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Shaping the Future

Michael Levine, Ph.D.

Contact Information:

Lab Number:

(310)825-2763

Office Phone Number:

310-825-7595

Work Address:

Laboratory
NPI
Los Angeles, CA 90095
UNITED STATES
Office
NPI
Los Angeles, CA 90095
UNITED STATES

Email Address:

mlevine@mednet.ucla.edu

Chair, Interdepartmental Undergraduate Program

Neuroscience IDP

Professor, Psychiatry and Biobehavioral Sciences

Associate Director for Education, Brain Research Institute

Professor in Residence, Semel Institute for Neuroscience and Human Behavior

Member, ACCESS Program

Access Neuroscience Home Area

Center for Developmental Neurobiology (MRRC)

Center for Neurodegenerative Disease Studies

Neuroengineering Training Program


Detailed Biography:

Neurophysiological mechanisms underlying neurodegenerative disorders. Our primary research interests are directed toward understanding the mechanisms underlying neuronal dysfunction in the basal ganglia and cortex in neurodegenerative disorders. The research consists of a multidisciplinary approach combining neurophysiological, morphological and molecular techniques. This research has evolved into several major projects: 1) Examining the physiological changes in mutant mouse models of Huntington's disease, 2) Assessment of neuromodulation in the striatum as in pertains to Parkinson's disease and assessment of new gentic mouse models of Parkinson's disease and 3) Examining cellular cortical electrophysiological and morphological abnormalities occurring in children suffering from intractable pediatric epilepsy. The first area of research involves using mutant murine models of Huntington's disease to understand how this neurological disorder physiologically affects cellular function. We study different types of mouse models, each with a unique part of the human Huntington's disease gene inserted into the mouse genome. We examine physiological function and morphological changes in striatal and cortical neurons, the two primary areas affected in Huntington's disease. The studies on neuromodulation have concentrated on examining interactions among receptor subtypes in the striatum and othe nuclei of the basal ganglia as well as new genetic models of Parkinson's disease. These studies emanate from our initial observations that the direction of dopamine modulation of electrophysiological responses induced by activation of excitatory amino acid receptors is dependent upon the subtypes of excitatory amino acid and dopamine receptors activated. This observation could explain many of the inconsistencies in the literature concerning the modulatory role of dopamine in the striatum and other nuclei. One of the goals of these studies is to learn the rules that guide dopaminergic modulation, to identify their mechanisms and to examine how this modulation is altered in models of Parkinson's disease to help design rational therapies for this disorder. The third area examines alterations in development of electrophysiological properties of human neocortical neurons. Pathological neocortical tissue is obtained from children suffering from pediatric epilepsy and undergoing surgery to alleviate intractable seizures. These experiments study "abnormal-appearing" neurons and they have shown that a population of neurons with altered voltage-dependent intrinsic currents and in some cases altered ligand-gated currents occurs.

Publications:

Cepeda Carlos, Levine Michael S   2B or Not 2B: A Tail of Two NMDA Receptor Subunits Neuron, 2012; 74(3): 426-8.
Cummings Damian M, Alaghband Yasaman, Hickey Miriam A, Joshi Prasad R, Hong S Candice, Zhu Chunni, Ando Timothy K, André Véronique M, Cepeda Carlos, Watson Joseph B, Levine Michael S   A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington's disease Journal of neurophysiology, 2012; 107(2): 677-91.
Cepeda Carlos, Levine Michael S   Dopamine-NMDA Receptor Interactions: Twenty Years Later Developmental neuroscience, 2012; .
Cepeda Carlos, André Véronique M, Hauptman Jason S, Yamazaki Irene, Huynh My N, Chang Julia W, Chen Jane Y, Fisher Robin S, Vinters Harry V, Levine Michael S, Mathern Gary W   Enhanced GABAergic network and receptor function in pediatric cortical dysplasia Type IIB compared with Tuberous Sclerosis Complex Neurobiology of disease, 2012; 45(1): 310-21.
Hickey Miriam A, Zhu Chunni, Medvedeva Vera, Lerner Renata P, Patassini Stefano, Franich Nicholas R, Maiti Panchanan, Frautschy Sally A, Zeitlin Scott, Levine Michael S, Chesselet Marie-Françoise   Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease Molecular neurodegeneration, 2012; 7(3): 12.
Ma Yao-Ying, Cepeda Carlos, Chatta Payush, Franklin Lana, Evans Christopher J, Levine Michael S   Regional and cell-type-specific effects of DAMGO on striatal D1 and D2 dopamine receptor-expressing medium-sized spiny neurons ASN neuro, 2012; 4(2): .
André Véronique M, Fisher Yvette E, Levine Michael S   Altered Balance of Activity in the Striatal Direct and Indirect Pathways in Mouse Models of Huntington's Disease Frontiers in systems neuroscience, 2011; 5(4): 46.
Kim Soong Ho, Thomas Carlos A, André Véronique M, Cummings Damian M, Cepeda Carlos, Levine Michael S, Ehrlich Michelle E   Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function ASN neuro, 2011; 3(3): e00060.
Wu Nanping, Joshi Prasad R, Cepeda Carlos, Masliah Eliezer, Levine Michael S   Alpha-synuclein overexpression in mice alters synaptic communication in the corticostriatal pathway Journal of neuroscience research, 2010; 88(8): 1764-76.
Cummings Damian M, Cepeda Carlos, Levine Michael S   Alterations in striatal synaptic transmission are consistent across genetic mouse models of Huntington's disease ASN neuro, 2010; 2(3): e00036.
Cepeda Carlos, André Véronique M, Yamazaki Irene, Hauptman Jason S, Chen Jane Y, Vinters Harry V, Mathern Gary W, Levine Michael S   Comparative study of cellular and synaptic abnormalities in brain tissue samples from pediatric tuberous sclerosis complex and cortical dysplasia type II Epilepsia, 2010; 51 Suppl 3(29): 160-5.
André Véronique M, Cepeda Carlos, Levine Michael S   Dopamine and glutamate in Huntington's disease: A balancing act CNS neuroscience & therapeutics, 2010; 16(3): 163-78.
André Véronique M, Cepeda Carlos, Cummings Damian M, Jocoy Emily L, Fisher Yvette E, William Yang X, Levine Michael S   Dopamine modulation of excitatory currents in the striatum is dictated by the expression of D1 or D2 receptors and modified by endocannabinoids The European journal of neuroscience, 2010; 31(1): 14-28.
Cepeda Carlos, Cummings Damian M, André Véronique M, Holley Sandra M, Levine Michael S   Genetic mouse models of Huntington's disease: focus on electrophysiological mechanisms ASN neuro, 2010; 2(2): e00033.
André Véronique M, Cepeda Carlos, Vinters Harry V, Huynh My, Mathern Gary W, Levine Michael S   Interneurons, GABAA currents, and subunit composition of the GABAA receptor in type I and type II cortical dysplasia Epilepsia, 2010; 51 Suppl 3(29): 166-70.
