Aarno J Palotie, M.D., Ph.D.

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Work Titles
UCLA Professor, Orthopaedic Surgery
Education:
Degrees:
M.D.
Ph.D.

Contact Information:

Email Address:

apalotie@mednet.ucla.edu


Work Phone Number:

310-794-5948

310-794-5948

Work Address:

Office
Gonda
Los Angeles, CA 90095

4357A Gonda Cntr
Campus - 708822
CA

Laboratory
Gonda
Los Angeles, CA 90095


Detailed Biography:

Migraine, genetics of complex traits Dr. Palotie?s laboratory has a special interest in the genetics of migraine. Migraine is a common neurological disorder showing clustering in families. Family and twin studies suggest a strong genetic component, especially in migraine which is accompanied by aura symptoms. The mode of inheritance is unclear but based on segregation analysis, a polygenic inheritance is most likely. With the benefits of the genetically isolated population of Finland, Dr. Palotie?s group aims to identify genetic loci contributing to the predisposition of migraine disease. Dr Palotie?s laboratory also has a tradition of visual physical mapping and development of high resolution fluorescence in situ hybridization (FISH) techniques used in positional cloning. Thus Dr. Palotie is managing the FISH core unit, located on the first floor of the Gonda (Goldschmied) Neuroscience & Genetics Research Center

Publications:

A selected list of publications:

Virolainen E, Wessman M, Hovatta I, Niemi KM, Ignatius J, Saarialho-Kere U, Kere J, Peltonen L, Palotie A   Assignment of a novel locus for Autosomal Recessive Congenital Ichtyosis to Chromosome 19p13.1-p13.2, America Journal of Human Genetics, 2000; 66: 1132-1137.
Stenman J, Finne P, Stahls A, Grenman R, Steman U-H, Palotie A, Orpana A   Accurate determination of relative messenger RNA levels by RT-PCR, Nature Biotechnology, 1999; 17: 720-722.
Horelli-Kuitunen N, Aaltonen J, Yaspo ML, Eeva M, Wessman M, Peltonen L, Palotie A   Mapping ESTs by fiber-FISH Genome research. , 1999; 9(1): 62-71.
Aaltonen J, Bjorses P, Perheentupa J, Horelli-Kuitunen N, Palotie A, Peltonen L (Group I). Lee YS, Francis F, Henning S, Thiel C, Lehrach H, Yaspo M-L (Group II)   An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. The Finnish-German APECED Consortium. Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Nature genetics. , 1997; 17(4): 399-403.
Mikkola H, Muszbek L, Laiho E, Syrjala M, Hamalainen E, Haramura G, Salmi T, Peltonen L, Palotie A   Molecular mechanism of a mild phenotype in coagulation factor XIII deficiency: Asplicing mutation permeitting partial correct splicing of the FXIII A-subunit, Blood, 1997; 89, 4: 1279-1287.
Laiho E, Ignatius J, Mikkola H, Yee VC, Teller DC, Niemi K-M, Saarialho-Kere U, Kere J, Palotie A   Transglutaminase 1 Mutations in Autosomal Recessive Congenital Ichtyosis: Private and Recurrent Mutations in an Isolated Population, Am J Human Genetics, 1997; 61: 529-538.
Heiskanen, M Peltonen, L Palotif, A   Visual mapping by high resolution FISH Trends in genetics : TIG. , 1996; 12(10): 379-82.
Mikkola H, Yee VC, Syrjala M, Seitz R, Egbring R, Petrini P, Ljung R, Ingerslev J, Teller DC, Peltonen L, Palotie A   Four novel mutations in deficiency of coagulation factor XIII: Consequences to expression and structure of the A-subunit, Blood, 1996; 87: 141-151.

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