Alan J. Waring

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Work Titles
The Lundquist Institute for Biomedical Innovation Professor, MOLECULAR MEDICINE
UCLA Professor, Medicine

Contact Information:

Email Address:

awaring@ucla.edu

Work Email Address:

awaring@lundquist.org


Fax Number:

(310) 782-3813

Work Phone Number:

(310) 974-9576

Laboratory Address:

1124 West Carson Street
Torrance, CA 90502


Detailed Biography:

Antimicrobial Peptides, Antiviral Peptides, Macromolecules, Surface Chemistry, Biophysics, Lung Surfactant

Publications:

A selected list of publications:

Lee Myungwoon, Yao Hongwei, Kwon Byungsu, Waring Alan J, Ruchala Peter, Singh Chandan, Hong Mei   Conformation and Trimer Association of the Transmembrane Domain of the Parainfluenza Virus Fusion Protein in Lipid Bilayers from Solid-State NMR: Insights into the Sequence Determinants of Trimer Structure and Fusion Activity Journal of molecular biology, 2018; 430(5): 695-709.
Sakurai Reiko, Lee Cindy, Shen Humphrey, Waring Alan J, Walther Frans J, Rehan Virender K   A Combination of the Aerosolized PPAR-γ Agonist Pioglitazone and a Synthetic Surfactant Protein B Peptide Mimic Prevents Hyperoxia-Induced Neonatal Lung Injury in Rats Neonatology, 2018; 113(4): 296-304.
Waring Alan J, Gupta Monik, Gordon Larry M, Fujii Gary, Walther Frans J   Stability of an amphipathic helix-hairpin surfactant peptide in liposomes Biochimica et biophysica acta, 2016; 1858(12): 3113-3119.
Henderson J Michael, Waring Alan J, Separovic Frances, Lee Ka Yee C   Antimicrobial Peptides Share a Common Interaction Driven by Membrane Line Tension Reduction Biophysical journal, 2016; 111(10): 2176-2189.
Walther Frans J, Gordon Larry M, Waring Alan J   Design of Surfactant Protein B Peptide Mimics Based on the Saposin Fold for Synthetic Lung Surfactants Biomedicine hub, 2016; 1(3): 2176-2189.
Chakraborty Aishik, Hui Erica, Waring Alan J, Dhar Prajnaparamita   Combined effect of synthetic protein, Mini-B, and cholesterol on a model lung surfactant mixture at the air-water interface Biochimica et biophysica acta, 2016; 1858(4): 904-12.
Chaili Siyang, Cheung Ambrose L, Bayer Arnold S, Xiong Yan Q, Waring Alan J, Memmi Guido, Donegan Niles, Yang Soo-Jin, Yeaman Michael R   The GraS Sensor in Staphylococcus aureus Mediates Resistance to Host Defense Peptides Differing in Mechanisms of Action Infection and immunity, 2016; 84(2): 459-66.
Micewicz Ewa D, Bahattab Omar S O, Willars Gary B, Waring Alan J, Navab Mohamad, Whitelegge Julian P, McBride William H, Ruchala Piotr   Small lipidated anti-obesity compounds derived from neuromedin U European journal of medicinal chemistry, 2015; 101: 616-26.
Yao Hongwei, Lee Michelle W, Waring Alan J, Wong Gerard C L, Hong Mei   Viral fusion protein transmembrane domain adopts β-strand structure to facilitate membrane topological changes for virus-cell fusion Proceedings of the National Academy of Sciences of the United States of America, 2015; 101: .
Gupta Rohun, Hernández-Juviel José M, Waring Alan J, Walther Frans J   Synthetic lung surfactant reduces alveolar-capillary protein leakage in surfactant-deficient rabbits Experimental lung research, 2015; 41(5): 293-9.
Cheung Ambrose L, Bayer Arnold S, Yeaman Michael R, Xiong Yan Q, Waring Alan J, Memmi Guido, Donegan Niles, Chaili Siyang, Yang Soo-Jin   Site-specific mutation of the sensor kinase GraS in Staphylococcus aureus alters the adaptive response to distinct cationic antimicrobial peptides Infection and immunity, 2014; 82(12): 5336-45.
