Nigel Maidment, Ph.D.

Work Titles and Affiliation
UCLA Professor, Psychiatry and Biobehavioral Sciences
Ph.D., University of Nottingham, U.K.

Contact Information:

Email Address:


Home Page

Lab Number:

(310) 206 7890

Office Phone Number:

(310) 206-7767

Work Address:

MRL Building
Los Angeles, CA 90095
MRL Building, Room 2770
675 Charles Young Drive So.
Los Angeles, CA 90095

Detailed Biography:

Professor Maidment received B.Sc., M.Sc. and Ph.D. degrees from the Universities of Reading, Southampton and Nottingham, U.K. His doctorate work was on in vivo voltammetry and microdialysis studies of the action of antipsychotic drugs on dopamine transmission in the laboratory of Prof. Charles Marsden. He received post-doctoral training at Stanford University in the laboratory of Prof. Jack Barchas where he developed microdialysis-radioimmunoassy procedures for studying neuropeptide transmission in the limbic system, joining the UCLA faculty in 1990.


Mendez Ian A, Ostlund Sean B, Maidment Nigel T, Murphy Niall P   Involvement of Endogenous Enkephalins and β-Endorphin in Feeding and Diet-Induced Obesity Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015; 40(9): 2103-12.
Peñagarikano Olga, Lázaro María T, Lu Xiao-Hong, Gordon Aaron, Dong Hongmei, Lam Hoa A, Peles Elior, Maidment Nigel T, Murphy Niall P, Yang X William, Golshani Peyman, Geschwind Daniel H   Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism Science translational medicine, 2015; 7(271): 271ra8.
Ostlund Sean B, LeBlanc Kimberly H, Kosheleff Alisa R, Wassum Kate M, Maidment Nigel T   Phasic mesolimbic dopamine signaling encodes the facilitation of incentive motivation produced by repeated cocaine exposure Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014; 39(10): 2441-9.
Wassum Kate M, Greenfield Venuz Y, Linker Kay E, Maidment Nigel T, Ostlund Sean B   Inflated reward value in early opiate withdrawal Addiction biology, 2014; 39(10): .
Ostlund Sean B, Kosheleff Alisa R, Maidment Nigel T   Differential effects of systemic cholinergic receptor blockade on Pavlovian incentive motivation and goal-directed action selection Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014; 39(6): 1490-7.
Grygoruk Anna, Chen Audrey, Martin Ciara A, Lawal Hakeem O, Fei Hao, Gutierrez Gabriel, Biedermann Traci, Najibi Rod, Hadi Richard, Chouhan Amit K, Murphy Niall P, Schweizer Felix E, Macleod Gregory T, Maidment Nigel T, Krantz David E   The redistribution of Drosophila vesicular monoamine transporter mutants from synaptic vesicles to large dense-core vesicles impairs amine-dependent behaviors The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014; 34(20): 6924-37.
Cui Yijun, Ostlund Sean B, James Alex S, Park Chang Sin, Ge Weihong, Roberts Kristofer W, Mittal Nitish, Murphy Niall P, Cepeda Carlos, Kieffer Brigitte L, Levine Michael S, Jentsch James David, Walwyn Wendy M, Sun Yi E, Evans Christopher J, Maidment Nigel T, Yang X William   Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward Nature neuroscience, 2014; 17(2): 254-61.
Ostlund Sean B, Kosheleff Alisa, Maidment Nigel T, Murphy Niall P   Decreased consumption of sweet fluids in mu opioid receptor knockout mice: a microstructural analysis of licking behavior Psychopharmacology, 2013; 229(1): 105-13.
Leblanc Kimberly H, Maidment Nigel T, Ostlund Sean B   Impact of repeated intravenous cocaine administration on incentive motivation depends on mode of drug delivery Addiction biology, 2013; 229(1): .
LeBlanc Kimberly H, Maidment Nigel T, Ostlund Sean B   Repeated cocaine exposure facilitates the expression of incentive motivation and induces habitual control in rats PloS one, 2013; 8(4): e61355.
Tolosa Vanessa M, Wassum Kate M, Maidment Nigel T, Monbouquette Harold G   Electrochemically deposited iridium oxide reference electrode integrated with an electroenzymatic glutamate sensor on a multi-electrode array microprobe Biosensors & bioelectronics, 2013; 42(8): 256-60.
Wassum Kate M, Ostlund Sean B, Loewinger Gabriel C, Maidment Nigel T   Phasic mesolimbic dopamine release tracks reward seeking during expression of pavlovian-to-instrumental transfer Biological psychiatry, 2013; 73(8): 747-55.
