Stephen Smale, Ph.D.

A Short Biography:

Stephen T. Smale is a molecular immunologist and biochemist who arrived at UCLA in 1990 as an Assistant Professor in the Department of Microbiology and Immunology within the UCLA School of Medicine. In 1999, he was promoted to Professor and, in 2014, to Distinguished Professor, in the Department of Microbiology, Immunology, and Molecular Genetics, which spans the UCLA College of Letters and Science and the David Geffen School of Medicine. From 1990 to 2007, he was also a Howard Hughes Medical Institute Investigator. Dr. Smale graduated Magna Cum Laude from Cornell University, with Honors and Distinction in Chemistry. He received his Ph.D. in Biochemistry from the University of California, Berkeley under the mentorship of Dr. Robert Tjian. He then was a Helen Hay Whitney Foundation postdoctoral fellow with Nobelist Dr. David Baltimore at the Whitehead Institute, MIT. At UCLA, Dr. Smale previously served as Vice Chair of the Department of Microbiology, Immunology, and Molecular Genetics, Director of Basic and Translational Research for the UCLA Jonsson Comprehensive Cancer Center, Director of the Howard Hughes Medical Institute Science Education Program, and Co-Director of the UCLA-Caltech Medical Scientist Training Program. He currently serves as Vice Dean for Research in the David Geffen School of Medicine and Chair of the School of Medicine's Research Initiative in Immunity, Inflammation, Infection, and Transplantation (UCLA I3T). The research in Dr. Smale's laboratory focuses on gene regulation during inflammatory and innate immune responses and during lymphocyte development and leukemogenesis.

Work Titles and Affiliation
UCLA Chair, Immunity, Inflammation, Infection, & Transplantation (I3T) Research Initiative Distinguished Professor, Microbiology, Immunology & Molecular Genetics Vice Dean for Research, David Geffen School of Medicine at UCLA

Contact Information:

Email Address:

Lab Number:

(310) 206-4946

Office Phone Number:

(310) 206-4777

Laboratory Address:

6-535 MRL
675 Charles E. Young Drive South
Los Angeles, CA 90095

Mailing Address:

Box 951489
Los Angeles, CA 90095

Office Address:

6-730 MRL
675 Charles E. Young Drive South
Los Angeles, CA 90095


Tong AJ, Liu X, Thomas BJ, Lissner MM, Baker MR, Senagolage MD, Allred AL, Barish GD, Smale ST   A stringent systems approach uncovers gene-specific mechanisms regulating inflammation Cell, 2016; 165: 165-179.
Arenzana TL, Schjerven H, Smale ST   Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor Genes & Dev, 2015; 29: 1801-1816.
Lissner ML, Thomas BJ, Wee K, Tong AJ, Kollmann TR, Smale ST   Age-related gene expression differences in monocytes from human neonates, young adults, and older adults, PLoS One, 2015; 10: e0132061.
Smale ST, Tarakhovsky A, Natoli G   Chromatin contributions to the regulation of innate immunity Annual Review of Immunology, 2014; 32: 489-911.
Smale ST   Transcriptional regulation in the immune system: a status report Trends Immunol, 2014; 35: 190-194.
Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST   Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros Nature Immunol, 2013; 14: 1073-1083.
Smale ST, Plevy SE, Weinmann AS, Zhou L, Ramirez-Carrozzi VR, Pope SD, Bhatt DM, Tong AJ   Toward an understanding of the gene-specific and global logic of inducible gene transcription Cold Spring Harb Symp Quant Biol, 2013; 78: 61-68.
Bhatt DM, Pandya-Jones A, Tong AJ, Barozzi I, Lissner MM, Natoli G, Black DL, Smale ST   Transcript dynamics of pro inflammatory genes revealed by sequence analysis of subcellular RNA fractions Cell, 2012; 150: 279-290.
Xu J, Smale ST   Designing an enhancer landscape Cell, 2012; 151: 929-931.
Negishi H, Yanai H, Nakajima A, Koshiba R, Atarashi K, Matsuda A, Matsuki K, Miki S, Doi T, Aderem A, Nishio J, Smale ST, Honda K, Taniguchi T   Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses Nature Immunol, 2012; 13: 659-666.
Siggers T, Chang AB, Teixeira A, Wong D, Williams KJ, Ahmed B, Ragoussis J, Udalova IA, Smale ST, Bulyk ML   Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-kB family DNA binding Nature Immunol, 2011; 13: 95-102.
Smale ST   Hierarchies of NF-kB target-gene regulation Nature Immunol, 2011; 12: 689-694.
Smale ST   Seq-ing LPS-induced enhancers, Immunity, 2010; 32: 296-297.
Ramirez-Carrozzi VR, Braas D, Bhatt DM, Cheng CS, Hong C, Doty KR, Black JC, Hoffmann A, Carey M, Smale ST   A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling Cell, 2009; 138: 114-128.
Xu J, Watts JA, Pope SD, Gadue P, Kamps M, Plath K, Zaret KS, Smale ST   Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells Genes & Dev, 2009; 23: 2824-2838.
Carey M, Peterson CL, and Smale ST   Transcriptional regulation in eukaryotes: Concepts, strategies, and techniques, Second edition, , 2009; Cold Spring Harbor Laboratory Press: .
Smale ST, Dorshkind K   Hematopoiesis flies high with Ikaros Nature Immunol, 2006; 7: 367-369.
Li CC, Ramirez-Carrozzi VR, Smale ST   Pursuing global gene regulation "logic" via RNA interference and chromatin immunoprecipitation Nature Immunol, 2006; 7: 692-697.
Ramirez-Carrozzi VR, Nazarian AA, Li CC, Gore SL, Sridharan R, Imbalzano AN, Smale ST   Selective and antagonistic functions of SWI/SNF and Mi-2b nucleosome remodeling complexes during an inflammatory response Genes & Dev, 2006; 20: 282-296.
Sanjabi S, Williams KJ, Saccani S, Zhou L, Hoffmann A, Ghosh G, Gerondakis S, Natoli G, Smale ST   A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation Genes & Dev, 2005; 19: 2138-2151.
Su RC, Brown KE, Saaber S, Fisher AG, Merkenschlager M, Smale ST   Dynamic assembly of silent chromatin during thymocyte maturation Nature Genetics, 2004; 36: 502-506.
Papathanasiou P, Perkins AC, Cobb BS, Ferrini R, Sridharan R, Hoyne GF, Nelms KA, Smale ST, Goodnow CC   Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor Immunity, 2003; 19: 131-144.
Smale ST, Kadonaga JT   The RNA polymerase II core promoter Annual Review of Biochemistry, 2003; 72: 449-479.
McCarty AS, Kleiger G, Eisenberg D, Smale ST   Selective dimerization of a C2H2 zinc finger subfamily Molecular Cell, 2003; 11: 459-470.
Dovat S, Ronni T, Russell D, Ferrini R, Cobb BS, Smale ST   A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains Genes & Dev, 2002; 16: 2985-2990.
Smale ST and Fisher AG   Chromatin structure and gene regulation in the immune system Annual Review of Immunology, 2002; 20: 427-462.
Smale ST   Core promoters: active contributors to combinatorial gene regulation Genes & Dev, 2001; 15: 2503-2508.
Trinh LA, Ferrini R, Cobb BS, Weinmann AS, Hahm K, Ernst P, Garraway IP, Merkenschlager M, Smale ST   Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator Genes & Dev, 2001; 15: 1817-1832.
Weinmann AS, Mitchell DM, Sanjabi S, Bradley MN, Hoffmann A, Liou HC, Smale ST   Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event Nature Immunol, 2001; 2: 51-57.
Cobb BS, Morales-Alcelay S, Kleiger G, Brown KE, Fisher AG, Smale ST   Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding Genes & Dev, 2000; 14: 2146-2160.
Carey M and Smale ST   Transcriptional regulation in eukaryotes: Concepts, strategies, and techniques, , 2000; Cold Spring Harbor Laboratory Press: .
Brightbill HD, Libraty DH, Krutzik SR, Yang RB, Belisle JT, Bleharski JR, Maitland M, Norgard MV, Plevy SE, Smale ST, Brennan PJ, Bloom BR, Godowski PJ, Modlin RL   Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors Science, 1999; 285: 732-736.
Ernst P, Hahm K, Cobb BS, Brown KE, Trinh LA, McCarty AS, Merkenschlager M, Klug CA, Fisher AG, Smale ST   Mechanisms of transcriptional regulation in lymphocyte progenitors: insight from an analysis of the terminal transferase promoter Cold Spr Harb Symp Quant Biol, 1999; 64: 87-97.
Hahm K, Cobb BS, McCarty AS, Brown KE, Klug CA, Lee R, Akashi K, Weissman IL, Fisher AG, and Smale ST   Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin Genes & Dev, 1998; 12: 782-796.
Smale ST, Jain A, Kaufmann J, Emami KH, Lo K, Garraway IP   The initiator element: a paradigm for core promoter heterogeneity within metazoan protein-coding genes Cold Spr Harb Symp Quant Biol, 1998; 63: 21-31.
Brown KE, Guest SS, Smale ST, Hahm K, Merkenschlager M, Fisher AG   Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin Cell, 1997; 91: 845-854.
Kaufmann J, Verrijzer CP, Shao J, Smale ST   CIF, an essential cofactor for TFIID-dependent initiator function Genes & Dev, 1996; 10: 873-886.

