Steven Jacobsen, Ph.D.


Work Titles
UCLA HHMI Investigator, Department of Molecular Cell and Developmental Biology, Molecular, Cell, and Developmental Biology Professor, Biological Chemistry
Education:
Degrees:
Ph.D.
Ph.D., University of Minnesota, St. Paul MN
B.S., Cal Poly State University, San Luis Obispo, CA

Contact Information:

Work Email Address:

jacobsen@ucla.edu


Website:

Research Website

Lab Number:

(310) 206-3336

Office Phone Number:

(310) 825-0182

Work Phone Number:

(310) 825-7896

Laboratory Address:

Laboratory
TLSB 4045


Mailing Address:

Mailing Address
Dept. of MCD Biology
P. O. Box 957239
610 Charles E. Young Drive East
Campus code 723905
Los Angeles, CA 90095


Office Address:

Office
TLSB 4028


Research Interest:

Mechanisms of epigenetic gene regulation by DNA methylation

Our lab studies epigenetic gene regulation in plants and animals.  The work focuses on modifications of chromatin including cytosine DNA methylation, histone modifications, and the role of non-coding RNAs in gene regulation. About 70% our effort is aimed at using Arabidopsis thaliana as a model genetic system to study how conserved epigenetic modifications function in gene silencing and activation.  The other 30% is focused on mouse and human epigenetic regulation.  Current efforts are aimed at understanding mechanisms of RNA directed DNA methylation, the action of the conserved MORC proteins in gene silencing processes in plants and animals, and antisilencing mechanisms that function to oppose silencing mechanisms.  We also have a program focused on targeting various epigenetic modifications using CRISPR systems.  The main approaches we use are genetic screens, genomics and bioinformatics, and biochemistry and structural biology.

Detailed Biography:

Steve Jacobsen did his PhD at the University of Minnesota and postdoctoral studies at the California Institute of Technology with Elliot Meyerowitz. He joined the department of Molecular Cell and Developmental Biology in 1998. He has recieved two young investigator awards for his research, from the Searle Scholars and Beckman Young Investigator Programs. He was named an HHMI Investigator since 2005, received Phillip C. Hamm Memorial Lecture Award in 2008, Charles A. Shull Award for outstanding investigations in the field of plant biology in 2009, and was elected to National Academy of Sciences and American Academy of Arts and Sciences in 2011 and 2016 respectively.

Publications:

Wollmann Heike, Stroud Hume, Yelagandula Ramesh, Tarutani Yoshiaki, Jiang Danhua, Jing Li, Jamge Bhagyshree, Takeuchi Hidenori, Holec Sarah, Nie Xin, Kakutani Tetsuji, Jacobsen Steven E, Berger Frédéric   The histone H3 variant H3.3 regulates gene body DNA methylation in Arabidopsis thaliana Genome biology, 2017; 18(1): 94.
Weiser Natasha E, Yang Danny X, Feng Suhua, Kalinava Natallia, Brown Kristen C, Khanikar Jayshree, Freeberg Mallory A, Snyder Martha J, Csankovszki Györgyi, Chan Raymond C, Gu Sam G, Montgomery Taiowa A, Jacobsen Steven E, Kim John K   MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality Developmental cell, 2017; 41(4): 408-423.e7.
Feng Wei, Hale Christopher J, Over Ryan S, Cokus Shawn J, Jacobsen Steven E, Michaels Scott D   Large-scale heterochromatin remodeling linked to overreplication-associated DNA damage Proceedings of the National Academy of Sciences of the United States of America, 2017; 114(2): 406-411.
Lahmy Sylvie, Pontier Dominique, Bies-Etheve Natacha, Laudié Michèle, Feng Suhua, Jobet Edouard, Hale Christopher J, Cooke Richard, Hakimi Mohamed-Ali, Angelov Dimitar, Jacobsen Steven E, Lagrange Thierry   Evidence for ARGONAUTE4-DNA interactions in RNA-directed DNA methylation in plants Genes & development, 2016; 30(23): 2565-2570.
Ausin Israel, Feng Suhua, Yu Chaowei, Liu Wanlu, Kuo Hsuan Yu, Jacobsen Elise L, Zhai Jixian, Gallego-Bartolome Javier, Wang Lin, Egertsdotter Ulrika, Street Nathaniel R, Jacobsen Steven E, Wang Haifeng   DNA methylome of the 20-gigabase Norway spruce genome Proceedings of the National Academy of Sciences of the United States of America, 2016; 113(50): E8106-E8113.
Li Sisi, Yen Linda, Pastor William A, Johnston Jonathan B, Du Jiamu, Shew Colin J, Liu Wanlu, Ho Jamie, Stender Bryan, Clark Amander T, Burlingame Alma L, Daxinger Lucia, Patel Dinshaw J, Jacobsen Steven E   Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin Proceedings of the National Academy of Sciences of the United States of America, 2016; 113(35): E5108-16.
Bewick Adam J, Ji Lexiang, Niederhuth Chad E, Willing Eva-Maria, Hofmeister Brigitte T, Shi Xiuling, Wang Li, Lu Zefu, Rohr Nicholas A, Hartwig Benjamin, Kiefer Christiane, Deal Roger B, Schmutz Jeremy, Grimwood Jane, Stroud Hume, Jacobsen Steven E, Schneeberger Korbinian, Zhang Xiaoyu, Schmitz Robert J   On the origin and evolutionary consequences of gene body DNA methylation Proceedings of the National Academy of Sciences of the United States of America, 2016; 113(32): 9111-6.
Groth Martin, Moissiard Guillaume, Wirtz Markus, Wang Haifeng, Garcia-Salinas Carolina, Ramos-Parra Perla A, Bischof Sylvain, Feng Suhua, Cokus Shawn J, John Amala, Smith Danielle C, Zhai Jixian, Hale Christopher J, Long Jeff A, Hell Ruediger, Díaz de la Garza Rocío I, Jacobsen Steven E   MTHFD1 controls DNA methylation in Arabidopsis Nature communications, 2016; 7(32): 11640.
Hale Christopher J, Potok Magdalena E, Lopez Jennifer, Do Truman, Liu Ao, Gallego-Bartolome Javier, Michaels Scott D, Jacobsen Steven E   Identification of Multiple Proteins Coupling Transcriptional Gene Silencing to Genome Stability in Arabidopsis thaliana PLoS genetics, 2016; 12(6): e1006092.
Harris C Jake, Husmann Dylan, Liu Wanlu, Kasmi Farid El, Wang Haifeng, Papikian Ashot, Pastor William A, Moissiard Guillaume, Vashisht Ajay A, Dangl Jeffery L, Wohlschlegel James A, Jacobsen Steven E   Arabidopsis AtMORC4 and AtMORC7 Form Nuclear Bodies and Repress a Large Number of Protein-Coding Genes PLoS genetics, 2016; 12(5): e1005998.
Pastor William A, Chen Di, Liu Wanlu, Kim Rachel, Sahakyan Anna, Lukianchikov Anastasia, Plath Kathrin, Jacobsen Steven E, Clark Amander T   Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory Cell stem cell, 2016; 18(3): 323-9.
Li Sisi, Yang Zhenlin, Du Xuan, Liu Rui, Wilkinson Alex W, Gozani Or, Jacobsen Steven E, Patel Dinshaw J, Du Jiamu   Structural Basis for the Unique Multivalent Readout of Unmodified H3 Tail by Arabidopsis ORC1b BAH-PHD Cassette Structure (London, England : 1993), 2016; 24(3): 486-94.
Mala Samaranayake, Pierre-Olivier Esteve, Hang Gyeong Chin, George R. Feehery, Mihika Pradhan, Steven E. Jacobsen, Michael F. Carey, and Sriharsa Pradhan   Transcription coupled DNA methylation mediated by RNA Pol II and DNMT1, Epigenetic Diagnosis & Therapy, 2015; 1: 132-140.
Wang Haifeng, Beyene Getu, Zhai Jixian, Feng Suhua, Fahlgren Noah, Taylor Nigel J, Bart Rebecca, Carrington James C, Jacobsen Steven E, Ausin Israel   CG gene body DNA methylation changes and evolution of duplicated genes in cassava Proceedings of the National Academy of Sciences of the United States of America, 2015; 112(44): 13729-34.
Zhai Jixian, Bischof Sylvain, Wang Haifeng, Feng Suhua, Lee Tzuu-Fen, Teng Chong, Chen Xinyuan, Park Soo Young, Liu Linshan, Gallego-Bartolome Javier, Liu Wanlu, Henderson Ian R, Meyers Blake C, Ausin Israel, Jacobsen Steven E   A One Precursor One siRNA Model for Pol IV-Dependent siRNA Biogenesis Cell, 2015; 163(2): 445-55.
Yazdi Puya G, Pedersen Brian A, Taylor Jared F, Khattab Omar S, Chen Yu-Han, Chen Yumay, Jacobsen Steven E, Wang Ping H   Increasing Nucleosome Occupancy Is Correlated with an Increasing Mutation Rate so Long as DNA Repair Machinery Is Intact PloS one, 2015; 10(8): e0136574.
Yazdi Puya G, Pedersen Brian A, Taylor Jared F, Khattab Omar S, Chen Yu-Han, Chen Yumay, Jacobsen Steven E, Wang Ping H   Nucleosome Organization in Human Embryonic Stem Cells PloS one, 2015; 10(8): e0136314.
Du Jiamu, Johnson Lianna M, Jacobsen Steven E, Patel Dinshaw J   DNA methylation pathways and their crosstalk with histone methylation Nature reviews. Molecular cell biology, 2015; 16(9): 519-32.
Morselli Marco, Pastor William A, Montanini Barbara, Nee Kevin, Ferrari Roberto, Fu Kai, Bonora Giancarlo, Rubbi Liudmilla, Clark Amander T, Ottonello Simone, Jacobsen Steven E, Pellegrini Matteo   In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse eLife, 2015; 4(8): e06205.