Fitzmaurice Arthur G, Rhodes Shannon L, Lulla Aaron, Murphy Niall P, Lam Hoa A, O'Donnell Kelley C, Barnhill Lisa, Casida John E, Cockburn Myles, Sagasti Alvaro, Stahl Mark C, Maidment Nigel T, Ritz Beate, Bronstein Jeff M   Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(2): 636-41.
Chen Audrey, Ng Fanny, Lebestky Tim, Grygoruk Anna, Djapri Christine, Lawal Hakeem O, Zaveri Harshul A, Mehanzel Filmon, Najibi Rod, Seidman Gabriel, Murphy Niall P, Kelly Rachel L, Ackerson Larry C, Maidment Nigel T, Jackson F Rob, Krantz David E   Dispensable, redundant, complementary, and cooperative roles of dopamine, octopamine, and serotonin in Drosophila melanogaster Genetics, 2013; 193(1): 159-76.
Blouin Ashley M, Fried Itzhak, Wilson Charles L, Staba Richard J, Behnke Eric J, Lam Hoa A, Maidment Nigel T, Karlsson Karl Æ, Lapierre Jennifer L, Siegel Jerome M   Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction Nature communications, 2013; 4(1): 1547.
Ostlund Sean B, Kosheleff Alisa R, Maidment Nigel T   Relative response cost determines the sensitivity of instrumental reward seeking to dopamine receptor blockade Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012; 37(12): 2653-60.
LeBlanc Kimberly H, Ostlund Sean B, Maidment Nigel T   Pavlovian-to-instrumental transfer in cocaine seeking rats Behavioral neuroscience, 2012; 126(5): 681-9.
Wassum Kate M, Ostlund Sean B, Maidment Nigel T   Phasic mesolimbic dopamine signaling precedes and predicts performance of a self-initiated action sequence task Biological psychiatry, 2012; 71(10): 846-54.
Laurent Vincent, Leung Beatrice, Maidment Nigel, Balleine Bernard W   ?- and ?-opioid-related processes in the accumbens core and shell differentially mediate the influence of reward-guided and stimulus-guided decisions on choice The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(5): 1875-83.
Wassum Kate M, Tolosa Vanessa M, Tseng Tina C, Balleine Bernard W, Monbouquette Harold G, Maidment Nigel T   Transient extracellular glutamate events in the basolateral amygdala track reward-seeking actions The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(8): 2734-46.
Ostlund Sean B, Maidment Nigel T   Dopamine receptor blockade attenuates the general incentive motivational effects of noncontingently delivered rewards and reward-paired cues without affecting their ability to bias action selection Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012; 37(2): 508-19.
Wassum Kate M, Ostlund Sean B, Balleine Bernard W, Maidment Nigel T   Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling Learning & memory (Cold Spring Harbor, N.Y.), 2011; 18(7): 475-83.
Lam Hoa A, Wu Nanping, Cely Ingrid, Kelly Rachel L, Hean Sindalana, Richter Franziska, Magen Iddo, Cepeda Carlos, Ackerson Larry C, Walwyn Wendy, Masliah Eliezer, Chesselet Marie-Françoise, Levine Michael S, Maidment Nigel T   Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human ?-synuclein Journal of neuroscience research, 2011; 89(7): 1091-102.
Remage-Healey Luke, Dong Stephanie, Maidment Nigel T, Schlinger Barney A   Presynaptic control of rapid estrogen fluctuations in the songbird auditory forebrain The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(27): 10034-8.
Lam Hoa, Maga Matthew, Pradhan Amynah, Evans Christopher J, Maidment Nigel T, Hales Tim G, Walwyn Wendy   Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking ?-arrestin 2 Molecular pain, 2011; 7(17): 24.
Wu Ming-Fung, Nienhuis Robert, Maidment Nigel, Lam Hoa A, Siegel Jerome M   Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and cataplexy The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(17): 6305-10.
Wassum Kate M, Cely Ingrid C, Balleine Bernard W, Maidment Nigel T   Micro-opioid receptor activation in the basolateral amygdala mediates the learning of increases but not decreases in the incentive value of a food reward The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(5): 1591-9.
Ostlund Sean B, Wassum Kate M, Murphy Niall P, Balleine Bernard W, Maidment Nigel T   Extracellular dopamine levels in striatal subregions track shifts in motivation and response cost during instrumental conditioning The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(1): 200-7.
