David Chia, Ph.D.

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A Short Biography:

Dr. David Chia's major research interest is in the development of bio-markers for the early detection of cancers. Chia and his colleagues are involved in two National Cancer Institute (NCI)-sponsored studies designed to evaluate the efficacy of screening a population of normal individuals for a variety of tumor-associated markers in reducing mortality from prostate, lung, colon and ovarian cancers. The researchers measure the prostate-specific antigen, PSA, and another cancer antigen, Ca-125, levels in a large normal population as part of a national study, but are interested in several other tumor markers as well. Chia is also a member of the Early Detection Research Network (EDRN), a scientific consortium sponsored by NCI, which will develop and validate molecular markers for earlier cancer detection and risk assessment and ready the tests for clinical use. Chia's laboratory serves as the bio-marker validation laboratory and is involved in technology development, quality control, refinement and high-throughput testing. The researchers have constructed tissue micro-array for prostate and breast cancers and are currently in the process of making a lung array.
Work Titles
CTSI Member, CTSI
UCLA Professor, Pathology and Laboratory Medicine Professor, Transplant/Immunogenetics Testing Member, JCCC Cancer and Stem Cell Biology Program Area Member, JCCC Molecular Epidemiology Program Area
Education:
Degrees:
Ph.D., University of California, Los Angeles

Contact Information:

Email Address:

dchia@mednet.ucla.edu

Work Email Address:

dchia@mednet.ucla.edu


Website:

Web Profile

Work Phone Number:

(310) 206-4549

Office Address:

10833 Le Conte Ave.
1P-250
Los Angeles, CA 90095


Work Address:

3131 Reed
CAMPUS - 165222
CA

Office
Rehab cntr
Los Angeles, CA 90095


Publications:

A selected list of publications:

Ho Melissa E, Quek Sue-Ing, True Lawrence D, Morrissey Colm, Corey Eva, Vessella Robert L, Dumpit Ruth, Nelson Peter S, Maresh Erin L, Mah Vei, Alavi Mohammed, Kim Sara R, Bagryanova Lora, Horvath Steve, Chia David, Goodglick Lee, Liu Alvin Y   Prostate cancer cell phenotypes based on AGR2 and CD10 expression Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2013; .
Zhang Lei, Xiao Hua, Zhou Hui, Santiago Silverio, Lee Jay M, Garon Edward B, Yang Jieping, Brinkmann Ole, Yan Xinmin, Akin David, Chia David, Elashoff David, Park No-Hee, Wong David T W   Development of transcriptomic biomarker signature in human saliva to detect lung cancer Cellular and molecular life sciences : CMLS, 2012; 69(19): 3341-50.
Huynh Thu P, Mah Vei, Sampson Valerie B, Chia David, Fishbein Michael C, Horvath Steve, Alavi Mohammad, Wu Debbie C, Harper Jeffrey, Sarafian Ted, Dubinett Steven M, Langhans Sigrid A, Goodglick Lee, Rajasekaran Ayyappan K   Na,K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancer American journal of physiology. Lung cellular and molecular physiology, 2012; 302(11): L1150-8.
Elashoff David, Zhou Hui, Reiss Jean, Wang Jianghua, Xiao Hua, Henson Bradley, Hu Shen, Arellano Martha, Sinha Uttam, Le Anh, Messadi Diana, Wang Marilene, Nabili Vishad, Lingen Mark, Morris Darly, Randolph Timothy, Feng Ziding, Akin David, Kastratovic Dragana A, Chia David, Abemayor Elliot, Wong David T W   Prevalidation of salivary biomarkers for oral cancer detection Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2012; 21(4): 664-72.
Andriole Gerald L, Crawford E David, Grubb Robert L, Buys Saundra S, Chia David, Church Timothy R, Fouad Mona N, Isaacs Claudine, Kvale Paul A, Reding Douglas J, Weissfeld Joel L, Yokochi Lance A, O'Brien Barbara, Ragard Lawrence R, Clapp Jonathan D, Rathmell Joshua M, Riley Thomas L, Hsing Ann W, Izmirlian Grant, Pinsky Paul F, Kramer Barnett S, Miller Anthony B, Gohagan John K, Prorok Philip C, Prorok Philip C   Prostate cancer screening in the randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: mortality results after 13 years of follow-up Journal of the National Cancer Institute, 2012; 104(2): 125-32.
Farrell James J, Zhang Lei, Zhou Hui, Chia David, Elashoff David, Akin David, Paster Bruce J, Joshipura Kaumudi, Wong David T W   Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer Gut, 2012; 61(4): 582-8.
Xie Chong, Kim Hyun J, Haw Jonathan G, Kalbasi Anusha, Gardner Brian K, Li Gang, Rao Jianyu, Chia David, Liong Monty, Punzalan Rubio R, Marks Leonard S, Pantuck Allan J, de la Taille Alexandre, Wang Guomin, Mukouyama Hideki, Zeng Gang   A novel multiplex assay combining autoantibodies plus PSA has potential implications for classification of prostate cancer from non-malignant cases Journal of translational medicine, 2011; 9(22): 43.
Lee Yu-Hsiang, Zhou Hui, Reiss Jean K, Yan Xinmin, Zhang Lei, Chia David, Wong David T W   Direct saliva transcriptome analysis Clinical chemistry, 2011; 57(9): 1295-302.
Buys Saundra S, Partridge Edward, Black Amanda, Johnson Christine C, Lamerato Lois, Isaacs Claudine, Reding Douglas J, Greenlee Robert T, Yokochi Lance A, Kessel Bruce, Crawford E David, Church Timothy R, Andriole Gerald L, Weissfeld Joel L, Fouad Mona N, Chia David, O'Brien Barbara, Ragard Lawrence R, Clapp Jonathan D, Rathmell Joshua M, Riley Thomas L, Hartge Patricia, Pinsky Paul F, Zhu Claire S, Izmirlian Grant, Kramer Barnett S, Miller Anthony B, Xu Jian-Lun, Prorok Philip C, Gohagan John K, Berg Christine D, Berg Christine D   Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial JAMA : the journal of the American Medical Association, 2011; 305(22): 2295-303.
Mah Vei, Marquez Diana, Alavi Mohammad, Maresh Erin L, Zhang Li, Yoon Nam, Horvath Steve, Bagryanova Lora, Fishbein Michael C, Chia David, Pietras Richard, Goodglick Lee   Expression levels of estrogen receptor beta in conjunction with aromatase predict survival in non-small cell lung cancer Lung cancer (Amsterdam, Netherlands), 2011; 74(2): 318-25.
Huerta-Yepez Sara, Yoon Nam K, Hernandez-Cueto Angeles, Mah Vei, Rivera-Pazos Clara M, Chatterjee Devasis, Vega Mario I, Maresh Erin L, Horvath Steve, Chia David, Bonavida Benjamin, Goodglick Lee   Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival BMC cancer, 2011; 11(4): 259.
