Thomas T. Yoshikawa


Work Titles
UCLA Professor, Medicine
|reorganize| Member, General Medicine and Health Services

Contact Information:

Email Address:

toyoshik@cdrewu.edu


Work Phone Number:

(310) 668-4574

Publications:

A selected list of publications:

  Continuation or discontinuation of pioglitazone when starting bedtime insulin in patients with poorly controlled type 2 diabetes in an inner-city population, , 2015; .
  11ß-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue, , 2014; .
  Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling, , 2014; .
  Effect of long term vitamin D supplementation on biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D, , 2014; .
  Nicotine in combination with a high-fat diet causes intramyocellular mitochondrial abnormalities in male mice, , 2014; .
  A Review of Programs, Components and Outcomes in Biomedical Research Faculty Development, , 2013; .
  Adolescence is a period of development characterized by short- and long-term vulnerability to the rewarding effects of nicotine and reduced sensitivity to the anorectic effects of this drug, , 2013; .
Ren X, Lutfy K, Mangubat M, Ferrini MG, Lee ML, Liu Y, Friedman TC   Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake, , 2013; .
  Enhanced nicotine self-administration and suppressed dopaminergic systems in a rat model of diabetes, , 2013; .
  Facing facts: the impact of the face-to-face requirement, , 2013; .
Nie Y, Ferrini MG, Liu Y, Anghel A, Espinosa EV, Stuart RC, Lutfy K, Nillni EA, Friedman TC   Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2, , 2013; .
  Mutations in KCNJ11 are associated with the development of autosomal dominant, early-onset type 2 diabetes, , 2013; .
  Specific reduction of G6PT may contribute to downregulation of hepatic 11ß-HSD1 in diabetic mice, , 2013; .
  Transgenic overexpression of hexose-6-phosphate dehydrogenase in adipose tissue causes local glucocorticoid amplification and lipolysis in male mice, , 2013; .
  Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice, , 2012; .
  Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III, , 2012; .
Yoshikawa TT   Future direction of geriatrics: "gerogeriatrics", J Am Geriatr Soc, 2012; .
Davidson MB, Duran P, Lee ML, Friedman TC   High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D, , 2012; .
  Nicotine stimulates secretion of corticosterone via both CRH and AVP receptors, , 2012; .
  The rewarding action of acute cocaine is reduced in ß-endorphin deficient but not in µ opioid receptor knockout mice, , 2012; .
  When death precedes birth: experience of a palliative care team on a labor and delivery unit, , 2012; .
Yoshikawa TT   Changes for the Journal of the American Geriatrics Society effective January 1, 2012, J Am Geriatr Soc, 2011; .
Mangubat M, Lutfy K, Lee ML, Pulido L, Stout D, Davis R, Shin CS, Shahbazian M, Seasholtz S, Sinha-Hikim A, Sinha-Hikim I, O'Dell LE, Lyzlov A, Liu Y, Friedman TC   Effect of nicotine on body composition in mice, , 2011; .
Yoshikawa TT   Journal of the American Geriatrics Society at 10 years: achievements and future directions, J Am Geriatr Soc, 2011; .
  Vitamin D supplementation to prevent the progression of prediabetes to diabetes: getting closer to a recommendation, , 2011; .
Anghel A, Jamieson CA, Ren X, Young J, Porche R, Ozigbo E, Ghods DE, Lee ML, Liu Y, Lutfy K, Friedman TC   Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake, , 2010; .
Friedman TC, Ghods DE, Shahinian HK, Zachery L, Shayesteh N, Seasholtz S, Zuckerbraun E, Lee ML, McCutcheon IE   High prevalence of normal tests assessing hypercortisolism in subjects with mild and episodic Cushing's syndrome suggests that the paradigm for diagnosis and exclusion of Cushing's syndrome requires multiple testing, , 2010; .
  Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic a-cells in mouse models of ß-cell regeneration, , 2010; .
  Stress-induced analgesia and endogenous opioid peptides: the importance of stress duration, , 2010; .
  The Behavioral and Pharmacological Actions of NMDA Receptor Antagonism are Conserved in Zebrafish Larvae, , 2010; .
  Tissue-specific dysregulation of hexose-6-phosphate dehydrogenase and glucose-6-phosphate transporter production in db/db mice as a model of type 2 diabetes, , 2010; .
Friedlander AH, Yoshikawa TT, Chang DS, Feliciano Z, Scully C   Atrial fibrillation: pathogenesis, medical-surgical management and dental implications, J Am Dent Assoc, 2009; .
High KP, Bradley SF, Gravenstein S, Mehr DR, Quagliarello VJ, Richards C, Yoshikawa TT   Clinical practice guideline for the evaluation of fever and infection in older adult residents of long-term care facilities: 2008 update by the Infectious Diseases Society of America, J Am Geriatr Soc, 2009; .