Zhang Shuaibin, Zhou Bing, Kang Yanyuan, Cui Xia, Liu Ao, Deleris Angelique, Greenberg Maxim V C, Cui Xiekui, Qiu Qi, Lu Falong, Wohlschlegel James A, Jacobsen Steven E, Cao Xiaofeng   C-terminal domains of a histone demethylase interact with a pair of transcription factors and mediate specific chromatin association Cell discovery, 2015; 1(1): 76-81.
Zhong Xuehua, Hale Christopher J, Nguyen Minh, Ausin Israel, Groth Martin, Hetzel Jonathan, Vashisht Ajay A, Henderson Ian R, Wohlschlegel James A, Jacobsen Steven E   Domains rearranged methyltransferase3 controls DNA methylation and regulates RNA polymerase V transcript abundance in Arabidopsis Proceedings of the National Academy of Sciences of the United States of America, 2015; 112(3): 911-6.
Song Xian Jun, Kuroha Takeshi, Ayano Madoka, Furuta Tomoyuki, Nagai Keisuke, Komeda Norio, Segami Shuhei, Miura Kotaro, Ogawa Daisuke, Kamura Takumi, Suzuki Takamasa, Higashiyama Tetsuya, Yamasaki Masanori, Mori Hitoshi, Inukai Yoshiaki, Wu Jianzhong, Kitano Hidemi, Sakakibara Hitoshi, Jacobsen Steven E, Ashikari Motoyuki   Rare allele of a previously unidentified histone H4 acetyltransferase enhances grain weight, yield, and plant biomass in rice Proceedings of the National Academy of Sciences of the United States of America, 2015; 112(1): 76-81.
Pastor William A, Stroud Hume, Nee Kevin, Liu Wanlu, Pezic Dubravka, Manakov Sergei, Lee Serena A, Moissiard Guillaume, Zamudio Natasha, Bourc'his Déborah, Aravin Alexei A, Clark Amander T, Jacobsen Steven E   MORC1 represses transposable elements in the mouse male germline Nature communications, 2014; 5(1): 5795.
Groth Martin, Stroud Hume, Feng Suhua, Greenberg Maxim V C, Vashisht Ajay A, Wohlschlegel James A, Jacobsen Steven E, Ausin Israel   SNF2 chromatin remodeler-family proteins FRG1 and -2 are required for RNA-directed DNA methylation Proceedings of the National Academy of Sciences of the United States of America, 2014; 111(49): 17666-71.
Feng Suhua, Cokus Shawn J, Schubert Veit, Zhai Jixian, Pellegrini Matteo, Jacobsen Steven E   Genome-wide Hi-C analyses in wild-type and mutants reveal high-resolution chromatin interactions in Arabidopsis Molecular cell, 2014; 55(5): 694-707.
Du Jiamu, Johnson Lianna M, Groth Martin, Feng Suhua, Hale Christopher J, Li Sisi, Vashisht Ajay A, Gallego-Bartolome Javier, Wohlschlegel James A, Patel Dinshaw J, Jacobsen Steven E   Mechanism of DNA methylation-directed histone methylation by KRYPTONITE Molecular cell, 2014; 55(3): 495-504.
Tsagaratou Ageliki, Äijö Tarmo, Lio Chan-Wang J, Yue Xiaojing, Huang Yun, Jacobsen Steven E, Lähdesmäki Harri, Rao Anjana   Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation Proceedings of the National Academy of Sciences of the United States of America, 2014; 111(32): E3306-15.
Sequeira-Mendes Joana, Aragüez Irene, Peiró Ramón, Mendez-Giraldez Raul, Zhang Xiaoyu, Jacobsen Steven E, Bastolla Ugo, Gutierrez Crisanto   The Functional Topography of the Arabidopsis Genome Is Organized in a Reduced Number of Linear Motifs of Chromatin States The Plant cell, 2014; 26(6): 2351-2366.
Yelagandula Ramesh, Stroud Hume, Holec Sarah, Zhou Keda, Feng Suhua, Zhong Xuehua, Muthurajan Uma M, Nie Xin, Kawashima Tomokazu, Groth Martin, Luger Karolin, Jacobsen Steven E, Berger Frédéric   The histone variant H2A.W defines heterochromatin and promotes chromatin condensation in Arabidopsis Cell, 2014; 158(1): 98-109.
Zhong Xuehua, Du Jiamu, Hale Christopher J, Gallego-Bartolome Javier, Feng Suhua, Vashisht Ajay A, Chory Joanne, Wohlschlegel James A, Patel Dinshaw J, Jacobsen Steven E   Molecular mechanism of action of plant DRM de novo DNA methyltransferases Cell, 2014; 157(5): 1050-60.
Moissiard Guillaume, Bischof Sylvain, Husmann Dylan, Pastor William A, Hale Christopher J, Yen Linda, Stroud Hume, Papikian Ashot, Vashisht Ajay A, Wohlschlegel James A, Jacobsen Steven E   Transcriptional gene silencing by Arabidopsis microrchidia homologues involves the formation of heteromers Proceedings of the National Academy of Sciences of the United States of America, 2014; 111(20): 7474-9.
Huang Yun, Chavez Lukas, Chang Xing, Wang Xue, Pastor William A, Kang Jinsuk, Zepeda-Martínez Jorge A, Pape Utz J, Jacobsen Steven E, Peters Bjoern, Rao Anjana   Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells Proceedings of the National Academy of Sciences of the United States of America, 2014; 111(4): 1361-6.
Johnson Lianna M, Du Jiamu, Hale Christopher J, Bischof Sylvain, Feng Suhua, Chodavarapu Ramakrishna K, Zhong Xuehua, Marson Giuseppe, Pellegrini Matteo, Segal David J, Patel Dinshaw J, Jacobsen Steven E   SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation Nature, 2014; 507(7490): 124-8.
Stroud Hume, Do Truman, Du Jiamu, Zhong Xuehua, Feng Suhua, Johnson Lianna, Patel Dinshaw J, Jacobsen Steven E   Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis Nature structural & molecular biology, 2014; 21(1): 64-72.
Widman Nicolas, Feng Suhua, Jacobsen Steven E, Pellegrini Matteo   Epigenetic differences between shoots and roots in Arabidopsis reveals tissue-specific regulation Epigenetics, 2014; 9(2): 236-42.
Greenberg Maxim V C, Deleris Angelique, Hale Christopher J, Liu Ao, Feng Suhua, Jacobsen Steven E   Interplay between active chromatin marks and RNA-directed DNA methylation in Arabidopsis thaliana PLoS genetics, 2013; 9(11): e1003946.
Hongmei Li-Byarlay, Yang Li, Hume Stroud, Suhua Feng, Thomas C. Newman, Megan Kaneda, Kirk K. Hou, Kim C. Worley, Christine G. Elsik, Samuel A. Wickline, Steven E. Jacobsen, Jian Ma, and, Gene E. Robinson   RNA interference knockdown of DNA methyl-transferase 3 affects gene alternative splicing in the honey bee Proc Natl Acad Sci U S A, 2013; 110(31): 12750-12755.
