Kenneth L. Lange, Ph.D.

A Short Biography:

Kenneth Lange is the Rosenfeld Professor of Computational Genetics and Chair of the Department of Human Genetics at University of California, Los Angeles. He previously served as chair of the UCLA Department of Biomathematics. From 1994 to 1998 he was Professor of Biostatistics and Mathematics and the Pharmacia & Upjohn Foundation Research Professor at the University of Michigan. He has authored four advanced textbooks and published more than 200 scientific papers in the areas of genetic epidemiology, population genetics, membrane physiology, demography, oncology, medical imaging, stochastic processes, and optimization theory. Many of his landmark papers predate by a decade or more the current flood of biological applications of hidden Markov chains, Markov chain Monte Carlo, and high-dimensional optimization.

Work Titles
UCLA Chair, Human Genetics Professor, Statistics Maxine and Eugene Rosenfeld Professor of Computational Genetics, Human Genetics Professor, Biomathematics
Education:
Degrees:
Ph.D., Massachusetts Institute of Technology (M.I.T), Cambridge, MA, 1968 - 1971
M.S., Massachusetts Institute of Technology (M.I.T), Cambridge, MA, 1967 - 1968
B.S., Michigan State University, 1967

Contact Information:

Email Address:

klange@ucla.edu

Work Email Address:

klange@mednet.ucla.edu


Website:

Web-Profile

Fax Number:

(310) 825-8685

Office Phone Number:

310-206-8076

Mailing Address:

Mail Code: 708822
Los Angeles , CA 90095


Office Address:

695 Charles E. Young Drive South
Los Angeles, CA 90095


Detailed Biography:

Kenneth Lange is the Maxine and Eugene Rosenfeld Professor of Computational Genetics and Chair of the Department of Human Genetics. He previously served as chair of the Department of Biomathematics for nine years and has held permanent or visiting appointments at the University of New Hampshire, University of Michigan, University of Helsinki, M.I.T, Harvard, and Stanford. He has authored four advanced textbooks and published nearly 200 scientific papers.

Two themes dominate Dr. Lange's research. One is the development of novel mathematical methods in optimization theory, applied probability, and computational statistics. The other is a devotion to realistic biological modeling. Although there is bound to be a tension between these two poles, the advancement of the biomedical sciences depends on bridging the gap. His contributions to genetic epidemiology, population genetics, membrane physiology, demography, oncology, and medical imaging highlight some of the connections. Many of his landmark papers predate by a decade or more the current flood of biological applications of hidden Markov chains, Markov chain Monte Carlo, and high-dimensional optimization.

Dr. Lange has also made important software contributions to the human genetics community. His program Mendel is the Swiss army knife of statistical genetics packages. He and faculty colleague Eric Sobel are constantly adding new utilities, with a recent emphasis on special handling of the enormous data sets generated by SNP (single nucleotide polymorphism) association studies.

Neil Risch, Michael Boehnke, Daniel Weeks, Eric Sobel, Eric Schadt, and Laura Lazzeroni are among his former graduate students. This list constitutes a Who's Who of statistical genetics. He continues to mentor and inspire bright students who combine mathematical talent with biological curiosity.

Books

>Lange K (2004) Optimization. Springer-Verlag, New York
Lange K (2003) Applied Probability. Springer-Verlag, New York
Lange K (2002) Mathematical and Statistical Methods for Genetic Analysis, 2nd ed.
       Springer-Verlag, New York
Lange K (1999) Numerical Analysis for Statisticians. Springer-Verlag, New York

Publications:

Sehl Mary, Zhou Hua, Sinsheimer Janet S, Lange Kenneth L   Extinction models for cancer stem cell therapy Mathematical biosciences, 2011; 234(2): 132-46.
Ranola John M O, Ahn Sangtae, Sehl Mary, Smith Desmond J, Lange Kenneth   A Poisson model for random multigraphs Bioinformatics (Oxford, England), 2010; 26(16): 2004-11.
Zhou Hua, Lange Kenneth L   On the Bumpy Road to the Dominant Mode Scandinavian journal of statistics, theory and applications, 2010; 37(4): 612-631.
Sehl Mary, Alekseyenko Alexander V, Lange Kenneth L   Accurate stochastic simulation via the step anticipation tau-leaping (SAL) algorithm Journal of computational biology : a journal of computational molecular cell biology, 2009; 16(9): 1195-208.
Sehl Mary E, Sinsheimer Janet S, Zhou Hua, Lange Kenneth L   Differential destruction of stem cells: implications for targeted cancer stem cell therapy Cancer research, 2009; 69(24): 9481-9.
Alexander David H, Novembre John, Lange Kenneth   Fast model-based estimation of ancestry in unrelated individuals Genome research, 2009; 19(9): 1655-64.
Wu Tong Tong, Chen Yi Fang, Hastie Trevor, Sobel Eric, Lange Kenneth   Genome-wide association analysis by lasso penalized logistic regression Bioinformatics (Oxford, England), 2009; 25(6): 714-21.
de Leeuw J, Lange K   Sharp quadratic majorization in one dimension, Computational Stat Data Analysis, 2009; 53: 2471–2484.
Lange K, Wu T   An MM algorithm for multicategory vertex discriminant analysis, J Computational Graphical Stat, 2008; 17: 527–544.
Sabatti C, Lange K   Bayesian Gaussian mixture models for high density genotyping arrays, JASA, 2008; 103: 89–100.
Wu TT, Lange K   Coordinate descent algorithms for lasso penalized regression, Annals Appl Stat, 2008; 2: 224–244.
Suchard MA, Lange K, Sinsheimer JS   Efficiency of protein production from mRNA, J Stat Theory Practice, 2008; 2: 173–182.
Sinsheimer JS, Plaisier CL, Huertas-Vazquez A, Aguilar-Salinas C, Tusie-Luna T, Pajukanta P, Lange K   Estimating ethnic admixture from pedigree data, Amer J Hum Genet, 2008; 82: 748–755.
Park CC, Ahn S, Bloom JS, Lin A, Wang RT, Wu TT, Sekar A, Khan AH, Farr CJ, Lusis AJ, Leahy RM, Lange K, Smith DJ   Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids, Nature Genetics, 2008; 40: 421–429.
Bauman LE, Sinsheimer JS, Sobel EM, Lange K   Mixed effects models for quantitative trait loci mapping with inbred strains, Genetics, 2008; 180: 1743-1761.
Ayers KL, Lange K   Penalized estimation of haplotype frequencies, Bioinformatics, 2008; 24: 1596–1602.
Lange K   Reflections on The Cauchy-Schwarz Master Class, The Mathematical Scientist, 2008; 33: 1–7.
Ayers KL, Sabatti C, Lange K   A dictionary model for haplotyping, genotype calling, and association testing, Genet Epid, 2007; 31: 672-683.
Chen GK, Slaten E, Ophoff RA, Lange K   Accommodating chromosome inversions in linkage analysis, Amer J Hum Genet, 2006; 79: 238–251.
Crespi CM, Lange K   Estimation for the simple linear Boolean model, Methodology Computing Appl Prob, 2006; 8: 559–571.
Presson AP, Sobel E, Lange K, Papp JC   Merging microsatellite data, J Comp Biol, 2006; 13: 1131–1147.
Ayers KL, Sabatti C, Lange K   Reconstructing ancestral haplotypes with a dictionary model, J Comp Biol, 2006; 13: 767–785.
Lange K, Sobel E   Variance component models for X-linked QTLs, Genet Epid, 2006; 30: 380–383.
Cantor RM, Chen GK, Pajukanta P, Lange K   Association testing in a linked region using large pedigrees, Amer J Hum Genet, 2005; 76: 538–542.
Lange K, Sinsheimer JS, Sobel E   Association testing with Mendel, Genet Epid, 2005; 29: 36–50.
Bauman L, Almasy L, Blangero J, Duggirala R, Sinsheimer JS, Lange K   Fishing for pleiotropic QTLs in a polygenic sea, Ann Hum Genet, 2005; 69: 590-611.
