Research in the Carpenter laboratory addresses the role of reelin signaling in regulating cell migration in the brain and mammary gland. Reelin signaling has been widely recognized as an essential factor in determining cell position during brain development. The Carpenter laboratory has developed a mouse model that explores interactions between reelin signaling and embryonic exposure to organophosphate pesticides, both of which are implicated as contributing factors to autism. These studies have shown that decreased reelin signaling can cause identifiable changes in cell position and morphology, and that the addition of pesticide exposure can affect both of these things. The Carpenter laboratory has also demonstrated a unique role for reelin signaling in regulating the development of the mouse mammary gland. Loss of reelin signaling impacts mammary ductal development, and direct exposure to reelin affects the migratory ability of mammary epithelial cells. Recent findings have also demonstrated a role for reelin signaling in regulating the metastatic migration of breast cancer cells.
Vosko Andrew, van Diepen Hester C, Kuljis Dika, Chiu Andrew M, Heyer Djai, Terra Huub, Carpenter Ellen, Michel Stephan, Meijer Johanna H, Colwell Christopher S Role of vasoactive intestinal peptide in the light input to the circadian system The European journal of neuroscience, 2015; 42(2): 1839-48.
Carpenter Ellen M, Llamas Carlos, Buck Billy E, Malinin Theodore I Induction of neural tissue markers by micronized human spinal cord implants Journal of neuroscience research, 2015; 93(3): 495-503.
Barrientos-DurÃ¡n Antonio, Carpenter Ellen M, Zur Nieden Nicole I, Malinin Theodore I, RodrÃguez-Manzaneque Juan Carlos, Zanello Laura P Carboxyl-modified single-wall carbon nanotubes improve bone tissue formation in vitro and repair in an in vivo rat model International journal of nanomedicine, 2014; 9(4): 4277-91.
Abadesco Autumn D, Cilluffo Marianne, Yvone Griselda M, Carpenter Ellen M, Howell Brian W, Phelps Patricia E Novel Disabled-1-expressing neurons identified in adult brain and spinal cord The European journal of neuroscience, 2014; 39(4): 579-92.
Mullen Brian R, Khialeeva Elvira, Hoffman Daniel B, Ghiani Cristina A, Carpenter Ellen M Decreased reelin expression and organophosphate pesticide exposure alters mouse behaviour and brain morphology ASN neuro, 2013; 5(1): e00106.
Rebustini Ivan T, Hayashi Toru, Reynolds Andrew D, Dillard Melvin L, Carpenter Ellen M, Hoffman Matthew P miR-200c regulates FGFR-dependent epithelial proliferation via Vldlr during submandibular gland branching morphogenesis Development (Cambridge, England), 2012; 139(1): 191-202.
Hirose Megumi, Niewiadomski Pawel, Tse Gary, Chi Gloria C, Dong Hongmei, Lee Alice, Carpenter Ellen M, Waschek James A Pituitary adenylyl cyclase-activating peptide counteracts hedgehog-dependent motor neuron production in mouse embryonic stem cell cultures Journal of neuroscience research, 2011; 89(9): 1363-74.
Khialeeva, E., Lane, T. F., and Carpenter, E. M. Disruption of reelin signaling alters mammary gland morphogenesis, Development, 2011; 138: 767-778.
Khialeeva Elvira, Lane Timothy F, Carpenter Ellen M Disruption of reelin signaling alters mammary gland morphogenesis Development (Cambridge, England), 2011; 138(4): 767-76.
Ghiani Cristina A, Mattan Natalia S, Nobuta Hiroko, Malvar Jemily S, Boles Julie, Ross Michael G, Waschek James A, Carpenter Ellen M, Fisher Robin S, de Vellis Jean Early effects of lipopolysaccharide-induced inflammation on foetal brain development in rat ASN neuro, 2011; 3(4): .
Hostikka, S. L., Gong, J., and Carpenter, E. M. Axial and appendicular skeletal transformation, ligament alterations, and motor neuron loss in Hoxc10 mutants, International Journal of Biological Sciences, 2009; 5: 397-410.