Marquez-Garban Diana C, Mah Vei, Alavi Mohammad, Maresh Erin L, Chen Hsiao-Wang, Bagryanova Lora, Horvath Steve, Chia David, Garon Edward, Goodglick Lee, Pietras Richard J   Progesterone and estrogen receptor expression and activity in human non-small cell lung cancer Steroids, 2011; 76(9): 910-20.
Presson Angela P, Yoon Nam K, Bagryanova Lora, Mah Vei, Alavi Mohammad, Maresh Erin L, Rajasekaran Ayyappan K, Goodglick Lee, Chia David, Horvath Steve   Protein expression based multimarker analysis of breast cancer samples BMC cancer, 2011; 11(4): 230.
Maresh Erin L, Mah Vei, Alavi Mohammad, Horvath Steve, Bagryanova Lora, Liebeskind Emily S, Knutzen Laura A, Zhou Yong, Chia David, Liu Alvin Y, Goodglick Lee   Differential expression of anterior gradient gene AGR2 in prostate cancer BMC cancer, 2010; 10(12): 680.
Zhang Lei, Xiao Hua, Karlan Scott, Zhou Hui, Gross Jenny, Elashoff David, Akin David, Yan Xinmin, Chia David, Karlan Beth, Wong David T   Discovery and preclinical validation of salivary transcriptomic and proteomic biomarkers for the non-invasive detection of breast cancer PloS one, 2010; 5(12): e15573.
Yoon Nam K, Maresh Erin L, Elshimali Yahya, Li Ai, Horvath Steve, Seligson David B, Chia David, Goodglick Lee   Elevated MED28 expression predicts poor outcome in women with breast cancer BMC cancer, 2010; 10(13): 335.
Yoon Nam K, Maresh Erin L, Shen Dejun, Elshimali Yahya, Apple Sophia, Horvath Steve, Mah Vei, Bose Shikha, Chia David, Chang Helena R, Goodglick Lee   Higher levels of GATA3 predict better survival in women with breast cancer Human pathology, 2010; 41(12): 1794-801.
Ooi Aik T, Mah Vei, Nickerson Derek W, Gilbert Jennifer L, Ha Vi Luan, Hegab Ahmed E, Horvath Steve, Alavi Mohammad, Maresh Erin L, Chia David, Gower Adam C, Lenburg Marc E, Spira Avrum, Solis Luisa M, Wistuba Ignacio I, Walser Tonya C, Wallace William D, Dubinett Steven M, Goodglick Lee, Gomperts Brigitte N   Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer Cancer research, 2010; 70(16): 6639-48.
Zhang Lei, Farrell James J, Zhou Hui, Elashoff David, Akin David, Park No-Hee, Chia David, Wong David T   Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer Gastroenterology, 2010; 138(3): 949-57.e1-7.
Mutch Matthew G, Schoen Robert E, Fleshman James W, Rall Christopher J N, Dry Sarah, Seligson David, Charabaty Aline, Chia David, Umar Asad, Viner Jaye, Hawk Ernest, Pinsky Paul F   A multicenter study of prevalence and risk factors for aberrant crypt foci Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2009; 7(5): 568-74.
Marrero Paul F, Feng Paul F, Wang Paul F, Nguyen Paul F, Befeler Paul F, Roberts Paul F, Reddy Paul F, Harnois Paul F, Llovet Paul F, Normolle Paul F, Dalhgren Paul F, Chia Paul F, Lok Paul F, Wagner Paul F, Srivastava Paul F, Schwartz Paul F   Alpha-fetoprotein, Des-gamma Carboxyprothrombin, and Lectin-Bound Alpha-fetoprotein in Early Hepatocellular Carcinoma AFP, DCP, and AFP-L3 in Hepatocellular carcinoma Gastroenterology, 2009; 7(5): .
Seligson David B, Horvath Steve, McBrian Matthew A, Mah Vei, Yu Hong, Tze Sheila, Wang Qun, Chia David, Goodglick Lee, Kurdistani Siavash K   Global levels of histone modifications predict prognosis in different cancers The American journal of pathology, 2009; 174(5): 1619-28.
Yoon Nam K, Seligson David B, Chia David, Elshimali Yahya, Sulur Giri, Li Ai, Horvath Steve, Maresh Erin, Mah Vei, Bose Shikha, Bonavida Benjamin, Goodglick Lee   Higher expression levels of 14-3-3sigma in ductal carcinoma in situ of the breast predict poorer outcome Cancer biomarkers : section A of Disease markers, 2009; 5(4): 215-24.
Andriole Gerald L, Crawford E David, Grubb Robert L, Buys Saundra S, Chia David, Church Timothy R, Fouad Mona N, Gelmann Edward P, Kvale Paul A, Reding Douglas J, Weissfeld Joel L, Yokochi Lance A, O'Brien Barbara, Clapp Jonathan D, Rathmell Joshua M, Riley Thomas L, Hayes Richard B, Kramer Barnett S, Izmirlian Grant, Miller Anthony B, Pinsky Paul F, Prorok Philip C, Gohagan John K, Berg Christine D, Berg Christine D   Mortality results from a randomized prostate-cancer screening trial The New England journal of medicine, 2009; 360(13): 1310-9.
Yanagawa Jane, Walser Tonya C, Zhu Li X, Hong Longsheng, Fishbein Michael C, Mah Vei, Chia David, Goodglick Lee, Elashoff David A, Luo Jie, Magyar Clara E, Dohadwala Mariam, Lee Jay M, St John Maie A, Strieter Robert M, Sharma Sherven, Dubinett Steven M   Snail promotes CXCR2 ligand-dependent tumor progression in non-small cell lung carcinoma Clinical cancer research : an official journal of the American Association for Cancer Research, 2009; 15(22): 6820-9.