Law Julie A, Du Jiamu, Hale Christopher J, Feng Suhua, Krajewski Krzysztof, Palanca Ana Marie S, Strahl Brian D, Patel Dinshaw J, Jacobsen Steven E   Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1 Nature, 2013; 498(7454): 385-9.
Pao-Yang Chen, Amit Ganguly, Liudmilla Rubbi, Luz Orozco, Marco Morselli, Davin Ashraf, Artur Jaroszewicz, Suhua Feng, Steven E. Jacobsen, Atsushi Nakano, Sherin Devaskar, and Matteo Pellegrini   Intrauterine calorie restriction affects placental DNA Methylation and gene expression Physiol Genomics, 2013; 45: 565-576.
Vincent John J, Huang Yun, Chen Pao-Yang, Feng Suhua, Calvopiña Joseph H, Nee Kevin, Lee Serena A, Le Thuc, Yoon Alexander J, Faull Kym, Fan Guoping, Rao Anjana, Jacobsen Steven E, Pellegrini Matteo, Clark Amander T   Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells Cell stem cell, 2013; 12(4): 470-8.
Yifeng Xu, Yizhong Wang, Hume Stroud, Xiaofeng Gu, Bo Sun, Eng-Seng Gan, Kian-Hong Ng, Steven E. Jacobsen, Yuehui He, and Toshiro Ito   A Matrix Protein Silences Transposons and Repeats through Interaction with Retinoblastoma-Associated Proteins Current Biology, 2013; 23: 345-350.
Stroud Hume, Greenberg Maxim V C, Feng Suhua, Bernatavichute Yana V, Jacobsen Steven E   Comprehensive analysis of silencing mutants reveals complex regulation of the Arabidopsis methylome Cell, 2013; 152(1-2): 352-64.
Stroud Hume, Ding Bo, Simon Stacey A, Feng Suhua, Bellizzi Maria, Pellegrini Matteo, Wang Guo-Liang, Meyers Blake C, Jacobsen Steven E   Plants regenerated from tissue culture contain stable epigenome changes in rice eLife, 2013; 2(1-2): e00354.
Maria Colomé-Tatché, Sandra Cortijo, René Wardenaar, Lionel Morgado, Benoit Lahouze, Alexis Sarazin, Mathilde Etcheverry, Antoine Martin, Suhua Feng, Evelyne Duvernois-Berthet, Karine Labadie, Patrick Wincker, Steven E. Jacobsen, Ritsert C. Jansen, Vincent Colot, and Frank Johannes   Features of the Arabidopsis recombination landscape resulting from the combined loss of sequence variation and DNA methylation Proc. Nat. Acad. Sci. U. S. A, 2012; 109(40): 16240-16245.
Jiamu Du, Xuehua Zhong, Yana V. Bernatavichute, Hume Stroud, Suhua Feng, Elena Caro, Ajay A. Vashisht, Jolyon Terragni, Hang Gyeong Chin, Andy Tu, Jonathan Hetzel, James A. Wohlschlegel, Sriharsa Pradhan, Dinshaw J. Patel, and Steven E. Jacobsen   Dual Binding of Chromomethylase Domains to H3K9me2-containing Nucleosomes Directs DNA Methylation in Plants Cell, 2012; 151: 167-180.
Zhong Xuehua, Hale Christopher J, Law Julie A, Johnson Lianna M, Feng Suhua, Tu Andy, Jacobsen Steven E   DDR complex facilitates global association of RNA polymerase V to promoters and evolutionarily young transposons Nature structural & molecular biology, 2012; 19(9): 870-5.
Stroud Hume, Hale Christopher J, Feng Suhua, Caro Elena, Jacob Yannick, Michaels Scott D, Jacobsen Steven E   DNA methyltransferases are required to induce heterochromatic re-replication in Arabidopsis PLoS genetics, 2012; 8(7): e1002808.
Chodavarapu Ramakrishna K, Feng Suhua, Ding Bo, Simon Stacey A, Lopez David, Jia Yulin, Wang Guo-Liang, Meyers Blake C, Jacobsen Steven E, Pellegrini Matteo   Transcriptome and methylome interactions in rice hybrids Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(30): 12040-5.
Paul B. Talbert, Kami Ahmad, Genevieve Almouzni, Juan Ausio, Frederic Berger, Prem L. Bhalla, William M. Bonner, W. Zacheus Cande, Brian P. Chadwick, Simon W L Chan, George A M Cross, Liwang Cui, Stefan I. Dimitrov, Detlef Doenecke, Jose M. Eirin-Lopez, Martin A. Gorovsky, Sandra B. Hake, Barbara A. Hamkalo, Sarah Holec, Steven E. Jacobsen, Kinga Kamieniarz, Saadi Khochbin, Andreas G. Ladurner, David Landsman, John A. Latham, Benjamin Loppin, Harmit S. Malik, William F. Marzluff, John R. Pehrson, Jan Postberg, Robert Schneider, Mohan B. Singh, M. Mitchell Smith, Eric Thompson, Maria-Elena Torres Padilla, David John Tremethick, Bryan M. Turner, Jakob Harm Waterborg, Heike Wollmann, Ramesh Yelagandula, Bing Zhu and Steven Henikoff   A unified phylogeny-based nomenclature for histone variants Epigenetics & Chromatin, 2012; 5:7 (19 pages): .
Frederic Pontvianne, Todd Blevins, Chinmayi Chandrasekhara, Wei Feng, Hume Stroud, Steven E. Jacobsen, Scott D. Michaels, and Craig S. Pikaard   Histone methyltransferases regulating rRNA gene dose and dosage control in Arabidopsis Genes and Development, 2012; 26: 945-957.
Angelique Deleris, Hume Stroud, Yana Bernatavichute, Elizabeth Johnson, Gregor Klein, Daniel Schubert, Steven E. Jacobsen   Loss of the DNA Methyltransferase MET1 Induces H3K9 Hypermethylation at PcG Target Genes and Redistribution of H3K27 Trimethylation to Transposons in Arabidopsis thaliana PLoS Genetics, 2012; 8:e1003062(11): 1-13.
Tetsu Kinoshita and Steven E. Jacobsen   Opening the Door to Epigenetics in PCP Plant Cell Physiology, 2012; 53(5): 763-765.
The EPIC Planning Committee: Fred Berger, XiaoFeng Cao, Vicki Chandler, Liz Dennis, Rob Martienssen, Blake Meyers, Craig Pikaard, Jim Peacock, Eric Richards, Doris Wagner, Detlef Weigel, Vincent Colot, Roger Deal, Caroline Dean, Joe Ecker, Mary Gehring, Zhizhong Gong, Brian Gregory, Gutierrez Rodrigo, Jose Gutierrez-Marcos, Mitsuyasu Hasebe, Il-Doo Hwang, Steven E. Jacobsen, Tetsuji Kakutani, Jiayang Li, Scott Michaels, Yoo-Sun Noh, Nick Provart, Matt Vaughn   Reading the Second Code:Mapping Epigenomes to Understand Plant Growth, Development, and Adaptation to the Environment The Plant Cell, 2012; 24: 2257-2261.
Elena Caro, Hume Stroud, Maxim V. C. Greenberg, Yana V. Bernatavichute, Suhua Feng, Martin Groth, Ajay A. Vashisht, James Wohlschlegel, Steve E. Jacobsen   The SET-Domain Protein SUVR5 Mediates H3K9me2 Deposition and Silencing at Stimulus Response Genes in a DNA Methylation Independent Manner PLoS Genetics, 2012; 8:e1002995(10): 1-12.
