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Alcino Silva, Ph.D.
Contact Information:
Work Phone Number:
310-794-6609
Work Address:
Laboratory Gonda Ctr Los Angeles, CA 90095 UNITED STATES
Office Gonda Ctr. Los Angeles, CA 90095 UNITED STATES
Director,
Behavioral Testing Core
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Professor,
Psychology
Tennenbaum Center for the Biology of Creativity
Behavioral Neuroscience
Neurobiology
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Member,
ACCESS Program: Dept. of Neurobiology
Neuroscience IDP
Brain Research Institute
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A Short Biography:
During his post-doctoral work at the Massachusetts Institute of Technology with Nobel Laureate Dr. Susumu Tonegawa, Dr. Alcino J. Silva pioneered the field of Molecular and Cellular Cognition. His first independent position (1992) was with the Cold Spring Harbor Laboratory, NY, where his research group had a key role in the development of Molecular and Cellular Cognition into a mainstream neuroscience field. In 2002 Dr. Silva founded and became the first President of the Molecular and Cellular Cognition Society, an international organization with more than 4000 members and with branches in North America, Asia and Europe. In 2006/2007 Dr. Silva served as Scientific Director of the Intramural Program of the National Institute of Mental Health. He is currently Professor of Neurobiology, Psychiatry & Biobehavioral Sciences, and Psychology. He heads the Center for Genetic Studies of Cortical Plasticity, directs the UCLA Integrative Center for Learning and Memory. He also serves in the Board of Regents of the University of Minho, Portugal.
Detailed Biography:
Alcino Silva was born in Portugal in 1961, but his family moved to Luanda, Angola, when he was 3 years old. He came to the United States to attend Rutgers University in 1979. There, he worked with William Sofer on Drosophila tRNA non-sense suppressors and minored on philosophy (epistemology). In 1983 he joined the graduate program of human genetics at the University of Utah, where he worked with Ray White, a pioneer in Human Genetics, on the inheritance of epigenetic information (Silva et al, 1988; Cell PMID: 2898978). While a graduate student, Dr. Silva organized yearly graduate symposia where leading luminaries from the Arts and Sciences shared their insights on the nature of innovation and creativity.
During his post-doctoral work at the Massachusetts Institute of Technology with Nobel Laureate Dr. Susumu Tonegawa (1988-92), Dr. Alcino J. Silva introduced transgenic mice to neuroscience studies of learning and memory and pioneered the field of Molecular and Cellular Cognition (Silva et al, Science 1992, PMIDs 1321493 &1378648). His first independent position (1992) was with the Cold Spring Harbor Laboratory, NY, where his research group had a key role in the development of Molecular and Cellular Cognition into a mainstream neuroscience field. In 2002 Dr. Silva founded and became the first President of the Molecular and Cellular Cognition Society, an international organization with more than 4000 members and with branches in North America, Asia and Europe.
Besides work on molecular and cellular cognition, his laboratory also works on developing approaches for systematic studies of scientific practices. The goal is to develop pragmatic, validated, general principles for increasing the efficiency of science.
In 2006/2007 Dr. Silva served as Scientific Director of the Intramural Program of the National Institute of Mental Health. He is currently Professor of Neurobiology, Psychiatry & Biobehavioral Sciences, and Psychology. He currently heads the Center for Genetic Studies of Cortical Plasticity, and serves as the co-director of Plasticity and Learning studies at UCLA. He also serves in the Board of Regents of the University of Minho, Portugal. He has been awarded a number of prizes and distinctions, including most recently the Order of Prince Henry (2008), the highest award given by the Portuguese Government to a Private citizen, the Marco Canavezes Medal of Science (2008), and the Senior Roche Award For Translational Neuroscience (2009).
Publications:
Shilyansky Carrie, Karlsgodt Katherine H, Cummings Damian M, Sidiropoulou Kyriaki, Hardt Molly, James Alex S, Ehninger Dan, Bearden Carrie E, Poirazi Panayiota, Jentsch J David, Cannon Tyrone D, Levine Michael S, Silva Alcino J
Neurofibromin regulates corticostriatal inhibitory networks during
working memory performance.
Proceedings of the National Academy of Sciences of the United States of America,
2010; 107(29):
13141-6.
Zhou Yu, Takahashi Eiki, Li Weidong, Halt Amy, Wiltgen Brian, Ehninger Dan, Li Guo-Dong, Hell Johannes W, Kennedy Mary B, Silva Alcino J
Interactions between the NR2B receptor and CaMKII modulate synaptic
plasticity and spatial learning.
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2007; 27(50):
13843-53.
Li Weidong, Zhou Yu, Jentsch J David, Brown Robert A M, Tian Xiaoli, Ehninger Dan, Hennah William, Peltonen Leena, Lönnqvist Jouko, Huttunen Matti O, Kaprio Jaakko, Trachtenberg Joshua T, Silva Alcino J, Cannon Tyrone D
Specific developmental disruption of disrupted-in-schizophrenia-1
function results in schizophrenia-related phenotypes in mice.
Proceedings of the National Academy of Sciences of the United States of America,
2007; 104(46):
18280-5.
Kushner Steven A, Elgersma Ype, Murphy Geoffrey G, Jaarsma Dick, van Woerden Geeske M, Hojjati Mohammad Reza, Cui Yijun, LeBoutillier Janelle C, Marrone Diano F, Choi Esther S, De Zeeuw Chris I, Petit Ted L, Pozzo-Miller Lucas, Silva Alcino J
Modulation of presynaptic plasticity and learning by the
H-ras/extracellular signal-regulated kinase/synapsin I signaling
pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2005; 25(42):
9721-34.
Costa Rui M, Drew Camilla, Silva Alcino J
Notch to remember.
Trends in neurosciences,
2005; 28(8):
429-35.
Elgersma Ype, Fedorov Nikolai B, Ikonen Sami, Choi Esther S, Elgersma Minetta, Carvalho Ofelia M, Giese Karl Peter, Silva Alcino J
Inhibitory autophosphorylation of CaMKII controls PSD association,
plasticity, and learning.
Neuron,
2002; 36(3):
493-505.
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