Anahid Jewett, Ph.D., M.P.H.

A Short Biography:

Dr. Jewett is Professor and Director of tumor immunology laboratory in the Division of Oral Biology and Medicine, and Wintraub Center for reconstructive biotechnology at UCLA School of Medicine and Dentistry. She has membership in Johnsson Comprehensive Cancer Center (JCCC) and is a member of UCLA Tumor Immunology subgroup.

Work Titles
UCLA Professor, Dentistry
Education:
Degrees:
Ph.D.
M.P.H.

Contact Information:

Work Email Address:

ajewett@ucla.edu


Work Phone Number:

(310) 206-3970

Work Address:

Division of Oral Biology, School of Dentistry
Campus - 166815
CA

Office
CHS B3-088
CA


Research Interest:

Dr. Jewett’s work is concentrated on the mechanisms of inactivation and cell death of Natural Killer cells. These cells play crucial effector functions in the host defense against viral and bacterial infections and malignant transformation. Dr. Jewett has shown that cytotoxic function of NK cells is significantly suppressed in the tumor microenvironment by a number of distinct effectors. She has previously demonstrated the role of NK cells in specific elimination of stem cells and not their differentiated counterparts. Indeed, she was the first to coin the term “split anergy” for the function of NK cells. She has also discovered that there is a stage wise susceptibility to NK cell mediated cytotoxicity in many tumors in which case the poorly differentiated tumors were lysed much more than their moderately differentiated tumors. The well differentiated tumors were lysed the least when compared to either the moderately differentiated tumors or to poorly differentiated tumors. She have also reported that inhibition of differentiation or reversion of cells to a less-differentiated stage by blocking key genes significantly augmented NK cell cytotoxicity against both transformed and healthy cells. Therefore, she has proposed that the two stages of NK cell maturation namely CD16+CD56dimCD69- NK cells were important for the selection of stem cells whereas the CD16dim/-CD56dim/+CD69+NK cells were important for differentiation and eventual regeneration of the tissues and the resolution of inflammation, thus serving as regulatory NK cells (NKreg). The concept of split anergy in NK cells and generation of NKreg and its contribution to cell differentiation, tissue repair and regeneration and in tumor resistance remains important areas of studies in her laboratory. In addition to studies on NK cells she also works on two other projects: 1- the mechanism of toxicity and allergic responses induced by HEMA and TEGDMA and 2-bacterial mediated regulation of immune function. Briefly, she has determined the detailed mechanisms of uptake and clearance of HEMA and TEGDMA, two chemical resins, which are in widespread use as biomaterials in dentistry. Finally, she has characterized an oral bacterium, which induces significant levels of lymphocyte apoptosis. Moreover, she is now studying the role of probiotics in conditioning of NK cells to support differentiation, tissue repair and regeneration and resolution of inflammation.

Detailed Biography:

Dr. Jewett joined the faculty of School of Dentistry in 1997 after being a member of the department of Microbiology and Immunology in UCLA School of Medicine, and since then she has trained more than 100 students at different stages of their graduate, dental and medical careers in her laboratory. She received her Master’s degree in infectious disease epidemiology from School of Public Health at UCLA and her doctorate degree from the departments of Microbiology and Immunology and pathology at UCLA School of Medicine. She has received a number of honors and awards and holds memberships in a number of professional organizations. She serves on the editorial board of journals including Journal of Cancer, PLOS journals, Journal of Immunology , Journal of Clinical Immunology, Journal of Infection and Immunity, Journal of Cellular Immunology, Journal of Leukocyte Biology, Journal of Dental Research, American Journal of Pathology and Blood, to name a few. She was a reviewed member of NIH study section “innate immunity and inflammation” and has been serving on several NIH study sections notably “Innate Immunity and Host Disease”, ‘Transplantation, Tolerance and Tumor Immunology” and “Immunology fellowships”. She has also served as a grant reviewer for proposals from other countries such as England, Qatar, Amsterdam to name a few. She holds a number of patents, and has given more than 150 invited lectures and presentations and has published more than 80 articles in high impact factor peer reviewed journals. She has active on-going research collaborations nationally and internationally with investigators from Slovenia, Poland, Germany, Thailand, Japan, Portugal, South Korea and Sweden. She has served as a member of the organizing committee for a number of national and international conferences. She has served as the Principal investigator on NIH funded studies in oral cancer and resin toxicity and hypersensitivity in addition to a number of other intramural and extramural funding. She currently serves on a number of schoolwide senate committees and she was the chair of Research Advisory Committee in the School of Dentistry, and currently serves as the chair of Rules and Jurisdictions campuswide.

