Sotirios Ray Tetradis, D.D.S., Ph.D.


Work Titles
CTSI Member, CTSI
UCLA Professor, Dentistry Advisor, Oral Biology PhD Program Member, JCCC Signal Transduction and Therapeutics Program Area
Education:
Degrees:
D.D.S., University of Athens, Greece, 1985 - 1989
Ph.D., University of Connecticut Health Center, CT, 1989 - 1996
Education:
1996 University of Connecticut Health Center, CT, Oral Radiology

Contact Information:

Email Address:

sotirist@dent.ucla.edu

Work Email Address:

stetradis@dentistry.ucla.edu


Website:

Web-Profile

Fax Number:

310-206-6485

Work Phone Number:

310-825-2880

310-825-5712

Laboratory Address:

Laboratory
10833 Le Conte Ave.
CHS 53-031
Los Angeles, CA 90095


Office Address:

10833 Le Conte Avenue
CHS 53-068
Los Angeles, CA 90095


Detailed Biography:

Sotirios Tetradis, D.D.S., Ph.D. is a professor and the chair of the Section of Oral and Maxillofacial Radiology in the Division of Diagnostic and Surgical Sciences at the UCLA School of Dentistry. He also serves as an advisor to the combined D.D.S./Ph.D. program in oral biology. "To create knowledge, educate bright students, participate in patient care, and be in the forefront of technologic advances are exciting qualities of an academic career. UCLA offers the perfect combination of all in my clinical and research interest areas

Publications:

Deconde Adam S, Sidell Douglas, Lee Min, Bezouglaia Olga, Low Kyle, Elashoff David, Grogan Tristan, Tetradis Sotirios, Aghaloo Tara, St John Maie   Bone morphogenetic protein-2-impregnated biomimetic scaffolds successfully induce bone healing in a marginal mandibular defect The Laryngoscope, 2013; 123(5): 1149-55.
Oliveira Matheus L, Tosoni Guilherme M, Lindsey David H, Mendoza Kristopher, Tetradis Sotirios, Mallya Sanjay M   Influence of anatomical location on CT numbers in cone beam computed tomography Oral surgery, oral medicine, oral pathology and oral radiology, 2013; 115(4): 558-64.
Kang Ben, Cheong Simon, Chaichanasakul Thawinee, Bezouglaia Olga, Atti Elisa, Dry Sarah M, Pirih Flavia Q, Aghaloo Tara L, Tetradis Sotirios   Periapical disease and bisphosphonates induce osteonecrosis of the jaws in mice Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2013; 115(4): .
Barghan Sevin, Tetradis Sotirios, Nervina Jeanne M   Skeletal and soft-tissue incidental findings on cone-beam computed tomography images American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2013; 143(6): 888-892.
Pirih Flavia, Lu Jinxiu, Ye Fei, Bezouglaia Olga, Atti Elisa, Ascenzi Maria-Grazia, Tetradis Sotirios, Demer Linda, Aghaloo Tara, Tintut Yin   Adverse effects of hyperlipidemia on bone regeneration and strength Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2012; 27(2): 309-18.
Barghan S, Tetradis S, Mallya Sm   Application of cone beam computed tomography for assessment of the temporomandibular joints Australian dental journal, 2012; 57 Suppl 1(6): 109-18.
Sidell Douglas R, Aghaloo Tara, Tetradis Sotirios, Lee Min, Bezouglaia Olga, DeConde Adam, St John Maie A   Composite mandibulectomy: a novel animal model Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2012; 146(6): 932-7.
Barghan Sevin, Merrill Robert, Tetradis Sotirios   Cone beam computed tomography imaging in the evaluation of the temporomandibular joint Texas dental journal, 2012; 129(3): 289-302.
Tetradis Sotirios, White Stuart C, Service Susan K   Dental x-rays and risk of meningioma; the jury is still out The journal of evidence-based dental practice, 2012; 12(3): 174-7.
Ghazalpour Anatole, Rau Christoph D, Farber Charles R, Bennett Brian J, Orozco Luz D, van Nas Atila, Pan Calvin, Allayee Hooman, Beaven Simon W, Civelek Mete, Davis Richard C, Drake Thomas A, Friedman Rick A, Furlotte Nick, Hui Simon T, Jentsch J David, Kostem Emrah, Kang Hyun Min, Kang Eun Yong, Joo Jong Wha, Korshunov Vyacheslav A, Laughlin Rick E, Martin Lisa J, Ohmen Jeffrey D, Parks Brian W, Pellegrini Matteo, Reue Karen, Smith Desmond J, Tetradis Sotirios, Wang Jessica, Wang Yibin, Weiss James N, Kirchgessner Todd, Gargalovic Peter S, Eskin Eleazar, Lusis Aldons J, LeBoeuf Renée C   Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits Mammalian genome : official journal of the International Mammalian Genome Society, 2012; 23(9-10): 680-92.
Dwyer Jennifer R, Donkor Jimmy, Zhang Peixiang, Csaki Lauren S, Vergnes Laurent, Lee Jessica M, Dewald Jay, Brindley David N, Atti Elisa, Tetradis Sotirios, Yoshinaga Yuko, De Jong Pieter J, Fong Loren G, Young Stephen G, Reue Karen   Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(37): E2486-95.
Tyndall Donald A, Price Jeffery B, Tetradis Sotirios, Ganz Scott D, Hildebolt Charles, Scarfe William C, Scarfe William C   Position statement of the American Academy of Oral and Maxillofacial Radiology on selection criteria for the use of radiology in dental implantology with emphasis on cone beam computed tomography Oral surgery, oral medicine, oral pathology and oral radiology, 2012; 113(6): 817-26.
Tetradis Sotirios, Anstey Paul, Graff-Radford Steven   Cone beam computed tomography in the diagnosis of dental disease Texas dental journal, 2011; 128(7): 620-8.
Sage Andrew P, Lu Jinxiu, Atti Elisa, Tetradis Sotirios, Ascenzi Maria-Grazia, Adams Douglas J, Demer Linda L, Tintut Yin   Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011; 26(6): 1197-206.
