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Marie-Francoise Chesselet, M.D., Ph.D.
Contact Information:
Fax Number:
(310) 267-1786
Work Phone Number:
(310) 267-1781
Laboratory Address:
Laboratory B117 Reed UNITED STATES
Work Address:
UCLA Neuro / Neurobiology BOX 951769, B-114 RNRC Los Angeles, CA 90095 UNITED STATES
Chair,
Neurobiology
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Professor,
Neurology
Neurobiology
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Member,
ACCESS Program: Dept. of Neurobiology
Neuroengineering Training Program
Neuroscience IDP
Brain Research Institute
CTSI
Center for Neurodegenerative Disease Studies
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Faculty,
Molecular Toxicology IDP
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Detailed Biography:
Marie-Françoise Chesselet, MD, PhD, is the Charles H. Markham Professor of Neurology and the Chair of the Department of Neurobiology in the David Geffen School of Medicine at UCLA. After receiving her MD and PhD degrees in Paris, France, she held research positions in France and Faculty positions at the Medical College of Pennsylvania and the University of Pennsylvania before joining UCLA in 1996. In 1997 she established the Center for the Study of Parkinson?s Disease at UCLA and directs the UCLA Morris K. Udall Center of Excellence for Parkinson?s Disease Research and the Center for Gene Environment in Parkinson?s Disease, both supported by the National Institute of Health (NIH), as well as the UCLA Advanced Center for Parkinson Disease Research of the American Parkinson Disease Association, and she serves on the Science Advisory Boards of several private foundations. Her work is additionally supported by the NIH, the Michael J. Fox Foundation, Cure HD Initiative, the Hereditary Foundation, and biopharmaceutical companies.
Publications:
Fleming Sheila M, Mulligan Caitlin K, Richter Franziska, Mortazavi Farzad, Lemesre Vincent, Frias Carmen, Zhu Chunni, Stewart Alistair, Gozes Illana, Morimoto Bruce, Chesselet Marie-Françoise
A pilot trial of the microtubule-interacting peptide (NAP) in mice
overexpressing alpha-synuclein shows improvement in motor function and
reduction of alpha-synuclein inclusions.
Molecular and cellular neurosciences,
2010;
.
Hoang Tuan, Choi Dong-Kug, Nagai Makiko, Wu Du-Chu, Nagata Tetsuya, Prou Delphine, Wilson Glenn L, Vila Miquel, Jackson-Lewis Vernice, Dawson Valina L, Dawson Ted M, Chesselet Marie-Françoise, Przedborski Serge
Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse
model of Parkinson disease.
Free radical biology & medicine,
2009; 47(7):
1049-56.
Lu Xiao-Hong, Fleming Sheila M, Meurers Bernhard, Ackerson Larry C, Mortazavi Farzad, Lo Victor, Hernandez Daniela, Sulzer David, Jackson George R, Maidment Nigel T, Chesselet Marie-Francoise, Yang X William
Bacterial artificial chromosome transgenic mice expressing a truncated
mutant parkin exhibit age-dependent hypokinetic motor deficits,
dopaminergic neuron degeneration, and accumulation of proteinase
K-resistant alpha-synuclein.
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2009; 29(7):
1962-76.
Chou Arthur P, Maidment Nigel, Klintenberg Rebecka, Casida John E, Li Sharon, Fitzmaurice Arthur G, Fernagut Pierre-Olivier, Mortazavi Farzad, Chesselet Marie-Francoise, Bronstein Jeff M
Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the
proteasome.
The Journal of biological chemistry,
2008; 283(50):
34696-703.
Effros Rita B, Austad Steven, Blau Helen, Chesselet Marie-Francoise, Ingram Donald, Johnson Thomas E, Kaeberlein Matt, Lundblad Vicki, McCarter Roger, McElhaney Janet, Saag Michael
The biological sciences section program at the 60th Annual Meeting of
the Gerontological Society of America.
The journals of gerontology. Series A, Biological sciences and medical sciences,
2008; 63(4):
331-7.
Litvan Irene, Chesselet Marie-Francoise, Gasser Thomas, Di Monte Donato A, Parker Davis, Hagg Theo, Hardy John, Jenner Peter, Myers Richard H, Price Donald, Hallett Mark, Langston William J, Lang Anthony E, Halliday Glenda, Rocca Walter, Duyckaerts Charles, Dickson Dennis W, Ben-Shlomo Yoav, Goetz Christopher G, Melamed Eldad
The etiopathogenesis of Parkinson disease and suggestions for future
research. Part II.
Journal of neuropathology and experimental neurology,
2007; 66(5):
329-36.
Litvan Irene, Halliday Glenda, Hallett Mark, Goetz Christopher G, Rocca Walter, Duyckaerts Charles, Ben-Shlomo Yoav, Dickson Dennis W, Lang Anthony E, Chesselet Marie-Francoise, Langston William J, Di Monte Donato A, Gasser Thomas, Hagg Theo, Hardy John, Jenner Peter, Melamed Eldad, Myers Richard H, Parker Davis, Price Donald L
The etiopathogenesis of Parkinson disease and suggestions for future
research. Part I.
Journal of neuropathology and experimental neurology,
2007; 66(4):
251-7.
Dewing Phoebe, Chiang Charleston W K, Sinchak Kevin, Sim Helena, Fernagut Pierre-Olivier, Kelly Sabine, Chesselet Marie-Francoise, Micevych Paul E, Albrecht Kenneth H, Harley Vincent R, Vilain Eric
Direct regulation of adult brain function by the male-specific factor
SRY.
Current biology : CB,
2006; 16(4):
415-20.
Young Henry E, Duplaa Cecile, Romero-Ramos Marina, Chesselet Marie-Francoise, Vourc'h Patrick, Yost Michael J, Ericson Kurt, Terracio Louis, Asahara Takayuki, Masuda Haruchika, Tamura-Ninomiya Sayaka, Detmer Kristina, Bray Robert A, Steele Timothy A, Hixson Douglas, el-Kalay Mohammad, Tobin Brian W, Russ Roy D, Horst Michael N, Floyd Julie A, Henson Nicholas L, Hawkins Kristina C, Groom Jaime, Parikh Amar, Blake Lisa, Bland Laura J, Thompson Angela J, Kirincich Amy, Moreau Catherine, Hudson John, Bowyer Frank P, Lin T J, Black Asa C
Adult reserve stem cells and their potential for tissue engineering.
Cell biochemistry and biophysics,
2004; 40(1):
1-80.
Goldberg Matthew S, Fleming Sheila M, Palacino James J, Cepeda Carlos, Lam Hoa A, Bhatnagar Anushree, Meloni Edward G, Wu Nanping, Ackerson Larry C, Klapstein Gloria J, Gajendiran Mahadevan, Roth Bryan L, Chesselet Marie-Francoise, Maidment Nigel T, Levine Michael S, Shen Jie
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of
dopaminergic neurons.
The Journal of biological chemistry,
2003; 278(44):
43628-35.
Romero-Ramos Marina, Vourc'h Patrick, Young Henry E, Lucas Paul A, Wu Young, Chivatakarn Onanong, Zaman Rumina, Dunkelman Noushin, el-Kalay Mohammad A, Chesselet Marie-Françoise
Neuronal differentiation of stem cells isolated from adult muscle.
Journal of neuroscience research,
2002; 69(6):
894-907.
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