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Shaping the Future

Oliver Hankinson, Ph.D.

Contact Information:

Fax Number:

310-794-9272

Lab Number:

310-206-6803

Work Phone Number:

(310) 825-2936
310-794-9271

Work Address:

Office
Factor Building 13-244 -240 -232 -230
CHS
UCLA
Los Angeles, CA 90095
UNITED STATES
13-186 CHS
CAMPUS - 173216
CA
UNITED STATES
Laboratory
Factor Building
CHS
UCLA
Los Angeles, CA 90095
UNITED STATES

Work Email Address:

ohank@mednet.ucla.edu

Website:

  

Home Page:

     Molecular Toxicology


Director, ACCESS Program: Dept. of Molecular Toxicology

Professor, Pathology and Laboratory Medicine

Member, ACCESS Program

Access Gene Regulation Home Area

Access Molecular Pharmacology: Therapeutics, Diagnostics, and Biology of Disease Home Area

JCCC Cancer and Stem Cell Biology Program Area

JCCC Molecular Epidemiology Program Area

Pharmacology Home Area

Faculty, Cellular and Molecular Pathology PhD Program

Molecular Toxicology IDP


A Short Biography:

Dr. Hankinson is a Professor of Pathology and Laboratory Medicine, and Director of the Doctoral Program in Molecular Toxicology.

Detailed Biography:

Dr. Hankinson is a Professor of Pathology and Laboratory Medicine, and Director of the Doctoral Program in Molecular Toxicology. He received his Ph.D. in genetics from Cambridge University, England, in 1972. He did postdoctoral research in mammalian cell genetics at Harvard University, the University of Colorado, and the University of California, Berkeley, before joining the UCLA faculty in 1979. He was Director of the Carcinogenesis program of the UCLA Jonsson Comprehensive Cancer Center from 1994 to 2003, and Vice-Chair for Research of the Department of Pathology from 1997 to 2003. In 2000 he was founding director of the Molecular Toxicology Ph.D. program. He received the 2011 Distinguished Toxicology Award from the Society of Toxicology.

Publications:

Solaimani Parrisa, Damoiseaux Robert, Hankinson Oliver   Genome Wide RNAi High Throughput Screen Identifies Proteins Necessary for the AHR-Dependent Induction of CYP1A1 by 2,3,7,8-Tetrachlorodibenzo-ρ-dioxin Toxicological sciences : an official journal of the Society of Toxicology, 2013; .
Ingelman-Sundberg Magnus, Zhong Xiaobo, Hankinson Oliver, Beedanagari Sudheer, Yu Ai-Ming H, Peng Lai, Osawa Yoichi   Potential Role of Epigenetic Mechanisms in the Regulation of Drug Metabolism and Transport Drug metabolism and disposition: the biological fate of chemicals, 2013; .
Baay-Guzman Guillermina J, Bebenek Ilona G, Zeidler Michelle, Hernandez-Pando Rogelio, Vega Mario I, Garcia-Zepeda Eduardo A, Antonio-Andres Gabriela, Bonavida Benjamin, Riedl Marc, Kleerup Eric, Tashkin Donald P, Hankinson Oliver, Huerta-Yepez Sara   HIF-1 expression is associated with CCL2 chemokine expression in airway inflammatory cells: implications in allergic airway inflammation Respiratory research, 2012; 13: 60.
Bui Peter, Solaimani Parrisa, Wu Xiaomeng, Hankinson Oliver   2,3,7,8-Tetrachlorodibenzo-p-dioxin treatment alters eicosanoid levels in several organs of the mouse in an aryl hydrocarbon receptor-dependent fashion Toxicology and applied pharmacology, 2012; 259(2): 143-51.
Bebenek Ilona G, Solaimani Parrisa, Bui Peter, Hankinson Oliver   CYP2S1 is negatively regulated by corticosteroids in human cell lines Toxicology letters, 2012; 209(1): 30-4.
Bui Peter, Imaizumi Satoshi, Beedanagari Sudheer Reddy, Reddy Srinivasa T, Hankinson Oliver   Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids Drug metabolism and disposition: the biological fate of chemicals, 2011; 39(2): 180-90.
Quesada Arnulfo, Bui Peter H, Homanics Gregg E, Hankinson Oliver, Handforth Adrian   Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor European journal of pharmacology, 2011; 39(2): .
Beedanagari Sudheer R, Taylor Robert T, Bui Peter, Wang Feng, Nickerson Derek W, Hankinson Oliver   Role of epigenetic mechanisms in differential regulation of the dioxin-inducible human CYP1A1 and CYP1B1 genes Molecular pharmacology, 2010; 78(4): 608-16.
Beedanagari Sudheer R, Taylor Robert T, Hankinson Oliver   Differential regulation of the dioxin-induced Cyp1a1 and Cyp1b1 genes in mouse hepatoma and fibroblast cell lines Toxicology letters, 2010; 194(1-2): 26-33.
Wang Feng, Zhang Ruixue, Wu Xiaomeng, Hankinson Oliver   Roles of coactivators in hypoxic induction of the erythropoietin gene PloS one, 2010; 5(4): e10002.
Shi S, Yoon DY, Hodge-Bell K, Huerta-Yepez S, Hankinson O.   Aryl hydrocarbon nuclear translocator (hypoxia inducible factor 1beta) activity is required more during early than late tumor growth Mol Carcinog, 2010; 49(2): 157-65.
Bui Peter H, Hsu Erin L, Hankinson Oliver   Fatty acid hydroperoxides support cytochrome P450 2S1-mediated bioactivation of benzo[a]pyrene-7,8-dihydrodiol Molecular pharmacology, 2009; 76(5): 1044-52.
Bui Peter H, Hankinson Oliver   Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli Molecular pharmacology, 2009; 76(5): 1031-43.
Shi Shengli, Yoon Diana Y, Hodge-Bell Kimberly C, Bebenek Ilona G, Whitekus Michael J, Zhang Ruixue, Cochran Alistair J, Huerta-Yepez Sara, Yim Sun-Hee, Gonzalez Frank J, Jaiswal Anil K, Hankinson Oliver   The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene Carcinogenesis, 2009; 30(11): 1957-61.
Beedanagari Sudheer R, Bebenek Ilona, Bui Peter, Hankinson Oliver   Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes Toxicological sciences : an official journal of the Society of Toxicology, 2009; 110(1): 61-7.
Bui, P.H. Hsu, E.L. Hankinson, O.   Fatty Acid Hydroperoxides Support CYP2S1-Mediated Bioactivation of Benzo[a]pyrene7,8-dihydrodiol, Mol Pharmacol. , 2009; [Epub ahead of print].
Bui, P.H. Hankinson, O.   Functional Characterization of Human Cytochrom P450 2S1 Using a Synthetic Gene-Expressed Protein in E.Coli, Mol. Pharmacol. , 2009; [Epub ahead of print] .
Hsu, E. L. Chen, N. Westbrook, A. Wang, F. Zhang, R. Taylor, R. T. Hankinson, O.   Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals J Oncol, 2009; 2009(number): 491985.
Taylor, R. T. Wang, F. Hsu, E. L. Hankinson, O.   Roles of coactivator proteins in dioxin induction of CYP1A1 and CYP1B1 in human breast cancer cells Toxicol Sci, 2009; 107(1): 1-8.
Shi, S. Yoon, D. Hodge-Bell, K. Bebenek, I. Whitekus, M. Zhang, R. Cochran, A. Huerta Yepez, S. Yim, S.-H. Gonzalez, F.J. Jaiswal, A. Hankinson, O.   The Aryl Hydrocarbon Receptor Nuclear Translocator (Arnt) is required for tumor initiation by benzo(a)pyrene, Carcinogenesis. , 2009; [Epub ahead of print] .
Buchler, P. Reber, H. A. Tomlinson, J. S. Hankinson, O. Kallifatidis, G. Friess, H. Herr, I. Hines, O. J.   Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer Neoplasia, 2009; 11(2): 196-206.
Hankinson Oliver   Repression of aryl hydrocarbon receptor transcriptional activity by epidermal growth factor Molecular interventions, 2009; 9(3): 116-8.
Hsu Erin L, Chen Natalie, Westbrook Aya, Wang Feng, Zhang Ruixue, Taylor Robert T, Hankinson Oliver   Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals Journal of oncology, 2009; 2009(2): 491985.
