Peter Edwards, Ph.D.


Work Titles
UCLA Distinguished Professor, Biological Chemistry Professor, Medicine Member, JCCC Gene Regulation Program Area Faculty, Cardiology
Education:
Degrees:
Ph.D., University of Liverpool, England
B.Sc., University of Liverpool, England
Academic Experience:
Stanford University
Professional Societies:
2006 Canadian Lipoprotein Conference, Rubinstein Lecturer
1997 University of Rome, Italy, Visiting Professor
1976 American Heart Association, Established Investigator

Contact Information:

Work Email Address:

pedwards@mednet.ucla.edu


Work Phone Number:

(310) 206-3717

Mailing Address:

Biological Chemistry
615 Charles E. Young Dr. South
BSRB, Room 310
Box 951737
Los Angeles, CA 90095


Office Address:

Office
MRL 3726
Los Angeles, CA 90095


Work Address:

Laboratory
MRL 3230, 3240
Los Angeles, CA 90095


Research Interest:

Transcription and Signaling by Cholesterol and Bile Acids

Peter Edwards, a professor in both the Department of Biological Chemistry and the Department of Medicine, has had a long term interest in defining the mechanisms involved in the regulation of cholesterol synthesis and homeostasis. Current studies are centered on the roles of FXR and LXR, two nuclear receptors that are activated by endogenous oxysterols and bile acids, respectively. His laboratory has made significant contributions to our understanding of how these nuclear receptors control the levels of plasma cholesterol and glucose and affect various diseased states, including the development of atherosclerosis and pulmonary lipidosis.

In 2000 his laboratory identified ABCG1, a member of the ATP binding cassette family of trans-membrane transporters, as a direct target of LXR. They also demonstrated that ABCG1 plays a key role in transporting cholesterol out of macrophages to high density lipoprotein, thus providing a new link between LXR and the prevention of cholesterol deposition in cells. Current studies are aimed at understanding the molecular mechanisms involved in the control of sterol/cholesterol homeostasis by LXR, and by both ABCG1 and the related transporter ABCG4.

In 2006 the Edwards laboratory provided the initial report that identified a critical role for FXR in promoting both hypoglycemia and hypolipidemia. Current efforts are directed at understanding which genes and pathways are important in the FXR-dependent decrease in plasma lipid and glucose levels. Answers to these questions may provide alternative strategies to treat patients with metabolic syndrome or type II diabetes.

Transcription and Signaling by Cholesterol and Bile Acids

Peter Edwards, a professor in both the Department of Biological Chemistry and the Department of Medicine, has had a long term interest in defining the mechanisms involved in the regulation of cholesterol synthesis and homeostasis. Current studies are centered on the roles of FXR and LXR, two nuclear receptors that are activated by endogenous oxysterols and bile acids, respectively. His laboratory has made significant contributions to our understanding of how these nuclear receptors control the levels of plasma cholesterol and glucose and affect various diseased states, including the development of atherosclerosis and pulmonary lipidosis.

In 2000 his laboratory identified ABCG1, a member of the ATP binding cassette family of trans-membrane transporters, as a direct target of LXR. They also demonstrated that ABCG1 plays a key role in transporting cholesterol out of macrophages to high density lipoprotein, thus providing a new link between LXR and the prevention of cholesterol deposition in cells. Current studies are aimed at understanding the molecular mechanisms involved in the control of sterol/cholesterol homeostasis by LXR, and by both ABCG1 and the related transporter ABCG4.

In 2006 the Edwards laboratory provided the initial report that identified a critical role for FXR in promoting both hypoglycemia and hypolipidemia. Current efforts are directed at understanding which genes and pathways are important in the FXR-dependent decrease in plasma lipid and glucose levels. Answers to these questions may provide alternative strategies to treat patients with metabolic syndrome or type II diabetes.

Publications:

Sene Abdoulaye, Khan Aslam A, Cox Douglas, Nakamura Rei E I, Santeford Andrea, Kim Bryan M, Sidhu Rohini, Onken Michael D, Harbour J William, Hagbi-Levi Shira, Chowers Itay, Edwards Peter A, Baldan Angel, Parks John S, Ory Daniel S, Apte Rajendra S   Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration Cell metabolism, 2013; 17(4): 549-61.
de Aguiar Vallim Thomas Q, Tarling Elizabeth J, Kim Tammy, Civelek Mete, Baldán Ángel, Esau Christine, Edwards Peter A   MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor Circulation research, 2013; 112(12): 1602-12.
de Aguiar Vallim Thomas Q, Tarling Elizabeth J, Edwards Peter A   Pleiotropic roles of bile acids in metabolism Cell metabolism, 2013; 17(5): 657-69.
Tarling Elizabeth J, de Aguiar Vallim Thomas Q, Edwards Peter A   Role of ABC transporters in lipid transport and human disease Trends in endocrinology and metabolism: TEM, 2013; 24(7): 342-50.
Bennett Brian J, de Aguiar Vallim Thomas Q, Wang Zeneng, Shih Diana M, Meng Yonghong, Gregory Jill, Allayee Hooman, Lee Richard, Graham Mark, Crooke Rosanne, Edwards Peter A, Hazen Stanley L, Lusis Aldons J   Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation Cell metabolism, 2013; 17(1): 49-60.
Zhang Yanqiao, Ge Xuemei, Heemstra Lydia A, Chen Wei-Dong, Xu Jiesi, Smith Joseph L, Ma Huiyan, Kasim Neda, Edwards Peter A, Novak Colleen M   Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice Molecular endocrinology (Baltimore, Md.), 2012; 26(2): 272-80.
Tarling Elizabeth J, Edwards Peter A   ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(49): 19719-24.
Lee Florence Ying, de Aguiar Vallim Thomas Quad, Chong Hansook Kim, Zhang Yanqiao, Liu Yaping, Jones Stacey A, Osborne Timothy F, Edwards Peter A   Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity Molecular endocrinology (Baltimore, Md.), 2010; 24(8): 1626-36.
Bojanic Dragana D, Tarr Paul T, Gale Greg D, Smith Desmond J, Bok Dean, Chen Bryan, Nusinowitz Steven, Lövgren-Sandblom Anita, Björkhem Ingemar, Edwards Peter A   Differential expression and function of ABCG1 and ABCG4 during development and aging Journal of lipid research, 2010; 51(1): 169-81.
Chong Hansook Kim, Infante Aniello M, Seo Young-Kyo, Jeon Tae-Il, Zhang Yanqiao, Edwards Peter A, Xie Xiaohui, Osborne Timothy F   Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1 Nucleic acids research, 2010; 38(18): 6007-17.
Yin Liya, Ma Huiyan, Ge Xuemei, Edwards Peter A, Zhang Yanqiao   Hepatic Hepatocyte Nuclear Factor 4{alpha} Is Essential for Maintaining Triglyceride and Cholesterol Homeostasis Arteriosclerosis, thrombosis, and vascular biology, 2010; 39(42): .
Zhang Yanqiao, Yin Liya, Anderson Jody, Ma Huiyan, Gonzalez Frank J, Willson Timothy M, Edwards Peter A   Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia The Journal of biological chemistry, 2010; 285(5): 3035-43.
Tarling Elizabeth J, Bojanic Dragana D, Tangirala Rajendra K, Wang Xuping, Lovgren-Sandblom Anita, Lusis Aldons J, Bjorkhem Ingemar, Edwards Peter A   Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis Arteriosclerosis, thrombosis, and vascular biology, 2010; 30(6): 1174-80.
Jiang Yan J, Lu Biao, Tarling Elizabeth J, Kim Peggy, Man M-Q, Crumrine Debbie, Edwards Peter A, Elias Peter M, Feingold Kenneth R   Regulation of ABCG1 expression in human keratinocytes and murine epidermis Journal of lipid research, 2010; 51(11): 3185-95.
Vallim Thomas Quad de Aguiar, Edwards Peter A   Bile acids have the gall to function as hormones Cell metabolism, 2009; 10(3): 162-4.
Tarr Peter A, Tarling Peter A, Bojanic Peter A, Edwards Peter A, Baldán Peter A   Emerging new paradigms for ABCG transporters Biochimica et biophysica acta, 2009; 50 Suppl: .
Baldán Angel, Bojanic Dragana D, Edwards Peter A   The ABCs of sterol transport Journal of lipid research, 2009; 50 Suppl: S80-5.
Tarr Paul T, Edwards Peter A   ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2 Journal of lipid research, 2008; 49(1): 169-82.
Zhang Yanqiao, Edwards Peter A   FXR signaling in metabolic disease FEBS letters, 2008; 582(1): 10-8.