Levine Michael S, Cepeda Carlos, André Véronique M   Location, location, location: contrasting roles of synaptic and extrasynaptic NMDA receptors in Huntington's disease Neuron, 2010; 65(2): 145-7.
Shilyansky Carrie, Karlsgodt Katherine H, Cummings Damian M, Sidiropoulou Kyriaki, Hardt Molly, James Alex S, Ehninger Dan, Bearden Carrie E, Poirazi Panayiota, Jentsch J David, Cannon Tyrone D, Levine Michael S, Silva Alcino J   Neurofibromin regulates corticostriatal inhibitory networks during working memory performance Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(29): 13141-6.
Joshi Prasad R, Wu Nan-Ping, André Véronique M, Cummings Damian M, Cepeda Carlos, Joyce John A, Carroll Jeffrey B, Leavitt Blair R, Hayden Michael R, Levine Michael S, Bamford Nigel S   Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(8): 2414-27.
Cummings Damian M, André Véronique M, Uzgil Besim O, Gee Steven M, Fisher Yvette E, Cepeda Carlos, Levine Michael S   Alterations in cortical excitation and inhibition in genetic mouse models of Huntington's disease The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(33): 10371-86.
Graham Rona K, Pouladi Mahmoud A, Joshi Prasad, Lu Ge, Deng Yu, Wu Nan-Ping, Figueroa Bryan E, Metzler Martina, André Véronique M, Slow Elizabeth J, Raymond Lynn, Friedlander Robert, Levine Michael S, Leavitt Blair R, Hayden Michael R   Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(7): 2193-204.
Graham Rona K, Pouladi Mahmoud A, Joshi Prasad, Lu Ge, Deng Yu, Wu Nan-Ping, Figueroa Bryan E, Metzler Martina, André Véronique M, Slow Elizabeth J, Raymond Lynn, Friedlander Robert, Levine Michael S, Leavitt Blair R, Hayden Michael R   Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(7): 2193-204.
Cepeda Carlos, André Véronique M, Yamazaki Irene, Wu Nanping, Kleiman-Weiner Max, Levine Michael S   Differential electrophysiological properties of dopamine D1 and D2 receptor-containing striatal medium-sized spiny neurons The European journal of neuroscience, 2008; 27(3): 671-82.
Cummings Damian M, Yamazaki Irene, Cepeda Carlos, Paul David L, Levine Michael S   Neuronal coupling via connexin36 contributes to spontaneous synaptic currents of striatal medium-sized spiny neurons Journal of neuroscience research, 2008; 86(10): 2147-58.
André Véronique M, Cepeda Carlos, Vinters Harry V, Huynh My, Mathern Gary W, Levine Michael S   Pyramidal cell responses to gamma-aminobutyric acid differ in type I and type II cortical dysplasia Journal of neuroscience research, 2008; 86(14): 3151-62.
Bamford Nigel S, Zhang Hui, Joyce John A, Scarlis Christine A, Hanan Whitney, Wu Nan-Ping, André Véronique M, Cohen Rachel, Cepeda Carlos, Levine Michael S, Harleton Erin, Sulzer David   Repeated exposure to methamphetamine causes long-lasting presynaptic corticostriatal depression that is renormalized with drug readministration Neuron, 2008; 58(1): 89-103.
Mathern Gary W, Andres Marissa, Salamon Noriko, Chandra P Sarat, Andre Veronique M, Cepeda Carlos, Levine Michael S, Leite Joao P, Neder Luciano, Vinters Harry V   A hypothesis regarding the pathogenesis and epileptogenesis of pediatric cortical dysplasia and hemimegalencephaly based on MRI cerebral volumes and NeuN cortical cell densities Epilepsia, 2007; 48 Suppl 5(2): 74-8.
Wu Nanping, Cepeda Carlos, Zhuang Xiaoxi, Levine Michael S   Altered corticostriatal neurotransmission and modulation in dopamine transporter knock-down mice Journal of neurophysiology, 2007; 98(1): 423-32.