Fei Hao, Chow Dawnis M, Chen Audrey, Romero-Calderón Rafael, Ong Wei S, Ackerson Larry C, Maidment Nigel T, Simpson Julie H, Frye Mark A, Krantz David E   Mutation of the Drosophila vesicular GABA transporter disrupts visual figure detection The Journal of experimental biology, 2010; 213(Pt 10): 1717-30.
Ostlund Sean B, Maidment Nigel T, Balleine Bernard W   Alcohol-Paired Contextual Cues Produce an Immediate and Selective Loss of Goal-directed Action in Rats Frontiers in integrative neuroscience, 2010; 4(1): .
Lu Xiao-Hong, Fleming Sheila M, Meurers Bernhard, Ackerson Larry C, Mortazavi Farzad, Lo Victor, Hernandez Daniela, Sulzer David, Jackson George R, Maidment Nigel T, Chesselet Marie-Francoise, Yang X William   Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(7): 1962-76.
Simon Jeff M, Daniels Jeff M, Romero-Calderòn Jeff M, Grygoruk Jeff M, Chang Jeff M, Najibi Jeff M, Shamouelian Jeff M, Salazar Jeff M, Solomon Jeff M, Ackerson Jeff M, Maidment Jeff M, Diantonio Jeff M, Krantz Jeff M   Drosophila Vesicular Monoamine Transporter Mutants can adapt to Reduced or Eliminated Vesicular Stores of Dopamine and Serotonin Genetics, 2008; 283(50): .
Chou Arthur P, Maidment Nigel, Klintenberg Rebecka, Casida John E, Li Sharon, Fitzmaurice Arthur G, Fernagut Pierre-Olivier, Mortazavi Farzad, Chesselet Marie-Francoise, Bronstein Jeff M   Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome The Journal of biological chemistry, 2008; 283(50): 34696-703.
Romero-Calderón Rafael, Uhlenbrock Guido, Borycz Jolanta, Simon Anne F, Grygoruk Anna, Yee Susan K, Shyer Amy, Ackerson Larry C, Maidment Nigel T, Meinertzhagen Ian A, Hovemann Bernhard T, Krantz David E   A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system PLoS genetics, 2008; 4(11): e1000245.
Remage-Healey Luke, Maidment Nigel T, Schlinger Barney A   Forebrain steroid levels fluctuate rapidly during social interactions Nature neuroscience, 2008; 11(11): 1327-34.
Wassum Kate M, Tolosa Vanessa M, Wang Jianjun, Walker Eric, Monbouquette Harold G, Maidment Nigel T   Silicon Wafer-Based Platinum Microelectrode Array Biosensor for Near Real-Time Measurement of Glutamate in Vivo Sensors (Basel, Switzerland), 2008; 8(8): 5023-5036.
Walker Eric, Wang Jianjun, Hamdi Naser, Monbouquette Harold G, Maidment Nigel T   Selective detection of extracellular glutamate in brain tissue using microelectrode arrays coated with over-oxidized polypyrrole The Analyst, 2007; 132(11): 1107-11.
Kliem Michele A, Maidment Nigel T, Ackerson Larry C, Chen Sugong, Smith Yoland, Wichmann Thomas   Activation of nigral and pallidal dopamine D1-like receptors modulates basal ganglia outflow in monkeys Journal of neurophysiology, 2007; 98(3): 1489-500.
Sang Tzu-Kang, Chang Hui-Yun, Lawless George M, Ratnaparkhi Anuradha, Mee Lisa, Ackerson Larry C, Maidment Nigel T, Krantz David E, Jackson George R   A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(5): 981-92.
Walwyn, W. M. Wei, W. Xie, C. W. Chiu, K. Kieffer, B. L. Evans, C. J. Maidment, N. T.   Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons Neuroscience, 2006; 142(2): 493-503.
Walwyn, W. M. Matsuka, Y. Arai, D. Bloom, D. C. Lam, H. Tran, C. Spigelman, I. Maidment, N. T.   HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy Exp Neurol, 2006; 198(1): 260-70.
Chang, H. Y. Grygoruk, A. Brooks, E. S. Ackerson, L. C. Maidment, N. T. Bainton, R. J. Krantz, D. E.   Overexpression of the Drosophila vesicular monoamine transporter increases motor activity and courtship but decreases the behavioral response to cocaine Mol Psychiatry, 2006; 11(1): 99-113.
Zeitzer Jamie M, Morales-Villagran Alberto, Maidment Nigel T, Behnke Eric J, Ackerson Larry C, Lopez-Rodriguez Faustino, Fried Itzhak, Engel Jerome, Wilson Charles L   Extracellular adenosine in the human brain during sleep and sleep deprivation: an in vivo microdialysis study Sleep, 2006; 29(4): 455-61.
Phillips Janice M, Lam Hoa A, Ackerson Larry C, Maidment Nigel T   Blockade of mGluR glutamate receptors in the subthalamic nucleus ameliorates motor asymmetry in an animal model of Parkinson's disease The European journal of neuroscience, 2006; 23(1): 151-60.
Shoblock James R, Maidment Nigel T   Constitutively active micro opioid receptors mediate the enhanced conditioned aversive effect of naloxone in morphine-dependent mice Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006; 31(1): 171-7.