Attie Alan D, Witztum Joseph L, Edwards Peter A, Lusis Jake A   In memoriam: Roger A. Davis (1945-2008) Journal of lipid research, 2008; 49(11): 2279-80.
Bensinger Steven J, Bradley Michelle N, Joseph Sean B, Zelcer Noam, Janssen Edith M, Hausner Mary Ann, Shih Roger, Parks John S, Edwards Peter A, Jamieson Beth D, Tontonoz Peter   LXR signaling couples sterol metabolism to proliferation in the acquired immune response Cell, 2008; 134(1): 97-111.
Baldán Angel, Gomes Aldrin V, Ping Peipei, Edwards Peter A   Loss of ABCG1 results in chronic pulmonary inflammation Journal of immunology (Baltimore, Md. : 1950), 2008; 180(5): 3560-8.
Hubbert M, Zhang Y, Lee FY, Edwards PA   Regulation of hepatic Insig-2 by the farnesoid X receptor, Mol. Endo, 2007; 21: 1359-69.
Hubbert Melissa L, Zhang Yanqiao, Lee Florence Y, Edwards Peter A   Regulation of hepatic Insig-2 by the farnesoid X receptor Molecular endocrinology (Baltimore, Md.), 2007; 21(6): 1359-69.
Lee H, Hubbert ML, Osborne TF, Woodford K, Zerangue N, Edwards PA   Regulation of the sodium/sulfate co-transporter by farnesoid X receptor alpha, J Biol. Chem, 2007; 282(30): 21653-61.
Lee Hans, Hubbert Melissa L, Osborne Timothy F, Woodford Katherine, Zerangue Noa, Edwards Peter A   Regulation of the sodium/sulfate co-transporter by farnesoid X receptor alpha The Journal of biological chemistry, 2007; 282(30): 21653-61.
Shih DM, Kast-Woelbern HR, Wong J, Xia YR, Edwards PA, Lusis AJ.   A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids, J Lipid Res, 2006; 47(2): 384-92.
Shih Diana M, Kast-Woelbern Heidi R, Wong Jack, Xia Yu-Rong, Edwards Peter A, Lusis Aldons J   A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids Journal of lipid research, 2006; 47(2): 384-92.
Baldan A, Tarr P, Lee R, Edwards PA   ATP-binding cassette transporter G1 and lipid homeostasis, Curr Opin Lipidol, 2006; 17(3): 227-32.
Baldán Angel, Tarr Paul, Lee Richard, Edwards Peter A   ATP-binding cassette transporter G1 and lipid homeostasis Current opinion in lipidology, 2006; 17(3): 227-32.
Zhang Y, Lee FY, Barrera G, Lee H, Vales C, Gonzalez FJ, Willson TM, Edwards PA.   Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice, Proc Natl Acad Sci U S A, 2006; 103(4): 1006-11.
Zhang Yanqiao, Lee Florence Ying, Barrera Gabriel, Lee Hans, Vales Charisse, Gonzalez Frank J, Willson Timothy M, Edwards Peter A   Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice Proceedings of the National Academy of Sciences of the United States of America, 2006; 103(4): 1006-11.
Baldan A, Tarr P, Vales CS, Frank J, Shimotake TK, Hawgood S, Edwards PA   Deletion of the transmembrane transporter ABCG1 results in progressive pulmonary lipidosis, J Biol Chem, 2006; 281(39): 29401-10.
Baldán Angel, Tarr Paul, Vales Charisse S, Frank Joy, Shimotake Thomas K, Hawgood Sam, Edwards Peter A   Deletion of the transmembrane transporter ABCG1 results in progressive pulmonary lipidosis The Journal of biological chemistry, 2006; 281(39): 29401-10.
Zhang Y, Wang X, Vales C, Lee FY, Lee H, Lusis AJ, Edwards PA   FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice, Arterioscler Thromb Vasc Biol, 2006; 26(10): 2316-21.
Zhang Yanqiao, Wang Xuping, Vales Charisse, Lee Florence Ying, Lee Hans, Lusis Aldons J, Edwards Peter A   FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice Arteriosclerosis, thrombosis, and vascular biology, 2006; 26(10): 2316-21.
Lee H, Zhang Y, Lee FY, Nelson SF, Gonzalez FJ, Edwards PA   FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine, J. Lipid Res, 2006; 47(1): 201-14.
Lee Hans, Zhang Yanqiao, Lee Florence Y, Nelson Stanley F, Gonzalez Frank J, Edwards Peter A   FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine Journal of lipid research, 2006; 47(1): 201-14.
Lee FY, Lee H, Hubbert ML, Edwards PA, Zhang Y.   FXR, a multipurpose nuclear receptor, Trends Biochem Sci, 2006; 31(10): 572-80.
Lee Florence Y, Lee Hans, Hubbert Melissa L, Edwards Peter A, Zhang Yanqiao   FXR, a multipurpose nuclear receptor Trends in biochemical sciences, 2006; 31(10): 572-80.