Greenawalt DM, Cui X, Wu Y, Lin Y, Wang H-Y, Luo M, Tereshchenko IV, Hu G, Li J-Y, Chu Y, Azaro MA, DeCoste CJ, Chimge N-O, Gao R, Shen L, Shih WJ, Lange K, Li H   Strong correlation between meiotic crossovers and haplotype structure on the long arm of chromosome 21, Genome Res, 2005; 16: 208–214.
Sabatti C, Rohlin L, Lange K, Liao JC   Vocabulon: a dictionary model approach for reconstruction and localization of transcription factor binding sites, Bioinformatics, 2005; 21: 922–931.
Hunter DR, Lange K   A tutorial on MM algorithms, Amer Statistician, 2004; 58: 30–37.
Lange K   Computational statistics and optimization theory at UCLA, Amer Statistician, 2004; 58: 9–11.
Dorman K, Sinsheimer JS, Lange K   In the garden of branching processes, SIAM Review, 2004; 46: 202–229.
Lilja HE, Suviolahti E, Soro-Paavonen A, Hiekkalinna T, Day A, Lange K, Sobel E, Taskinen M-R, Peltonen L, Perola M, Pajukanta P   Locus for quantitative HDL-cholesterol on chromosome 10q in Finnish families with dyslipidemia, J Lipid Res, 2004; 45: 1876–1884.
Lange EM, Lange K   Powerful allele-sharing statistics for non-parametric linkage analysis, Hum Hered, 2004; 57: 49–58.
Lange K, Sinsheimer JS   The pedigree trimming problem, Hum Hered, 2004; 58: 108–11.
Schadt EE, Sinsheimer JS, Lange K   Applications of codon and rate variation models in molecular phylogeny, Mol Biol Evol, 2002; 19: 1550–1562.
Hunter DR, Lange K   Computing estimates in the proportional odds model, Ann Inst Stat Math, 2002; 54: 155.
Sobel E, Papp J, Lange K   Detection and integration of genotyping errors in statistical genetics, Amer J Hum Genet, 2002; 496–508.
Lange K, Redelings B. Edited by Sneyd J   Disease gene dynamics in a population isolate. An Introduction to Mathematical Modeling in Physiology, Cell Biology, and Immunology, American Mathematical Society, Providence, RI, 2002; 119–138.
Sabatti C, Lange K   Genomewide motif identification using a dictionary model, Proceedings IEEE, 2002; 90: 1803–1810.
Liao W-H, Lange K, Huang S-C, Bergsneider M   Optimal design in PET data acquisition: a new approach using simulated annealing and component-wise Metropolis updating, Nuclear Science Symposium Conference Record, IEEE, 2002; 4: 1979–1983.
Ro Kyung M, Cantor Rita M, Lange Kenneth L, Ahn Samuel S   Palmar hyperhidrosis: evidence of genetic transmission Journal of vascular surgery, 2002; 35(2): 382-6.
Ro KM, Cantor RM, Lange K, Ahn SS   Palmer hyperhidrosis: evidence of genetic transmission, J Vascular Surgery, 2002; 35: 382–386.
Berloff N, Perola M, Lange K   Spline methods for comparison of physical and genetic maps, J Comp Biol, 2002; 9: 465–476.
Liao W-H, Huang S-C, Lange K, Bergsneider M. Edited by Senda M, Kimura Yuichi, Herscovitch P, Kimura Yui   Use of MM algorithm for regularization of parametric images in dynamic PET, Brain Imaging Using PET, 2002; 107–114.
Perola M, Ohman M, Hiekkalinna T, Leppavuori J, Pajukanta P, Wessman M, Koskenvuo M, Palotie A, Lange K, Kaprio J, Peltonen L   Quantitative-trait locus analysis of body mass index and stature, by combined analysis of genome scans of five Finnish study groups, Amer J Hum Genet, 2001; 69: 117-123.
Sinsheimer JS, McKenzie CA, Keavney B, Lange K   SNPs and snails and puppy dogs’ tails: analysis of SNP data using the gamete competition model, Ann Hum Genet, 2001; 65: 483–490.
Douglas JA, Boehnke M, Lange K   A multipoint method for detecting genotyping errors and mutations in sibling-pair linkage data, Amer J Hum Genet, 2000; 66: 1287–1297.