MeSH Terms:

What is MeSH?

Medical Subject Headings

We have integrated Faculty Profiles with the U.S. National Library of Medicine's MeSH terms. For every publication added to a profile, we pull its MeSH terms and display it here. This enhancement allows you to search for research themes of our faculty members.

Click on any of the terms below to see additional researchers with similar keywords.

MeSH is:

  • an acronym for Medical Subject Headings.
  • the U.S. National Library of Medicine's controlled vocabulary (thesaurus).
  • a vocabulary that gives uniformity and consistency to the indexing and cataloging of biomedical literature.
  • a distinctive feature of MEDLINE.
  • arranged in a hierarchical manner called the MeSH Tree Structures.
  • updated annually.

MeSH Vocabulary includes four types of terms:

  • Headings
  • Subheadings
  • Supplementary Concept Records
  • Publication Characteristics (or Types)

Over 26,000 MeSH headings (also called "main headings" or "descriptors" represents concepts found in the biomedical literature

Subheadings - (also called qualifiers) are attached to MeSH headings to describe a specific aspect of a concept.

Supplementary Concept Records are over 200,000 terms in a separate thesaurus from the Medical Subject Headings. These are primarily substance terms, but also include some protocols and rare desease terms. These terms are updated weekly.

Publication Characteristics or (Publication Types) describe the type of publication being indexed; i.e., what the item is, not what the article is about.

Information from U.S. National Library of Medicine.

