(Henry) Sung-Cheng Huang, D.Sc.


Work Titles
UCLA Professor, Biomathematics Member, JCCC Cancer Molecular Imaging Member, Molecular Pharmacology GPB Home Area Member, Physics & Biology in Medicine GPB Home Area Professor Emeritus, Molecular & Medical Pharmacology
Education:
Degrees:
D.Sc.

Contact Information:

Work Email Address:

hhuang@mednet.ucla.edu


Website:

Huang Lab

Fax Number:

310-825-4517

Office Phone Number:

310-825-6647

Laboratory Address:

Laboratory
B2-085C CHS
Los Angeles, CA 90095


Office Address:

Office
B2-085H CHS
Los Angeles, CA 90095


Publications:

A selected list of publications:

Huang, SC Stout, DB Yee, RE Satyamurthy, N Barrio, JR   Distribution volume of radiolabeled large neutral amino acids in brain tissue Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. , 1998; 18(12): 1288-93.
Huang, SC, Zhou, Y,   Spatially-coordinated regression for image-wise model fitting to dynamic PET data for generating parametric images., IEEE Transactions on Nuclear Science, 1998; 45: 1194-1199.
Choi Y, Huang SC, Hawkins RA, Kim JY, Kim BT, Hoh CK, Chen K, Phelps ME, Schelbert HR   Quantification of myocardial blood flow using N-13 ammonia and PET: comparison of tracer methods, J. Nucl. Med, 1999; 40: 1045-1055.
Huang SC   Anatomy of SUV (Standardized Uptake Value), Nuclear Medicine & Biology, 2000; 27: 643-646.
Small, GW Ercoli, LM Silverman, DH Huang, SC Komo, S Bookheimer, SY Lavretsky, H Miller, K Siddarth, P Rasgon, NL Mazziotta, JC Saxena, S Wu, HM Mega, MS Cummings, JL Saunders, AM Pericak-Vance, MA Roses, AD Barrio, JR Phelps, ME   Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America. , 2000; 97(11): 6037-42.
Bergsneider, M Hovda, DA Lee, SM Kelly, DF McArthur, DL Vespa, PM Lee, JH Huang, SC Martin, NA Phelps, ME Becker, DP   Dissociation of cerebral glucose metabolism and level of consciousness during the period of metabolic depression following human traumatic brain injury Journal of neurotrauma. , 2000; 17(5): 389-401.
Yee, RE Huang, SC Stout, DB Irwin, I Shoghi-Jadid, K Togaski, DM DeLanney, LE Langston, JW Satyamurthy, N Farahani, KF Phelps, ME Barrio, JR   Nigrostriatal reduction of aromatic L-amino acid decarboxylase activity in MPTP-treated squirrel monkeys: in vivo and in vitro investigations Journal of neurochemistry. , 2000; 74(3): 1147-57.
Shoghi-Jadid K, Huang SC, Stout DB, Yee RE, Yeh EL, Farahani KF, Satyamurthy N, Phelps ME, Barrio JR   Striatal kinetic modeling of FDOPA with a cerebellar-derived constraint on the distribution volume of 3OMFD: a positron emission tomography (PET) investigation using non-human primates, J. Cereb. Blood Flow Metab, 2000; 20: 1134-1148.
Zhou Y, Huang SC, Bergsneider M, Wong DF   Improved parametric image generation using spatial-temporal analysis of dynamic PET studies, Neuroimaging, , 2002; 15: 697-707.
Small, GW Agdeppa, ED Kepe, V Satyamurthy, N Huang, SC Barrio, JR   In vivo brain imaging of tangle burden in humans Journal of molecular neuroscience : MN. , 2002; 19(3): 323-7.
Shoghi-Jadid K, Small GW, Agdeppa ED, Kepe V, Ercoli LM, Siddarth P, Read S, Satyamurthy N, Petric A, Huang SC, Barrio JR   Localization of Neurofibrillary Tangles (NFTs) and Beta-Amyloid Plaques (APs) in the Brains of Living Patients with Alzheimer?s Disease, Am J. Geriatric Psychiatry, 2002; 10: 24-35.