Tuck Melissa K, Chan Daniel W, Chia David, Godwin Andrew K, Grizzle William E, Krueger Karl E, Rom William, Sanda Martin, Sorbara Lynn, Stass Sanford, Wang Wendy, Brenner Dean E   Standard operating procedures for serum and plasma collection: early detection research network consensus statement standard operating procedure integration working group Journal of proteome research, 2009; 8(1): 113-7.
Planque Chris, Li Lin, Zheng Yingye, Soosaipillai Antoninus, Reckamp Karen, Chia David, Diamandis Eleftherios P, Goodglick Lee   A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma Clinical cancer research : an official journal of the American Association for Cancer Research, 2008; 14(5): 1355-62.
Grubb Robert L, Pinsky Paul F, Greenlee Robert T, Izmirlian Grant, Miller Anthony B, Hickey Thomas P, Riley Thomas L, Mabie Jerome E, Levin David L, Chia David, Kramer Barnett S, Reding Douglas J, Church Timothy R, Yokochi Lance A, Kvale Paul A, Weissfeld Joel L, Urban Donald A, Buys Saundra S, Gelmann Edward P, Ragard Lawrence R, Crawford E David, Prorok Philip C, Gohagan John K, Berg Christine D, Andriole Gerald L   Prostate cancer screening in the Prostate, Lung, Colorectal and Ovarian cancer screening trial: update on findings from the initial four rounds of screening in a randomized trial BJU international, 2008; 102(11): 1524-30.
Mah Vei, Seligson David B, Li Ai, Márquez Diana C, Wistuba Ignacio I, Elshimali Yahya, Fishbein Michael C, Chia David, Pietras Richard J, Goodglick Lee   Aromatase expression predicts survival in women with early-stage non small cell lung cancer Cancer research, 2007; 67(21): 10484-90.
Briman Mikhail, Artukovic Erika, Zhang Li, Chia David, Goodglick Lee, Gruner George   Direct electronic detection of prostate-specific antigen in serum Small (Weinheim an der Bergstrasse, Germany), 2007; 3(5): 758-62.
Seligson David B, Hongo Fumiya, Huerta-Yepez Sara, Mizutani Yoichi, Miki Tsuneharu, Yu Hong, Horvath Steve, Chia David, Goodglick Lee, Bonavida Benjamin   Expression of X-linked inhibitor of apoptosis protein is a strong predictor of human prostate cancer recurrence Clinical cancer research : an official journal of the American Association for Cancer Research, 2007; 13(20): 6056-63.
Weiss Jocelyn M, Huang Wen-Yi, Rinaldi Sabina, Fears Thomas R, Chatterjee Nilanjan, Chia David, Crawford E David, Kaaks Rudolf, Hayes Richard B   IGF-1 and IGFBP-3: Risk of prostate cancer among men in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial International journal of cancer. Journal international du cancer, 2007; 121(10): 2267-73.
Pinsky Paul F, Andriole Gerald, Crawford E David, Chia David, Kramer Barnett S, Grubb Robert, Greenlee Robert, Gohagan John K   Prostate-specific antigen velocity and prostate cancer gleason grade and stage Cancer, 2007; 109(8): 1689-95.
Shen Dejun, Nooraie Farzad, Elshimali Yahya, Lonsberry Victor, He Jianbo, Bose Shikha, Chia David, Seligson David, Chang Helena R, Goodglick Lee   Decreased expression of annexin A1 is correlated with breast cancer development and progression as determined by a tissue microarray analysis Human pathology, 2006; 37(12): 1583-91.
Crawford E David, Pinsky Paul F, Chia David, Kramer Barnett S, Fagerstrom Richard M, Andriole Gerald, Reding Douglas, Gelmann Edward P, Levin David L, Gohagan John K   Prostate specific antigen changes as related to the initial prostate specific antigen: data from the prostate, lung, colorectal and ovarian cancer screening trial The Journal of urology, 2006; 175(4): 1286-90; discussion 1290.
Pinsky Paul F, Kramer Barnett S, Crawford E David, Grubb Robert L, Urban Donald A, Andriole Gerald L, Chia David, Levin David L, Gohagan John K   Prostate volume and prostate-specific antigen levels in men enrolled in a large screening trial Urology, 2006; 68(2): 352-6.
Seligson David, Horvath Steve, Huerta-Yepez Sara, Hanna Stephanie, Garban Hermes, Roberts Alice, Shi Tao, Liu Xueli, Chia David, Goodglick Lee, Bonavida Benjamin   Expression of transcription factor Yin Yang 1 in prostate cancer International journal of oncology, 2005; 27(1): 131-41.
Shen Dejun, Chang Helena R, Chen Zugen, He Jianbo, Lonsberry Victor, Elshimali Yahya, Chia David, Seligson David, Goodglick Lee, Nelson Stanley F, Gornbein Jeffrey A   Loss of annexin A1 expression in human breast cancer detected by multiple high-throughput analyses Biochemical and biophysical research communications, 2005; 326(1): 218-27.