Adrenal Cortex Hormones Adult Affect Albumins Amino Acid Sequence Animal Experimentation Animals Anti-Inflammatory Agents Antigens Atherosclerosis Autoimmune Diseases Automobile Driving B-Lymphocytes Bacterial Infections Base Sequence Binding Sites Biological Assay Biology Bone Marrow CCAAT-Enhancer-Binding Protein-beta CCAAT-Enhancer-Binding Proteins CD8-Positive T-Lymphocytes Catalytic Domain Cell Communication Cell Differentiation Cell Line Cell Lineage Cell Nucleus Cell-Free System Cells Cells, Cultured Centromere Chromatin Chromatin Immunoprecipitation Cluster Analysis Communicable Diseases Communication Consensus Conserved Sequence CpG Islands Cycloheximide Cytogenetics Cytokines DNA DNA Footprinting DNA Methylation DNA Nucleotidylexotransferase DNA Nucleotidyltransferases DNA, Complementary DNA-Binding Proteins Dendritic Cells Diagnosis Dimerization Disease Disease Progression Dissection Drosophila Proteins Elements Embryonic Stem Cells Endoderm Enhancer Elements, Genetic Environment Enzyme-Linked Immunosorbent Assay Ephrin-A2 Exons Family Fibroblasts Fingers Fluorescence Foxes Gastrulation Gene Expression Gene Expression Profiling Gene Expression Regulation Gene Expression Regulation, Developmental Gene Expression Regulation, Enzymologic Gene Silencing Gene Targeting Genes Genes, Immunoglobulin Genome Genomics Goals HeLa Cells Health Hematopoiesis Hematopoietic Stem Cells Herpes Simplex Virus Protein Vmw65 Heterochromatin High-Throughput Nucleotide Sequencing Histone Deacetylases Histones Homologous Recombination Human Experimentation Humans Hypersensitivity Ikaros Transcription Factor Immune System Immunity Immunity, Innate Immunoprecipitation Infection Inflammation Interferon Regulatory Factor-3 Interferon Type I Interferon-beta Interferon-gamma Interleukin-10 Interleukin-12 Interleukin-12 Subunit p40 Interleukin-15 Interleukin-23 Interleukin-9 Interphase Investments Kidney Kinetics Knowledge Laboratories Lead Leadership Learning Leprosy Leukemia Libraries Ligands Lipid A Lipopolysaccharides Liver Logic Lymphocyte Activation Lymphocytes Lymphoma Lymphopoiesis Macrophage Activation Macrophages Macrophages, Peritoneal Maintenance Membrane Glycoproteins Methods Methylation Mi-2 Nucleosome Remodeling and Deacetylase Complex Mice Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains Mice, Transgenic Microscopy, Confocal Models, Biological Models, Genetic Models, Molecular Molecular Sequence Data Multigene Family Mutagenesis Mutagenesis, Site-Directed Mutation Mycobacterium leprae NF-kappa B Names Nature Nuclear Proteins Nucleosomes Nucleotidyltransferases Oligonucleotides Patients Peer Review Peptide Fragments Peptides Pharmaceutical Preparations Phenotype Phosphorylation Physiological Processes Pilot Projects Plasmids Pluripotent Stem Cells Point Mutation Polymerase Chain Reaction Polyribonucleotide Nucleotidyltransferase Promoter Regions, Genetic Protein Binding Protein Biosynthesis Protein Multimerization Protein Structure, Tertiary Protein Subunits Protein Synthesis Inhibitors Proteins Proto-Oncogene Proteins Proto-Oncogene Proteins c-rel Public Health Publications Publishing RNA RNA Nucleotidyltransferases RNA Polymerase II RNA, Messenger Receptors, Cell Surface Recombinant Fusion Proteins Recombinant Proteins Research Research Personnel Reverse Transcriptase Polymerase Chain Reaction Role Science Seeds Sequence Analysis Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Serum Signal Transduction Small Molecule Libraries Societies Sp1 Transcription Factor Stem Cells Structure-Activity Relationship Suggestion T-Lymphocytes TATA Box TATA-Box Binding Protein Th1 Cells Thymus Gland Time Time Factors Tissues Toll-Like Receptor 4 Toll-Like Receptors Trans-Activators Transcription Factor AP-1 Transcription Factor RelA Transcription Factor TFIID Transcription Factors Transcription Factors, TFII Transcription Termination, Genetic Transcription, Genetic Transcriptional Activation Transfection Transgenes Translating Translations Tumor Suppressor Proteins Up-Regulation Virus Latency Vitamin D Vitamins Work Zinc Fingers

Does this profile need updating? Contact Us