Misra, M., Shah, V., Carpenter, E., McCaffery, P., and Lance-Jones, C Restricted patterns of Hoxd10 and Hoxd11 set segmental differences in motoneurons subtype complement in the lumbosacral spinal cord, Developmental Biology, 2009; 330: 54-72.
Misra Mala, Shah Veeral, Carpenter Ellen, McCaffery Peter, Lance-Jones Cynthia Restricted patterns of Hoxd10 and Hoxd11 set segmental differences in motoneuron subtype complement in the lumbosacral spinal cord Developmental biology, 2009; 330(1): 54-72.
Hostikka Sirkka Liisa, Gong Jun, Carpenter Ellen M Axial and appendicular skeletal transformations, ligament alterations, and motor neuron loss in Hoxc10 mutants International journal of biological sciences, 2009; 5(5): 397-410.
Malinin Theodore I, Carpenter Ellen M, Temple H Thomas Particulate bone allograft incorporation in regeneration of osseous defects; importance of particle sizes The open orthopaedics journal, 2007; 1(1): 19-24.
Carpenter Ellen M, Gendler El, Malinin Theodore I, Temple H Thomas Effect of hydrogen peroxide on osteoinduction by demineralized bone American journal of orthopedics (Belle Mead, N.J.), 2006; 35(12): 562-7.
Choe Andrea, Phun Huy Q, Tieu David D, Hu Yan Hong, Carpenter Ellen M Expression patterns of Hox10 paralogous genes during lumbar spinal cord development Gene expression patterns : GEP, 2006; 6(7): 730-7.
Choe, A., Phun, H. Q., Tieu, D. D., Hy, Y. H., and Carpenter, E. M. Expression patterns of Hox10 paralogous genes during lumbar spinal cord development Gene Expression Patterns, 2006; 7: 730-737.
Hedlund, E., Karsten, S. L., Kudo, L., Geschwind, D. H., and Carpenter, E. M. Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development Journal of Neuroscience Research, 2004; 75: 307-319.
Hedlund Eva, Karsten Stanislav L, Kudo Lili, Geschwind Daniel H, Carpenter Ellen M Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development Journal of neuroscience research, 2004; 75(3): 307-19.
Lin Amy W, Carpenter Ellen M Hoxa10 and Hoxd10 coordinately regulate lumbar motor neuron patterning Journal of neurobiology, 2003; 56(4): 328-37.
Carpenter, EM Hox genes and spinal cord development Developmental Neuroscience. , 2002; 24(1): 24-34.
Anderson Tonya R, Hedlund Eva, Carpenter Ellen M Differential Pax6 promoter activity and transcript expression during forebrain development Mechanisms of development, 2002; 114(1-2): 171-5.
Anderson, TR Hedlund, E Carpenter, EM Differential Pax6 promoter activity and transcript expression during forebrain development Mechanisms of Development. , 2002; 114(1-2): 171-5.
Carpenter Ellen M Hox genes and spinal cord development Developmental neuroscience, 2002; 24(1): 24-34.
Wahba, GM Hostikka, SL Carpenter, EM The paralogous Hox genes Hoxa10 and Hoxd10 interact to pattern the mouse hindlimb peripheral nervous system and skeleton Developmental Biology. , 2001; 231(1): 87-102.
de la Cruz, CC Der-Avakian, A Spyropoulos, DD Tieu, DD Carpenter, EM Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development Developmental Biology. , 1999; 216(2): 595-610.
Carpenter, EM Goddard, JM Davis, AP Nguyen, TP Capecchi, MR Targeted disruption of Hoxd-10 affects mouse hindlimb development Development (Cambridge, England) , 1997; 124(22): 4505-14.
Carpenter, EM Goddard, JM Chisaka, O Manley, NR Capecchi, MR Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain Development (Cambridge, England) , 1993; 118(4): 1063-75.
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