André Véronique M, Wu Nanping, Yamazaki Irene, Nguyen Snow T, Fisher Robin S, Vinters Harry V, Mathern Gary W, Levine Michael S, Cepeda Carlos   Cytomegalic interneurons: a new abnormal cell type in severe pediatric cortical dysplasia Journal of neuropathology and experimental neurology, 2007; 66(6): 491-504.
Chesselet Marie-Françoise, Plotkin Joshua L, Wu Nanping, Levine Michael S   Development of striatal fast-spiking GABAergic interneurons Progress in brain research, 2007; 160(2): 261-72.
Hernández-Echeagaray Elizabeth, Cepeda Carlos, Ariano Marjorie A, Lobo Mary Kay, Sibley David R, Levine Michael S   Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtype Neurochemical research, 2007; 32(2): 229-40.
Cepeda Carlos, André Véronique M, Wu Nanping, Yamazaki Irene, Uzgil Besim, Vinters Harry V, Levine Michael S, Mathern Gary W   Immature neurons and GABA networks may contribute to epileptogenesis in pediatric cortical dysplasia Epilepsia, 2007; 48 Suppl 5(2): 79-85.
Gu Xiaofeng, André Véronique M, Cepeda Carlos, Li Shi-Hua, Li Xiao-Jiang, Levine Michael S, Yang X William   Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease Molecular neurodegeneration, 2007; 2(6): 8.
Cepeda Carlos, Wu Nanping, André Véronique M, Cummings Damian M, Levine Michael S   The corticostriatal pathway in Huntington's disease Progress in neurobiology, 2007; 81(5-6): 253-71.
André Véronique M, Cepeda Carlos, Venegas Angela, Gomez Yeranui, Levine Michael S   Altered cortical glutamate receptor function in the R6/2 model of Huntington's disease Journal of neurophysiology, 2006; 95(4): 2108-19.
Ali Noore J, Levine Michael S   Changes in expression of N-methyl-D-aspartate receptor subunits occur early in the R6/2 mouse model of Huntington's disease Developmental neuroscience, 2006; 28(3): 230-8.
Salamon Noriko, Andres Marissa, Chute Dennis J, Nguyen Snow T, Chang Julia W, Huynh My N, Chandra P Sarat, Andre Veronique M, Cepeda Carlos, Levine Michael S, Leite Joao P, Neder Luciano, Vinters Harry V, Mathern Gary W   Contralateral hemimicrencephaly and clinical-pathological correlations in children with hemimegalencephaly Brain : a journal of neurology, 2006; 129(Pt 2): 352-65.
Cepeda Carlos, Levine Michael S   Dysfunctional channels are making noise in CAG triplet repeat disorders Experimental neurology, 2006; 202(2): 267-70.
Cepeda Carlos, André Véronique M, Levine Michael S, Salamon Noriko, Miyata Hajime, Vinters Harry V, Mathern Gary W   Epileptogenesis in pediatric cortical dysplasia: the dysmature cerebral developmental hypothesis Epilepsy & behavior : E&B, 2006; 9(2): 219-35.
Cepeda Carlos, Levine Michael S   Where do you think you are going? The NMDA-D1 receptor trap Science's STKE : signal transduction knowledge environment, 2006; 2006(333): pe20.
Klapstein Gloria J, Levine Michael S   Age-dependent biphasic changes in ischemic sensitivity in the striatum of Huntington's disease R6/2 transgenic mice Journal of neurophysiology, 2005; 93(2): 758-65.
Starling Amaal J, André Véronique M, Cepeda Carlos, de Lima Marianne, Chandler Scott H, Levine Michael S   Alterations in N-methyl-D-aspartate receptor sensitivity and magnesium blockade occur early in development in the R6/2 mouse model of Huntington's disease Journal of neuroscience research, 2005; 82(3): 377-86.
Cepeda Carlos, André Véronique M, Vinters Harry V, Levine Michael S, Mathern Gary W   Are cytomegalic neurons and balloon cells generators of epileptic activity in pediatric cortical dysplasia? Epilepsia, 2005; 46 Suppl 5(2): 82-8.
Gajendiran Mahadevan, Cepeda Carlos, Kha Hoa Ton, Sison Jessica D, Levine Michael S   Electrophysiological alterations in subthalamic neurons after unilateral dopamine depletion in the rat Journal of neuroscience research, 2005; 80(2): 203-10.
