No-Hee Park, D.M.D., Ph.D.

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A Short Biography:

No-Hee Park, D.M.D., Ph.D. is dean emeritus of the UCLA School of Dentistry. He is also a distinguished professor of Medicine in the David Geffen School of Medicine at UCLA, as well as the distinguished professor of dentistry at the UCLA School of Dentistry. He was the first Korean-born American to be appointed dean in a major U.S. University. On June 30, 2016, after 18 years of service as dean of the School, Dr. Park retired from the position and returned to his academic life for teaching, research and service programs. Dr. No-Hee Park is known as a major scientist in the oral and craniofacial research community with over 185 scientific research publications. His contribution to the understanding of the mechanisms of oral cancer development has been enormous, which has resulted in a new mode of therapy.
Work Titles
UCLA Dean Emeritus, Distinguished Professor, Dentistry Distinguished Professor, Hematology-Oncology Distinguished Professor, Medicine
Education:
Degrees:
D.M.D., Harvard School of Dental Medicine, Boston, MA, 1980 - 1982
Ph.D., Medical College of Georgia, Augusta, GA, 1971 - 1978
Academic Experience:
1978 - 1980 Virology, Eye Res. Institute, Harvard Medical School, Boston, MA

Contact Information:

Work Email Address:

nhpark@dentistry.ucla.edu


Website:

UCLA School of Dentistry

Work Phone Number:

(310) 825-0339

Mailing Address:

10833 Le Conte Avenue Rm 43-005 CHS
Los Angeles, CA 90095


Work Address:

Office
10833 La Conte Avenue
43-005
Los Angeles, CA 90095


Detailed Biography:

Dr. No-Hee Park is a prominent scientist in oral and craniofacial research, with more than 185 scientific publications in distinguished research journals. His major research activities have been in oral (head & neck) cancer and aging research. Dr. Park's contribution to the understanding of the mechanisms of oral cancer development is enormous, and resulted in new mode of therapy. In the early stage of his career (1975-1983), Dr. Park developed animal models to evaluate the therapeutic efficacy of antiviral agents and to study the molecular mechanisms of numerous antiviral agents (e.g., Zovirax®) against herpes simplex virus. In later stages of his research career (since 1983), Dr. Park began to investigate the mechanisms of human oral cancer development. Initially, he found the combined carcinogenicity of herpes simplex virus (HSV: this virus causes cold sores around the human mouth) and cancer-causing chemicals found in tobacco. Then he investigated and clearly documented the combined role of tobacco (or chemical carcinogens derived from tobacco extract) and the virus on the development of oral cancer in laboratory animals. More recently, Dr. Park (1) developed an in vitro system (extremely useful for studying the mechanisms of oral cancer development) and clearly documented the role of human papillomavirus (HPV: this virus causes warts and may be related to other cancers) in the development of oral cancer; (2) clearly documented the close association between chromosome (cellular DNA) instability and cancer development; (3) developed many cell lines that are useful for cancer research; (4) documented a new aging model in test tubes, using cells derived from the human mouth; and (5) successfully converted normal human epithelial cells into mesenchymal cells, which were able to differentiate to bony cells and fat cells. Currently his major interests are in the areas of cellular aging, molecular carcinogenesis and stem cell research. Through his cancer and aging research, Dr. Park has provided significant contributions to enhance the wellbeing of individuals and society, particularly by elucidating the role of human papillomavirus in the development of human cancer. Dr. Park’s research has been well funded by both NIH and private foundations, and he has been a member of many research organizations, including American Association for Advanced Science (AAAS), American Association for Cancer Research (AACR), International Association for Dental Research (IADR), American Society for Microbiology (ASM), etc. He has also served on Editorial Boards for many research journals, including European Journal of Cancer (Oral Oncology), Journal of Dental Research, International Journal of Oncology, Journal of Biotechnology, Odontology, and International Journal of Oral Biology. Additionally, for more than a decade, Dr. Park has served as a member of a number of NIH grant review committees for both the National Cancer Institute and the National Institute of Dental Research. Dr. Park has received numerous awards and honors, and recognition by his peers, including the Distinguished Scientist Award from International Association for Dental Research (IADR), Alumnus of the Year Awards from Medical College of Georgia and Seoul National University (both School of Dentistry and University wide), the Award as the Most Achieved Dental Educator from the Gies /ADEA (American Dental Education Association) Foundation, the Silver Anniversary Award from Harvard University, No-Hee Park Endowed Chair at UCLA, Distinguished Professorship at UCLA, and AAAS (American Association for Advancement of Science) Fellow, etc. Dr. Park received his DDS (Doctor of Dental Surgery) degree from the Seoul National University College of Dentistry in 1968 and a clinical certificate in Periodontics in 1971. He received his PhD in Pharmacology in 1978 from the Medical College of Georgia, completed his postdoctoral fellowship at the Harvard Medical School-affiliated Eye Research Institute and earned his DMD (Doctor of Medicine in Dentistry) degree from the Harvard School of Dental Medicine in 1982. He then served two years as faculty at Harvard Medical School and Harvard School of Dental Medicine, before joining the faculty of the UCLA School of Dentistry in 1984. He became Director of the UCLA Dental Research Institute in 1995, where he served until June 2002, and in 1997, he was appointed Associate Dean for Research at the School of Dentistry and created the UCLA Wound Healing Research Center. As dean for 18 years, from 1998-2016, he directed a $90 million enterprise with 400 full and part-time faculty, 450 students (DDS, PhD, and MS Programs), 91 dental residents, over 100 foreign clinical trainees, and a staff of 300 employees. He has also trained more than 100 research students, postdoctoral fellows, and visiting faculty members from overseas during the past several decades. Most of his trainees are presently faculty members of dental schools, medical schools and colleges of life science in the United States and many other countries including Europe, Korea, Japan and China.

