Laboratory
635 Charles E Young Drive South
NRB 304
Los Angeles, CA 90095
Office
Department of Psychiatry and Biobehavioral Sciences
Mental Retardation Research Center
635 Charles E Young Drive South
NRB 303
Mail Code 733222
Los Angeles, CA 90095
Research in the Carpenter laboratory addresses the role of reelin signaling in regulating cell migration in the brain and mammary gland. Reelin signaling has been widely recognized as an essential factor in determining cell position during brain development. The Carpenter laboratory has developed a mouse model that explores interactions between reelin signaling and embryonic exposure to organophosphate pesticides, both of which are implicated as contributing factors to autism. These studies have shown that decreased reelin signaling can cause identifiable changes in cell position and morphology, and that the addition of pesticide exposure can affect both of these things. The Carpenter laboratory has also demonstrated a unique role for reelin signaling in regulating the development of the mouse mammary gland. Loss of reelin signaling impacts mammary ductal development, and direct exposure to reelin affects the migratory ability of mammary epithelial cells. Recent findings have also demonstrated a role for reelin signaling in regulating the metastatic migration of breast cancer cells.
Does this profile need updating? Contact Us