Rachelle Hope Crosbie

Title(s)Professor, Integrative Biology And Physiology
SchoolCollege of Letters and Science
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    Title(s)Professor, Neurology


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    1. The extracellular matrix differentially directs myoblast motility and differentiation in distinct forms of muscular dystrophy: Dystrophic matrices alter myoblast motility. Matrix Biol. 2024 Apr 04. Long AM, Kwon JM, Lee G, Reiser NL, Vaught LA, O'Brien JG, Page PGT, Hadhazy M, Reynolds JC, Crosbie RH, Demonbreun AR, McNally EM. PMID: 38582404.
      View in: PubMed   Mentions:
    2. The super-healing MRL strain promotes muscle growth in muscular dystrophy through a regenerative extracellular matrix. JCI Insight. 2024 Jan 04; 9(3). O'Brien JG, Willis AB, Long AM, Kwon J, Lee G, Li FW, Page PG, Vo AH, Hadhazy M, Spencer MJ, Crosbie RH, Demonbreun AR, McNally EM. PMID: 38175727.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. The super-healing MRL strain promotes muscle growth in muscular dystrophy through a regenerative extracellular matrix. bioRxiv. 2023 Jun 30. O'Brien JG, Willis AB, Long AM, Kwon J, Lee G, Li F, Page PGT, Vo AH, Hadhazy M, Crosbie RH, Demonbreun AR, McNally EM. PMID: 37425960; PMCID: PMC10327155.
      View in: PubMed   Mentions:
    4. Engineering multicomponent tissue by spontaneous adhesion of myogenic and adipogenic microtissues cultured with customized scaffolds. Food Res Int. 2023 10; 172:113080. Kawecki NS, Norris SCP, Xu Y, Wu Y, Davis AR, Fridman E, Chen KK, Crosbie RH, Garmyn AJ, Li S, Mason TG, Rowat AC. PMID: 37689860.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis. NPJ Regen Med. 2023 Mar 15; 8(1):16. Stearns-Reider KM, Hicks MR, Hammond KG, Reynolds JC, Maity A, Kurmangaliyev YZ, Chin J, Stieg AZ, Geisse NA, Hohlbauch S, Kaemmer S, Schmitt LR, Pham TT, Yamauchi K, Novitch BG, Wollman R, Hansen KC, Pyle AD, Crosbie RH. PMID: 36922514; PMCID: PMC10017766.
      View in: PubMed   Mentions: 2  
    6. Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways. Skelet Muscle. 2023 01 06; 13(1):1. McCourt JL, Stearns-Reider KM, Mamsa H, Kannan P, Afsharinia MH, Shu C, Gibbs EM, Shin KM, Kurmangaliyev YZ, Schmitt LR, Hansen KC, Crosbie RH. PMID: 36609344; PMCID: PMC9817407.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    7. High-Throughput Screening to Identify Modulators of Sarcospan. Methods Mol Biol. 2023; 2587:479-493. Shu C, Mokhonova E, Crosbie RH. PMID: 36401045.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Sarcospan increases laminin-binding capacity of α-dystroglycan to ameliorate DMD independent of Galgt2. Hum Mol Genet. 2022 03 03; 31(5):718-732. Mamsa H, Stark RL, Shin KM, Beedle AM, Crosbie RH. PMID: 34581784; PMCID: PMC8895749.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    9. Loss of sarcospan exacerbates pathology in mdx mice, but does not affect utrophin amelioration of disease. Hum Mol Genet. 2021 04 26; 30(3-4):149-159. Gibbs EM, McCourt JL, Shin KM, Hammond KG, Marshall JL, Crosbie RH. PMID: 33432327; PMCID: PMC8091037.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    10. Quantitative immuno-mass spectrometry imaging of skeletal muscle dystrophin. Sci Rep. 2021 01 13; 11(1):1128. Bishop DP, Westerhausen MT, Barthelemy F, Lockwood T, Cole N, Gibbs EM, Crosbie RH, Nelson SF, Miceli MC, Doble PA, Wanagat J. PMID: 33441839; PMCID: PMC7806610.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. High-throughput screening identifies modulators of sarcospan that stabilize muscle cells and exhibit activity in the mouse model of Duchenne muscular dystrophy. Skelet Muscle. 2020 09 18; 10(1):26. Shu C, Parfenova L, Mokhonova E, Collado JR, Damoiseaux R, Campagna J, John V, Crosbie RH. PMID: 32948250; PMCID: PMC7499884.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury. Cell. 2020 08 06; 182(3):545-562.e23. Yokota T, McCourt J, Ma F, Ren S, Li S, Kim TH, Kurmangaliyev YZ, Nasiri R, Ahadian S, Nguyen T, Tan XHM, Zhou Y, Wu R, Rodriguez A, Cohn W, Wang Y, Whitelegge J, Ryazantsev S, Khademhosseini A, Teitell MA, Chiou PY, Birk DE, Rowat AC, Crosbie RH, Pellegrini M, Seldin M, Lusis AJ, Deb A. PMID: 32621799; PMCID: PMC7415659.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    13. Mitochondrial Dysfunction Is an Early Consequence of Partial or Complete Dystrophin Loss in mdx Mice. Front Physiol. 2020; 11:690. Moore TM, Lin AJ, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Nguyen CQ, Yackly A, Mahata SK, Wanagat J, Stiles L, Turcotte LP, Crosbie RH, Zhou Z. PMID: 32636760; PMCID: PMC7317021.