Publications:

A selected list of publications:

Gong D, Wu NC, Xie Y, Feng J, Tong L, Brulois KF, Luan H, Du Y, Jung JU, Wang CY, Kang MK, Park NH, Sun R, Wu TT.   Kaposi's sarcoma-associated herpesvirus ORF18 and ORF30 are essential for late gene expression during lytic replication Journal of Virology, 2014; 88(19): 11369-82.
Yu B, Chang J, Liu Y, Li J, Hezaimi KA, Park N-H, Wang C-Y   Non-Canonical Wnt4 Prevents Skeletal Aging and Inflammation by Inhibiting NF-κB Nature Medicine, 2014; 20(9): 1009-17.
Chen W, Liu ZX, Shin KH, Oh JE, Kim RH, Jiang M, Park N-H, Kang MK   Grainyhead-like 2 (GRHL2) inhibits keratinocyte differentiation through epigenetic mechanism Cell Death and Disease, 2012; Dec 20(3): e450.
Ye Ling, Fan Zhipeng, Yu Bo, Chang Jia, Al Hezaimi Khalid, Zhou Xuedong, Park No-Hee, Wang Cun-Yu   Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs Cell Stem cell, 2012; 11(1): 50-61.
Lee Sung Hee, Hong Hannah S, Liu Zi Xiao, Kim Reuben H, Kang Mo K, Park No-Hee, Shin Ki-Hyuk   TNFα enhances cancer stem cell-like phenotype via Notch-Hes1 activation in oral squamous cell carcinoma cells Biochemical and biophysical research communications, 2012; 424(1): 58-64.
Shin Ki-Hyuk, Pucar Ana, Kim Reuben H, Bae Susan D, Chen Wei, Kang Mo K, Park No-Hee   Identification of senescence-inducing microRNAs in normal human keratinocytes International journal of oncology, 2011; 39(5): 1205-11.
Zhang Lei, Xiao Hua, Zhou Hui, Santiago Silverio, Lee Jay M, Garon Edward B, Yang Jieping, Brinkmann Ole, Yan Xinmin, Akin David, Chia David, Elashoff David, Park No-Hee, Wong David T W   Development of transcriptomic biomarker signature in human saliva to detect lung cancer Cellular and Molecular Life Sciences : CMLS, 2012; 69(19): 3341-50.
Dong Qinghua, Oh Ju-Eun, Chen Wei, Kim Roy, Kim Reuben H, Shin Ki-Hyuk, McBride William H, Park No-Hee, Kang Mo K   Radioprotective effects of Bmi-1 involve epigenetic silencing of oxidase genes and enhanced DNA repair in normal human keratinocytes The Journal of investigative dermatology, 2011; 131(6): 1216-25.
Oh Ju-Eun, Kim Reuben H, Shin Ki-Hyuk, Park No-Hee, Kang Mo K   DeltaNp63α protein triggers epithelial-mesenchymal transition and confers stem cell properties in normal human keratinocytes The Journal of biological chemistry, 2011; 286(44): 38757-67.
Shin Ki-Hyuk, Bae Susan D, Hong Hannah S, Kim Reuben H, Kang Mo K, Park No-Hee   miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras Biochemical and biophysical research communications, 2011; 404(4): 896-902.
Chen Wei, Dong Qinghua, Shin Ki-Hyuk, Kim Reuben H, Oh Ju-Eun, Park No-Hee, Kang Mo K   Grainyhead-like 2 enhances the human telomerase reverse transcriptase gene expression by inhibiting DNA methylation at the 5'-CpG island in normal human keratinocytes The Journal of biological chemistry, 2010; 285(52): 40852-63.