Walwyn Wendy, Maidment Nigel T, Sanders Matthew, Evans Christopher J, Kieffer Brigitte L, Hales Tim G   Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons Molecular pharmacology, 2005; 68(6): 1688-98.
Galvan Adriana, Villalba Rosa M, West Sara M, Maidment Nigel T, Ackerson Larry C, Smith Yoland, Wichmann Thomas   GABAergic modulation of the activity of globus pallidus neurons in primates: in vivo analysis of the functions of GABA receptors and GABA transporters Journal of neurophysiology, 2005; 94(2): 990-1000.
Skoubis, P. D. Lam, H. A. Shoblock, J. Narayanan, S. Maidment, N. T.   Endogenous enkephalins, not endorphins, modulate basal hedonic state in mice Eur J Neurosci, 2005; 21(5): 1379-84.
John Joshi, Wu Ming-Fung, Maidment Nigel T, Lam Hoa A, Boehmer Lisa N, Patton Melanie, Siegel Jerome M   Developmental changes in CSF hypocretin-1 (orexin-A) levels in normal and genetically narcoleptic Doberman pinschers The Journal of physiology, 2004; 560(Pt 2): 587-92.
West Andrew B, Kapatos Gregory, O'Farrell Casey, Gonzalez-de-Chavez Fanny, Chiu Kelvin, Farrer Matthew J, Maidment Nigel T   N-myc regulates parkin expression The Journal of biological chemistry, 2004; 279(28): 28896-902.
Narayanan, S. Lam, H. Christian, L. Levine, M. S. Grandy, D. Rubinstein, M. Maidment, N. T.   Endogenous opioids mediate basal hedonic tone independent of dopamine D-1 or D-2 receptor activation Neuroscience, 2004; 124(1): 241-6.
Walwyn, W. M. Keith, D. E., Jr. Wei, W. Tan, A. M. Xie, C. W. Evans, C. J. Kieffer, B. L. Maidment, N. T.   Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice Neuroscience, 2004; 123(1): 111-21.
Murphy, N. P. Tan, A. M. Lam, H. A. Maidment, N. T.   Nociceptin/orphanin FQ modulation of rat midbrain dopamine neurons in primary culture Neuroscience, 2004; 127(4): 929-40.
West Andrew B, Maidment Nigel T   Genetics of parkin-linked disease Human genetics, 2004; 114(4): 327-36.
Lutfy Kabirullah, Eitan Shoshana, Bryant Camron D, Yang Yu C, Saliminejad Nazli, Walwyn Wendy, Kieffer Brigitte L, Takeshima Hiroshi, Carroll F Ivy, Maidment Nigel T, Evans Christopher J   Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003; 23(32): 10331-7.
Goldberg Matthew S, Fleming Sheila M, Palacino James J, Cepeda Carlos, Lam Hoa A, Bhatnagar Anushree, Meloni Edward G, Wu Nanping, Ackerson Larry C, Klapstein Gloria J, Gajendiran Mahadevan, Roth Bryan L, Chesselet Marie-Francoise, Maidment Nigel T, Levine Michael S, Shen Jie   Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons The Journal of biological chemistry, 2003; 278(44): 43628-35.
Rocha, L. Maidment, N. T.   Opioid peptide release in the rat hippocampus after kainic acid-induced status epilepticus Hippocampus, 2003; 13(4): 472-80.
Lopez-Rodriguez, F. Wilson, C. L. Maidment, N. T. Poland, R. E. Engel, J.   Total sleep deprivation increases extracellular serotonin in the rat hippocampus Neuroscience, 2003; 121(2): 523-30.
Lutfy Kabirullah, Khaliq Imran, Carroll F Ivy, Maidment Nigel T   Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats Psychopharmacology, 2002; 164(2): 168-76.
Zeitzer, J. M. Maidment, N. T. Behnke, E. J. Ackerson, L. C. Fried, I. Engel, J., Jr. Wilson, C. L.   Ultradian sleep-cycle variation of serotonin in the human lateral ventricle Neurology, 2002; 59(8): 1272-4.
Murphy Niall P, Lam Hoa A, Chen Zhenping, Pintar John E, Maidment Nigel T   Heroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene Brain research, 2002; 953(1-2): 276-80.
Neubert John K, Matsuka Yoshizo, Maidment Nigel T, Spigelman Igor   Microdialysis in trigeminal ganglia Brain research. Brain research protocols, 2002; 10(2): 102-8.
Maidment Nigel T, Chen Yiling, Tan Aiko M, Murphy Niall P, Leslie Frances M   Rat ventral midbrain dopamine neurons express the orphanin FQ/nociceptin receptor ORL-1 Neuroreport, 2002; 13(9): 1137-40.
Kiyashchenko Lyudmila I, Mileykovskiy Boris Y, Maidment Nigel, Lam Hoa A, Wu Ming-Fung, John Joshi, Peever John, Siegel Jerome M   Release of hypocretin (orexin) during waking and sleep states The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002; 22(13): 5282-6.