      View in: PubMed   Mentions: 39  
    14. Enhanced Methods for Needle Biopsy and Cryopreservation of Skeletal Muscle in Older Adults. J Cytol Histol. 2020; 11(2). Lee CC, Hoang A, Segovia D, Herbst A, Barthelemy F, Gibbs E, Crosbie R, Nelson SF, Miceli C, Wanagat J. PMID: 32566369; PMCID: PMC7304549.
      View in: PubMed   Mentions: 7  
    15. Development of a high-throughput screen to identify small molecule enhancers of sarcospan for the treatment of Duchenne muscular dystrophy. Skelet Muscle. 2019 12 12; 9(1):32. Shu C, Kaxon-Rupp AN, Collado JR, Damoiseaux R, Crosbie RH. PMID: 31831063; PMCID: PMC6907331.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    16. Student Satisfaction and Learning Outcomes in Asynchronous Online Lecture Videos. CBE Life Sci Educ. 2019 12; 18(4):ar55. Choe RC, Scuric Z, Eshkol E, Cruser S, Arndt A, Cox R, Toma SP, Shapiro C, Levis-Fitzgerald M, Barnes G, Crosbie RH. PMID: 31675279; PMCID: PMC6829069.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    17. Spp1 (osteopontin) promotes TGFβ processing in fibroblasts of dystrophin-deficient muscles through matrix metalloproteinases. Hum Mol Genet. 2019 10 15; 28(20):3431-3442. Kramerova I, Kumagai-Cresse C, Ermolova N, Mokhonova E, Marinov M, Capote J, Becerra D, Quattrocelli M, Crosbie RH, Welch E, McNally EM, Spencer MJ. PMID: 31411676; PMCID: PMC7345878.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    18. Large in-frame 5' deletions in DMD associated with mild Duchenne muscular dystrophy: Two case reports and a review of the literature. Neuromuscul Disord. 2019 11; 29(11):863-873. Gibbs EM, Barthélémy F, Douine ED, Hardiman NC, Shieh PB, Khanlou N, Crosbie RH, Nelson SF, Miceli MC. PMID: 31672265; PMCID: PMC7092699.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    19. Stabilization of the cardiac sarcolemma by sarcospan rescues DMD-associated cardiomyopathy. JCI Insight. 2019 04 30; 5. Parvatiyar MS, Brownstein AJ, Kanashiro-Takeuchi RM, Collado JR, Dieseldorff Jones KM, Gopal J, Hammond KG, Marshall JL, Ferrel A, Beedle AM, Chamberlain JS, Renato Pinto J, Crosbie RH. PMID: 31039133; PMCID: PMC6629091.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    20. Sarcospan: a small protein with large potential for Duchenne muscular dystrophy. Skelet Muscle. 2013 Jan 03; 3(1):1. Marshall JL, Crosbie-Watson RH. PMID: 23282144; PMCID: PMC3599653.