Kim Reuben H, Lieberman Mark B, Lee Rachel, Shin Ki-Hyuk, Mehrazarin Shebli, Oh Ju-Eun, Park No-Hee, Kang Mo K   Bmi-1 extends the life span of normal human oral keratinocytes by inhibiting the TGF-beta signaling Experimental cell research, 2010; 316(16): 2600-8.
Tseng Han-Ching, Arasteh Aida, Paranjpe Avina, Teruel Antonia, Yang Wendy, Behel Armin, Alva Jackelyn A, Walter Gina, Head Christian, Ishikawa Tomo-o, Herschman Harvey R, Cacalano Nicholas, Pyle April D, Park No-Hee, Jewett Anahid   Increased lysis of stem cells but not their differentiated cells by natural killer cells; de-differentiation or reprogramming activates NK cells PloS one, 2010; 5(7): e11590.
Zhang Lei, Farrell James J, Zhou Hui, Elashoff David, Akin David, Park No-Hee, Chia David, Wong David T   Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer Gastroenterology, 2010; 138(3): 949-57.e1-7.
Kang X, W Chen, RH Kim, M Kang and N-H Park   Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells Oncogene, 2009; 28: 565-574.
Kim Reuben H, Kim Roy, Chen Wei, Hu Shen, Shin Ki-Hyuk, Park No-Hee, Kang Mo K   Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells Carcinogenesis, 2008; 29(12): 2425-31.
Shin Ki-Hyuk, Kim Reuben H, Kim Roy H, Kang Mo K, Park No-Hee   hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip Biochemical and biophysical research communications, 2008; 372(4): 880-5.
Cacalano Nicholas A, Le David, Paranjpe Avina, Wang Mei-Ying, Fernandez Augustine, Evazyan Tandik, Park No-Hee, Jewett Anahid   Regulation of IGFBP6 gene and protein is mediated by the inverse expression and function of c-jun N-terminal kinase (JNK) and NFkappaB in a model of oral tumor cells Apoptosis : an international journal on programmed cell death, 2008; 13(12): 1439-49.
Shin Ki-Hyuk, Kim Reuben H, Kang Mo K, Kim Roy H, Kim Steve G, Lim Philip K, Yochim Ji Min, Baluda Marcel A, Park No-Hee   p53 promotes the fidelity of DNA end-joining activity by, in part, enhancing the expression of heterogeneous nuclear ribonucleoprotein G DNA repair, 2007; 6(6): 830-40.
Kim Reuben H, Kang Mo K, Shin Ki-Hyuk, Oo Zin M, Han Thomas, Baluda Marcel A, Park No-Hee   Bmi-1 cooperates with human papillomavirus type 16 E6 to immortalize normal human oral keratinocytes Experimental cell research, 2007; 313(3): 462-72.
Oh K.J., Kalinina A., Park N.-H. and Bagchi S.   Deregulation of eIF4E: 4E-BP1 in differentiated human papillomavirus-containing cells leads to high levels of expression of the E7 oncoprotein J. Virol, 2006; 80: 7079-7088.
Shin Ki-Hyuk, Kang Mo K, Kim Reuben H, Christensen Russell, Park No-Hee   Heterogeneous nuclear ribonucleoprotein G shows tumor suppressive effect against oral squamous cell carcinoma cells Clinical cancer research : an official journal of the American Association for Cancer Research, 2006; 12(10): 3222-8.
Kang Mo K, Kim Reuben H, Shin Ki-Hyuk, Zhong Weiguong, Faull Kym F, Park No-Hee   Senescence-associated decline in the intranuclear accumulation of hOGG1-alpha and impaired 8-oxo-dG repair activity in senescing normal human oral keratinocytes in vivo Experimental cell research, 2005; 310(1): 186-95.
