but not NOD2/CARD15 genotype. Am J Gastroenterol. 2004 Dec; 99(12):2376-84. Arnott ID, Landers CJ, Nimmo EJ, Drummond HE, Smith BK, Targan SR, Satsangi J. PMID: 15571586.
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    200. Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression. J Immunol. 2004 Nov 15; 173(10):6241-7. Gonsky R, Deem RL, Bream J, Young HA, Targan SR. PMID: 15528362.
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    201. Expression and regulation of the chemokine receptor CXCR3 on lymphocytes from normal and inflammatory bowel disease mucosa. Inflamm Bowel Dis. 2004 Nov; 10(6):778-88. Papadakis KA, Prehn J, Zhu D, Landers C, Gaiennie J, Fleshner PR, Targan SR. PMID: 15626897.
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    202. Elevated flagellin-specific immunoglobulins in Crohn's disease. Am J Physiol Gastrointest Liver Physiol. 2005 Feb; 288(2):G403-6. Sitaraman SV, Klapproth JM, Moore DA, Landers C, Targan S, Williams IR, Gewirtz AT. PMID: 15388489.
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    203. Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel disease. Am J Surg Pathol. 2004 Sep; 28(9):1204-11. Geller SA, Dubinsky MC, Poordad FF, Vasiliauskas EA, Cohen AH, Abreu MT, Tran T, Martin P, Vierling JM, Targan SR. PMID: 15316320.
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    204. High-level serum antibodies to bacterial antigens are associated with antibiotic-induced clinical remission in Crohn's disease: a pilot study. Dig Dis Sci. 2004 Aug; 49(7-8):1280-6. Mow WS, Landers CJ, Steinhart AH, Feagan BG, Croitoru K, Seidman E, Greenberg GR, Targan SR. PMID: 15387358.
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    205. A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2. J Biol Chem. 2004 Sep 24; 279(39):41249-57. Bream JH, Hodge DL, Gonsky R, Spolski R, Leonard WJ, Krebs S, Targan S, Morinobu A, O'Shea JJ, Young HA. PMID: 15271977.
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    206. A pilot study of adalimumab in infliximab-allergic patients. Inflamm Bowel Dis. 2004 Jul; 10(4):333-8. Youdim A, Vasiliauskas EA, Targan SR, Papadakis KA, Ippoliti A, Dubinsky MC, Lechago J, Paavola J, Loane J, Lee SK, Gaiennie J, Smith K, Do J, Abreu MT. PMID: 15475739.
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    207. Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation. Clin Immunol. 2004 Jul; 112(1):66-77. Prehn JL, Mehdizadeh S, Landers CJ, Luo X, Cha SC, Wei P, Targan SR. PMID: 15207783.
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    208. LIGHT expression by mucosal T cells may regulate IFN-gamma expression in the intestine. J Immunol. 2004 Jul 01; 173(1):251-8. Cohavy O, Zhou J, Granger SW, Ware CF, Targan SR. PMID: 15210782.
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    209. The spectrum of gastrointestinal toxicity and effect on disease activity of selective cyclooxygenase-2 inhibitors in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2004 Jul; 10(4):352-6. Matuk R, Crawford J, Abreu MT, Targan SR, Vasiliauskas EA, Papadakis KA. PMID: 15475742.
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    210. TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells. J Immunol. 2004 Jun 01; 172(11):7002-7. Papadakis KA, Prehn JL, Landers C, Han Q, Luo X, Cha SC, Wei P, Targan SR. PMID: 15153521.
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    211. Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest. 2004 May; 113(9):1296-306. Lodes MJ, Cong Y, Elson CO, Mohamath R, Landers CJ, Targan SR, Fort M, Hershberg RM. PMID: 15124021; PMCID: PMC398429.
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    212. High incidence of anergy in inflammatory bowel disease patients limits the usefulness of PPD screening before infliximab therapy. Clin Gastroenterol Hepatol. 2004 Apr; 2(4):309-13. Mow WS, Abreu-Martin MT, Papadakis KA, Pitchon HE, Targan SR, Vasiliauskas EA. PMID: 15067625.
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    214. Initial experience with wireless capsule enteroscopy in the diagnosis and management of inflammatory bowel disease. Clin Gastroenterol Hepatol. 2004 Jan; 2(1):31-40. Mow WS, Lo SK, Targan SR, Dubinsky MC, Treyzon L, Abreu-Martin MT, Papadakis KA, Vasiliauskas EA. PMID: 15017630.
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    215. 6-thioguanine can cause serious liver injury in inflammatory bowel disease patients. Gastroenterology. 2003 Aug; 125(2):298-303. Dubinsky MC, Vasiliauskas EA, Singh H, Abreu MT, Papadakis KA, Tran T, Martin P, Vierling JM, Geller SA, Targan SR, Poordad FF. PMID: 12891528.
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    216. CC chemokine receptor 9 expression defines a subset of peripheral blood lymphocytes with mucosal T cell phenotype and Th1 or T-regulatory 1 cytokine profile. J Immunol. 2003 Jul 01; 171(1):159-65. Papadakis KA, Landers C, Prehn J, Kouroumalis EA, Moreno ST, Gutierrez-Ramos JC, Hodge MR, Targan SR. PMID: 12816994.
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    217. Thioguanine: a potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine. Am J Gastroenterol. 2003 May; 98(5):1058-63. Dubinsky MC, Feldman EJ, Abreu MT, Targan SR, Vasiliauskas EA. PMID: 12809828.
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    218. CD2 mediates activation of the IFN-gamma intronic STAT binding region in mucosal T cells. Eur J Immunol. 2003 May; 33(5):1152-62. Gonsky R, Deem RL, Young HA, Targan SR. PMID: 12731040.
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    219. Challenges in IBD Research: updating the scientific agendas. Inflamm Bowel Dis. 2003 May; 9(3):137-53. Elson CO, Sartor RB, Targan SR, Sandborn WJ. PMID: 12792219.
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    220. A novel NOD2/CARD15 haplotype conferring risk for Crohn disease in Ashkenazi Jews. Am J Hum Genet. 2003 Mar; 72(3):509-18. Sugimura K, Taylor KD, Lin YC, Hang T, Wang D, Tang YM, Fischel-Ghodsian N, Targan SR, Rotter JI, Yang H. PMID: 12577202; PMCID: PMC1180227.
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    221. Anti-CD2O chimeric monoclonal antibody (rituximab) treatment of immune-mediated thrombocytopenia associated with Crohn's disease. Gastroenterology. 2003 Feb; 124(2):583. Papadakis KA, Rosenbloom B, Targan SR. PMID: 12557172.
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    222. Biologic therapy of inflammatory bowel disease. Gastroenterology. 2002 May; 122(6):1592-608. Sandborn WJ, Targan SR. PMID: 12016425.
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    223. 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease. Gastroenterology. 2002 Apr; 122(4):904-15. Dubinsky MC, Yang H, Hassard PV, Seidman EG, Kam LY, Abreu MT, Targan SR, Vasiliauskas EA. PMID: 11910342.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCTClinical Trials
    224. Biology of inflammation in Crohn's disease: mechanisms of action of anti-TNF-a therapy. Can J Gastroenterol. 2000 Sep; 14 Suppl C:13C-16C. Targan SR. PMID: 11023555.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
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