Wu, M. F. John, J. Maidment, N. Lam, H. A. Siegel, J. M.   Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement Am J Physiol Regul Integr Comp Physiol, 2002; 283(5): R1079-86.
Lutfy Kabirullah, Maidment Nigel T   Sensitization does not develop to cocaine-induced potentiation of the antinociceptive effect of morphine Brain research bulletin, 2002; 58(1): 7-12.
Narayanan Shridhar, Lutfy Kabirullah, Maidment Nigel   Sensitization to cocaine after a single intra-cerebral injection of orphanin FQ/nociceptin Behavioural brain research, 2002; 131(1-2): 97-103.
Narayanan, S. Lutfy, K. Maidment, N.   Sensitization to cocaine after a single intra-cerebral injection of orphanin FQ/nociceptin Behav Brain Res, 2002; 131(1-2): 97-103.
Matsuka, Y. Neubert, J. K. Maidment, N. T. Spigelman, I.   Concurrent release of ATP and substance P within guinea pig trigeminal ganglia in vivo Brain Res, 2001; 915(2): 248-55.
Murphy, N. P. Lam, H. A. Maidment, N. T.   A comparison of morphine-induced locomotor activity and mesolimbic dopamine release in C57BL6, 129Sv and DBA2 mice J Neurochem, 2001; 79(3): 626-35.
Fried, I. Wilson, C. L. Morrow, J. W. Cameron, K. A. Behnke, E. D. Ackerson, L. C. Maidment, N. T.   Increased dopamine release in the human amygdala during performance of cognitive tasks Nat Neurosci, 2001; 4(2): 201-6.
Skoubis, P. D. Matthes, H. W. Walwyn, W. M. Kieffer, B. L. Maidment, N. T.   Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out mice Neuroscience, 2001; 106(4): 757-63.
Lutfy, K. Hossain, S. M. Khaliq, I. Maidment, N. T.   Orphanin FQ/nociceptin attenuates the development of morphine tolerance in rats Br J Pharmacol, 2001; 134(3): 529-34.
Neubert, J. K. Maidment, N. T. Matsuka, Y. Adelson, D. W. Kruger, L. Spigelman, I.   Inflammation-induced changes in primary afferent-evoked release of substance P within trigeminal ganglia in vivo Brain Res, 2000; 871(2): 181-91.
Park, S. P. Lopez-Rodriguez, F. Wilson, C. L. Maidment, N. Matsumoto, Y. Engel, J., Jr.   In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep-wakefulness Brain Res, 1999; 833(2): 291-6.
Murphy, N. P. Lee, Y. Maidment, N. T.   Orphanin FQ/nociceptin blocks acquisition of morphine place preference Brain Res, 1999; 832(1-2): 168-70.
Fried, I. Wilson, C. L. Maidment, N. T. Engel, J., Jr. Behnke, E. Fields, T. A. MacDonald, K. A. Morrow, J. W. Ackerson, L.   Cerebral microdialysis combined with single-neuron and electroencephalographic recording in neurosurgical patients. Technical note J Neurosurg, 1999; 91(4): 697-705.
Walwyn, W. M. Ta-Haung, J. Ackerson, L. Maidment, N. T. Edgerton, V. R.   Extracellular glutamate in the dorsal horn of the lumbar spinal cord in the freely moving rat during hindlimb stepping Pharmacol Biochem Behav, 1999; 63(4): 581-8.
Rocha, L. Ondarza-Rovira, R. Maidment, N. T.   Gabapentin modifies extracellular opioid peptide content in amygdala: a microdialysis study Epilepsy Res, 1999; 35(1): 13-20.
Rocha, L. Cano, A. Cruz, C. Omana-Zapata, I. Villalobos, R. Maidment, N. T.   Opioid peptide systems following a subconvulsant dose of pentylenetetrazol in rats Epilepsy Res, 1999; 37(2): 141-50.
Narayanan, S. Maidment, N. T.   Orphanin FQ and behavioral sensitization to cocaine Pharmacol Biochem Behav, 1999; 63(2): 271-7.
Murphy, N. P. Maidment, N. T.   Orphanin FQ/nociceptin modulation of mesolimbic dopamine transmission determined by microdialysis J Neurochem, 1999; 73(1): 179-86.
Lutfy, K. Sharza, S. A. Maidment, N. T.   Tolerance develops to the inhibitory effect of orphanin FQ on morphine-induced antinociception in the rat Neuroreport, 1999; 10(1): 103-6.
King, B. H. Cromwell, H. C. Lee, H. T. Behrstock, S. P. Schmanke, T. Maidment, N. T.   Dopaminergic and glutamatergic interactions in the expression of self-injurious behavior Dev Neurosci, 1998; 20(2-3): 180-7.
Olive, M. F. Anton, B. Micevych, P. Evans, C. J. Maidment, N. T.   Presynaptic versus postsynaptic localization of mu and delta opioid receptors in dorsal and ventral striatopallidal pathways J Neurosci, 1997; 17(19): 7471-9.
Rocha, L. L. Evans, C. J. Maidment, N. T.   Amygdala kindling modifies extracellular opioid peptide content in rat hippocampus measured by microdialysis J Neurochem, 1997; 68(2): 616-24.