Micewicz Ewa D, Luong Hai T, Jung Chun-Ling, Waring Alan J, McBride William H, Ruchala Piotr   Novel dimeric Smac analogs as prospective anticancer agents Bioorganic & medicinal chemistry letters, 2014; 24(6): 1452-7.
Walther Frans J, Hernández-Juviel José M, Waring Alan J   Aerosol delivery of synthetic lung surfactant PeerJ, 2014; 2(1): e403.
Gebremariam Teclegiorgis, Liu Mingfu, Luo Guanpingsheng, Bruno Vincent, Phan Quynh T, Waring Alan J, Edwards John E, Filler Scott G, Yeaman Michael R, Ibrahim Ashraf S   CotH3 mediates fungal invasion of host cells during mucormycosis The Journal of clinical investigation, 2014; 124(1): 237-50.
Walther Frans J, Waring Alan J, Hernández-Juviel José M, Ruchala Piotr, Wang Zhengdong, Notter Robert H, Gordon Larry M   Surfactant protein C peptides with salt-bridges ("ion-locks") promote high surfactant activities by mimicking the α-helix and membrane topography of the native protein PeerJ, 2014; 2(1): e485.
Walther Frans J, Hernández-Juviel José M, Gordon Larry M, Waring Alan J   Synthetic surfactant containing SP-B and SP-C mimics is superior to single-peptide formulations in rabbits with chemical acute lung injury PeerJ, 2014; 2(1): e393.
Kwon Byungsu, Waring Alan J, Hong Mei   A 2H solid-state NMR study of lipid clustering by cationic antimicrobial and cell-penetrating peptides in model bacterial membranes Biophysical journal, 2013; 105(10): 2333-42.
Wood Matthew P, Cole Amy L, Ruchala Piotr, Waring Alan J, Rohan Lisa C, Marx Preston, Tarwater Patrick M, Gupta Phalguni, Cole Alexander M   A compensatory mutation provides resistance to disparate HIV fusion inhibitor peptides and enhances membrane fusion PloS one, 2013; 8(2): e55478.
Sharifahmadian Mahzad, Sarker Muzaddid, Palleboina Dharamaraju, Waring Alan J, Walther Frans J, Morrow Michael R, Booth Valerie   Role of the N-terminal seven residues of surfactant protein B (SP-B) PloS one, 2013; 8(9): e72821.
Bertani Philippe, Vidovic Verica, Yang Tran-Chin, Rendell Jennifer, Gordon Larry M, Waring Alan J, Bechinger Burkhard, Booth Valerie   Orientation and depth of surfactant protein B C-terminal helix in lung surfactant bilayers Biochimica et biophysica acta, 2012; 1818(5): 1165-72.
Lam Kin Lok H, Wang Hao, Siaw Ting Ann, Chapman Matthew R, Waring Alan J, Kindt James T, Lee Ka Yee C   Mechanism of structural transformations induced by antimicrobial peptides in lipid membranes Biochimica et biophysica acta, 2012; 1818(2): 194-204.
Shieh Ian C, Waring Alan J, Zasadzinski Joseph A   Visualizing the analogy between competitive adsorption and colloid stability to restore lung surfactant function Biophysical journal, 2012; 102(4): 777-86.
Dhar Prajnaparamita, Eck Elizabeth, Israelachvili Jacob N, Lee Dong Woog, Min Younjin, Ramachandran Arun, Waring Alan J, Zasadzinski Joseph A   Lipid-protein interactions alter line tensions and domain size distributions in lung surfactant monolayers Biophysical journal, 2012; 102(1): 56-65.
Holten-Andersen Niels, Michael Henderson J, Walther Frans J, Waring Alan J, Ruchala Piotr, Notter Robert H, Lee Ka Yee C   KL₄ peptide induces reversible collapse structures on multiple length scales in model lung surfactant Biophysical journal, 2011; 101(12): 2957-65.
Lamers Ryan P, Eade Colleen R, Waring Alan J, Cole Amy L, Cole Alexander M   Characterization of the retrocyclin analogue RC-101 as a preventative of Staphylococcus aureus nasal colonization Antimicrobial agents and chemotherapy, 2011; 55(11): 5338-46.