Israel Ausin, Maxim V.C. Greenberg, Carey Fei Li, and Steven E. Jacobsen   The splicing factor SR45 affects the RNA-directed DNA methylation pathway in Arabidopsis Epigenetics, 2012; 7(1): 29-33.
Moissiard Guillaume, Cokus Shawn J, Cary Joshua, Feng Suhua, Billi Allison C, Stroud Hume, Husmann Dylan, Zhan Ye, Lajoie Bryan R, McCord Rachel Patton, Hale Christopher J, Feng Wei, Michaels Scott D, Frand Alison R, Pellegrini Matteo, Dekker Job, Kim John K, Jacobsen Steven E   MORC family ATPases required for heterochromatin condensation and gene silencing Science (New York, N.Y.), 2012; 336(6087): 1448-51.
Israel Ausin, Maxim V. C. Greenberg, Dhirendra K. Simanshu, Christopher J. Hale, Ajay A. Vashisht, Stacey A. Simon, Tzuu-fen Lee, Suhua Feng, Sophia D. Espanola, Blake C. Meyers, James A. Wohlschlegel, Dinshaw J. Patel, and Steven E. Jacobsen   INVOLVED IN DE NOVO 2 containing complex involved in RNA-directed DNA methylation in Arabidopsis Proc. Nat. Acad. Sci. U. S. A, 2012; 109(22): 8374-8381.
Stroud Hume, Otero Sofía, Desvoyes Bénédicte, Ramírez-Parra Elena, Jacobsen Steven E, Gutierrez Crisanto   Genome-wide analysis of histone H3.1 and H3.3 variants in Arabidopsis thaliana Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(14): 5370-5.
Sylvain Foret, Robert Kucharski, Matteo Pellegrini, Suhua Feng, Steven E. Jacobsen, Gene E. Robinson, and Ryszard Maleszka   DNA methylation dynamics, metabolic fluxes, gene splicing, and alternative phenotypes in honey bees Proc. Nat. Acad. Sci. U. S. A, 2012; 109(13): 4968-4973.
Christopher J. Hale and Steven E. Jacobsen   Equal-parenting policy Nature, 2012; 482: 42-44.
Pao-Yang Chen, Suhua Feng, Jong Wha J. Joo, Steven E. Jacobsen and Matteo Pellegrini   A comparative analysis of DNA methylation across human embryonic stem cell lines Genome Biology, 2011; 12: R62.
Stroud Hume, Feng Suhua, Morey Kinney Shannon, Pradhan Sriharsa, Jacobsen Steven E   5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells Genome biology, 2011; 12(6): R54.
Law Julie A, Vashisht Ajay A, Wohlschlegel James A, Jacobsen Steven E   SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV PLoS genetics, 2011; 7(7): e1002195.
Eerappa Rajakumara, Julie A. Law, Dhirendra K. Simanshu, Philipp Voigt, Lianna M. Johnson, Danny Reinberg, Dinshaw J. Patel, and Steven E. Jacobsen   A dual flip out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. Genes and Development, 2011; 25: 137-152.
Maxim V.C. Greenberg, Israel Ausin, Simon W.L. Chan, Shawn J. Cokus, Josh T. Cuperus, Suhua Feng, Julie A. Law, Carolyn Chu, Matteo Pellegrini, James C. Carrington and Steven E. Jacobsen   Identification of genes required for de novo DNA methylation in Arabidopsis Epigenetics, 2011; 6(3): 344-354.
Shannon Morey Kinney, Hang Gyeong Chin, Jurate Bitinaite, Yu Zheng, Pierre Olivier Esteve, Romualdas Vaisvila, Suhua Feng, Hume Stroud, Steven E. Jacobsen and Sriharsa Pradhan   Tissue Specific Distribution and Dynamic Changes of 5 hydroxymethylcytosine in Mammalian Genome Journal of Biological Chemistry, 2011; 286: 24685-24693.
Feng Suhua, Jacobsen Steven E   Epigenetic modifications in plants: an evolutionary perspective Current opinion in plant biology, 2011; 14(2): 179-86.
Celina Costas, Maria de la Paz Sanchez, Hume Stroud, Yanchun Yu, Juan Carlos Oliveros, Suhua Feng, Alberto Benguria, Irene López-Vidriero, Xiaoyu Zhang, Roberto Solano, Steven E. Jacobsen and Crisanto Gutierrez   Genome-wide mapping of Arabidopsis origins of DNA replication and their associated epigenetic signatures Nature Structural and Molecular Biology, 2011; 18(3): 395-400.
Bifeng Yuan, Jing Zhang, Hongxia Wang, Lei Xiong, Qian Cai, Tina Wang, Steven Jacobsen, Sriharsa Pradhan, and Yinsheng Wang   6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1 Cancer Research, 2011; 71: 1904-1911.
Feng Suhua, Rubbi Liudmilla, Jacobsen Steven E, Pellegrini Matteo   Determining DNA methylation profiles using sequencing Methods in molecular biology (Clifton, N.J.), 2011; 733(2): 223-38.
Deleris Angelique, Greenberg Maxim V C, Ausin Israel, Law Rona W Y, Moissiard Guillaume, Schubert Daniel, Jacobsen Steven E   Involvement of a Jumonji-C domain-containing histone demethylase in DRM2-mediated maintenance of DNA methylation EMBO reports, 2010; 11(12): 950-5.
Feng Suhua, Jacobsen Steven E, Reik Wolf   Epigenetic reprogramming in plant and animal development Science (New York, N.Y.), 2010; 330(6004): 622-7.
Henderson Ian R, Deleris Angelique, Wong William, Zhong Xuehua, Chin Hang Gyeong, Horwitz Gregory A, Kelly Krystyna A, Pradhan Sriharsa, Jacobsen Steven E   The de novo cytosine methyltransferase DRM2 requires intact UBA domains and a catalytically mutated paralog DRM3 during RNA-directed DNA methylation in Arabidopsis thaliana PLoS genetics, 2010; 6(10): e1001182.
Chodavarapu Ramakrishna K, Feng Suhua, Bernatavichute Yana V, Chen Pao-Yang, Stroud Hume, Yu Yanchun, Hetzel Jonathan A, Kuo Frank, Kim Jin, Cokus Shawn J, Casero David, Bernal Maria, Huijser Peter, Clark Amander T, Krämer Ute, Merchant Sabeeha S, Zhang Xiaoyu, Jacobsen Steven E, Pellegrini Matteo   Relationship between nucleosome positioning and DNA methylation Nature, 2010; 466(7304): 388-92.
Christian Popp, Wendy Dean, Suhua Feng, Shawn J. Cokus, Simon Andrews, Matteo Pellegrini, Steven E. Jacobsen and Wolf Reik   Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency Nature, 2010; 463: 1101-1105.
Yannick Jacob, Hume Stroud, Chantal LeBlanc, Suhua Feng, Luting Zhuo, Elena Caro, Christiane Hassel, Crisanto Gutierrez, Scott D. Michaels and Steven E. Jacobsen   Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases Nature, 2010; 466: 987-993.
Law Julie A, Ausin Israel, Johnson Lianna M, Vashisht Ajay A, Zhu Jian-Kang, Wohlschlegel James A, Jacobsen Steven E   A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis Current biology : CB, 2010; 20(10): 951-6.