Hattori, N Huang, SC Wu, HM Yeh, E Glenn, TC Vespa, PM McArthur, D Phelps, ME Hovda, DA Bergsneider, M   Correlation of regional metabolic rates of glucose with glasgow coma scale after traumatic brain injury Journal of nuclear medicine : official publication, Society of Nuclear Medicine. , 2003; 44(11): 1709-16.
Agdeppa ED, Kepe V, Petri A, Satyamurthy N, Liu J, Huang SC, Small GW, Cole GM, Barrio JR.   In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrile, Neuroscience. , 2003; 117(3):: 723-30.
Wu, HM Huang, SC Hattori, N Glenn, TC Vespa, PM Yu, CL Hovda, DA Phelps, ME Bergsneider, M   Selective metabolic reduction in gray matter acutely following human traumatic brain injury Journal of neurotrauma. , 2004; 21(2): 149-61.
Wilks, M, Protas, H, Wardak, M, Kepe, V, Small, GW, Barrio, JR, Huang, SC   Automated VOI Analysis in FDDNP PET Using Structural Warping: Validation Through Classification of Alzheimer's Disease Patients, International Journal of Alzheimer's Disease, 2012; 2012: 512069.
Wong KP, Zhang, X, Huang, SC,   Improved derivation of input function in dynamic mouse F-18-FDG PET using bladder radioactivity kinetics, Molecular Imaging and Biology, 2013; DOI: 10.1007/s11307-013-0610-6: .
Leow A, Yu CL, Lee SJ, Huang SC, Nicolson R, Hayashi KM, Protas H, Toga AW, Thompson P,   Brain structural mapping using a noval hybrid implicit/explicit framework based on the level-set method, NeuroImage, 2005; 24(3): 910-927.
Vespa, P, Bergsneider M, Hattori N, Wu HM, Huang SC, Martin NA, Glenn TC, McArthur DL, Hovda DA,   Metabolic Crisis without Brain Ischemia is Common after Traumatic Brain Injury: A Combined Microdialysis and Positron Emission Tomography Study, J Cereb Blood Flow and Metab, 2005; 25(6): 763-774.
Huang SC, Truong D, Wu HM, Chatziioannou AF, Shao W, Wu AM, Phelps ME,   An Internet-based Kinetic Imaging System (KIS) for MicroPET, Molecular Imaging and Biology, 2005; 7: 330-341.
Kepe, V., Barrio, JR, Huang, S.C., Shoghi-Jadid, K., Ercoli, L, Siddarth, P., Cole, G.M., Satyamurthy, N., Small, G.M., Phelps, M.E.,   Serotonin 1A Receptors in the Living Brain of Alzheimer’s Disease Patients, Proceedings of National Academy of Science, 2006; 103(3): 702-707.
Kreissl, M.C., H.M. Wu, D.B. Stout, W. Ladno, T.H. Schindler, X. Zhang, J.O. Prior, A.F. Chatziioannou, S.C. Huang, H.R. Schelbert,   Non-invasive measurement of cardiovascular function in mice with ultra-high temporal resolution small animal PET, J. Nucl. Med, 2006; 47: 974-980.
Small GW, Kepe V, Ercoli LM, Siddarth P, Miller KJ, Bookheimer SY, Lavretsky H, Cole GM, Vinters HV, Thompson PM, Huang S-C, Satyamurthy N, Phelps ME, Barrio JR,   Positron Emission Tomography scanning of cerebral amyloid and Tau deposits in mild cognitive impairment, The New England Journal of Medicine, 2006; 355: 2652-63.
Wu, HM, Sui, G, Lee, CC, Prins, ML, Ladno, W, Lin, HD, Yu, AS, Phelps, ME, Huang, SC,   In vivo quantitation of glucose metabolism in mice using microPET imaging and a microfluidic device, J. Nucl. Med, 2007; 48(5): 837-845.
Ferl, G.Z., Wu, H.M., Zhang, X., Kreissl, M.C., Huang, S.C.   Estimation of the 18F-FDG Input Function in Mice Using Dynamic microPET and Minimal Blood Sample Data, Journal of Nuclear Medicine, 2007; 48: 2037-2045.
Barrio, JR, Kepe, V, Satyamurthy, N, Huang, SC   Amyloid and Tau Imaging, Neuronal Losses and Function in Early Dementia, Journal of Health, Nutrition and Aging, 2008; 12: 61-68.
Huang, SC   Role of kinetic modeling in biomedical imaging, Journal of Medical Sciences/NDMC, 2008; 28(2): 057-064.