Baldan A, Pei L, Lee R, Tarr P, Tangirala RK, Weinstein MM, Frank J, Li AC, Tontonoz P, Edwards PA   Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow, Arterioscler Thromb Vasc Biol, 2006; 26(10): 2301-7.
Baldán Angel, Pei Liming, Lee Richard, Tarr Paul, Tangirala Rajendra K, Weinstein Michael M, Frank Joy, Li Andrew C, Tontonoz Peter, Edwards Peter A   Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow Arteriosclerosis, thrombosis, and vascular biology, 2006; 26(10): 2301-7.
Arai Satoko, Shelton John M, Chen Mingyi, Bradley Michelle N, Castrillo Antonio, Bookout Angie L, Mak Puiying A, Edwards Peter A, Mangelsdorf David J, Tontonoz Peter, Miyazaki Toru   A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development Cell metabolism, 2005; 1(3): 201-13.
Arai S, Shelton JM, Chen M, Bradley MN, Castrillo A, Bookout AL, Mak PA, Edwards PA, Mangelsdorf DJ, Tontonoz P, Miyazaki T   A role for the apoptosis inhibitory factor Aim/Sp alpha/Api6 in atherosclerosis development, Cell Metabolism, 2005; 1: 201-213.
Kennedy Matthew A, Barrera Gabriel C, Nakamura Kotoka, Baldán Angel, Tarr Paul, Fishbein Michael C, Frank Joy, Francone Omar L, Edwards Peter A   ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation Cell metabolism, 2005; 1(2): 121-31.
Kennedy MA, Barrera GC, Nakamura K, Bald?!n A, Tarr P, Fishbein MC, Frank J, Francone OL, Edwards PA   ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation Cell metabolism. , 2005; 1(2): 121-31.
Anisfeld Andrew M, Kast-Woelbern Heidi R, Lee Hans, Zhang Yanqiao, Lee Florence Y, Edwards Peter A   Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling Journal of lipid research, 2005; 46(3): 458-68.
Anisfeld AM, Kast-Woelbern HR, Lee H, Zhang Y, Lee FY, Edwards PA   Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling Journal of lipid research. , 2005; 46(3): 458-68.
Lee FL, Kast-Woelbern HR, Chang J, Fishbein MC, Edwards PA   Alpha-A-crystallin is a target gene of the Farnesoid X-activated Receptor (FXR) in human livers, J. Biol. Chem, 2005; .
Lee Florence Y, Kast-Woelbern Heidi R, Chang Jenny, Luo Guizhen, Jones Stacey A, Fishbein Michael C, Edwards Peter A   Alpha-crystallin is a target gene of the farnesoid X-activated receptor in human livers The Journal of biological chemistry, 2005; 280(36): 31792-800.
Nakamura K, Kennedy MA, Bald?!n A, Bojanic DD, Lyons K, Edwards PA   Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein The Journal of biological chemistry. , 2004; 279(44): 45980-9.
Nakamura Kotoka, Kennedy Matthew A, Baldán Angel, Bojanic Dragana D, Lyons Karen, Edwards Peter A   Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein The Journal of biological chemistry, 2004; 279(44): 45980-9.
Zhang YQ, Castellani LW, Sinal CJ, Gonzalez FJ, Edwards PA   Peroxisome Proliferator-Activated Receptor-gamma Coactivator 1alpha (PGC-alpha) Regulates Triglyceride Metabolism by Activation of the Nuclear receptor FXR, Genes and Development, 2004; 18: 157-169.
Zhang Yanqiao, Castellani Lawrence W, Sinal Christopher J, Gonzalez Frank J, Edwards Peter A   Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR Genes & development, 2004; 18(2): 157-69.
Downes Michael, Verdecia Mark A, Roecker A J, Hughes Robert, Hogenesch John B, Kast-Woelbern Heidi R, Bowman Marianne E, Ferrer Jean-Luc, Anisfeld Andrew M, Edwards Peter A, Rosenfeld John M, Alvarez Jacqueline G A, Noel Joseph P, Nicolaou K C, Evans Ronald M   A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR Molecular cell, 2003; 11(4): 1079-92.
Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel JP, Nicolaou KC, Evans RM   A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR Molecular cell. , 2003; 11(4): 1079-92.
Zhang Y, Kast-Woelbern HR, Edwards PA   Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation The Journal of biological chemistry. , 2003; 278(1): 104-10.
Zhang Yanqiao, Kast-Woelbern Heidi R, Edwards Peter A   Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation The Journal of biological chemistry, 2003; 278(1): 104-10.