Feng Suhua, Cokus Shawn J, Zhang Xiaoyu, Chen Pao-Yang, Bostick Magnolia, Goll Mary G, Hetzel Jonathan, Jain Jayati, Strauss Steven H, Halpern Marnie E, Ukomadu Chinweike, Sadler Kirsten C, Pradhan Sriharsa, Pellegrini Matteo, Jacobsen Steven E   Conservation and divergence of methylation patterning in plants and animals Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(19): 8689-94.
Law Julie A, Jacobsen Steven E   Establishing, maintaining and modifying DNA methylation patterns in plants and animals Nature reviews. Genetics, 2010; 11(3): 204-20.
Ian R. Henderson, Simon R. Chan, Xiaofeng Cao, Lianna Johnson and Steven E. Jacobsen   Accurate sodium bisulfite sequencing in plants Epigenetics, 2010; 5(1): 47-49.
Ausin Israel, Mockler Todd C, Chory Joanne, Jacobsen Steven E   IDN1 and IDN2 are required for de novo DNA methylation in Arabidopsis thaliana Nature structural & molecular biology, 2009; 16(12): 1325-7.
Pradhan Sriharsa, Chin Hang Gyeong, Estève Pierre-Olivier, Jacobsen Steven E   SET7/9 mediated methylation of non-histone proteins in mammalian cells Epigenetics : official journal of the DNA Methylation Society, 2009; 4(6): 383-7.
Miura Kotaro, Agetsuma Masakazu, Kitano Hidemi, Yoshimura Atsushi, Matsuoka Makoto, Jacobsen Steven E, Ashikari Motoyuki   A metastable DWARF1 epigenetic mutant affecting plant stature in rice Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(27): 11218-23.
Jacob Yannick, Feng Suhua, LeBlanc Chantal A, Bernatavichute Yana V, Stroud Hume, Cokus Shawn, Johnson Lianna M, Pellegrini Matteo, Jacobsen Steven E, Michaels Scott D   ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing Nature structural & molecular biology, 2009; 16(7): 763-8.
Jong Kyong Kim, Pierre Esteve, Steven E. Jacobsen and Sriharsa Pradhan   UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells Nucleic Acids Research, 2009; 37(2): 493-505.
Law Julie A, Jacobsen Steven E   Molecular biology. Dynamic DNA methylation Science (New York, N.Y.), 2009; 323(5921): 1568-9.
Estève Pierre-Olivier, Chin Hang Gyeong, Benner Jack, Feehery George R, Samaranayake Mala, Horwitz Gregory A, Jacobsen Steven E, Pradhan Sriharsa   Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(13): 5076-81.
Nicolas Widman, Steven E. Jacobsen and Matteo Pellegrini   Determining the conservation of DNA methylation in Arabidopsis Epigenetics, 2009; 4(2): 119-124.
Zhang Xiaoyu, Bernatavichute Yana V, Cokus Shawn, Pellegrini Matteo, Jacobsen Steven E   Genome-wide analysis of mono-, di- and trimethylation of histone H3 lysine 4 in Arabidopsis thaliana Genome biology, 2009; 10(6): R62.
Kraft Edward, Bostick Magnolia, Jacobsen Steven E, Callis Judy   ORTH/VIM proteins that regulate DNA methylation are functional ubiquitin E3 ligases The Plant journal : for cell and molecular biology, 2008; 56(5): 704-15.
Blake C. Meyers, Michael J. Axtell, Bonnie Bartel, David P. Bartel, David Baulcombe, John L. Bowman, Xiaofeng Cao, James C. Carrington, Xuemei Chen, Pamela J. Green, Sam Griffiths-Jones, Steven E. Jacobsen, Allison C. Mallory, Robert A. Martienssen, R. Scott Poethig, Yijun Qi, Herve Vaucheret, Olivier Voinnet,Yuichiro Watanabe, Detlef Weigel, and Jian-Kang Zhu   Criteria for Annotation of Plant MicroRNAs The Plant Cell, 2008; 20: 3186-3190.
Carey F. Li, Ian R. Henderson, Liang Song, Nina Fedoroff, Thierry Lagrange, Steven E. Jacobsen.   Dynamic Regulation of ARGONAUTE4 within Multiple Nuclear Bodies in Arabidopsis thaliana, PLoS Genetics, 2008; 4(2): article e27.
Yana V. Bernatavichute, Xiaoyu Zhang, Shawn Cokus, Matteo Pellegrini & Steven E. Jacobsen   Genome-wide association of histone H3 lysine nine methylation with CHG DNA methylation in Arabidopsis thaliana, PLoS ONE, 2008; 3, e3156: .
Juliana J. Oh, Baher N. Boctor, Cynthia A. Jimenez, Roberto Lopez, Ashley K. Koegel, Eileen O. Taschereau, Diana T. Phan, Steven E. Jacobsen, Dennis J. Slamon   Promoter methylation study of the H37/RBM5 tumor suppressor gene from the 3p21.3 human lung cancer tumor suppressor locus, Human Genetics, 2008; 123: 55-64.
Lianna M. Johnson, Julie A. Law, Anuj Khattar, Ian R. Henderson, Steven E. Jacobsen   SRA-Domain Proteins Required for DRM2-Mediated De Novo DNA Methylation, PLoS Genetics, 2008; 4(11): e1000280.
Ian R. Henderson & Steven E. Jacobsen   Sequencing sliced ends reveals microRNA targets, Nature Biotechnology, 2008; 26: 881-882.
Shawn J. Cokus, Suhua Feng, Xiaoyu Zhang, Zugen Chen, Barry Merriman, Christian D. Haudenschild, Sriharsa Pradhan, Stanley F. Nelson, Matteo Pellegrini & Steven E. Jacobsen   Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning, Nature, 2008; 452: 215-219.
Ian R. Henderson & Steven E. Jacobsen   Tandem repeats upstream of the Arabidopsis endogene SDC recruit non-CG DNA methylation and initiate siRNA spreading, Genes and Development, 2008; 22: 1597–1606.
Alan M. Jones, Joanne Chory, Jeffery L. Dangl, Mark Estelle, Steven E. Jacobsen, Elliot M. Meyerowitz, Magnus Nordborg & Detlef Weigel   The Impact of Arabidopsis on Human Health: Diversifying Our Portfolio, Cell, 2008; 133: 939-943.
Hideharu Hashimoto, John R. Horton, Xing Zhang, Magnolia Bostick, Steven E. Jacobsen & Xiaodong Cheng   The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix, Nature, 2008; 455: 826-829.
Ian R. Henderson and Steven E. Jacobsen   Epigenetic inheritance in plants, Nature, 2007; 447: 418-424.
Mahmoud El-Shami, Dominique Pontier, Sylvie Lahmy, Laurence Braun, Claire Picart, Danielle Vega, Mohamed-Ali Hakimi, Steven E. Jacobsen, Richard Cooke and Thierry Lagrange   Reiterated WG/GW motifs form functionally and evolutionarily conserved ARGONAUTE-binding platforms in RNAi-related components, Genes & Development, 2007; 21: 2539-2544.
Xiaoyu Zhang, Ian R. Henderson, Cheng Lu, Pamela J. Green, and Steven E. Jacobsen   Role of RNA polymerase IV in plant small RNA metabolism Proceedings of the National Academy of Sciences, 2007; 104: 4536-4541.