Kang Mo K, Shin Ki-Hyuk, Yip Felix K, Park No-Hee   Normal human oral keratinocytes demonstrate abnormal DNA end joining activity during replicative senescence Mechanisms of ageing and development, 2005; 126(4): 475-9.
Li Y, St John MA, Zhou X, Kim Y, Sinha U, Jordan RC, Eisele D, Abemayor E, Elashoff D,Park NH, Wong DT   Salivary transcriptome diagnostics for oral cancer detection Clinical cancer research : an official journal of the American Association for Cancer Research. , 2004; 10(24): 8442-50.
Kang MK, Kameta A, Baluda MA, Park NH   Telomere shortening does not occur during postmaturational aging in situ in normal human oral fibroblasts Mech Ageing Dev, 2003; 124(8-9): 873-6.
Kang MK, Kameta A, Shin KH, Baluda MA, Kim HR, Park NH   Senescence-associated genes in normal human oral keratinocytes Experimental cell research. , 2003; 287(2): 272-81.
Chow Yen-Hung, Yu Duan, Zhang Jun-Ying, Xie Yiming, Wei O Lu-Chen, Chiu Christopher, Foroohar Mani, Yang Otto O, Park No-Hee, Chen Irvin S Y, Pang Shen   gp120-Independent infection of CD4(-) epithelial cells and CD4(+) T-cells by HIV-1 Journal of acquired immune deficiency syndromes (1999), 2002; 30(1): 1-8.
Kang Mo K, Swee Jerry, Kim Reuben H, Baluda Marcel A, Park No-Hee   The telomeric length and heterogeneity decrease with age in normal human oral keratinocytes Mechanisms of ageing and development, 2002; 123(6): 585-92.
Liu, X., Nishitani, J., McQuirter J.L., Baluda, M. and Park, N.-H.   The temperature sensitive mutant p53-143ala extends in vitro life span, promotes errors in DNA replication and impairs DNA repair in normal human oral keratinocytes Cell. Mol. Biol. , 2002; 47: 1169-1178.
Pang, S., Kang, M., Kung, S, Yu, D., Lee, A., Poon, B., Chen, I.S.Y. and Park, N.-H.   Anticancer effect of lentiviral vector capable of expressing HIV-1 Vpr Clinical Cancer Res, 2001; 7: 3567-3573.
Kim, H., Christensen, R., Kang, M., Park, Noh-Hyun, Sapp, P. and Park, N.-H.   Elevated expression of hTERT is associated with dysplastic cell transformation during human oral carcinogenesis in situ Clinical Cancer Res, 2001; 7: 3079-3086.
Pang S, Yu D, An D S, Baldwin G C, Xie Y, Poon B, Chow Y H, Park N H, Chen I S   Human immunodeficiency virus Env-independent infection of human CD4(-) cells Journal of virology, 2000; 74(23): 10994-1000.
Zhou, H, Lin, A., Gu, Z., Chen, S., Park, N.-H. and Chiu, R.   TPA-induced JNK phospatase inhibition required for JNK activity induced by TPA in immortalized or transformed epithelial cells J. Biol. Chem, 2000; 275: 22868-22875.
Kang, M., Bibb, C., Baluda, M. A., Rey O. and Park, N.-H.   In vitro replication and differentiation of normal human oral keratinocytes Experimental Cell Res (featured article of the Journal), 2000; 258: 288-297.
