Publications:
A selected list of publications:
Kirkby Nicholas S, Zaiss Anne K, Urquhart Paula, Jiao Jing, Austin Philip J, Al-Yamani Malak, Lundberg Martina H, MacKenzie Louise S, Warner Timothy D, Nicolaou Anna, Herschman Harvey R, Mitchell Jane A
LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene
expression pattern reveals non-vascular sites of COX-2 expression
PloS one,
2013; 8(7):
e69524.
Hill Reginald, Li Yunfeng, Tran Linh M, Dry Sarah, Calvopina Joseph Hargan, Garcia Alejandro, Kim Christine, Wang Ying, Donahue Timothy R, Herschman Harvey R, Wu Hong
Cell intrinsic role of COX-2 in pancreatic cancer development
Molecular cancer therapeutics,
2012; 11(10):
2127-37.
Austin Wayne R, Armijo Amanda L, Campbell Dean O, Singh Arun S, Hsieh Terry, Nathanson David, Herschman Harvey R, Phelps Michael E, Witte Owen N, Czernin Johannes, Radu Caius G
Nucleoside salvage pathway kinases regulate hematopoiesis by linking
nucleotide metabolism with replication stress
The Journal of experimental medicine,
2012; 209(12):
2215-28.
Campbell Dean O, Yaghoubi Shahriar S, Su Ying, Lee Jason T, Auerbach Martin S, Herschman Harvey, Satyamurthy Nagichettiar, Czernin Johannes, Lavie Arnon, Radu Caius G
Structure-guided engineering of human thymidine kinase 2 as a positron
emission tomography reporter gene for enhanced phosphorylation of
non-natural thymidine analog reporter probe
The Journal of biological chemistry,
2012; 287(1):
446-54.
Zhang Weizhou, Kater Arnon P, Widhopf George F, Chuang Han-Yu, Enzler Thomas, James Danelle F, Poustovoitov Maxim, Tseng Ping-Hui, Janz Siegfried, Hoh Carl, Herschman Harvey, Karin Michael, Kipps Thomas J
B-cell activating factor and v-Myc myelocytomatosis viral oncogene
homolog (c-Myc) influence progression of chronic lymphocytic leukemia
Proceedings of the National Academy of Sciences of the United States of America,
2010; 107(44):
18956-60.
Tseng Han-Ching, Arasteh Aida, Paranjpe Avina, Teruel Antonia, Yang Wendy, Behel Armin, Alva Jackelyn A, Walter Gina, Head Christian, Ishikawa Tomo-o, Herschman Harvey R, Cacalano Nicholas, Pyle April D, Park No-Hee, Jewett Anahid
Increased lysis of stem cells but not their differentiated cells by
natural killer cells; de-differentiation or reprogramming activates NK
cells
PloS one,
2010; 5(7):
e11590.
Toy Gerald, Austin Wayne R, Liao Hsiang-I, Cheng Donghui, Singh Arun, Campbell Dean O, Ishikawa Tomo-o, Lehmann Lynn W, Satyamurthy Nagichettiar, Phelps Michael E, Herschman Harvey R, Czernin Johannes, Witte Owen N, Radu Caius G
Requirement for deoxycytidine kinase in T and B lymphocyte
development
Proceedings of the National Academy of Sciences of the United States of America,
2010; 107(12):
5551-6.
Johnson Stuart L, Franz Christoph, Kuhn Stephanie, Furness David N, Rüttiger Lukas, Münkner Stefan, Rivolta Marcelo N, Seward Elizabeth P, Herschman Harvey R, Engel Jutta, Knipper Marlies, Marcotti Walter
Synaptotagmin IV determines the linear Ca2+ dependence of vesicle
fusion at auditory ribbon synapses
Nature neuroscience,
2010; 13(1):
45-52.
Lomenick Brett, Hao Rui, Jonai Nao, Chin Randall M, Aghajan Mariam, Warburton Sarah, Wang Jianing, Wu Raymond P, Gomez Fernando, Loo Joseph A, Wohlschlegel James A, Vondriska Thomas M, Pelletier Jerry, Herschman Harvey R, Clardy Jon, Clarke Catherine F, Huang Jing
Target identification using drug affinity responsive target stability
(DARTS)
Proceedings of the National Academy of Sciences of the United States of America,
2009; 106(51):
21984-9.
