Charles R. Marshall


Work Titles
UCLA Associate Professor, Medicine Member, Molecular Biology

Contact Information:

Work Phone Number:

(310) 206-2303

(310) 206-2304

Detailed Biography:

Research Interest: An analysis of how the complex promoter of the early development gene even-skipped (eve) evolved in Drosophila. My laboratory focuses on evolutionary problems, drawing on data and experimental procedures from developmetal biology, genetics, paleontology and molecular & morphological phylogenetics. Current projects include: 1) An analysis of how the complex promoter of the early development gene even-skipped (eve) evolved in Drosophila. To this end we are characterizing the eve promoter in a more primitive insect, the red flour beetle Tribolium. 2) A phylogenetic analysis of sea urchins using the taxonomic distribution of middle repetitive DNA families within the group. The approach should be the first homoplasy-free molecular phylogenetic approach, unless there has been fairly extensive horizontal transfer of DNA between the urchin species. 3) We are also actively exploring new statistical approaches for assessing the robustness of phylogenetic trees and assessing the incompleteness of the fossil record. There is also a general interest in the how the fossil and rocks records contribute to our understanding of evolution. Students are encouraged to develop their own projects under the broad evolutionary umbrella within the laboratory and, if necessary, in conjunction with other laboratories at UCLA.

Publications:

A selected list of publications:

Marshall, C.R.   Mass extinction probed, Nature, 1998; 392: 17-19.
Maley, LE Marshall, CR   The coming of age of molecular systematics Science. , 1998; 279(5350): 505-6.
Marshall, C.R.   Statistical and computational problems in reconstructing evolutionary histories from DNA data, Computing Science and Statistics, 1997; 29(2): 218-226.
Marshall, CR Ward, PD   Sudden and Gradual Molluscan Extinctions in the Latest Cretaceous of Western European Tethys Science, 1996; 274(5291): 1360-3.
Hirsch, AM McKhann, HI Reddy, A Liao, J Fang, Y Marshall, CR   Assessing horizontal transfer of nifHDK genes in eubacteria: nucleotide sequence of nifK from Frankia strain HFPCcI3 Molecular biology and evolution. , 1995; 12(1): 16-27.
Marshall, C.R   Confidence intervals on stratigraphic ranges: partial relaxation of the assumption of a random distribution of fossil horizons, Paleobiology, 1994; 20: 459-469.
Marshall, C.R., E.C. Raff, and R.A. Raff   Dollo?s law and the death and resurrection of genes, Proceedings of the National Academy of Sciences, 1994; 91: 12283-12287.
Raff, R.A., C.R. Marshall, and J.M. Turbeville   Using DNA sequences to unravel the Cambrian radiation of the animal phyla, Annual Review of Ecology and Systematics, 1994; 25: 351-375.
Marshall, C Schultze, HP   Relative importance of molecular, neontological, and paleontological data in understanding the biology of the vertebrate invasion of land Journal of molecular evolution. , 1992; 35(2): 93-101.
Marshall, CR   Character analysis and the integration of molecular and morphological data in an understanding of sand dollar phylogeny Molecular biology and evolution. , 1992; 9(2): 309-22.
Marshall, CR   Substitution bias, weighted parsimony, and amniote phylogeny as inferred from 18S rRNA sequences Molecular biology and evolution. , 1992; 9(2): 370-7; author reply 378.
Marshall, CR   Statistical tests and bootstrapping: assessing the reliability of phylogenies based on distance data Molecular biology and evolution. , 1991; 8(3): 386-91.

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