John Lu, Ph.D.

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Work Titles
UCLA Professor Emeritus, Neurobiology
Education:
Degrees:
Ph.D.

Contact Information:

Email Address:

jlu@mednet.ucla.edu


Work Phone Number:

310-206-5017

310-206-8915

Work Address:

Laboratory
Center for Health Sciences
Los Angeles, CA 90095

Office
CHS
Los Angeles, CA 90095


Detailed Biography:

Reproductive senescence and neuroendocrine aging

We investigate the interactions between ovarian and neuroendocrine functions during aging by assessing how aging-associated changes in follicular dynamics and steroid production influence the neuroendocrine control of hypothalamic gonadotropin-releasing hormone (GnRH) and pituitary gonadotropin secretion. Our recent work has found that, in middle-aged rats, a cessation of spontaneous ovulatory cycles is due to a diminished hypothalamic response to estradiol stimulation on GnRH release, not to a depletion of ovarian follicles. Successive administration of progesterone to these acyclic females not only reinstates and maintains regular ovulatory cycles until very old age, but also preserves normal gonadotropin surge responses to estradiol plus progesterone challenge.

Publications:

A selected list of publications:

LaPolt PS, Lu JKH   Factors influencing the onset of female reproductive senescence, Functional Neurobiology of Aging, 2001; 761-768.
LaPolt PS, Lu JKH   Factors influencing the onset of female reproductive senescence, Functional Neurobiology of Aging, 2001; 761-768.
LaPolt PS, Lu JKH   Factors influencing the onset of female reproductive senescence, Functional Neurobiology of Aging, 2001; 761-768.
LaPolt PS, Lu JKH   Factors influencing the onset of female reproductive senescence, Functional Neurobiology of Aging, 2001; 761-768.
Yi SE, LaPolt PS, Chen J, Lu JKH, Lyons KM   The type 1 BMP receptor BMPRIB is essential for the female reproductive function, Proc Natl Acad Sci, 2001; 98: 7994-7999.
Anzalone, CR Hong, LS Lu, JK LaPolt, PS   Influences of age and ovarian follicular reserve on estrous cycle patterns, ovulation, and hormone secretion in the Long-Evans rat Biology of reproduction. , 2001; 64(4): 1056-62.
LaPolt, PS Lu, JK   Effects of aging on luteinizing hormone secretion, ovulation, and ovarian tissue-type plasminogen activator expression Experimental biology and medicine (Maywood, N.J.) , 2001; 226(2): 127-32.
LaPolt, PS Matt, DW Lu, JK   Progesterone implants delay age-related declines in regular estrous cyclicity and the ovarian follicular reserve in Long-Evans rats Biology of reproduction. , 1998; 59(1): 197-201.
Day, JR Morales, TH Lu, JK   Male stimulation of luteinizing hormone surge, progesterone secretion and ovulation in spontaneously persistent-estrous, aging rats Biology of reproduction. , 1988; 38(5): 1019-26.
Matt, DW Coquelin, A Lu, JK   Neuroendocrine control of luteinizing hormone secretion and reproductive function in spontaneously persistent-estrous aging rats Biology of reproduction. , 1987; 37(5): 1198-206.

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