Anthony Campagnoni, Ph.D.
Work Phone Number:
UCLA Neuroscience Research Building
Department of Psychiatry and Biobehavioral Sciences
635 S. Charles Young Drive
Mail Code 733222
Los Angeles, CA 90095
47-4481 NPI, 760 Westwood Plaza
CAMPUS - 175919
Los Angeles, CA 90095
Psychiatry and Biobehavioral Sciences
Semel Institute for Neuroscience and Human Behavior
Basic/Translational Research, Jonsson Comprehensive Cancer Center
Brain Research Institute
Molecular and cellular mechanisms regulating neuronal and glial cell function in the central nervous system
Dr. Campagnoni's research covers three areas:
1. Exploring the roles of a novel Myelin Basic Protein sequence-containing gene in neural development in process extension and migration. In the past year Campagnoni and colleagues have continued their studies on a novel gene, which they call the Golli gene, that overlaps and includes the myelin basic protein gene. Campagnoni's team have been actively pursuing the function of the protein products of this gene. Campagnoni's laboratory have completed an extensive series of studies to determine where and when the protein products are expressed, and have found that they are expressed in neurons and in oligodendrocytes in mice and in humans. Golli proteins are expressed in pioneering neurons in the developing nervous system and Campagnoni believes that they are involved in process extension and neuronal migration early in development. Campagnoni and colleagues have produced several "immortalized" mouse cell lines in which these Golli proteins are synthesized and they appear to be associated with the cytoskeleton. Under certain conditions, in vivo and in vitro, the Golli proteins are found to be transported into the nuclei of some neurons, where Campagnoni believes they have a second role, possibly in regulating gene expression.
2. Autoimmune implications of a Myelin Basic Protein sequence-containing gene expression in the thymus, spleen, and lymph nodes. Studies on the expression of the Golli products have opened up a new research area for the laboratory. Campagnoni's team find that Golli proteins (which contain myelin basic protein sequences) are expressed in the thymus, spleen and lymph nodes of the immune system. This prompted them to search for the expression of other myelin protein antigens in these immune tissues and have found that the myelin proteolipid proteins are also expressed in human t
Jacobs Erin C, Reyes Samuel D, Campagnoni Celia W, Irene Givogri M, Kampf Kathy, Handley Vance, Spreuer Vilma, Fisher Robin, Macklin Wendy, Campagnoni Anthony T
Targeted overexpression of a golli-myelin basic protein isoform to
oligodendrocytes results in aberrant oligodendrocyte maturation and
Martin Melanie, Reyes Samuel D, Hiltner Timothy D, Givogri M Irene, Tyszka J Michael, Fisher Robin, Campagnoni Anthony T, Fraser Scott E, Jacobs Russell E, Readhead Carol
T(2)-weighted microMRI and evoked potential of the visual system
measurements during the development of hypomyelinated transgenic mice.
Molnár Zoltán, Hoerder-Suabedissen Anna, Wang Wei Zhi, DeProto Jamin, Davies Kay, Lee Sheena, Jacobs Erin C, Campagnoni Anthony T, Paulsen Ole, Piñon Maria Carmen, Cheung Amanda F P
Genes involved in the formation of the earliest cortical circuits.
Novartis Foundation symposium,
212-24; discussion 224-9, 276-81.
Jacobs Erin C, Campagnoni Celia, Kampf Kathy, Reyes Samuel D, Kalra Vikram, Handley Vance, Xie Yuan-Yun, Hong-Hu Yan, Spreur Vilma, Fisher Robin S, Campagnoni Anthony T
Visualization of corticofugal projections during early cortical
development in a tau-GFP-transgenic mouse.
The European journal of neuroscience,
Jacobs Erin C, Pribyl Thomas M, Feng Ji-Ming, Kampf Kathy, Spreur Vilma, Campagnoni Celia, Colwell Christopher S, Reyes Samuel D, Martin Melanie, Handley Vance, Hiltner Timothy D, Readhead Carol, Jacobs Russell E, Messing Albee, Fisher Robin S, Campagnoni Anthony T
Region-specific myelin pathology in mice lacking the golli products of
the myelin basic protein gene.
The Journal of neuroscience : the official journal of the Society for Neuroscience,
Voskuhl Rhonda R, Pribyl Thomas M, Kampf Kathy, Handley Vance, Liu Hong-biao, Feng JiMing, Campagnoni Celia W, Soldan Samantha S, Messing Albee, Campagnoni Anthony T
Experimental autoimmune encephalomyelitis relapses are reduced in
heterozygous golli MBP knockout mice.
Journal of neuroimmunology,
Maverakis Emanual, Beech Jonathan, Stevens David B, Ametani Akio, Brossay Laurent, van den Elzen Peter, Mendoza Richard, Thai Quoc, Macias Luis H, Ethell Doug, Campagnoni Celia W, Campagnoni Anthony T, Sette Alessandro, Sercarz Eli E
Autoreactive T cells can be protected from tolerance induction through
competition by flanking determinants for access to class II MHC.
Proceedings of the National Academy of Sciences of the United States of America,