Keating Eleonora, Waring Alan J, Walther Frans J, Possmayer Fred, Veldhuizen Ruud A W, Petersen Nils O   A ToF-SIMS study of the lateral organization of lipids and proteins in pulmonary surfactant systems Biochimica et biophysica acta, 2011; 1808(3): 614-21.
Yount Nannette Y, Cohen Samuel E, Kupferwasser Deborah, Waring Alan J, Ruchala Piotr, Sharma Shantanu, Wasserman Karlman, Jung Chun-Ling, Yeaman Michael R   Context mediates antimicrobial efficacy of kinocidin congener peptide RP-1 PloS one, 2011; 6(11): e26727.
Su Yongchao, Waring Alan J, Ruchala Piotr, Hong Mei   Structures of β-hairpin antimicrobial protegrin peptides in lipopolysaccharide membranes: mechanism of gram selectivity obtained from solid-state nuclear magnetic resonance Biochemistry, 2011; 50(12): 2072-83.
Su Yongchao, Waring Alan J, Ruchala Piotr, Hong Mei   Membrane-bound dynamic structure of an arginine-rich cell-penetrating peptide, the protein transduction domain of HIV TAT, from solid-state NMR Biochemistry, 2010; 49(29): 6009-20.
Walther Frans J, Waring Alan J, Hernandez-Juviel Jose M, Gordon Larry M, Wang Zhengdong, Jung Chun-Ling, Ruchala Piotr, Clark Andrew P, Smith Wesley M, Sharma Shantanu, Notter Robert H   Critical structural and functional roles for the N-terminal insertion sequence in surfactant protein B analogs PloS one, 2010; 5(1): e8672.
Frey Shelli L, Pocivavsek Luka, Waring Alan J, Walther Frans J, Hernandez-Juviel Jose M, Ruchala Piotr, Lee Ka Yee C   Functional importance of the NH2-terminal insertion sequence of lung surfactant protein B American journal of physiology. Lung cellular and molecular physiology, 2010; 298(3): L335-47.
Micewicz Ewa D, Cole Amy L, Jung Chun-Ling, Luong Hai, Phillips Martin L, Pratikhya Pratikhya, Sharma Shantanu, Waring Alan J, Cole Alexander M, Ruchala Piotr   Grifonin-1: a small HIV-1 entry inhibitor derived from the algal lectin, Griffithsin PloS one, 2010; 5(12): e14360.
Cole Alexander M, Patton Dorothy L, Rohan Lisa C, Cole Amy L, Cosgrove-Sweeney Yvonne, Rogers Nicole A, Ratner Deena, Sassi Alexandra B, Lackman-Smith Carol, Tarwater Patrick, Ramratnam Bharat, Ruchala Piotr, Lehrer Robert I, Waring Alan J, Gupta Phalguni   The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques PloS one, 2010; 5(11): e15111.
Bourbigot Sarah, Fardy Liam, Waring Alan J, Yeaman Michael R, Booth Valerie   Structure of chemokine-derived antimicrobial Peptide interleukin-8alpha and interaction with detergent micelles and oriented lipid bilayers Biochemistry, 2009; 48(44): 10509-21.
Lehrer Robert I, Jung Grace, Ruchala Piotr, Wang Wei, Micewicz Ewa D, Waring Alan J, Gillespie Eugene J, Bradley Kenneth A, Ratner Adam J, Rest Richard F, Lu Wuyuan   Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins Infection and immunity, 2009; 77(9): 4028-40.
Yount Nannette Y, Kupferwasser Deborah, Spisni Alberto, Dutz Stephen M, Ramjan Zachary H, Sharma Shantanu, Waring Alan J, Yeaman Michael R   Selective reciprocity in antimicrobial activity versus cytotoxicity of hBD-2 and crotamine Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(35): 14972-7.
Navab Mohamad, Ruchala Piotr, Waring Alan J, Lehrer Robert I, Hama Susan, Hough Greg, Palgunachari Mayakonda N, Anantharamaiah G M, Fogelman Alan M   A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids Journal of lipid research, 2009; 50(8): 1538-47.
Doss Mona, White Mitchell R, Tecle Tesfaldet, Gantz Donald, Crouch Erika C, Jung Grace, Ruchala Piotr, Waring Alan J, Lehrer Robert I, Hartshorn Kevan L   Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D Journal of immunology (Baltimore, Md. : 1950), 2009; 182(12): 7878-87.