Bergasa, N. V. Mohajer, B. Maisonneuve, I. M. Ho, A. Maidment, N. T. Olive, F. Gunduz, M. Kreek, M. J.   Basal total opioid peptide release in the striatum of rats with cholestasis from bile duct resection: a study by the use of in vivo microdialysis Life Sci, 1997; 61(12): 1169-75.
Wilson, C. L. Maidment, N. T. Shomer, M. H. Behnke, E. J. Ackerson, L. Fried, I. Engel, J., Jr.   Comparison of seizure related amino acid release in human epileptic hippocampus versus a chronic, kainate rat model of hippocampal epilepsy Epilepsy Res, 1996; 26(1): 245-54.
Maidment, N. T. Tan, A. M. Bloom, D. C. Anton, B. Feldman, L. T. Stevens, J. G.   Expression of the lacZ reporter gene in the rat basal forebrain, hippocampus, and nigrostriatal pathway using a nonreplicating herpes simplex vector Exp Neurol, 1996; 139(1): 107-14.
Cromwell, H. C. Witte, E. A. Crawford, C. A. Ly, H. T. Maidment, N. T. King, B. H.   Pemoline produces ipsilateral turning behavior in unilateral 6-OHDA-lesioned rats Prog Neuropsychopharmacol Biol Psychiatry, 1996; 20(3): 503-14.
Rocha, L. Briones, M. Ackermann, R. F. Anton, B. Maidment, N. T. Evans, C. J. Engel, J., Jr.   Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems Epilepsy Res, 1996; 26(1): 105-113.
Olive, M. F. Bertolucci, M. Evans, C. J. Maidment, N. T.   Microdialysis reveals a morphine-induced increase in pallidal opioid peptide release Neuroreport, 1995; 6(8): 1093-6.
Bloom, D. C. Lokensgard, J. R. Maidment, N. T. Feldman, L. T. Stevens, J. G.   Long-term expression of genes in vivo using non-replicating HSV vectors Gene Ther, 1994; 1 Suppl 1: S36-8.
Rocha, L. Maidment, N. T. Evans, C. J. Ackermann, R. F. Engel, J., Jr.   Microdialysis reveals changes in extracellular opioid peptide levels in the amygdala induced by amygdaloid kindling stimulation Exp Neurol, 1994; 126(2): 277-83.
Anton, R. Kordower, J. H. Maidment, N. T. Manaster, J. S. Kane, D. J. Rabizadeh, S. Schueller, S. B. Yang, J. Rabizadeh, S. Edwards, R. H. et al.,   Neural-targeted gene therapy for rodent and primate hemiparkinsonism Exp Neurol, 1994; 127(2): 207-18.
Sulzer, D. Maidment, N. T. Rayport, S.   Amphetamine and other weak bases act to promote reverse transport of dopamine in ventral midbrain neurons J Neurochem, 1993; 60(2): 527-35.
Lo, E. H. Steinberg, G. K. Panahian, N. Maidment, N. T. Newcomb, R.   Profiles of extracellular amino acid changes in focal cerebral ischaemia: effects of mild hypothermia Neurol Res, 1993; 15(4): 281-7.
Sulzer, D. Pothos, E. Sung, H. M. Maidment, N. T. Hoebel, B. G. Rayport, S.   Weak base model of amphetamine action Ann N Y Acad Sci, 1992; 654: 525-8.
Maidment, N. T. Siddall, B. Rudolph, V. D. Evans, C. J.   Postmortem changes in rat brain extracellular opioid peptides revealed by microdialysis J Neurochem, 1991; 56(6): 1980-4.
Maidment, N. T. Brumbaugh, D. R. Rudolph, V. D. Erdelyi, E. Evans, C. J.   Microdialysis of extracellular endogenous opioid peptides from rat brain in vivo Neuroscience, 1989; 33(3): 549-57.
Gonzalez-Mora, J. L. Maidment, N. T. Guadalupe, T. Mas, M.   Post-mortem dopamine dynamics assessed by voltammetry and microdialysis Brain Res Bull, 1989; 23(4-5): 323-7.
Yeomans, J. S. Maidment, N. T. Bunney, B. S.   Excitability properties of medial forebrain bundle axons of A9 and A10 dopamine cells Brain Res, 1988; 450(1-2): 86-93.
Marsden, C. A. Martin, K. F. Routledge, C. Brazell, M. P. Maidment, N. T.   Application of intracerebral dialysis and in vivo voltammetry to pharmacological and physiological studies of amine neurotransmitters Ann N Y Acad Sci, 1986; 473: 106-25.
Crespi, F. Sharp, T. Maidment, N. T. Marsden, C. A.   Differential pulse voltammetry: simultaneous in vivo measurement of ascorbic acid, catechols and 5-hydroxyindoles in the rat striatum Brain Res, 1984; 322(1): 135-8.
Sharp, T. Maidment, N. T. Brazell, M. P. Zetterstrom, T. Ungerstedt, U. Bennett, G. W. Marsden, C. A.   Changes in monoamine metabolites measured by simultaneous in vivo differential pulse voltammetry and intracerebral dialysis Neuroscience, 1984; 12(4): 1213-21.
Crespi, F. Sharp, T. Maidment, N. Marsden, C.   Differential pulse voltammetry in vivo--evidence that uric acid contributes to the indole oxidation peak Neurosci Lett, 1983; 43(2-3): 203-7.