Taylor Robert T, Wang Feng, Hsu Erin L, Hankinson Oliver   Roles of coactivator proteins in dioxin induction of CYP1A1 and CYP1B1 in human breast cancer cells Toxicological sciences : an official journal of the Society of Toxicology, 2009; 107(1): 1-8.
Bui Peter H, Quesada Arnulfo, Handforth Adrian, Hankinson Oliver   The mibefradil derivative NNC55-0396, a specific T-type calcium channel antagonist, exhibits less CYP3A4 inhibition than mibefradil Drug metabolism and disposition: the biological fate of chemicals, 2008; 36(7): 1291-9.
Hsu, E. L. Chen, N. Westbrook, A. Wang, F. Zhang, R. Taylor, R. T. Hankinson, O.   CXCR4 and CXCL12 down-regulation: a novel mechanism for the chemoprotection of 3,3'-diindolylmethane for breast and ovarian cancers Cancer Lett, 2008; 265(1): 113-23.
Bui, P. H. Quesada, A. Handforth, A. Hankinson, O.   The mibefradil derivative NNC55-0396, a specific T-type calcium channel antagonist, exhibits less CYP3A4 inhibition than mibefradil Drug Metab Dispos, 2008; 36(7): 1291-9.
Hankinson, O.   Why does ARNT2 behave differently from ARNT? Toxicol Sci, 2008; 103(1): 1-3.
Wang, F. Zhang, R. Xia, T. Hsu, E. Cai, Y. Gu, Z. Hankinson, O.   Inhibitory effects of nitric oxide on invasion of human cancer cells Cancer Lett, 2007; 257(2): 274-82.
Hsu, E. L. Yoon, D. Choi, H. H. Wang, F. Taylor, R. T. Chen, N. Zhang, R. Hankinson, O.   A proposed mechanism for the protective effect of dioxin against breast cancer Toxicol Sci, 2007; 98(2): 436-44.
Wang, F. Shi, S. Zhang, R. Hankinson, O.   Comparative microarray analysis of gene expression in mouse Hepa-1c1c7 and B mutant cell lines - the effect of the aromatic hydrocarbon receptor on the phenotype of the cells in the absence of exogenous ligands, Gene Regulation and Systems Biology , 2007; 1: 49-56.
Rivera, S. P. Saarikoski, S. T. Sun, W. Hankinson, O.   Identification of novel dioxin-responsive genes by representational difference analysis Xenobiotica, 2007; 37(3): 271-9.
Rivera, S. P. Wang, F. Saarikoski, S. T. Taylor, R. T. Chapman, B. Zhang, R. Hankinson, O.   A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P4502S1 by both dioxin and hypoxia J Biol Chem, 2007; 282(15): 10881-93.
Wang, F. Shi, S. Zhang, R. Hankinson, O.   Identifying target genes of the aryl hydrocarbon receptor nuclear translocator (Arnt) using DNA microarray analysis Biol Chem, 2006; 387(9): 1215-8.
Saarikoski, S. T. Rivera, S. P. Hankinson, O. Husgafvel-Pursiainen, K.   CYP2S1: a short review Toxicol Appl Pharmacol, 2005; 207(2 Suppl): 62-9.
Rivera, S. P. Choi, H. H. Chapman, B. Whitekus, M. J. Terao, M. Garattini, E. Hankinson, O.   Identification of aldehyde oxidase 1 and aldehyde oxidase homologue 1 as dioxin-inducible genes Toxicology, 2005; 207(3): 401-9.
Hankinson, O.   Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor Arch Biochem Biophys, 2005; 433(2): 379-86.
Beischlag, T. V. Taylor, R. T. Rose, D. W. Yoon, D. Chen, Y. Lee, W. H. Rosenfeld, M. G. Hankinson, O.   Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia J Biol Chem, 2004; 279(52): 54620-8.
Wang, F. Zhang, R. Beischlag, T. V. Muchardt, C. Yaniv, M. Hankinson, O.   Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene J Biol Chem, 2004; 279(45): 46733-41.
  ARNT Atlas Genet Cytogenet Oncol Haematol, 2004; .
Wang, S. Ge, K. Roeder, R. G. Hankinson, O.   Role of mediator in transcriptional activation by the aryl hydrocarbon receptor J Biol Chem, 2004; 279(14): 13593-600.
Anilkumar, G. Rajasekaran, S. A. Wang, S. Hankinson, O. Bander, N. H. Rajasekaran, A. K.   Prostate-specific membrane antigen association with filamin A modulates its internalization and NAALADase activity Cancer Res, 2003; 63(10): 2645-8.
Saarikoski, S. T. Rivera, S. P. Hankinson, O.   Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia FEBS Lett, 2002; 530(1-3): 186-90.
Rivera, S. P. Saarikoski, S. T. Hankinson, O.   Identification of a novel dioxin-inducible cytochrome P450 Mol Pharmacol, 2002; 61(2): 255-9.
Beischlag, T. V. Wang, S. Rose, D. W. Torchia, J. Reisz-Porszasz, S. Muhammad, K. Nelson, W. E. Probst, M. R. Rosenfeld, M. G. Hankinson, O.   Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex Mol Cell Biol, 2002; 22(12): 4319-33.
Yoon, D. Y. Buchler, P. Saarikoski, S. T. Hines, O. J. Reber, H. A. Hankinson, O.   Identification of genes differentially induced by hypoxia in pancreatic cancer cells Biochem Biophys Res Commun, 2001; 288(4): 882-6.
Anttila, S. Tuominen, P. Hirvonen, A. Nurminen, M. Karjalainen, A. Hankinson, O. Elovaara, E.   CYP1A1 levels in lung tissue of tobacco smokers and polymorphisms of CYP1A1 and aromatic hydrocarbon receptor Pharmacogenetics, 2001; 11(6): 501-9.
Roth, M. D. Marques-Magallanes, J. A. Yuan, M. Sun, W. Tashkin, D. P. Hankinson, O.   Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol Am J Respir Cell Mol Biol, 2001; 24(3): 339-44.
Lei, X. D. Chapman, B. Hankinson, O.   Loss of cyp1a1 messenger rna expression due to nonsense-mediated decay Mol Pharmacol, 2001; 60(2): 388-93.
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