      View in: PubMed   Mentions: 29     Fields:    
    21. Myogenic Akt signaling attenuates muscular degeneration, promotes myofiber regeneration and improves muscle function in dystrophin-deficient mdx mice. Hum Mol Genet. 2011 Apr 01; 20(7):1324-38. Kim MH, Kay DI, Rudra RT, Chen BM, Hsu N, Izumiya Y, Martinez L, Spencer MJ, Walsh K, Grinnell AD, Crosbie RH. PMID: 21245083; PMCID: PMC3049356.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    22. CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs. Nat Genet. 2011 Jan; 43(1):72-8. Merveille AC, Davis EE, Becker-Heck A, Legendre M, Amirav I, Bataille G, Belmont J, Beydon N, Billen F, Clément A, Clercx C, Coste A, Crosbie R, de Blic J, Deleuze S, Duquesnoy P, Escalier D, Escudier E, Fliegauf M, Horvath J, Hill K, Jorissen M, Just J, Kispert A, Lathrop M, Loges NT, Marthin JK, Momozawa Y, Montantin G, Nielsen KG, Olbrich H, Papon JF, Rayet I, Roger G, Schmidts M, Tenreiro H, Towbin JA, Zelenika D, Zentgraf H, Georges M, Lequarré AS, Katsanis N, Omran H, Amselem S. PMID: 21131972; PMCID: PMC3509786.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansAnimalsCells
    23. Altered calcium pump and secondary deficiency of gamma-sarcoglycan and microspan in sarcoplasmic reticulum membranes isolated from delta-sarcoglycan knockout mice. Cell Calcium. 2010 Jul; 48(1):28-36. Solares-Pérez A, Alvarez R, Crosbie RH, Vega-Moreno J, Medina-Monares J, Estrada FJ, Ortega A, Coral-Vazquez R. PMID: 20638123; PMCID: PMC4859437.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    24. Emerging genetic therapies to treat Duchenne muscular dystrophy. Curr Opin Neurol. 2009 Oct; 22(5):532-8. Nelson SF, Crosbie RH, Miceli MC, Spencer MJ. PMID: 19745732; PMCID: PMC2856442.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    25. Myogenic Akt signaling upregulates the utrophin-glycoprotein complex and promotes sarcolemma stability in muscular dystrophy. Hum Mol Genet. 2009 Jan 15; 18(2):318-27. Peter AK, Ko CY, Kim MH, Hsu N, Ouchi N, Rhie S, Izumiya Y, Zeng L, Walsh K, Crosbie RH. PMID: 18986978; PMCID: PMC2638781.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    26. Sarcospan reduces dystrophic pathology: stabilization of the utrophin-glycoprotein complex. J Cell Biol. 2008 Nov 03; 183(3):419-27. Peter AK, Marshall JL, Crosbie RH. PMID: 18981229; PMCID: PMC2575773.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    27. Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex. Cell Motil Cytoskeleton. 2007 Jun; 64(6):461-73. Bekker JM, Colantonio JR, Stephens AD, Clarke WT, King SJ, Hill KL, Crosbie RH. PMID: 17366626.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    28. Disrupted mechanical stability of the dystrophin-glycoprotein complex causes severe muscular dystrophy in sarcospan transgenic mice. J Cell Sci. 2007 Mar 15; 120(Pt 6):996-1008. Peter AK, Miller G, Crosbie RH. PMID: 17311848.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    29. Structural and functional analysis of the sarcoglycan-sarcospan subcomplex. Exp Cell Res. 2007 Feb 15; 313(4):639-51. Miller G, Wang EL, Nassar KL, Peter AK, Crosbie RH. PMID: 17223103; PMCID: PMC3855351.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    30. Over-expression of Microspan, a novel component of the sarcoplasmic reticulum, causes severe muscle pathology with triad abnormalities. J Muscle Res Cell Motil. 2006; 27(8):545-58. Miller G, Peter AK, Espinoza E, Heighway J, Crosbie RH. PMID: 16823602.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    31. Hypertrophic response of Duchenne and limb-girdle muscular dystrophies is associated with activation of Akt pathway. Exp Cell Res. 2006 Aug 01; 312(13):2580-91. Peter AK, Crosbie RH. PMID: 16797529.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    32. Expanding the role of the dynein regulatory complex to non-axonemal functions: association of GAS11 with the Golgi apparatus. Traffic. 2006 May; 7(5):538-48. Colantonio JR, Bekker JM, Kim SJ, Morrissey KM, Crosbie RH, Hill KL. PMID: 16643277.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    33. Characterization of aquaporin-4 in muscle and muscular dystrophy. FASEB J. 2002 Jul; 16(9):943-9. Crosbie RH, Dovico SA, Flanagan JD, Chamberlain JS, Ownby CL, Campbell KP. PMID: 12087055.