  Hair analysis provides a historical record of cortisol levels in Cushing's syndrome, , 2009; .
  The effects of opioids and opioid analogs on animal and human endocrine systems, , 2009; .
  Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction, , 2008; .
  Oral opioids for chronic non-cancer pain: higher prevalence of hypogonadism in men than in women, , 2008; .
  Prevalence of GH and other anterior pituitary hormone deficiencies in adults with nonsecreting pituitary microadenomas and normal serum IGF-1 levels, , 2008; .
  Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice, , 2008; .
Pall ME, Lao MC, Patel SS, Lee ML, Ghods DE, Chandler DW, Friedman TC   Testosterone and bioavailable testosterone help to distinguish between mild Cushing's syndrome and polycystic ovarian syndrome, , 2008; .
  Dynamic pituitary MRI has high sensitivity and specificity for the diagnosis of mild Cushing's syndrome and should be part of the initial workup, , 2007; .
Norman DC, Wong MB, Yoshikawa TT   Fever of unknown origin in older persons, Infect Dis Clin North Am, 2007; .
Yoshikawa TT, Ouslander JG   Integrity in publishing: update on policies and statements on authorship, duplicate publications, and conflict of interest, J Am Geriatr Soc, 2007; .
  An update on the overnight dexamethasone suppression test for the diagnosis of Cushing's syndrome: limitations in patients with mild and/or episodic hypercortisolism, , 2006; .
  Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism, , 2006; .
  Differential involvement of enkephalins in analgesic tolerance, locomotor sensitization, and conditioned place preference induced by morphine, , 2006; .
  Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice, , 2006; .
Yoshikawa TT   Paul Beeson, MD: Today's Sir William Osler, J Am Geriatr Soc, 2006; .
  Repeated stress alters the ability of nicotine to activate the hypothalamic-pituitary-adrenal axis, , 2006; .
Yoshikawa TT, Ouslander JG   Supplements to medical journals: adding knowledge or subtracting from the public trust?, J Am Geriatr Soc, 2006; .
High K, Bradley S, Loeb M, Palmer R, Quagliarello V, Yoshikawa T   A new paradigm for clinical investigation of infectious syndromes in older adults: assessing functional status as a risk factor and outcome measure, J Am Geriatr Soc, 2005; .
  Endocrinomic profile of neurointermediate lobe pituitary prohormone processing in PC1/3- and PC2-Null mice using SELDI-TOF mass spectrometry, , 2005; .
Yoshikawa TT   Five more years--thank you!, J Am Geriatr Soc, 2005; .
  Glucose dependence of the regulated secretory pathway in alphaTC1-6 cells, , 2005; .
  Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice, , 2005; .
  Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter, , 2005; .
High KP, Bradley S, Loeb M, Palmer R, Quagliarello V, Yoshikawa T   A new paradigm for clinical investigation of infectious syndromes in older adults: assessment of functional status as a risk factor and outcome measure, Clin Infect Dis, 2004; .
  Acute chagas' disease presenting with a suprasellar mass and panhypopituitarism, , 2004; .
  New testosterone buccal system (Striant) delivers physiological testosterone levels: pharmacokinetics study in hypogonadal men, , 2004; .
  Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone, , 2004; .
Yoshikawa TT   State of the journal: 3 years and looking ahead, J Am Geriatr Soc, 2004; .
  Thyroid hormone regulation of prohormone convertase 1 (PC1): regional expression in rat brain and in vitro characterization of negative thyroid hormone response elements, , 2004; .
Yoshikawa TT, Reuben DB, Ouslander JG   Biographical sketch of David H. Solomon, MD, J Am Geriatr Soc, 2003; .
  Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice, , 2003; .
  Prohormone convertase 2 enzymatic activity and its regulation in neuro-endocrine cells and tissues, , 2003; .
  Androgen supplementation in older women: too much hype, not enough data, , 2002; .
Yoshikawa TT   Antimicrobial resistance and aging: beginning of the end of the antibiotic era?, J Am Geriatr Soc, 2002; .
Akhtar AJ, Alamy ME, Yoshikawa TT   Extrahepatic conditions and hepatic encephalopathy in elderly patients, Am J Med Sci, 2002; .
Yoshikawa TT   Resistant pathogens: considerations in geriatrics and infectious disease, J Am Geriatr Soc, 2002; .
Calvet HM, Yoshikawa TT   Infections in diabetes, Infect Dis Clin North Am, 2001; .
  Orthostatic hypotension and chronic fatigue syndrome, , 2001; .
  Reflections on going home, , 2001; .
  Regulation of prohormone convertase 1 (PC1) by thyroid hormone, , 2001; .
  Up-regulation of splenic prohormone convertases PC1 and PC2 in diabetic rats, , 2001; .