Shuster, M.,I., Han, L., Le Beau, M.M., Davis, E., Sawicki, M., Lese, C.M., Park, N.-H., Colicelli, J., Gollin, S. M.   Consistent pattern of RIN1 rearrangements in oral squamous cell carcinoma cell lines support a breakage-fusion-bridge cycle model for 11q13 amplification Genes, Chromosomes, & Cancer , 2000; 28: 153-163.
Rey O, Lee S and Park, N.-H.   The E7 oncoprotein of the human papillomavirus type 16 represses the transcription of human fibronectin Journal of Virology , 2000; 74: 4912-4918.
Rey, O., Lee, S., Baluda, M.A. and Park, N.-H.   The E7 oncoprotein of human papillomavirus type-16 interacts with F-actin in vivo and in vitro Virology (featured article of the journal), 2000; 268: 372-381.
Rey O, Lee S, Park N H   Impaired nucleotide excision repair in UV-irradiated human oral keratinocytes immortalized with type 16 human papillomavirus genome Oncogene, 1999; 18(50): 6997-7001.
Min, B. M., Woo, K. M., Lee, G. and Park, N.-H.   Terminal differentiation of normal human oral keratinocytes is associated with enhanced cellular TGF-β and phospholipase c-γ1 levels, and apoptotic cell death Experimental Cell Res, 1999; 249(2): 377-385.
Chang, D.D., Park, N.-H., Denny, C., Nelson, S. and Pe, M   Characterization of Gene Expression Differences during Oral Carcinogenesis by Parallel Analysis of Differentially Expressed Gene Fragments using Arrayed Filters Oncogene, 1998; 16(15): 1921-1930.
Kang, M.K., Guo, W. and Park, N.-H.   Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening telomeres Cell Growth & Differentiation, 1998; 9(1): 85-95.
Guo, W., Baluda, M.A. and Park, N.-H.   Ethanol upregulates the expression of p21WAF1/CIP1 and prolongs G1 transition via a p53-independent pathway in human epithelial cells, Oncogene, 1997; 15: 1143-1149.
Liu, X., Han, S., Baluda, M.A. and Park N.-H.   HPV-16 oncogenes E6 and E7 are mutagenic in normal human oral keratinocytes Oncogene, 1997; 14: 2347-2353.
Shin, K.-H., Tannyhill, R.J., Liu, X. and Park, N.-H.   Oncogenic transformation of HPV-immortalized human oral keratinocytes is associated with the genomic instability of cell Oncogene, 1996; 12: 1089-1096.
Park, N.-H., Gujuluva, C.N., Baek, J.-H., Min, B.-M. Cherrick, H.M. and Shin, K.-H.   Combined oral carcinogenicity of HPV-16 and benzo(a)pyrene: An in vitro multistep carcinogenesis model Oncogene, 1995; 10: 2145-2153.
Gujuluva C N, Baek J H, Shin K H, Cherrick H M, Park N H   Effect of UV-irradiation on cell cycle, viability and the expression of p53, gadd153 and gadd45 genes in normal and HPV-immortalized human oral keratinocytes Oncogene, 1994; 9(7): 1819-27.
Shin K H, Min B M, Cherrick H M, Park N H   Combined effects of human papillomavirus-18 and N-methyl-N'-nitro-N-nitrosoguanidine on the transformation of normal human oral keratinocytes Molecular carcinogenesis, 1994; 9(2): 76-86.
Kim Reuben H, Kang Mo K, Kim Terresa, Yang Paul, Bae Susan, Williams Drake W, Phung Samantha, Shin Ki-Hyuk, Hong Christine, Park No-Hee   Regulation of p53 during senescence in normal human keratinocytes Aging cell, 2015; 14(5): 838-46.