Verdelis K, Lukashova L, Atti E, Mayer-Kuckuk P, Peterson M G E, Tetradis S, Boskey A L, van der Meulen M C H   MicroCT morphometry analysis of mouse cancellous bone: intra- and inter-system reproducibility Bone, 2011; 49(3): 580-7.
Chen Weiwei, Zhang Xinli, Siu Ronald K, Chen Feng, Shen Jia, Zara Janette N, Culiat Cymbeline T, Tetradis Sotirios, Ting Kang, Soo Chia   Nfatc2 is a primary response gene of Nell-1 regulating chondrogenesis in ATDC5 cells Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011; 26(6): 1230-41.
Johnson Jared S, Meliton Vicente, Kim Woo Kyun, Lee Kwang-Bok, Wang Jeffrey C, Nguyen Khanhlinh, Yoo Dongwon, Jung Michael E, Atti Elisa, Tetradis Sotirios, Pereira Renata C, Magyar Clara, Nargizyan Taya, Hahn Theodore J, Farouz Francine, Thies Scott, Parhami Farhad   Novel oxysterols have pro-osteogenic and anti-adipogenic effects in vitro and induce spinal fusion in vivo Journal of cellular biochemistry, 2011; 112(6): 1673-84.
Aghaloo Tara L, Kang Ben, Sung Eric C, Shoff Michael, Ronconi Matthew, Gotcher Jack E, Bezouglaia Olga, Dry Sarah M, Tetradis Sotirios   Periodontal disease and bisphosphonates induce osteonecrosis of the jaws in the rat Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011; 112(6): .
Tetradis Sotirios, White Stuart C   A decade of cone beam computed tomography Journal of the California Dental Association, 2010; 38(1): 24-6.
Graham Lucia S, Tintut Yin, Parhami Farhad, Kitchen Christina M R, Ivanov Yevgeniv, Tetradis Sotirios, Effros Rita B   Bone density and hyperlipidemia: the T-lymphocyte connection Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2010; 25(11): 2460-9.
Barghan Sevin, Merrill Robert, Tetradis Sotirios   Cone beam computed tomography imaging in the evaluation of the temporomandibular joint Journal of the California Dental Association, 2010; 38(1): 33-9.
Tetradis Sotirios, Anstey Paul, Graff-Radford Steven   Cone beam computed tomography in the diagnosis of dental disease Journal of the California Dental Association, 2010; 38(1): 27-32.
Sage Andrew P, Lu Jinxiu, Atti Elisa, Tetradis Sotirios, Ascenzi Maria-Grazia, Adams Douglas J, Demer Linda L, Tintut Yin   Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2010; 10(6): .
Zinman Edwin J, White Stuart C, Tetradis Sotirios   Legal considerations in the use of cone beam computer tomography imaging Journal of the California Dental Association, 2010; 38(1): 49-56.
Chen Weiwei, Zhang Xinli, Siu Ronald K, Chen Feng, Shen Jia, Zara Janette N, Culiat Cymbeline T, Tetradis Sotirios, Ting Kang, Soo Chia   Nfatc2 is a primary response gene of Nell-1 regulating chondrogenesis in ATDC5 cells Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2010; 10(6): .
Kim Woo-Kyun, Meliton Vicente, Tetradis Sotirios, Weinmaster Gerry, Hahn Theodore J, Carlson Marc, Nelson Stanley F, Parhami Farhad   Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2010; 25(4): 782-95.
Aghaloo T L, Chaichanasakul T, Bezouglaia O, Kang B, Franco R, Dry S M, Atti E, Tetradis S   Osteogenic potential of mandibular vs. long-bone marrow stromal cells Journal of dental research, 2010; 89(11): 1293-8.
Aghaloo Tara L, Felsenfeld Alan L, Tetradis Sotirios   Osteonecrosis of the jaw in a patient on Denosumab Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2010; 68(5): 959-63.
Yarbrough Daniel K, Hagerman Elizabeth, Eckert Randal, He Jian, Choi Hyewon, Cao Nga, Le Karen, Hedger Jennifer, Qi Fengxia, Anderson Maxwell, Rutherford Bruce, Wu Ben, Tetradis Sotiris, Shi Wenyuan   Specific binding and mineralization of calcified surfaces by small peptides Calcified tissue international, 2010; 86(1): 58-66.
Armstrong Jonathan K, Han Bo, Kuwahara Kenrick, Yang Zhi, Magyar Clara E, Dry Sarah M, Atti Elisa, Tetradis Sotirios, Fisher Timothy C   The effect of three hemostatic agents on early bone healing in an animal model BMC surgery, 2010; 10(6): 37.
Kim Woo-Kyun, Meliton Vicente, Park Kye Won, Hong Cynthia, Tontonoz Peter, Niewiadomski Pawel, Waschek James A, Tetradis Sotirios, Parhami Farhad   Negative regulation of Hedgehog signaling by liver X receptors Molecular endocrinology (Baltimore, Md.), 2009; 23(10): 1532-43.