Plotkin Joshua L, Wu Nanping, Chesselet Marie-Françoise, Levine Michael S   Functional and molecular development of striatal fast-spiking GABAergic interneurons and their cortical inputs The European journal of neuroscience, 2005; 22(5): 1097-108.
Andres Marissa, Andre Veronique M, Nguyen Snow, Salamon Noriko, Cepeda Carlos, Levine Michael S, Leite Joao P, Neder Luciano, Vinters Harry V, Mathern Gary W   Human cortical dysplasia and epilepsy: an ontogenetic hypothesis based on volumetric MRI and NeuN neuronal density and size measurements Cerebral cortex (New York, N.Y. : 1991), 2005; 15(2): 194-210.
Ariano Marjorie A, Cepeda Carlos, Calvert Christopher R, Flores-Hernández Jorge, Hernández-Echeagaray Elizabeth, Klapstein Gloria J, Chandler Scott H, Aronin Neil, DiFiglia Marian, Levine Michael S   Striatal potassium channel dysfunction in Huntington's disease transgenic mice Journal of neurophysiology, 2005; 93(5): 2565-74.
Fleming Sheila M, Salcedo Jonathan, Fernagut Pierre-Olivier, Rockenstein Edward, Masliah Eliezer, Levine Michael S, Chesselet Marie-Françoise   Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004; 24(42): 9434-40.
Levine Michael S, Cepeda Carlos, Hickey Miriam A, Fleming Sheila M, Chesselet Marie-Françoise   Genetic mouse models of Huntington's and Parkinson's diseases: illuminating but imperfect Trends in neurosciences, 2004; 27(11): 691-7.
Bamford Nigel S, Zhang Hui, Schmitz Yvonne, Wu Nan-Ping, Cepeda Carlos, Levine Michael S, Schmauss Claudia, Zakharenko Stanislav S, Zablow Leonard, Sulzer David   Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals Neuron, 2004; 42(4): 653-63.
Cepeda Carlos, Starling Amaal J, Wu Nanping, Nguyen Oanh K, Uzgil Besim, Soda Takahiro, André Veronique M, Ariano Marjorie A, Levine Michael S   Increased GABAergic function in mouse models of Huntington's disease: reversal by BDNF Journal of neuroscience research, 2004; 78(6): 855-67.
Hernández-Echeagaray Elizabeth, Starling Amaal J, Cepeda Carlos, Levine Michael S   Modulation of AMPA currents by D2 dopamine receptors in striatal medium-sized spiny neurons: are dendrites necessary? The European journal of neuroscience, 2004; 19(9): 2455-63.
André Véronique M, Flores-Hernández Jorge, Cepeda Carlos, Starling Amaal J, Nguyen Snow, Lobo Mary Kay, Vinters Harry V, Levine Michael S, Mathern Gary W   NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue Cerebral cortex (New York, N.Y. : 1991), 2004; 14(6): 634-46.
Cepeda Carlos, Hurst Raymond S, Flores-Hernández Jorge, Hernández-Echeagaray Elizabeth, Klapstein Gloria J, Boylan Marea K, Calvert Christopher R, Jocoy Emily L, Nguyen Oanh K, André Véronique M, Vinters Harry V, Ariano Marjorie A, Levine Michael S, Mathern Gary W   Morphological and electrophysiological characterization of abnormal cell types in pediatric cortical dysplasia Journal of neuroscience research, 2003; 72(4): 472-86.
Goldberg Matthew S, Fleming Sheila M, Palacino James J, Cepeda Carlos, Lam Hoa A, Bhatnagar Anushree, Meloni Edward G, Wu Nanping, Ackerson Larry C, Klapstein Gloria J, Gajendiran Mahadevan, Roth Bryan L, Chesselet Marie-Francoise, Maidment Nigel T, Levine Michael S, Shen Jie   Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons The Journal of biological chemistry, 2003; 278(44): 43628-35.
Cepeda Carlos, Hurst Raymond S, Calvert Christopher R, Hernández-Echeagaray Elizabeth, Nguyen Oanh K, Jocoy Emily, Christian Lindsey J, Ariano Marjorie A, Levine Michael S   Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003; 23(3): 961-9.