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    34. NO vascular control in Duchenne muscular dystrophy. Nat Med. 2001 Jan; 7(1):27-9. Crosbie RH. PMID: 11135610.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    35. Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain. J Cell Biol. 2000 Sep 18; 150(6):1399-410. Crawford GE, Faulkner JA, Crosbie RH, Campbell KP, Froehner SC, Chamberlain JS. PMID: 10995444; PMCID: PMC2150715.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    36. Molecular and genetic characterization of sarcospan: insights into sarcoglycan-sarcospan interactions. Hum Mol Genet. 2000 Aug 12; 9(13):2019-27. Crosbie RH, Lim LE, Moore SA, Hirano M, Hays AP, Maybaum SW, Collin H, Dovico SA, Stolle CA, Fardeau M, Tomé FM, Campbell KP. PMID: 10942431.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    37. Biosynthesis of dystroglycan: processing of a precursor propeptide. FEBS Lett. 2000 Feb 18; 468(1):79-83. Holt KH, Crosbie RH, Venzke DP, Campbell KP. PMID: 10683445.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    38. Membrane targeting and stabilization of sarcospan is mediated by the sarcoglycan subcomplex. J Cell Biol. 1999 Apr 05; 145(1):153-65. Crosbie RH, Lebakken CS, Holt KH, Venzke DP, Straub V, Lee JC, Grady RM, Chamberlain JS, Sanes JR, Campbell KP. PMID: 10189375; PMCID: PMC2148225.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    39. Progressive muscular dystrophy in alpha-sarcoglycan-deficient mice. J Cell Biol. 1998 Sep 21; 142(6):1461-71. Duclos F, Straub V, Moore SA, Venzke DP, Hrstka RF, Crosbie RH, Durbeej M, Lebakken CS, Ettinger AJ, van der Meulen J, Holt KH, Lim LE, Sanes JR, Davidson BL, Faulkner JA, Williamson R, Campbell KP. PMID: 9744877; PMCID: PMC2141773.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    40. Caveolin-3 is not an integral component of the dystrophin glycoprotein complex. FEBS Lett. 1998 May 08; 427(2):279-82. Crosbie RH, Yamada H, Venzke DP, Lisanti MP, Campbell KP. PMID: 9607328.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    41. mdx muscle pathology is independent of nNOS perturbation. Hum Mol Genet. 1998 May; 7(5):823-9. Crosbie RH, Straub V, Yun HY, Lee JC, Rafael JA, Chamberlain JS, Dawson VL, Dawson TM, Campbell KP. PMID: 9536086.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    42. Sarcospan, the 25-kDa transmembrane component of the dystrophin-glycoprotein complex. J Biol Chem. 1997 Dec 12; 272(50):31221-4. Crosbie RH, Heighway J, Venzke DP, Lee JC, Campbell KP. PMID: 9395445.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    43. Muscular dystrophy. Utrophin to the rescue. Nature. 1996 Nov 28; 384(6607):308-9. Campbell KP, Crosbie RH. PMID: 8934508.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    44. Flexation of caldesmon: effect of conformation on the properties of caldesmon. J Muscle Res Cell Motil. 1995 Oct; 16(5):509-18. Crosbie RH, Chalovich JM, Reisler E. PMID: 8567938.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    45. Structural connectivity in actin: effect of C-terminal modifications on the properties of actin. Biophys J. 1994 Nov; 67(5):1957-64. Crosbie RH, Miller C, Cheung P, Goodnight T, Muhlrad A, Reisler E. PMID: 7858132; PMCID: PMC1225570.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    46. Caldesmon, N-terminal yeast actin mutants, and the regulation of actomyosin interactions. Biochemistry. 1994 Mar 22; 33(11):3210-6. Crosbie RH, Miller C, Chalovich JM, Rubenstein PA, Reisler E. PMID: 8136356.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    47. Interaction of caldesmon and myosin subfragment 1 with the C-terminus of actin. Biochem Biophys Res Commun. 1992 Apr 15; 184(1):239-45. Crosbie RH, Chalovich JM, Reisler E. PMID: 1567431.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    48. The interaction of caldesmon with the COOH terminus of actin. J Biol Chem. 1991 Oct 25; 266(30):20001-6. Crosbie R, Adams S, Chalovich JM, Reisler E. PMID: 1939062; PMCID: PMC1266291.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
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