Koya Richard C, Kimura Takahiro, Ribas Antoni, Rozengurt Nora, Lawson Gregory W, Faure-Kumar Emmanuelle, Wang He-jing, Herschman Harvey, Kasahara Noriyuki, Stripecke Renata
Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines
Molecular therapy : the journal of the American Society of Gene Therapy,
2007; 15(5):
971-80.
Chikazu Daichi, Li Xiaodong, Kawaguchi Hiroshi, Sakuma Yoko, Voznesensky Olga S, Adams Douglas J, Xu Manshan, Hoshi Kazuto, Katavic Vedran, Herschman Harvey R, Raisz Lawrence G, Pilbeam Carol C
Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfa1 binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. 2002
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
2005; 20(10):
1888-98.
Toyokuni Tatsushi, Kumar J S Dileep, Walsh Joseph C, Shapiro Alan, Talley John J, Phelps Michael E, Herschman Harvey R, Barrio Jorge R, Satyamurthy Nagichettiar
Synthesis of
4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new
[18F]fluorinated analogue of valdecoxib, as a potential radiotracer
for imaging cyclooxygenase-2 with positron emission tomography
Bioorganic & medicinal chemistry letters,
2005; 15(21):
4699-702.
Singh Vinita, Miranda Tina Branscombe, Jiang Wei, Frankel Adam, Roemer Martha E, Robb Victoria A, Gutmann David H, Herschman Harvey R, Clarke Steven, Newsham Irene F
DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo
Oncogene,
2004; 23(47):
7761-71.
Chikazu Daichi, Li Xiaodong, Kawaguchi Hiroshi, Sakuma Yoko, Voznesensky Olga S, Adams Douglas J, Xu Manshan, Hoshio Kazuto, Katavic Vedran, Herschman Harvey R, Raisz Lawrence G, Pilbeam Carol C
Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts
via a Cbfal binding site: role in effects of bone morphogenetic
protein 2 in vitro and in vivo
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
2002; 17(8):
1430-40.
Green Leeta A, Yap Cecelia S, Nguyen Khoi, Barrio Jorge R, Namavari Mohammad, Satyamurthy Nagichettiar, Phelps Michael E, Sandgren Eric P, Herschman Harvey R, Gambhir Sanjiv S
Indirect monitoring of endogenous gene expression by positron emission
tomography (PET) imaging of reporter gene expression in transgenic
mice
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging,
2002; 4(1):
71-81.
Liang Qianwa, Gotts Jeff, Satyamurthy Nagichettiar, Barrio Jorge, Phelps Michael E, Gambhir Sanjiv S, Herschman Harvey R
Noninvasive, repetitive, quantitative measurement of gene expression
from a bicistronic message by positron emission tomography, following
gene transfer with adenovirus
Molecular therapy : the journal of the American Society of Gene Therapy,
2002; 6(1):
73-82.
Lin Henry J, Lakkides Karen M, Keku Temitope O, Reddy Srinivasa T, Louie Andrew D, Kau Irving H, Zhou Haiyan, Gim Jason S Y, Ma Hoang L, Matthies Carl F, Dai Aihua, Huang Hsiao-Fen, Materi Alicia M, Lin Jesse H, Frankl Harold D, Lee Eric R, Hardy Steven I, Herschman Harvey R, Henderson Brian E, Kolonel Laurence N, Le Marchand Loïc, Garavito R Michael, Sandler Robert S, Haile Robert W, Smith William L
Prostaglandin H synthase 2 variant (Val511Ala) in African Americans
may reduce the risk for colorectal neoplasia
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
2002; 11(11):
1305-15.
Murphy Jennifer M, Armijo Amanda L, Nomme Julian, Lee Chi Hang, Smith Quentin A, Li Zheng, Campbell Dean O, Liao Hsiang-I, Nathanson David A, Austin Wayne R, Lee Jason T, Darvish Ryan, Wei Liu, Wang Jue, Su Ying, Damoiseaux Robert, Sadeghi Saman, Phelps Michael E, Herschman Harvey R, Czernin Johannes, Alexandrova Anastassia N, Jung Michael E, Lavie Arnon, Radu Caius G
Development of new deoxycytidine kinase inhibitors and noninvasive in
vivo evaluation using positron emission tomography
Journal of medicinal chemistry,
2013; 56(17):
6696-708.
Cherukuri Durga P, Ishikawa Tomo-O, Chun Patrick, Catapang Art, Elashoff David, Grogan Tristan R, Bugni James, Herschman Harvey R
Targeted Cox2 gene deletion in intestinal epithelial cells decreases
tumorigenesis in female, but not male, ApcMin/+ mice
Molecular oncology,
2014; 8(2):
169-77.