Hsiao Chie-Fang, Wu Nanping, Levine Michael S, Chandler Scott H   Development and serotonergic modulation of NMDA bursting in rat trigeminal motoneurons Journal of neurophysiology, 2002; 87(3): 1318-28.
Flores-Hernández Jorge, Cepeda Carlos, Hernández-Echeagaray Elizabeth, Calvert Christopher R, Jokel Eve S, Fienberg Allen A, Greengard Paul, Levine Michael S   Dopamine enhancement of NMDA currents in dissociated medium-sized striatal neurons: role of D1 receptors and DARPP-32 Journal of neurophysiology, 2002; 88(6): 3010-20.
Cepeda Carlos, Crawford Cynthia A, Margulies Jody E, Watson Joseph B, Levine Michael S, Cohen Randy W   Enhanced epileptogenic susceptibility in a genetic model of reactive synaptogenesis: the spastic Han-Wistar rat Developmental neuroscience, 2002; 24(4): 262-71.
Kim Ok-Jin, Ariano Marjorie A, Lazzarini Robert A, Levine Michael S, Sibley David R   Neurofilament-M interacts with the D1 dopamine receptor to regulate cell surface expression and desensitization The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002; 22(14): 5920-30.
Ariano Marjorie A, Aronin Neil, Difiglia Marian, Tagle Danilo A, Sibley David R, Leavitt Blair R, Hayden Michael R, Levine Michael S   Striatal neurochemical changes in transgenic models of Huntington's disease Journal of neuroscience research, 2002; 68(6): 716-29.
Rubinstein, M Cepeda, C Hurst, RS Flores-Hernandez, J Ariano, MA Falzone, TL Kozell, LB Meshul, CK Bunzow, JR Low, MJ Levine, MS Grandy, DK   Dopamine D4 receptor-deficient mice display cortical hyperexcitability The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2001; 21(11): 3756-63.
Cepeda, C., Hurst, R.S., Altemus, K.L., Flores-Hern ndez, J., Calvert, C.R, Jokel, E.S., Grandy, D.K., Low, M.J., Rubinstein, M., Ariano, M.A. and Levine, M.S.   Facilitated glutamatergic transmission in the striatum of D2 dopamine receptor-deficient mice, J. Neurophysiol, 2001; 85: 659-670.
Levine, MS Klapstein, GJ Koppel, A Gruen, E Cepeda, C Vargas, ME Jokel, ES Carpenter, EM Zanjani, H Hurst, RS Efstratiadis, A Zeitlin, S Chesselet, MF   Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease Journal of neuroscience research. , 1999; 58(4): 515-32.
Cepeda, C and Levine, M.S.   Dopamine and NMDA receptor interactions in the neostriatum, Dev. Neurosci, 1998; 20: 1-18.
Cepeda, C Colwell, CS Itri, JN Chandler, SH Levine, MS   Dopaminergic modulation of NMDA-induced whole cell currents in neostriatal neurons in slices: contribution of calcium conductances Journal of neurophysiology. , 1998; 79(1): 82-94.
Hickey Miriam A, Zhu Chunni, Medvedeva Vera, Franich Nicholas R, Levine Michael S, Chesselet Marie-Françoise   Evidence for behavioral benefits of early dietary supplementation with CoEnzymeQ10 in a slowly progressing mouse model of Huntington's disease Molecular and cellular neurosciences, 2012; 49(2): 149-57.
Markstein Michele, Markstein Peter, Markstein Vicky, Levine Michael S   Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo Proceedings of the National Academy of Sciences of the United States of America, 2002; 99(2): 763-8.
Lam Hoa A, Wu Nanping, Cely Ingrid, Kelly Rachel L, Hean Sindalana, Richter Franziska, Magen Iddo, Cepeda Carlos, Ackerson Larry C, Walwyn Wendy, Masliah Eliezer, Chesselet Marie-Françoise, Levine Michael S, Maidment Nigel T   Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein Journal of neuroscience research, 2011; 89(7): 1091-102.
André Véronique M, Cepeda Carlos, Fisher Yvette E, Huynh My, Bardakjian Nora, Singh Sumedha, Yang X William, Levine Michael S   Differential electrophysiological changes in striatal output neurons in Huntington's disease The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(4): 1170-82.