Xiaoyu Zhang, Sophie Germann, Bartlomiej J Blus, Sepideh Khorasanizadeh, Valerie Gaudin & Steven E Jacobsen   The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation Nature Structural & Molecular Biology, 2007; 14(9): 869-71.
Lianna M. Johnson, Magnolia Bostick, Xiaoyu Zhang, Edward Kraft, Ian Henderson, Judy Callis and Steven E. Jacobsen   The SRA methyl-cytosine-binding domain links DNA and histone methylation, Current Biology, 2007; 17(4): 379-384.
Magnolia Bostick, Jong Kyong Kim, Pierre-Olivier Esteve, Amander Clark, Sriharsa Pradhan, Steven E. Jacobsen   UHRF1 plays a role in maintaining DNA methylation in mammalian cells Science, 2007; 317: 1760-1764.
Xiaoyu Zhang, Oliver Clarenz, Shawn Cokus, Yana V. Bernatavichute, Matteo Pellegrini, Justin Goodrich and Steven E. Jacobsen   Whole-Genome Analysis of Histone H3 Lysine 27 Trimethylation in Arabidopsis PLoS Biology, 2007; 5(5): 1026-1035 (article e129).
Li CF, Pontes O, El-Shami M, Henderson IR, Bernatavichute YV, Chan SWL, Lagrange T, Pikaard CS and Jacobsen SE   An ARGONAUTE4-containing nuclear processing center colocalized with Cajal bodies in Arabidopsis thaliana Cell, 2006; 126: 93-106.
Henderson IR, Zhang X, Lu C, Johnson L, Meyers BC, Green PL and Jacobsen SE   Dissecting Arabidopsis thaliana DICER function in small RNA processing, gene silencing and DNA methylation patterning Nature Genetics, 2006; 38: 721-725.
Sung S, He Y, Eshoo TW, Tamada Y, Johnson L, Nakahigashi K, Goto K, Jacobsen SE and Amasino RM   Epigenetic maintenance of the vernalized state in Arabidopsis thaliana requires LIKE HETEROCHROMATIN PROTEIN 1 Nature Genetics, 2006; 38: 706-710.
Xiaoyu Zhang and Steven E. Jacobsen.   Genetic Analysis of DNA methyltransferases in Arabidopsis Cold Spring Harbor Symposia on Quantitative Biology, 2006; 71: 439-447.
Xiaoyu Zhang, Junshi Yazaki, Ambika Sundaresan, Shawn Cokus, Simon W. L. Chan, Huaming Chen, Ian R. Henderson, Paul Shinn, Matteo Pellegrini, Steve E. Jacobsen and Joseph R. Ecker   Genome-wide High-Resolution Mapping and Functional Analysis of DNA Methylation in Arabidopsis Cell, 2006; 126(6): 1189-1201.
Peng Peng, Simon W. L. Chan, Govind Shah, Steve E. Jacobsen   Increased outcrossing in hothead mutants, Nature, 2006; 443(doi: 10.1038/nature05251): .
Mylne JS, Barrett L, Tessadori F, Mesnage S, Johnson L, Bernatavichute YV, Jacobsen SE, Fransz P and Dean C   LHP1, the Arabidopsis homologue of HETEROCHROMATIN PROTEIN1, is required for epigenetic silencing of FLC Proc. Nat. Acad. Sci. U. S. A, 2006; 103: 5012-5017.
Goll MG, Kirpekar F, Maggert KA, Yoder JA, Hsieh CL, Zhang X, Golic KG, Jacobsen SE, Bestor TH   Methylation of tRNA-Asp by the DNA Methyltransferase Homolog Dnmt2 Science, 2006; 311: 395-398.
Cheng Lu, Karthik Kulkarni, Fr??d??ric F. Souret, Ramesh MuthuValliappan, Shivakundan Singh Tej, R. Scott Poethig, Ian R. Henderson, Steven E. Jacobsen, Wenzhong Wang, Pamela J. Green, and Blake C. Meyers   MicroRNAs and other small RNAs enriched in the Arabidopsis RNA-dependent RNA polymerase-2 mutant Genome Research, 2006; 16: 1276-1288.
Chan SWL, Henderson IR, Zhang X, Shah G, Chien JSC and Jacobsen SE   RNAi, DRD1, and histone methylation actively target developmentally important non-CG DNA methylation in Arabidopsis PLoS Genetics, 2006; 2(6): 791-797 (article e83).
Pontes O, Li CF, Nunes PC, Haag J, Ream T, Vitins A, Jacobsen SE and Pikkard CS   The Arabidopsis chromatin-modifying nuclear siRNA pathway involves a nucleolar RNA processing center Cell, 2006; 126: 79-92.
Simon W. L. Chan, Xiaoyu Zhang, Yana V. Bernatavichute, Steve E. Jacobsen   Two-step recruitment of RNA-directed DNA methylation to tandem repeats PLoS Biology, 2006; 4(11): 1923-1933 (article e363).
Tran RK, Zilberman D, de Busto C, Ditt RF, Henikoff JG, Lindroth AM, Delrow J, Boyle T, Kwong S, Bryson TD, Jacobsen SE and Henikoff S   Chromatin and siRNA pathways cooperate to maintain DNA methylation of small transposable elements in Arabidopsis Genome Biology, 2005; 6(R90): .
Zemach A, Li Y, Wayburn B, Ben-Meir H, Kiss V, Avivi Y, Kalchenko V, Jacobsen SE, Grafi G   DDM1 binds Arabidopsis methyl-CpG binding domain proteins and affects their subnuclear localization The Plant cell, 2005; 17(5): 1549-58.
Chan SW, Henderson IR, Jacobsen SE   Gardening the genome: DNA methylation in Arabidopsis thaliana Nature reviews. Genetics. , 2005; 6(5): 351-60.
Tran RK, Henikoff JG, Zilberman D, Ditt RF, Jacobsen SE, Henikoff S   DNA methylation profiling identifies CG methylation clusters in Arabidopsis genes Current biology : CB. , 2005; 15(2): 154-9.
Mockler TC, Chan S, Sundaresan A, Chen H, Jacobsen SE, Ecker JR   Applications of DNA tiling arrays for whole-genome analysis Genomics. , 2005; 85(1): 1-15.
Patnaik D, Chin HG, Esteve PO, Benner J, Jacobsen SE, Pradhan S   Substrate specificity and kinetic mechanism of mammalian G9a histone H3 methyltransferase The Journal of biological chemistry. , 2004; 279(51): 53248-58.
Lindroth AM, Shultis D, Jasencakova Z, Fuchs J, Johnson L, Schubert D, Patnaik D, Pradhan S, Goodrich J, Schubert I, Jenuwein T, Khorasanizadeh S, Jacobsen SE   Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3 The EMBO journal. , 2004; 23(21): 4286-96.
Morris KV, Chan SW, Jacobsen SE, Looney DJ   Small interfering RNA-induced transcriptional gene silencing in human cells Science. , 2004; 305(5688): 1289-92.
Zilberman D, Cao X, Johansen LK, Xie Z, Carrington JC, Jacobsen SE   Role of Arabidopsis ARGONAUTE4 in RNA-directed DNA methylation triggered by inverted repeats Current biology : CB. , 2004; 14(13): 1214-20.
Johnson L, Mollah S, Garcia BA, Muratore TL, Shabanowitz J, Hunt DF, Jacobsen SE   Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications Nucleic acids research. , 2004; 32(22): 6511-8.