Escuin-Ordinas Helena, Atefi Mohammad, Fu Yong, Cass Ashley, Ng Charles, Huang Rong Rong, Yashar Sharona, Comin-Anduix Begonya, Avramis Earl, Cochran Alistair J, Marais Richard, Lo Roger S, Graeber Thomas G, Herschman Harvey R, Ribas Antoni
COX-2 inhibition prevents the appearance of cutaneous squamous cell
carcinomas accelerated by BRAF inhibitors
Molecular oncology,
2014; 8(2):
250-60.
Nathanson David A, Armijo Amanda L, Tom Michelle, Li Zheng, Dimitrova Elizabeth, Austin Wayne R, Nomme Julian, Campbell Dean O, Ta Lisa, Le Thuc M, Lee Jason T, Darvish Ryan, Gordin Ari, Wei Liu, Liao Hsiang-I, Wilks Moses, Martin Colette, Sadeghi Saman, Murphy Jennifer M, Boulos Nidal, Phelps Michael E, Faull Kym F, Herschman Harvey R, Jung Michael E, Czernin Johannes, Lavie Arnon, Radu Caius G
Co-targeting of convergent nucleotide biosynthetic pathways for
leukemia eradication
The Journal of experimental medicine,
2014; 211(3):
473-86.
An Ying, Belevych Natalya, Wang Yufen, Zhang Hao, Nasse Jason S, Herschman Harvey, Chen Qun, Tarr Andrew, Liu Xiaoyu, Quan Ning
Prostacyclin mediates endothelial COX-2-dependent neuroprotective
effects during excitotoxic brain injury
Journal of inflammation research,
2014; 7:
57-67.
Zaiss Anne K, Zuber Johannes, Chu Chun, Machado Hidevaldo B, Jiao Jing, Catapang Arthur B, Ishikawa Tomo-o, Gil Jose S, Lowe Scott W, Herschman Harvey R
Reversible suppression of cyclooxygenase 2 (COX-2) expression in vivo
by inducible RNA interference
PloS one,
2014; 9(7):
e101263.
Wilhelms Daniel Björk, Kirilov Milen, Mirrasekhian Elahe, Eskilsson Anna, Kugelberg Unn Örtegren, Klar Christine, Ridder Dirk A, Herschman Harvey R, Schwaninger Markus, Blomqvist Anders, Engblom David
Deletion of prostaglandin E2 synthesizing enzymes in brain endothelial
cells attenuates inflammatory fever
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2014; 34(35):
11684-90.
Roulis Manolis, Nikolaou Christoforos, Kotsaki Elena, Kaffe Eleanna, Karagianni Niki, Koliaraki Vasiliki, Salpea Klelia, Ragoussis Jiannis, Aidinis Vassilis, Martini Eva, Becker Christoph, Herschman Harvey R, Vetrano Stefania, Danese Silvio, Kollias George
Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate
sensing to epithelial homeostasis
Proceedings of the National Academy of Sciences of the United States of America,
2014; 111(43):
E4658-67.
Jiao Jing, Ishikawa Tomo-O, Dumlao Darren S, Norris Paul C, Magyar Clara E, Mikulec Carol, Catapang Art, Dennis Edward A, Fischer Susan M, Herschman Harvey R
Targeted deletion and lipidomic analysis identify epithelial cell
COX-2 as a major driver of chemically induced skin cancer
Molecular cancer research : MCR,
2014; 12(11):
1677-88.
Vadivel Kanagasabai, Ponnuraj Sathya-Moorthy, Kumar Yogesh, Zaiss Anne K, Bunce Matthew W, Camire Rodney M, Wu Ling, Evseenko Denis, Herschman Harvey R, Bajaj Madhu S, Bajaj S Paul
Platelets contain tissue factor pathway inhibitor-2 derived from
megakaryocytes and inhibits fibrinolysis
The Journal of biological chemistry,
2014; 289(45):
31647-61.
Zaiss Anne K, Foley Erin M, Lawrence Roger, Schneider Lina S, Hoveida Hamidreza, Secrest Patrick, Catapang Arthur B, Yamaguchi Yu, Alemany Ramon, Shayakhmetov Dmitry M, Esko Jeffrey D, Herschman Harvey R
Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2
but Dispensable for Adenovirus 5 Liver Transduction In Vivo
Journal of virology,
2016; 90(1):
412-20.