MeSH Terms:

What is MeSH?

Medical Subject Headings

We have integrated Faculty Profiles with the U.S. National Library of Medicine's MeSH terms. For every publication added to a profile, we pull its MeSH terms and display it here. This enhancement allows you to search for research themes of our faculty members.

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MeSH is:

  • an acronym for Medical Subject Headings.
  • the U.S. National Library of Medicine's controlled vocabulary (thesaurus).
  • a vocabulary that gives uniformity and consistency to the indexing and cataloging of biomedical literature.
  • a distinctive feature of MEDLINE.
  • arranged in a hierarchical manner called the MeSH Tree Structures.
  • updated annually.

MeSH Vocabulary includes four types of terms:

  • Headings
  • Subheadings
  • Supplementary Concept Records
  • Publication Characteristics (or Types)

Over 26,000 MeSH headings (also called "main headings" or "descriptors" represents concepts found in the biomedical literature

Subheadings - (also called qualifiers) are attached to MeSH headings to describe a specific aspect of a concept.

Supplementary Concept Records are over 200,000 terms in a separate thesaurus from the Medical Subject Headings. These are primarily substance terms, but also include some protocols and rare desease terms. These terms are updated weekly.

Publication Characteristics or (Publication Types) describe the type of publication being indexed; i.e., what the item is, not what the article is about.

Information from U.S. National Library of Medicine.