Tang Ming, Waring Alan J, Hong Mei   Effects of arginine density on the membrane-bound structure of a cationic antimicrobial peptide from solid-state NMR Biochimica et biophysica acta, 2009; 1788(2): 514-21.
Van Lenten Brian J, Wagner Alan C, Jung Chun-Ling, Ruchala Piotr, Waring Alan J, Lehrer Robert I, Watson Andrew D, Hama Susan, Navab Mohamad, Anantharamaiah G M, Fogelman Alan M   Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I Journal of lipid research, 2008; 49(11): 2302-11.
Gordon Larry M, Nisthal Alex, Lee Andy B, Eskandari Sepehr, Ruchala Piotr, Jung Chun-Ling, Waring Alan J, Mobley Patrick W   Structural and functional properties of peptides based on the N-terminus of HIV-1 gp41 and the C-terminus of the amyloid-beta protein Biochimica et biophysica acta, 2008; 1778(10): 2127-37.
Langham Allison A, Khandelia Himanshu, Schuster Benjamin, Waring Alan J, Lehrer Robert I, Kaznessis Yiannis N   Correlation between simulated physicochemical properties and hemolycity of protegrin-like antimicrobial peptides: predicting experimental toxicity Peptides, 2008; 29(7): 1085-93.
Neville Frances, Ishitsuka Yuji, Hodges Chris S, Konovalov Oleg, Waring Alan J, Lehrer Robert, Lee Ka Yee C, Gidalevitz David   Protegrin interaction with lipid monolayers: Grazing incidence X-ray diffraction and X-ray reflectivity study Soft matter, 2008; 4(8): 1665-1674.
Walther Frans J, Waring Alan J, Hernandez-Juviel Jose M, Gordon Larry M, Schwan Adrian L, Jung Chun-Ling, Chang Yusuo, Wang Zhengdong, Notter Robert H   Dynamic surface activity of a fully synthetic phospholipase-resistant lipid/peptide lung surfactant PloS one, 2007; 2(10): e1039.
Notter Robert H, Schwan Adrian L, Wang Zhengdong, Waring Alan J   Novel phospholipase-resistant lipid/peptide synthetic lung surfactants Mini reviews in medicinal chemistry, 2007; 7(9): 932-44.
Tang Ming, Waring Alan J, Hong Mei   Phosphate-mediated arginine insertion into lipid membranes and pore formation by a cationic membrane peptide from solid-state NMR Journal of the American Chemical Society, 2007; 129(37): 11438-46.
Mani Rajeswari, Cady Sarah D, Tang Ming, Waring Alan J, Lehrer Robert I, Hong Mei   Membrane-dependent oligomeric structure and pore formation of a beta-hairpin antimicrobial peptide in lipid bilayers from solid-state NMR Proceedings of the National Academy of Sciences of the United States of America, 2006; 103(44): 16242-7.
Gallo Stephen A, Wang Wei, Rawat Satinder S, Jung Grace, Waring Alan J, Cole Alexander M, Lu Hong, Yan Xuxia, Daly Norelle L, Craik David J, Jiang Shibo, Lehrer Robert I, Blumenthal Robert   Theta-defensins prevent HIV-1 Env-mediated fusion by binding gp41 and blocking 6-helix bundle formation The Journal of biological chemistry, 2006; 281(27): 18787-92.
Longmuir Kenneth J, Robertson Richard T, Haynes Sherry M, Baratta Janie L, Waring Alan J   Effective targeting of liposomes to liver and hepatocytes in vivo by incorporation of a Plasmodium amino acid sequence Pharmaceutical research, 2006; 23(4): 759-69.
Booth Valerie, Waring Alan J, Walther Frans J, Keough Kevin M W   NMR structures of the C-terminal segment of surfactant protein B in detergent micelles and hexafluoro-2-propanol Biochemistry, 2004; 43(48): 15187-94.
Gordon Larry M, Mobley Patrick W, Pilpa Rosemarie, Sherman Mark A, Waring Alan J   Conformational mapping of the N-terminal peptide of HIV-1 gp41 in membrane environments using (13)C-enhanced Fourier transform infrared spectroscopy Biochimica et biophysica acta, 2002; 1559(2): 96-120.

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