Kirkby Nicholas S, Chan Melissa V, Zaiss Anne K, Garcia-Vaz Eliana, Jiao Jing, Berglund Lisa M, Verdu Elena F, Ahmetaj-Shala Blerina, Wallace John L, Herschman Harvey R, Gomez Maria F, Mitchell Jane A
Systematic study of constitutive cyclooxygenase-2 expression: Role of
NF-κB and NFAT transcriptional pathways
Proceedings of the National Academy of Sciences of the United States of America,
2016; 113(2):
434-9.
Kim Woosuk, Le Thuc M, Wei Liu, Poddar Soumya, Bazzy Jimmy, Wang Xuemeng, Uong Nhu T, Abt Evan R, Capri Joseph R, Austin Wayne R, Van Valkenburgh Juno S, Steele Dalton, Gipson Raymond M, Slavik Roger, Cabebe Anthony E, Taechariyakul Thotsophon, Yaghoubi Shahriar S, Lee Jason T, Sadeghi Saman, Lavie Arnon, Faull Kym F, Witte Owen N, Donahue Timothy R, Phelps Michael E, Herschman Harvey R, Herrmann Ken, Czernin Johannes, Radu Caius G
[18F]CFA as a clinically translatable probe for PET imaging of
deoxycytidine kinase activity
Proceedings of the National Academy of Sciences of the United States of America,
2016; 113(15):
4027-32.
Escuin-Ordinas Helena, Li Shuoran, Xie Michael W, Sun Lu, Hugo Willy, Huang Rong Rong, Jiao Jing, de-Faria Felipe Meira, Realegeno Susan, Krystofinski Paige, Azhdam Ariel, Komenan Sara Marie D, Atefi Mohammad, Comin-Anduix Begoña, Pellegrini Matteo, Cochran Alistair J, Modlin Robert L, Herschman Harvey R, Lo Roger S, McBride William H, Segura Tatiana, Ribas Antoni
Cutaneous wound healing through paradoxical MAPK activation by BRAF
inhibitors
Nature communications,
2016; 7:
12348.
Lin Meng-Chieh, Chen Shih-Yin, Tsai Ho-Min, He Pei-Lin, Lin Yen-Chun, Herschman Harvey, Li Hua-Jung
PGE
Stem cells (Dayton, Ohio),
2017; 35(2):
425-444.
Le Thuc M, Poddar Soumya, Capri Joseph R, Abt Evan R, Kim Woosuk, Wei Liu, Uong Nhu T, Cheng Chloe M, Braas Daniel, Nikanjam Mina, Rix Peter, Merkurjev Daria, Zaretsky Jesse, Kornblum Harley I, Ribas Antoni, Herschman Harvey R, Whitelegge Julian, Faull Kym F, Donahue Timothy R, Czernin Johannes, Radu Caius G
ATR inhibition facilitates targeting of leukemia dependence on
convergent nucleotide biosynthetic pathways
Nature communications,
2017; 8(1):
241.
Kirkby Nicholas S, Sampaio Walkyria, Etelvino Gisele, Alves Daniele T, Anders Katie L, Temponi Rafael, Shala Fisnik, Nair Anitha S, Ahmetaj-Shala Blerina, Jiao Jing, Herschman Harvey R, Xiaomeng Wang, Wahli Walter, Santos Robson A, Mitchell Jane A
Cyclooxygenase-2 Selectively Controls Renal Blood Flow Through a Novel
PPARβ/δ-Dependent Vasodilator Pathway
Hypertension (Dallas, Tex. : 1979),
2018; 71(2):
297-305.
Lin Meng-Chieh, Chen Shih-Yin, He Pei-Lin, Herschman Harvey, Li Hua-Jung
PGE
International journal of cancer,
2018; 143(6):
1440-1455.
Xu Shili, Catapang Arthur, Braas Daniel, Stiles Linsey, Doh Hanna M, Lee Jason T, Graeber Thomas G, Damoiseaux Robert, Shirihai Orian, Herschman Harvey R
A precision therapeutic strategy for hexokinase 1-null, hexokinase
2-positive cancers
Cancer & metabolism,
2018; 6:
7.
Xu, S., Catapang, A., Doh, H.M., Bayley, N.A., Lee, J.T., Braas, D., Graeber, T.G., Herschman, H.R.
Hexokinase-2 is targetable for HK1 negative, HK2 positive tumors from a wide variety of tissues of origin,
J. Nucl. Med,
2018; 59:
.