3,4-Dihydroxyphenylacetic Acid Accounting Acetylcholine Action Potentials Adolescent Adult Affect Aging Airway Remodeling Amines Amino Acid Sequence Amino Acids Ammonium Chloride Amphetamines Amygdala Analgesics, Opioid Analysis of Variance Animals Animals, Genetically Modified Apomorphine Arousal Ascorbic Acid Avoidance Learning Basal Ganglia Base Sequence Behavior Behavior Control Behavior, Animal Benztropine Biogenic Amines Biomarkers, Pharmacological Blood Pressure Bone Remodeling Brain Brain Chemistry Brain Mapping Cannabinoids Caudate Nucleus Cell Culture Techniques Cell Death Cell Line Cell Nucleus Cell Survival Cells Cells, Cultured Cerebral Cortex Choice Behavior Cholecystokinin Chromatography, High Pressure Liquid Clozapine Cocaine Cognition Conditioning (Psychology) Conditioning, Classical Conditioning, Operant Control Groups Corpus Striatum Cues Culture Cyclic AMP Cytoplasm DNA, Viral Dental Models Depression Dialysis Dibenzazepines Diet Dihydroxyphenylalanine Disease Disease Models, Animal Disease Progression Dogs Dopamine Dopamine Agonists Dopamine Antagonists Dopamine Uptake Inhibitors Dose-Response Relationship, Drug Drosophila Proteins Drosophila melanogaster Drug Interactions Drug Tolerance Eating Electrochemistry Electrodes Electrodes, Implanted Electroencephalography Electrophysiology Elements Endocytosis Endorphins Engineering Enkephalins Environment Enzyme Inhibitors Epilepsy Excitatory Amino Acid Agonists Exons Extinction, Psychological Extracellular Space Fluorescent Dyes Flupenthixol Food Food Deprivation Frontal Lobe Fungicides, Industrial GABA Antagonists Gene Expression Gene Expression Regulation Genes, Reporter Genetics Genotype Globus Pallidus Glutamates Glutamic Acid Goals Habits Habituation, Psychophysiologic Haloperidol Heroin Hippocampus Homeostasis Hot Temperature Humans Hydrogen-Ion Concentration Hydroxyindoleacetic Acid Hyperphagia Immunohistochemistry In Situ Hybridization Injections, Intraventricular Intracellular Signaling Peptides and Proteins Kainic Acid Kinetics Laboratories Larva Lead Learning Ligands Linear Models Literature Locomotion Logistic Models Longevity Macaca mulatta Maintenance Mass Spectrometry Memory Mesencephalon Metabolism Methods Mi-2 Nucleosome Remodeling and Deacetylase Complex Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Knockout Microdialysis Microelectrodes Microinjections Middle Aged Mitochondria Mitogen-Activated Protein Kinases Models, Anatomic Models, Animal Models, Biological Models, Cardiovascular Models, Chemical Models, Econometric Models, Economic Models, Educational Models, Genetic Models, Immunological Models, Molecular Models, Neurological Models, Nursing Models, Organizational Models, Psychological Models, Statistical Models, Structural Models, Theoretical Molecular Sequence Data Morphine Motivation Motor Activity Movement Muscimol Mutation Naloxone Naltrexone Narcotic Antagonists National Institute on Drug Abuse (U.S.) Nature Neostriatum Nerve Degeneration Neural Pathways Neuroanatomy Neurochemistry Neuronal Plasticity Neurons Neuropeptides Neuropharmacology Neurotensin Neurotransmitter Agents Neurotransmitter Transport Proteins Norepinephrine Nucleus Accumbens Opioid Peptides Optogenetics Oxidative Stress Oxidopamine Pain Measurement Parkinson Disease Pathology Pemoline Peptides Pharmaceutical Preparations Phenotype Phenylacetates Physiology Plasma Plasma Membrane Neurotransmitter Transport Proteins Population Postmortem Changes Potassium Presynaptic Terminals Promoter Regions, Genetic Proportional Hazards Models Prosencephalon Protein Precursors Protein Transport Proteins Proteome Publishing RNA, Messenger Radioimmunoassay Rats Rats, Inbred Strains Rats, Long-Evans Rats, Sprague-Dawley Rats, Wistar Reaction Time Reactive Oxygen Species Receptors, Dopamine D1 Receptors, Dopamine D2 Receptors, Opioid Receptors, Opioid, delta Receptors, Opioid, kappa Receptors, Opioid, mu Recycling Reinforcement (Psychology) Research Research Personnel Reward Role Safety-Based Drug Withdrawals Self Administration Self Medication Septal Nuclei Serotonin Serum Signal Transduction Sleep Deprivation Sleep, REM Somatostatin Stereotaxic Techniques Substance P Substance Withdrawal Syndrome Substance-Related Disorders Substantia Nigra Subthalamus Sucrose Synapses Synaptic Transmission Synaptic Vesicles Technology Tegmentum Mesencephali Thioridazine Time Time Factors Tissues Transfer (Psychology) Tyrosine 3-Monooxygenase Ubiquitin-Protein Ligases Ubiquitination Uncertainty Ventral Tegmental Area Ventricular Remodeling Vesicular Neurotransmitter Transport Proteins Wakefulness Work Xenograft Model Antitumor Assays Young Adult gamma-Aminobutyric Acid

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