Xie Z, Johansen LK, Gustafson AM, Kasschau KD, Lellis AD, Zilberman D, Jacobsen SE, Carrington JC   Genetic and functional diversification of small RNA pathways in plants PLoS biology. , 2004; 2(5): 642-652.
Jackson JP, Johnson L, Jasencakova Z, Zhang X, PerezBurgos L, Singh PB, Cheng X, Schubert I, Jenuwein T, Jacobsen SE   Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana Chromosoma. , 2004; 112(6): 308-15.
Chan SW, Zilberman D, Xie Z, Johansen LK, Carrington JC, Jacobsen SE   RNA silencing genes control de novo DNA methylation Science, 2004; 303(5662): 1336.
Kinoshita T, Miura A, Choi Y, Kinoshita Y, Cao X, Jacobsen SE, Fischer RL, Kakutani T   One-way control of FWA imprinting in Arabidopsis endosperm by DNA methylation Science. , 2004; 303(5657): 521-3.
Cao X, Aufsatz W, Zilberman D, Mette MF, Huang MS, Matzke M, Jacobsen SE   Role of the DRM and CMT3 methyltransferases in RNA-directed DNA methylation Current biology : CB. , 2003; 13(24): 2212-7.
Kato M, Miura A, Bender J, Jacobsen SE, Kakutani T   Role of CG and non-CG methylation in immobilization of transposons in Arabidopsis Current biology : CB. , 2003; 13(5): 421-6.
Zilberman D, Cao X, Jacobsen SE   ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation Science. , 2003; 299(5607): 716-9.
Cao X, Jacobsen SE   Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes Proceedings of the National Academy of Sciences of the United States of America. , 2002; 99 Suppl 4(Suppl 4): 16491-8.
Soppe WJ, Jasencakova Z, Houben A, Kakutani T, Meister A, Huang MS, Jacobsen SE, Schubert I, Fransz PF   DNA methylation controls histone H3 lysine 9 methylation and heterochromatin assembly in Arabidopsis The EMBO journal. , 2002; 21(23): 6549-59.
Schauer SE, Jacobsen SE, Meinke DW, Ray A   DICER-LIKE1: blind men and elephants in Arabidopsis development Trends in plant science. , 2002; 7(11): 487-91.
Johnson L, Cao X, Jacobsen S   Interplay between two epigenetic marks. DNA methylation and histone H3 lysine 9 methylation Current biology : CB. , 2002; 12(16): 1360-7.
Choi Y, Gehring M, Johnson L, Hannon M, Harada JJ, Goldberg RB, Jacobsen SE, Fischer RL   DEMETER, a DNA glycosylase domain protein, is required for endosperm gene imprinting and seed viability in arabidopsis Cell. , 2002; 110(1): 33-42.
Jackson JP, Lindroth AM, Cao X, Jacobsen SE   Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase Nature, 2002; 416(6880): 556-560.
Cao X, Jacobsen SE   Role of the Arabidopsis DRM methyltransferases in de novo DNA methylation and gene silencing Current Biology, 2002; 12(13): 1138-1144.
Malone CS, Miner MD, Doerr JR, Jackson JP, Jacobsen SE, Wall R, Teitell M   CmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing Proceedings of the National Academy of Sciences of the United States of America. , 2001; 98(18): 10404-9.
Eckardt NAA, Araki T, Benning C, Cubas P, Goodrich J, Jacobsen SE, Masson P, Nambara E, Simon R, Somerville S and Wasteneys G   Arabidopsis Research 2001 Plant Cell, 2001; 13: 1973-1982.
Lindroth AM, Cao X, Jackson JP, Zilberman D, McCallum CM, Henikoff S, Jacobsen SE   Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation Science. , 2001; 292(5524): 2077-80.
Kishimoto N, Sakai H, Jackson J, Jacobsen SE, Meyerowitz EM, Dennis ES, Finnegan EJ   Site specificity of the Arabidopsis METI DNA methyltransferase demonstrated through hypermethylation of the superman locus Plant molecular biology. , 2001; 46(2): 171-83.
Sakai H, Krizek BA, Jacobsen SE, Meyerowitz EM   Regulation of SUP expression identifies multiple regulators involved in arabidopsis floral meristem development The Plant cell. , 2000; 12(9): 1607-18.
Cao X, Springer NM, Muszynski MG, Phillips RL, Kaeppler S, Jacobsen SE   Conserved plant genes with similarity to mammalian de novo DNA methyltransferases PNAS, 2000; 97(9): 4979-4984.
Soppe WJJ, Jacobsen SE, Alonso-Blanco C, Jackson J, Kakutani T,Koornneef M and Peeters AJM   The late flowering phenotype of fwa mutants is caused by gain of function epi-alleles at a homeodomain gene Molecular Cell, 2000; 6(4): 791-802.
Jacobsen SE, Sakai H, Finnegan EJ, Cao X, Meyerowitz EM   Ectopic hypermethylation of flower-specific genes in Arabidopsis Current biology : CB. , 2000; 10(4): 179-86.
Jacobsen SE   Gene silencing: Maintaining methylation patterns Current biology : CB. , 1999; 9(16): R617-9.
Jacobsen SE, Running MP and Meyerowitz EM   Disruption of an RNA helicase/ RNAse III homologue in Arabidopsis causes unregulated cell division in floral meristems Development, 1999; 126(23): 5231-5243.
Jacobsen SE, Olszewski NE, Meyerowitz EM   SPINDLY's role in the gibberellin response pathway Symposia of the Society for Experimental Biology. , 1998; 51: 73-8.
Steven E. Jacobsen and Elliot M. Meyerowitz   Hypermethylated SUPERMAN epigenetic alleles in Arabidopsis Science, 1997; 277: 1100-1103.
Leon-Kloosterziel KM, Gil MA, Ruijs GJ, Jacobsen SE, Olszewski NE, Schwartz SH, Zeevaart JA, Koornneef M   Isolation and characterization of abscisic acid-deficient Arabidopsis mutants at two new loci The Plant journal : for cell and molecular biology. , 1996; 10(4): 655-61.
Jacobsen SE, Binkowski KA, Olszewski NE   SPINDLY, a tetratricopeptide repeat protein involved in gibberellin signal transduction in Arabidopsis Proceedings of the National Academy of Sciences of the United States of America. , 1996; 93(17): 9292-6.
Clark SE, Jacobsen SE, Levin JZ, Meyerowitz EM   The CLAVATA and SHOOT MERISTEMLESS loci competitively regulate meristem activity in Arabidopsis Development (Cambridge, England) , 1996; 122(5): 1567-75.
Jacobsen SE, Olszewski NE   Mutations at the SPINDLY locus of Arabidopsis alter gibberellin signal transduction The Plant cell. , 1993; 5(8): 887-96.
Jacobsen SE and Olszewski NE   Characterization of the arrest in anther development associated with gibberellin deficiency of the gib-1 mutant of tomato, Plant Physiology, 1991; 97: 409-414.

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