Anisfeld AM, Kast-Woelbern HR, Meyer ME, Jones SA, Zhang Y, Williams KJ, Willson T, Edwards PA   Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor The Journal of biological chemistry. , 2003; 278(22): 20420-8.
Anisfeld Andrew M, Kast-Woelbern Heidi R, Meyer Marie E, Jones Stacey A, Zhang Yanqiao, Williams Kevin J, Willson Timothy, Edwards Peter A   Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor The Journal of biological chemistry, 2003; 278(22): 20420-8.
Edwards Peter A, Kast Heidi R, Anisfeld Andrew M   BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis Journal of lipid research, 2002; 43(1): 2-12.
Mak Puiying A, Kast-Woelbern Heidi R, Anisfeld Andrew M, Edwards Peter A   Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors Journal of lipid research, 2002; 43(12): 2037-41.
Mak PA, Kast-Woelbern HR, Anisfeld AM, Edwards PA   Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors Journal of lipid research. , 2002; 43(12): 2037-41.
Edwards Peter A, Kennedy Matthew A, Mak Puiying A   LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis Vascular pharmacology, 2002; 38(4): 249-56.
Mak PA, Bryan A, Laffitte BA, Desrumaux C, Linda K, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA   Regulated Expression of the ApoE/C-I/C-IV/C-II Gene Cluster in Murine and Human Macrophages; a Critical Role for the Nuclear Receptors LXRa and LXRb, Journal of Biological Chemistry, 2002; 277: 31900-31908.
Mak Puiying A, Laffitte Bryan A, Desrumaux Catherine, Joseph Sean B, Curtiss Linda K, Mangelsdorf David J, Tontonoz Peter, Edwards Peter A   Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta The Journal of biological chemistry, 2002; 277(35): 31900-8.
Kast Heidi R, Goodwin Bryan, Tarr Paul T, Jones Stacey A, Anisfeld Andrew M, Stoltz Catherine M, Tontonoz Peter, Kliewer Steve, Willson Timothy M, Edwards Peter A   Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor The Journal of biological chemistry, 2002; 277(4): 2908-15.
Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA   Regulation of multidrug resistance-associated protein 2 (MRP2;ABCC2) by the nuclear receptors PXR, FXR, and CAR, J. Biol. Chem, 2002; 277: 2908-2915.
Chawla A, Boisvert WA, Lee C-H, Laffitte BA, Barak Y, Joseph SB, Liao D, Nagy L, Edwards PA, Curtiss LK, Evans RM, Tontonoz P   A PPARg-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis, Molecular Cell, 2001; 7: 161-171.
Kast HR, Nguyen CM, Anisfeld AM, Ericsson J, Edwards PA   CTP:phosphocholine cytidylyltransferase, a new sterol- and SREBP-responsive gene Journal of lipid research. , 2001; 42(8): 1266-72.
Kast HR, Nguyen CM, Anisfeld AM, Ericsson J, Edwards PA   CTP:phosphocholine cytidylyltransferase, a new sterol- and SREBP-responsive gene Journal of lipid research. , 2001; 42(8): 1266-72.
Kennedy MA, Venkateswaran A, Tarr PT, Xenarios I, Kudoh J, Shimizu N, Edwards PA   Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein The Journal of biological chemistry. , 2001; 276(42): 39438-47.
Kast HR, Nguyen CM, Sinal CJ, Jones SA, Laffitte BA, Reue K, Gonzalez FJ, Willson TM, Edwards PA   Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids Molecular endocrinology (Baltimore, Md.) , 2001; 15(10): 1720-8.
Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA   Regulation of multidrug resistance-associated protein 2 (MRP2;ABCC2) by the nuclear receptors PXR, FXR, and CAR, Journal of Biological Chemistry, 2001; 277: 2908-2915.
Venkateswaran A, Laffitte BA, Joseph SB, Mak PA, Wilpitz DC, Edwards PA, Tontonoz P   Control of Cellular Cholesterol Efflux by the Nuclear Receptor LXRa, Proceedings of the National Academy of Sciences, USA , 2000; 97: 12097-12102.
Venkateswaran A, Repa JJ, Lobaccaro JM, Bronson A, Mangelsdorf DJ, Edwards PA   Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols The Journal of biological chemistry. , 2000; 275(19): 14700-7.
Laffitte BA, Kast HR, Nguyen CM, Zavacki AM, Moore DD, Edwards PA   Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor The Journal of biological chemistry. , 2000; 275(14): 10638-47.

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