Buys Saundra S, Partridge Edward, Greene Mark H, Prorok Philip C, Reding Douglas, Riley Thomas L, Hartge Patricia, Fagerstrom Richard M, Ragard Lawrence R, Chia David, Izmirlian Grant, Fouad Mona, Johnson Christine C, Gohagan John K, Gohagan John K   Ovarian cancer screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial: findings from the initial screen of a randomized trial American journal of obstetrics and gynecology, 2005; 193(5): 1630-9.
Andriole Gerald L, Levin David L, Crawford E David, Gelmann Edward P, Pinsky Paul F, Chia David, Kramer Barnett S, Reding Douglas, Church Timothy R, Grubb Robert L, Izmirlian Grant, Ragard Lawrence R, Clapp Jonathan D, Prorok Philip C, Gohagan John K, Gohagan John K   Prostate Cancer Screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial: findings from the initial screening round of a randomized trial Journal of the National Cancer Institute, 2005; 97(6): 433-8.
Krysan Kostyantyn, Merchant Farrukh H, Zhu Li, Dohadwala Mariam, Luo Jie, Lin Ying, Heuze-Vourc'h Nathalie, Põld Mehis, Seligson David, Chia David, Goodglick Lee, Wang Hejing, Strieter Robert, Sharma Sherven, Dubinett Steven   COX-2-dependent stabilization of survivin in non-small cell lung cancer The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004; 18(1): 206-8.
Kang D, Andriole GL, Van De Vooren RC, Crawford D, Chia D, Urban DA, Reding D, Huang WY, Hayes RB   Risk behaviours and benign prostatic hyperplasia BJU international. , 2004; 93(9): 1241-5.
Croswell Jennifer Miller, Kramer Barnett S, Kreimer Aimee R, Prorok Phil C, Xu Jian-Lun, Baker Stuart G, Fagerstrom Richard, Riley Thomas L, Clapp Jonathan D, Berg Christine D, Gohagan John K, Andriole Gerald L, Chia David, Church Timothy R, Crawford E David, Fouad Mona N, Gelmann Edward P, Lamerato Lois, Reding Douglas J, Schoen Robert E   Cumulative incidence of false-positive results in repeated, multimodal cancer screening Annals of family medicine, 2010; 7(3): 212-22.
Pass Harvey I, Levin Stephen M, Harbut Michael R, Melamed Jonathan, Chiriboga Luis, Donington Jessica, Huflejt Margaret, Carbone Michele, Chia David, Goodglick Lee, Goodman Gary E, Thornquist Mark D, Liu Geoffrey, de Perrot Marc, Tsao Ming-Sound, Goparaju Chandra   Fibulin-3 as a blood and effusion biomarker for pleural mesothelioma The New England journal of medicine, 2012; 367(15): 1417-27.
Mills Dixie, Gordon Eva J, Casano Ashley, Lahti Sarah Michelle, Nguyen Tinh, Preston Alex, Tondre Julie, Wu Kuan, Yanase Tiffany, Chan Henry, Chia David, Esfandiari Mahtash, Himmel Tiffany, Love Susan M   The physiology of the normal human breast: an exploratory study Journal of physiology and biochemistry, 2011; 67(4): 621-7.
Sun Qiao-Yang, Ding Ling-Wen, Xiao Jin-Fen, Chien Wenwen, Lim Su-Lin, Hattori Norimichi, Goodglick Lee, Chia David, Mah Vei, Alavi Mohammad, Kim Sara R, Doan Ngan B, Said Jonathan W, Loh Xin-Yi, Xu Liang, Liu Li-Zhen, Yang Henry, Hayano Takahide, Shi Shuo, Xie Dong, Lin De-Chen, Koeffler H Phillip   SETDB1 accelerates tumorigenesis by regulating WNT signaling pathway The Journal of pathology, 2014; .
Wei Fang, Lin Chien-Chung, Joon Aron, Feng Ziding, Troche Gabriel, Lira Maruja E, Chia David, Mao Mao, Ho Chung-Liang, Su Wu-Chou, Wong David T W   Noninvasive Saliva-based EGFR Gene Mutation Detection in Patients with Lung Cancer American journal of respiratory and critical care medicine, 2014; 190(10): 1117-26.
Lau Chang, Kim Yong, Chia David, Spielmann Nadine, Eibl Guido, Elashoff David, Wei Fang, Lin Yi-Ling, Moro Aune, Grogan Tristan, Chiang Samantha, Feinstein Eric, Schafer Christopher, Farrell James, Wong David T W   Role of pancreatic cancer-derived exosomes in salivary biomarker development The Journal of biological chemistry, 2013; 288(37): 26888-97.
Hsing Ann W, Yeboah Edward, Biritwum Richard, Tettey Yao, De Marzo Angelo M, Adjei Andrew, Netto George J, Yu Kai, Li Yan, Chokkalingam Anand P, Chu Lisa W, Chia David, Partin Alan, Thompson Ian M, Quraishi Sabah M, Niwa Shelley, Tarone Robert, Hoover Robert N   High prevalence of screen detected prostate cancer in West Africans: implications for racial disparity of prostate cancer The Journal of urology, 2014; 192(3): 730-5.

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