Moldovan Sanda M, Nervina Jeanne M, Tetradis Sotirios, Camargo Paulo M   Regulation of Nur77 gene expression by prostanoids in cementoblastic cells Archives of oral biology, 2009; 54(5): 412-9.
Pirih Flavia Q, Abayahoudian Rosette, Elashoff David, Parhami Farhad, Nervina Jeanne M, Tetradis Sotirios   Nuclear receptor profile in calvarial bone cells undergoing osteogenic versus adipogenic differentiation Journal of cellular biochemistry, 2008; 105(5): 1316-26.
Magyar Clara E, Aghaloo Tara L, Atti Elisa, Tetradis Sotirios   Ostene, a new alkylene oxide copolymer bone hemostatic material, does not inhibit bone healing Neurosurgery, 2008; 63(4 Suppl 2): 373-8; discussion 378.
Amantea Christopher M, Kim Woo-Kyun, Meliton Vicente, Tetradis Sotirios, Parhami Farhad   Oxysterol-induced osteogenic differentiation of marrow stromal cells is regulated by Dkk-1 inhibitable and PI3-kinase mediated signaling Journal of cellular biochemistry, 2008; 105(2): 424-36.
Huang Michael S, Morony Sean, Lu Jinxiu, Zhang Zina, Bezouglaia Olga, Tseng Wendy, Tetradis Sotirios, Demer Linda L, Tintut Yin   Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts The Journal of biological chemistry, 2007; 282(29): 21237-43.
Richardson Jennifer A, Amantea Christopher M, Kianmahd Benjamin, Tetradis Sotirios, Lieberman Jay R, Hahn Theodore J, Parhami Farhad   Oxysterol-induced osteoblastic differentiation of pluripotent mesenchymal cells is mediated through a PKC- and PKA-dependent pathway Journal of cellular biochemistry, 2007; 100(5): 1131-45.
Aghaloo Tara L, Amantea Christopher M, Cowan Catherine M, Richardson Jennifer A, Wu Ben M, Parhami Farhad, Tetradis Sotirios   Oxysterols enhance osteoblast differentiation in vitro and bone healing in vivo Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2007; 25(11): 1488-97.
Pham L, Bezouglaia O, Camargo P M, Nervina J M, Tetradis S   Prostanoids induce egr1 gene expression in cementoblastic OCCM cells Journal of periodontal research, 2007; 42(5): 486-93.
Waterman Wayne R, Xu Li Lian, Tetradis Sotirios, Motyckova Gabriela, Tsukada Junichi, Saito Kazuyoshi, Webb Andrew C, Robinson Dwight R, Auron Philip E   Glucocorticoid inhibits the human pro-interleukin lbeta gene (ILIB) by decreasing DNA binding of transactivators to the signal-responsive enhancer Molecular immunology, 2006; 43(7): 773-82.
Nervina Jeanne M, Magyar Clara E, Pirih Flavia Q, Tetradis Sotirios   PGC-1alpha is induced by parathyroid hormone and coactivates Nurr1-mediated promoter activity in osteoblasts Bone, 2006; 39(5): 1018-25.
Aghaloo Tara L, Pirih Flavia Q, Shi Andrew, Bezouglaia Olga, Tetradis Sotirios   Parathyroid hormone induces mitogen-activated kinase phosphatase 1 in murine osteoblasts primarily through cAMP-protein kinase A signaling Journal of periodontology, 2006; 77(1): 21-30.
Nervina Jeanne M, Camargo Paulo M, Bezouglaia Olga, Tetradis Sotirios   Prostanoid- and interleukin-1-induced primary genes in cementoblastic cells Journal of periodontology, 2006; 77(8): 1362-70.
Pirih Flavia Q, Aghaloo Tara L, Bezouglaia Olga, Nervina Jeanne M, Tetradis Sotirios   Parathyroid hormone induces the NR4A family of nuclear orphan receptors in vivo Biochemical and biophysical research communications, 2005; 332(2): 494-503.
Camargo P M, Lagos R, Pirih F Q M, Benitez A, Nervina J M, Tetradis S   Prostaglandins E(2) and F(2alpha) enhance differentiation of cementoblastic cells Journal of periodontology, 2005; 76(2): 303-9.
Pirih Flavia Q, Tang Alan, Ozkurt Ibrahim C, Nervina Jeanne M, Tetradis Sotirios   Nuclear orphan receptor Nurr1 directly transactivates the osteocalcin gene in osteoblasts The Journal of biological chemistry, 2004; 279(51): 53167-74.
Kha Hoa Ton, Basseri Benjamin, Shouhed Daniel, Richardson Jennifer, Tetradis Sotirios, Hahn Theodore J, Parhami Farhad   Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2004; 19(5): 830-40.
Tetradis Sotirios, Kantor Mel L   Anomalies of the odontoid process discovered as incidental findings on cephalometric radiographs American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2003; 124(2): 184-9.