Perez Ricardo E, Shen Hong, Duan Lei, Kim Reuben H, Kim Terresa, Park No-Hee, Maki Carl G   Modeling the Etiology of p53-mutated Cancer Cells The Journal of biological chemistry, 2016; 291(19): 10131-47.
Chen Wei, Yi Jin Kyu, Shimane Tetsu, Mehrazarin Shebli, Lin Yi-Ling, Shin Ki-Hyuk, Kim Reuben H, Park No-Hee, Kang Mo K   Grainyhead-like 2 regulates epithelial plasticity and stemness in oral cancer cells Carcinogenesis, 2016; 37(5): 500-10.
Mehrazarin Shebli, Chen Wei, Oh Ju-Eun, Liu Zi X, Kang Kyung L, Yi Jin K, Kim Reuben H, Shin Ki-Hyuk, Park No-Hee, Kang Mo K   The p63 Gene Is Regulated by Grainyhead-like 2 (GRHL2) through Reciprocal Feedback and Determines the Epithelial Phenotype in Human Keratinocytes The Journal of biological chemistry, 2015; 290(32): 19999-20008.
Lee Sung Hee, Lee Chang-Ryul, Rigas Nicole Kristina, Kim Reuben H, Kang Mo K, Park No-Hee, Shin Ki-Hyuk   Human papillomavirus 16 (HPV16) enhances tumor growth and cancer stemness of HPV-negative oral/oropharyngeal squamous cell carcinoma cells via miR-181 regulation Papillomavirus research (Amsterdam, Netherlands), 2015; 1(2): 116-125.
Lee Sung Hee, Rigas Nicole Kristina, Lee Chang-Ryul, Bang April, Srikanth Sonal, Gwack Yousang, Kang Mo K, Kim Reuben H, Park No-Hee, Shin Ki-Hyuk   Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma Oncotarget, 2016; 7(28): 43239-43255.
Williams Drake W, Lee Cindy, Kim Terresa, Yagita Hideo, Wu Hongkun, Park Sil, Yang Paul, Liu Honghu, Shi Songtao, Shin Ki-Hyuk, Kang Mo K, Park No-Hee, Kim Reuben H   Impaired bone resorption and woven bone formation are associated with development of osteonecrosis of the jaw-like lesions by bisphosphonate and anti-receptor activator of NF-κB ligand antibody in mice The American journal of pathology, 2014; 184(11): 3084-93.
Lee Dong-Keun, Kim Sue Vin, Limansubroto Adelheid Nerisa, Yen Albert, Soundia Akrivoula, Wang Cun-Yu, Shi Wenyuan, Hong Christine, Tetradis Sotirios, Kim Yong, Park No-Hee, Kang Mo K, Ho Dean   Nanodiamond-Gutta Percha Composite Biomaterials for Root Canal Therapy ACS nano, 2015; 9(11): 11490-501.
Lee Sung Hee, Park Yongtae, Song Minju, Srikanth Sonal, Kim Sol, Kang Mo K, Gwack Yousang, Park No-Hee, Kim Reuben H, Shin Ki-Hyuk   Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells Biochemical and biophysical research communications, 2016; 473(4): 1309-1314.
Kim Sol, Williams Drake W, Lee Cindy, Kim Terresa, Arai Atsushi, Shi Songtao, Li Xinmin, Shin Ki-Hyuk, Kang Mo K, Park No-Hee, Kim Reuben H   IL-36 Induces Bisphosphonate-Related Osteonecrosis of the Jaw-Like Lesions in Mice by Inhibiting TGF-β-Mediated Collagen Expression Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017; 32(2): 309-318.
Sohn S, Park Y, Srikanth S, Arai A, Song M, Yu B, Shin K-H, Kang M K, Wang C, Gwack Y, Park N-H, Kim R H   The Role of ORAI1 in the Odontogenic Differentiation of Human Dental Pulp Stem Cells Journal of dental research, 2015; 94(11): 1560-7.

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