Pan, MH, Huang, SC, Liao, YP, Schaue, D, Wang, CC, Stout, DB, Barrio, JR, McBride, WH   3’[F-18]fluoro-3’-deosythymidine (FLT)-PET imaging of radiation responses in murine tumors, Molecular Imaging and Biology, 2008; 10: 325-334.
Ferl, G.Z., Dumont, R, Armijo, A, Haubner, R, Reischl, G, Hildebrandt, I, Su, H, Weber, W, Huang, SC   Derivation of a compartmental model for quantifying 64Cu-RGD peptide kinetics in tumor bearing mice, Journal of Nuclear Medicine, 2009; 50: 250-258.
Wardak, M., Wong, K.P., Shao, W., Dahlbom, M., Kepe, V., Satyamurthy, N., Small, G.W., Barrio, J.R., Huang, S.C.   Movement Correction for Improving Quantitative Analysis of Dynamic Brain 18F-FDDNP PET Images, Journal Nucl. Med, 2010; 51: 210–218.
Wong, KP, Wardak, M, Shao, W, Dahlbom M, Kepe, V, Liu, J, Satyamurthy, N, Small, GW, Barrio, JR, Huang, SC   Quantitative analysis of [F-18]FDDNP PET using subcortical white matter as reference region, European Journal of Nuclear Medicine, 2010; 37(3): 575-88.
Protas, H, Huang, SC, Kepe, V, Hayashi, K, Klunder, A, Braskie, MN, Ercoli, L, Bookheimer, S, Thompson, PM, Small, GW, Barrio, JR   FDDNP binding using MR derived cortical surface maps, NeuroImage, 2010; 49: 240-8.
Yu, AS, Hiryama, BA, Timbol, G, Liu, J, Basarah, E, Kepe, V, Satyamurthy, N, Huang, SC, Wright, EW, Barrio, JR   Functional expression of SGLTs in rat brain, American Journal of Physiology - Cell Physiology, 2010; 299(6): C1277-84.
Schiepers, C, Dahlbom, M, Chen, W, Cloughesy, T, Czernin, J, Phelps, ME, Huang, SC   Kinetics of 3’-deoxy-3’-[18F]fluoro-thymidine during treatment monitoring of recurrent high-grade glioma, J. Nucl. Med, 2010; 51: 720-7.
Wardak, M, Schiepers, C, Dahlbom, M., Satyamurthy, N, Cloughesy, T, Chen, W, Czernin, J, Phelps, ME, Huang, SC   Predicting Survival in Recurrent Brain Tumor Therapy with 18F-Fluoro-Thymidine PET, Clinical Cancer Research, 2011; 17: 6553-62.
Wong, KP, Sha, W, Zhang, X, Huang, SC   Effects of Administration Route, Dietary Condition and Blood Glucose Level on Kinetics and Uptake of 2-[18F]Fluoro-2-deoxy-D-glucose in Mice, J. Nucl. Med, 2011; 52: 800-807.
Maddahi J, Czernin J, Lazewatsky J, Huang SC, Dahlbom M, Schelbert H, Sparks R, Ehlgen A, Crane P, Zhu Q, Devine M, Phelps M   Phase I, First-in-Human Study of BMS747158, a Novel 18F-Labeled Tracer for Myocardial Perfusion PET: Dosimetry, Biodistribution, Safety, and Imaging Characteristics After a Single Injection at Rest, J. Nucl. Med, 2011; 52(9): 1490-1498.
Small, GW, Siddarth, P, Kepe, V, Ercoli, LM, Burggren AC, Bookheimer, SY, Miller, KJ, Kim, J, Lavretsky, H, Huang, S-C, Barrio, JR   PET of brain amyloid and tau predicts and tracks cognitive decline in people without dementia, Archives of Neurology, 2012; 69(2): 215-222.
Wong, KP, Kepe, V, Dahlbom, M, Satyamurthy, N, Small, GW, Barrio, JR, Huang, SC   Comparative evaluation of Logan and relative-equilibrium graphical methods for parametric imaging of dynamic [F-18]FDDNP PET determinations, NeuroImage, 2012; 60(1): 241-251.
Kepe, V, Moghbel, MC, Langstrom, B, Zaidi, H, Vinters, H, Huang, SC, Satyamurthy, N, Doudet, D, Mishani, E, Cohen, R, Hoilund-Carlsen, PF, Alavi, A, Barrio, JR   Amyloid-â Positron Emission Tomography Imaging Probes: A Critical Review, J. Alzheimer’s Disease, 2013; doi: 10.3233/JAD-130485: .
Sha, W, Ye, H, Iwamoto, KS, Wong, KP, Stout, D, McBride, W, Huang, SC   Factors Affecting Tumor FDG Uptake in Longitudinal Mouse PET Studies, EJNMMI Research, 2013; 3:51: .

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