Detailed Biography:
Dr. Watson received his Ph.D from the Department of Chemistry and Biochemistry at UCLA in 1985 in Jay Gralla's Laboratory in which he combined virology and protein biochemistry to identify early SV40 virus replication and transcription complexes associated with the nuclear matrix of eukaryotic cells. He then went on to do a postdoctoral fellowship in molecular biology of the nervous system in Dr. J. Gregor Sutcliffe's lab at The Scripps Research Institute in La Jolla, CA, where he began his initial studies of neurodegenerative diseases focusing on identifying novel genes relevant to Huntington's Disease (HD). He returned to UCLA in 1989 as a member of the Mental Retardation Research Center and the Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, studying synaptic targets of neurodegenerative diseases that include Parkinson's Disease (PD), HD, and Alzheimer's Disease. He has also served as the Vice Chair of the Neuroscience Undergraduate Interdepartmental Program for the UCLA campus and Outreach Program Director for the Brain Research Institute (BRI). He also served as an Associate Dean in the Graduate Division from 2012 until 2019. He is currently an Emeritus Professor in Psychiatry & Biobehavioral Sciences continuing his research in PD and HD.
Publications:
A selected list of publications:
Cepeda Carlos, Galvan Laurie, Holley Sandra M, Rao Shilpa P, André Véronique M, Botelho Elian P, Chen Jane Y, Watson Joseph B, Deisseroth Karl, Levine Michael S
Multiple sources of striatal inhibition are differentially affected in
Huntington's disease mouse models
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2013; 33(17):
7393-406.
Sarafian Theodore A, Ryan Christopher M, Souda Puneet, Masliah Eliezer, Kar Upendra K, Vinters Harry V, Mathern Gary W, Faull Kym F, Whitelegge Julian P, Watson Joseph B
Impairment of mitochondria in adult mouse brain overexpressing
predominantly full-length, N-terminally acetylated human α-synuclein
PloS one,
2013; 8(5):
e63557.
Chang Julia W, Arnold Monica M, Rozenbaum Anna, Caputo Anna, Schweizer Felix E, Huynh My, Mathern Gary W, Sarafian Theodore A, Watson Joseph B
Synaptoneurosome micromethod for fractionation of mouse and human
brain, and primary neuronal cultures
Journal of neuroscience methods,
2012; 211(2):
289-95.
Romero-Calderón Rafael, O'Hare Elizabeth D, Suthana Nanthia A, Scott-Van Zeeland Ashley A, Rizk-Jackson Angela, Attar Aida, Madsen Sarah K, Ghiani Cristina A, Evans Christopher J, Watson Joseph B
Project brainstorm: using neuroscience to connect college students
with local schools
PLoS biology,
2012; 10(4):
e1001310.
Cummings Damian M, Alaghband Yasaman, Hickey Miriam A, Joshi Prasad R, Hong S Candice, Zhu Chunni, Ando Timothy K, André Véronique M, Cepeda Carlos, Watson Joseph B, Levine Michael S
A critical window of CAG repeat-length correlates with phenotype
severity in the R6/2 mouse model of Huntington's disease
Journal of neurophysiology,
2012; 107(2):
677-91.
Watson, J.B.
Subtractive cDNA Hybridization and Brain: Then, Now, and Tomorrow,
Handbook of Molecular-Genetic Techniques for Brain and Behavior Research (Techniques in the Behavior,
1999; Vol. 13:
189-199.