Harold G. Martinson, Ph.D.

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A Short Biography:

Dr. Martinson received his Ph.D. in Molecular Biology from the University of California, Berkeley. He was a Postdoctoral Scholar at the University of California, San Francisco.

Click here for information about the Biochemistry and Molecular Biology (BMB) Graduate Program.


Work Titles
UCLA Lab Director, Martinson Lab Professor, Chemistry and Biochemistry Professor, Biochemistry, Molecular Biology Member, Chemistry and Biochemistry Member, Basic/Translational Research, Jonsson Comprehensive Cancer Center Member, Gene Regulation GPB Home Area Member, Graduate Program in Biochemistry, Molecular and Structural Biology Member, JCCC Gene Regulation Program Area Member, Molecular Biology Institute Researcher, Biochemistry Researcher, Development and Gene Regulation
Education:
Degrees:
Ph.D., UC Berkeley
Academic Experience:
University of California, San Francisco Postdoctoral Scholar

Contact Information:

Work Email Address:

hgm@chem.ucla.edu


Website:

http://www.biochemistry.ucla.edu/biochem/Faculty/Martinson/

Fax Number:

(310) 206-4038

Lab Number:

1 (310) 825-4916

Work Phone Number:

1 (310) 825-3767

Laboratory Address:

Young Hall 5033


Work Address:

Young Hall 5040A


Publications:

A selected list of publications:

Martinson Harold G   An active role for splicing in 3'-end formation Wiley interdisciplinary reviews. RNA, ; 2(4): 459-70.
Tsao David C, Park Noh Jin, Nag Anita, Martinson Harold G   Prolonged รก-amanitin treatment of cells for studying mutated polymerases causes degradation of DSIF160 and other proteins RNA (New York, N.Y.), 2012; 18(2): 222-9.
Martinson, H. G.   An active role for splicing in 3?-end formation Wiley Interdisciplinary Reviews: RNA, 2011; 2(4): 459?470.
Kazerouninia, A., Ngo, B. & H.G. Martinson   Poly(A) signal-dependent degradation of unprocessed nascent transcripts accompanies poly(A) signal-dependent transcriptional pausing in vitro RNA, 2010; 16: 197-210.
Kazerouninia Amir, Ngo Benson, Martinson Harold G   Poly(A) signal-dependent degradation of unprocessed nascent transcripts accompanies poly(A) signal-dependent transcriptional pausing in vitro RNA (New York, N.Y.), 2010; 16(1): 197-210.
Rigo, F. and H.G. Martinson   Polyadenylation releases mRNA from RNA polymerase II in a process that is licensed by splicing RNA, 2009; 15: 823-836.
Rigo Frank, Martinson Harold G   Polyadenylation releases mRNA from RNA polymerase II in a process that is licensed by splicing RNA (New York, N.Y.), 2009; 15(5): 823-36.
Rigo Frank, Martinson Harold G   Functional coupling of last-intron splicing and 3'-end processing to transcription in vitro: the poly(A) signal couples to splicing before committing to cleavage Molecular and cellular biology, 2008; 28(2): 849-62.
Nag Anita, Narsinh Kazim, Martinson Harold G   The poly(A)-dependent transcriptional pause is mediated by CPSF acting on the body of the polymerase Nature structural & molecular biology, 2007; 14(7): 662-9.
Nag Anita, Narsinh Kazim, Kazerouninia Amir, Martinson Harold G   The conserved AAUAAA hexamer of the poly(A) signal can act alone to trigger a stable decrease in RNA polymerase II transcription velocity RNA (New York, N.Y.), 2006; 12(8): 1534-44.
Nag A, Narsinh K, Kazerouninia A and Martinson HG   The conserved AAUAAA hexamer of the poly(A) signal can act alone to trigger a stable decrease in RNA polymerase II transcription velocity RNA, 2006; 12: 1534-1544.
Rigo Frank, Kazerouninia Amir, Nag Anita, Martinson Harold G   The RNA tether from the poly(A) signal to the polymerase mediates coupling of transcription to cleavage and polyadenylation Molecular cell, 2005; 20(5): 733-45.
Rigo F, Kazerouninia A, Nag A, Martinson HG   The RNA Tether from the Poly(A) Signal to the Polymerase Mediates Coupling of Transcription to Cleavage and Polyadenylation Molecular Cell, 2005; 20: 733-745.
Park Noh Jin, Tsao David C, Martinson Harold G   The two steps of poly(A)-dependent termination, pausing and release, can be uncoupled by truncation of the RNA polymerase II carboxyl-terminal repeat domain Molecular and cellular biology, 2004; 24(10): 4092-103.
Park NJ, Tsao DC, Martinson HG   The two steps of poly(A)-dependent termination, pausing and release, can be uncoupled by truncation of the RNA polymerase II carboxyl-terminal repeat domain Molecular and Cellular Biology. , 2004; 24(10): 4092-103.
Kim SJ, Martinson HG   Poly(A)-dependent transcription termination: continued communication of the poly(A) signal with the polymerase is required long after extrusion in vivo The Journal of Biological Chemistry. , 2003; 278(43): 41691-701.
Kim Steven J, Martinson Harold G   Poly(A)-dependent transcription termination: continued communication of the poly(A) signal with the polymerase is required long after extrusion in vivo The Journal of biological chemistry, 2003; 278(43): 41691-701.
Orozco IJ, Kim SJ, Martinson HG   The poly(A) signal, without the assistance of any downstream element, directs RNA polymerase II to pause in vivo and then to release stochastically from the template The Journal of Biological Chemistry. , 2002; 277(45): 42899-911.
Orozco Ian J, Kim Steven J, Martinson Harold G   The poly(A) signal, without the assistance of any downstream element, directs RNA polymerase II to pause in vivo and then to release stochastically from the template The Journal of biological chemistry, 2002; 277(45): 42899-911.
Tran DP, Kim SJ, Park NJ, Jew TM, Martinson HG   Mechanism of poly(A) signal transduction to RNA polymerase II in vitro Molecular and Cellular Biology. , 2001; 21(21): 7495-508.
Chao LC, Jamil A, Kim SJ, Huang L, Martinson HG   Assembly of the cleavage and polyadenylation apparatus requires about 10 seconds in vivo and is faster for strong than for weak poly(A) sites Molecular and Cellular Biology. , 1999; 19(8): 5588-600.
Yeung G, Choi LM, Chao LC, Park NJ, Liu D, Jamil A, Martinson HG   Poly(A)-driven and poly(A)-assisted termination: two different modes of poly(A)-dependent transcription termination Molecular and Cellular Biology. , 1998; 18(1): 276-89.

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