Fan R, Lange K. Edited by Gesztesy F, Holden H, Jost J, Paycha S, Rocker M, Scarlatti S   Asymptotic properties of the maximal subinterval of a Poisson process, Stochastic Processes, Physics and Geometry: New Interplays II: A Volume in Honor of Sergio Albeverio. American Mathematical Society, CMS Conference Proceedings Series, 2000; (29): 175–187.
Sinsheimer JS, Blangero J, Lange K   Gamete competition models, Amer J Hum Genet, 2000; 66: 1168-1172.
Guo SW, Lange K   Genetic mapping of complex traits: promises, problems, and prospects, Theor Pop Bio, 2000; (57): 1–11.
Dorman KS, Kaplan AH, Lange K, Sinsheimer JS   Mutation takes no vacation. Can structured treatment interruptions increase the risk of drug resistant HIV-1?, JAIDS, 2000; 25: 398–402.
Lange K, Hunter DR, Yang I   Optimization transfer using surrogate objective functions (with discussion), J Comput Graphical Stat, 2000; 9: 1-59.
Hunter DR, Lange K   Quantile regression via an MM algorithm, J Comput Graphical Stat, 2000; (9): 60–77.
Lange EM, Chen H, Brierley K, Livermore H, Wojno KJ, Langefeld CD, Lange K, Cooney KA   The polymorphic exon 1 androgen receptor CAG repeat in men with a potential inherited predisposition to prostate cancer, Cancer Epidemiology, Biomarkers, Prevention, 2000; (9): 439–442.
Peltonen L, Palotie A, Lange K   The use of population isolates for mapping complex traits, Nature Genetics Reviews, 2000; (1): 182–190.
Lange Kenneth, Papp Jeanette C, Sinsheimer Janet S, Sripracha Ram, Zhou Hua, Sobel Eric M   Mendel: the Swiss army knife of genetic analysis programs Bioinformatics (Oxford, England), 2013; 29(12): 1568-70.
Ranola John Michael, Langfelder Peter, Lange Kenneth, Horvath Steve   Cluster and propensity based approximation of a network BMC systems biology, 2013; 7(12): 21.
Chi Eric C, Zhou Hua, Chen Gary K, Del Vecchyo Diego Ortega, Lange Kenneth   Genotype imputation via matrix completion Genome research, 2013; 23(3): 509-18.
Chen Gary K, Wang Kai, Stram Alex H, Sobel Eric M, Lange Kenneth   Mendel-GPU: haplotyping and genotype imputation on graphics processing units Bioinformatics (Oxford, England), 2012; 28(22): 2979-80.
Zhang Zhongyang, Lange Kenneth, Sabatti Chiara   Reconstructing DNA copy number by joint segmentation of multiple sequences BMC bioinformatics, 2012; 13(22): 205.
Riley Lindsay, Zhou Hua, Lange Kenneth, Sinsheimer Janet S, Sehl Mary E   Determining duration of HER2-targeted therapy using stem cell extinction models PloS one, 2012; 7(12): e46613.
Wang Richard T, Ahn Sangtae, Park Christopher C, Khan Arshad H, Lange Kenneth, Smith Desmond J   Effects of genome-wide copy number variation on expression in mammalian cells BMC genomics, 2011; 12(12): 562.
Alexander David H, Lange Kenneth   Stability selection for genome-wide association Genetic epidemiology, 2011; 35(7): 722-8.
Day-Williams Aaron G, Blangero John, Dyer Thomas D, Lange Kenneth, Sobel Eric M   Linkage analysis without defined pedigrees Genetic epidemiology, 2011; 35(5): 360-70.
Alexander David H, Lange Kenneth   Enhancements to the ADMIXTURE algorithm for individual ancestry estimation BMC bioinformatics, 2011; 12(5): 246.
Zhou Hua, Alexander David, Lange Kenneth   A quasi-Newton acceleration for high-dimensional optimization algorithms Statistics and computing, 2011; 21(2): 261-273.
Zhou Hua, Lange Kenneth   A Fast Procedure for Calculating Importance Weights in Bootstrap Sampling Computational statistics & data analysis, 2011; 55(1): 26-33.
Day-Williams Aaron G, Blangero John, Dyer Thomas D, Lange Kenneth, Sobel Eric M   Unifying ideas for non-parametric linkage analysis Human heredity, 2011; 71(4): 267-80.
Zhang Zhongyang, Lange Kenneth, Ophoff Roel, Sabatti Chiara   RECONSTRUCTING DNA COPY NUMBER BY PENALIZED ESTIMATION AND IMPUTATION The annals of applied statistics, 2010; 4(4): 1749-1773.

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