  Glucocorticoid replacement is permissive for rapid eye movement sleep and sleep consolidation in patients with adrenal insufficiency, , 2000; .
  Interactions between the prohormone convertase 2 promoter and the thyroid hormone receptor, , 2000; .
  Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats, , 2000; .
  Self-reported sensitivity to chemical exposures in five clinical populations and healthy controls, , 2000; .
  Endocrine and metabolic evaluation of human immunodeficiency virus-infected patients with evidence of protease inhibitor-associated lipodystrophy, , 1999; .
  Low-dose hydrocortisone for chronic fatigue syndrome, , 1999; .
  Regulation of prohormone convertase 1 (PC1) by gp130-related cytokines, , 1999; .
  Comment on high urinary free cortisol excretion in a patient with psychogenic polydipsia, , 1998; .
  Intact leptin receptor is selectively expressed in human fetal pituitary and pituitary adenomas and signals human fetal pituitary growth hormone secretion, , 1998; .
  Enhanced brain opioid receptor activity precedes blood-brain barrier disruption, , 1997; .
  Inferior petrosal sinus AVP in patients with Cushing's syndrome, , 1997; .
  Leukemia inhibitory factor (LIF) modulates pro-opiomelanocortin (POMC) gene regulation in stably transfected AtT-20 cells overexpressing LIF, , 1997; .
  The hypothalamic-pituitary-adrenal axis of prairie voles (Microtus ochrogaster): evidence for target tissue glucocorticoid resistance, , 1997; .
  The longitudinal course of psychopathology in Cushing's syndrome after correction of hypercortisolism, , 1997; .
  Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM, , 1996; .
  Etiology of the differences in corticotropin-releasing hormone-induced adrenocorticotropin secretion of black and white women, , 1996; .
  Inferior petrosal sinus arginine vasopressin concentrations in normal volunteers and patients with Cushing's disease, , 1996; .
  Inferior petrosal sinus sampling in healthy subjects reveals a unilateral corticotropin-releasing hormone-induced arginine vasopressin release associated with ipsilateral adrenocorticotropin secretion, , 1996; .
  Presence of immunoreactive corticotropin-releasing hormone in human endometrium, , 1996; .
  Processing of pro-opiomelanocortin in GH3 cells: inhibition by prohormone convertase 2 (PC2) antisense mRNA, , 1996; .
  Characteristics of YAP3, a new prohormone processing aspartic protease from S. cerevisiae, , 1995; .
  Delta sleep-inducing peptide in normal humans and in patients with sleep apnea and narcolepsy, , 1995; .
  Frog prohormone convertase PC2 mRNA has a mammalian-like expression pattern in the central nervous system and is colocalized with a subset of thyrotropin-releasing hormone-expressing neurons, , 1995; .
  Immune corticotropin-releasing hormone is present in the eyes of and promotes experimental autoimmune uveoretinitis in rodents, , 1995; .
  In vitro processing of anthrax toxin protective antigen by recombinant PC1 (SPC3) and bovine intermediate lobe secretory vesicle membranes, , 1995; .
  Local expression of corticotropin-releasing hormone in inflammatory arthritis, , 1995; .
  Morning plasma free cortisol: inability to distinguish patients with mild Cushing syndrome from patients with pseudo-Cushing states, , 1995; .
  Pro-thyrotropin-releasing hormone processing by recombinant PC1, , 1995; .
  Processing of prothyrotropin-releasing hormone (Pro-TRH) by bovine intermediate lobe secretory vesicle membrane PC1 and PC2 enzymes, , 1995; .
  Pyroglutamyl peptidase-II ("thyroliberinase") activity in human serum: influence of weight and thyroid status, , 1995; .
  Yeast and mammalian basic residue-specific aspartic proteases in prohormone conversion, , 1995; .
  Corticotropin-releasing hormone production by a small cell carcinoma in a patient with ACTH-dependent Cushing's syndrome, , 1994; .
  Decreased delta-sleep and plasma delta-sleep-inducing peptide in patients with Cushing syndrome, , 1994; .
  Diurnal rhythm of plasma delta-sleep-inducing peptide in humans: evidence for positive correlation with body temperature and negative correlation with rapid eye movement and slow wave sleep, , 1994; .
  In vitro processing of proopiomelanocortin by recombinant PC1 (SPC3), , 1994; .
  Presence of immunoreactive corticotropin releasing hormone in thyroid lesions, , 1994; .
  Presence of immunoreactive corticotropin-releasing hormone in normal and polycystic human ovaries, , 1994; .
  Posterior subcapsular cataract in endogenous Cushing syndrome: an uncommon manifestation, , 1993; .
  Transsphenoidal resection in Cushing's disease: definition of success, , 1993; .

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