Jocoy Emily L, André Véronique M, Cummings Damian M, Rao Shilpa P, Wu Nanping, Ramsey Amy J, Caron Marc G, Cepeda Carlos, Levine Michael S   Dissecting the contribution of individual receptor subunits to the enhancement of N-methyl-d-aspartate currents by dopamine D1 receptor activation in striatum Frontiers in systems neuroscience, 2011; 5(4): 28.
Cepeda Carlos, Cummings Damian M, Hickey Miriam A, Kleiman-Weiner Max, Chen Jane Y, Watson Joseph B, Levine Michael S   Rescuing the Corticostriatal Synaptic Disconnection in the R6/2 Mouse Model of Huntington's Disease: Exercise, Adenosine Receptors and Ampakines PLoS currents, 2010; 2(4): .
Cande Jessica, Goltsev Yury, Levine Michael S   Conservation of enhancer location in divergent insects Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(34): 14414-9.
Lerner Jason T, Salamon Noriko, Hauptman Jason S, Velasco Tonicarlo R, Hemb Marta, Wu Joyce Y, Sankar Raman, Donald Shields W, Engel Jerome, Fried Itzhak, Cepeda Carlos, Andre Veronique M, Levine Michael S, Miyata Hajime, Yong William H, Vinters Harry V, Mathern Gary W   Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience Epilepsia, 2009; 50(6): 1310-35.
Davidson Eric H, Levine Michael S   Properties of developmental gene regulatory networks Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(51): 20063-6.
Hong Joung-Woo, Hendrix David A, Papatsenko Dmitri, Levine Michael S   How the Dorsal gradient works: insights from postgenome technologies Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(51): 20072-6.
Hong Joung-Woo, Hendrix David A, Levine Michael S   Shadow enhancers as a source of evolutionary novelty Science (New York, N.Y.), 2008; 321(5894): 1314.
Reed Darien E, Huang Xinhua M, Wohlschlegel James A, Levine Michael S, Senger Kate   DEAF-1 regulates immunity gene expression in Drosophila Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(24): 8351-6.
Gray Michelle, Shirasaki Dyna I, Cepeda Carlos, André Véronique M, Wilburn Brian, Lu Xiao-Hong, Tao Jifang, Yamazaki Irene, Li Shi-Hua, Sun Yi E, Li Xiao-Jiang, Levine Michael S, Yang X William   Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008; 28(24): 6182-95.
Hendrix David A, Hong Joung-Woo, Zeitlinger Julia, Rokhsar Daniel S, Levine Michael S   Promoter elements associated with RNA Pol II stalling in the Drosophila embryo Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(22): 7762-7.
Papatsenko Dmitri, Levine Michael S   Dual regulation by the Hunchback gradient in the Drosophila embryo Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(8): 2901-6.
Biemar Frédéric, Nix David A, Piel Jessica, Peterson Brant, Ronshaugen Matthew, Sementchenko Victor, Bell Ian, Manak J Robert, Levine Michael S   Comprehensive identification of Drosophila dorsal-ventral patterning genes using a whole-genome tiling array Proceedings of the National Academy of Sciences of the United States of America, 2006; 103(34): 12763-8.
Biemar Frédéric, Zinzen Robert, Ronshaugen Matthew, Sementchenko Victor, Manak J Robert, Levine Michael S   Spatial regulation of microRNA gene expression in the Drosophila embryo Proceedings of the National Academy of Sciences of the United States of America, 2005; 102(44): 15907-11.
Fairhurst Rick M, Kubak Bernard M, Shpiner Robert B, Levine Michael S, Pegues David A, Ardehali Abbas   Mycobacterium abscessus empyema in a lung transplant recipient The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2002; 21(3): 391-4.
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