Nervina J M, Tetradis S, Huang Y-F, Harrison D, Molina C, Kream B E   Expression of inducible cAMP early repressor is coupled to the cAMP-protein kinase A signaling pathway in osteoblasts Bone, 2003; 32(5): 483-90.
Pirih Flavia Q, Nervina Jeanne M, Pham Lee, Aghaloo Tara, Tetradis Sotirios   Parathyroid hormone induces the nuclear orphan receptor NOR-1 in osteoblasts Biochemical and biophysical research communications, 2003; 306(1): 144-50.
Ozkurt Ibrahim C, Tetradis Sotirios   Parathyroid hormone-induced E4BP4/NFIL3 down-regulates transcription in osteoblasts The Journal of biological chemistry, 2003; 278(29): 26803-9.
Tintut Yin, Parhami Farhad, Tsingotjidou Anastasia, Tetradis Sotirios, Territo Mary, Demer Linda L   8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway The Journal of biological chemistry, 2002; 277(16): 14221-6.
Zhang Yuzhi, Kaur Manjit, Price Brendan D, Tetradis Sotirios, Makrigiorgos G Mike   An amplification and ligation-based method to scan for unknown mutations in DNA Human mutation, 2002; 20(2): 139-47.
Kaur Manjit, Zhang Yuzhi, Liu Wei-Hua, Tetradis Sotirios, Price Brendan D, Makrigiorgos G Mike   Ligation of a primer at a mutation: a method to detect low level mutations in DNA Mutagenesis, 2002; 17(5): 365-74.
Tetradis S, Bezouglaia O, Tsingotjidou A   Parathyroid hormone induces expression of the nuclear orphan receptor Nurr1 in bone cells Endocrinology, 2001; 142(2): 663-70.
Tetradis S, Bezouglaia O, Tsingotjidou A, Vila A   Regulation of the nuclear orphan receptor Nur77 in bone by parathyroid hormone Biochemical and biophysical research communications, 2001; 281(4): 913-6.
Zhang Y, Price B D, Tetradis S, Chakrabarti S, Maulik G, Makrigiorgos G M   Reproducible and inexpensive probe preparation for oligonucleotide arrays Nucleic acids research, 2001; 29(13): E66-6.
Chakrabarti S, Price B D, Tetradis S, Fox E A, Zhang Y, Maulik G, Makrigiorgos G M   Highly selective isolation of unknown mutations in diverse DNA fragments: toward new multiplex screening in cancer Cancer research, 2000; 60(14): 3732-7.
Wara-aswapati N, Yang Z, Waterman W R, Koyama Y, Tetradis S, Choy B K, Webb A C, Auron P E   Cytomegalovirus IE2 protein stimulates interleukin 1beta gene transcription via tethering to Spi-1/PU.1 Molecular and cellular biology, 1999; 19(10): 6803-14.
White S C, Yoon D C, Tetradis S   Digital radiography in dentistry: what it should do for you Journal of the California Dental Association, 1999; 27(12): 942-52.
Maulik G, Botchway S, Chakrabarti S, Tetradis S, Price B, Makrigiorgos G M   Novel non-isotopic detection of MutY enzyme-recognized mismatches in DNA via ultrasensitive detection of aldehydes Nucleic acids research, 1999; 27(5): 1316-22.
Hurley M M, Tetradis S, Huang Y F, Hock J, Kream B E, Raisz L G, Sabbieti M G   Parathyroid hormone regulates the expression of fibroblast growth factor-2 mRNA and fibroblast growth factor receptor mRNA in osteoblastic cells Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1999; 14(5): 776-83.
Tetradis S, Kantor M L   Prevalence of skeletal and dental anomalies and normal variants seen in cephalometric and other radiographs of orthodontic patients American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 1999; 116(5): 572-7.
Tetradis S, Nervina J M, Nemoto K, Kream B E   Parathyroid hormone induces expression of the inducible cAMP early repressor in osteoblastic MC3T3-E1 cells and mouse calvariae Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1998; 13(12): 1846-51.
Kream B E, Tetradis S, Lafrancis D, Fall P M, Feyen J H, Raisz L G   Modulation of the effects of glucocorticoids on collagen synthesis in fetal rat calvariae by insulin-like growth factor binding protein-2 Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1997; 12(6): 889-95.
Tetradis S, Scaf G, Lurie A G, Freedman M L   Niobium filtration of conventional and high-frequency x-ray generator beams for intraoral radiography. Effects on absorbed doses, image density and contrast, and photon spectra Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1995; 80(2): 232-41.

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