Publications:

Kozlowska Anna K, Kaur Kawaljit, Topchyan Paytsar, Jewett Anahid   Novel strategies to target cancer stem cells by NK cells; studies in humanized mice Frontiers in bioscience (Landmark edition), 2017; 22: 370-384.
Kozlowska Anna K, Kaur Kawaljit, Topchyan Paytsar, Jewett Anahid   Adoptive transfer of osteoclast-expanded natural killer cells for immunotherapy targeting cancer stem-like cells in humanized mice Cancer immunology, immunotherapy : CII, 2016; 65(7): 835-45.
Latham Jason, Fong Hanson, Jewett Anahid, Johnson James D, Paranjpe Avina   Disinfection Efficacy of Current Regenerative Endodontic Protocols in Simulated Necrotic Immature Permanent Teeth Journal of endodontics, 2016; 42(8): 1218-25.
Sun Yujie, Kaur Kawaljit, Kanayama Keiichi, Morinaga Kenzo, Park Sil, Hokugo Akishige, Kozlowska Anna, McBride William H, Li Jun, Jewett Anahid, Nishimura Ichiro   Plasticity of Myeloid Cells during Oral Barrier Wound Healing and the Development of Bisphosphonate-related Osteonecrosis of the Jaw The Journal of biological chemistry, 2016; 291(39): 20602-16.
Aptsiauri Natalia, Jewett Anahid, Hurwitz Arthur A, Shurin Michael R, Umansky Viktor   Redefining cancer immunotherapy-optimization, personalization, and new predictive biomarkers: 4th Cancer Immunotherapy and Immunomonitoring (CITIM) meeting, April 27-30, 2015, Ljubljana, Slovenia Cancer immunology, immunotherapy : CII, 2016; 65(7): 875-83.
Kozlowska Anna K, Tseng Han-Ching, Kaur Kawaljit, Topchyan Paytsar, Inagaki Akihito, Bui Vickie T, Kasahara Noriyuki, Cacalano Nicholas, Jewett Anahid   Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells Cancer immunology, immunotherapy : CII, 2016; 65(9): 1085-97.
Bui Vickie T, Tseng Han-Ching, Kozlowska Anna, Maung Phyu Ou, Kaur Kawaljit, Topchyan Paytsar, Jewett Anahid   Augmented IFN-γ and TNF-α Induced by Probiotic Bacteria in NK Cells Mediate Differentiation of Stem-Like Tumors Leading to Inhibition of Tumor Growth and Reduction in Inflammatory Cytokine Release; Regulation by IL-10 Frontiers in immunology, 2015; 6(7): 576.
Tseng Han-Ching, Kanayama Keiichi, Kaur Kawaljit, Park So-Hyun, Park Sil, Kozlowska Anna, Sun Shuting, McKenna Charles E, Nishimura Ichiro, Jewett Anahid   Bisphosphonate-induced differential modulation of immune cell function in gingiva and bone marrow in vivo: role in osteoclast-mediated NK cell activation Oncotarget, 2015; 6(24): 20002-25.
Halder Ramesh C, Almasi Anasheh, Sagong Bien, Leung Jessica, Jewett Anahid, Fiala Milan   Curcuminoids and ω-3 fatty acids with anti-oxidants potentiate cytotoxicity of natural killer cells against pancreatic ductal adenocarcinoma cells and inhibit interferon γ production Frontiers in physiology, 2015; 6(28): 129.
Tseng Han-Ching, Arasteh Aida, Kaur Kawaljit, Kozlowska Anna, Topchyan Paytsar, Jewett Anahid   Differential Cytotoxicity but Augmented IFN-γ Secretion by NK Cells after Interaction with Monocytes from Humans, and Those from Wild Type and Myeloid-Specific COX-2 Knockout Mice Frontiers in immunology, 2015; 6(28): 259.
Tseng Han-Ching, Inagaki Akihito, Bui Vickie T, Cacalano Nicholas, Kasahara Noriyuki, Man Yan-Gao, Jewett Anahid   Differential Targeting of Stem Cells and Differentiated Glioblastomas by NK Cells Journal of Cancer, 2015; 6(9): 866-76.
Tseng Han-Ching, Kanayama Keiichi, Kaur Kawaljit, Park So-Hyun, Park Sil, Kozlowska Anna, Sun Shuting, McKenna Charles E, Nishimura Ichiro, Jewett Anahid   Erratum: Bisphosphonate-induced differential modulation of immune cell function in gingiva and bone marrow in vivo: Role in osteoclast-mediated NK cell activation Oncotarget, 2015; 6(38): 41398.
Marcela Romero Reyes and Anahid Jewett   Increased activation and survival of immune effectors during anti-TNF-α therapy: Lessons learned from TNF-/- mice, New Approaches combating Cancer & Aging, 2015; 2: 76-88.
Rezzadeh Kameron S, Hokugo Akishige, Jewett Anahid, Kozlowska Anna, Segovia Luis Andres, Zuk Patricia, Jarrahy Reza   Natural Killer Cells Differentiate Human Adipose-Derived Stem Cells and Modulate Their Adipogenic Potential Plastic and reconstructive surgery, 2015; 136(3): 503-10.
Park Sil, Kanayama Keiichi, Kaur Kawaljit, Tseng Han-Ching Helen, Banankhah Sina, Quje Davood Talebi, Sayre James W, Jewett Anahid, Nishimura Ichiro   Osteonecrosis of the Jaw Developed in Mice: DISEASE VARIANTS REGULATED BY γδ T CELLS IN ORAL MUCOSAL BARRIER IMMUNITY The Journal of biological chemistry, 2015; 290(28): 17349-66.
Magister Å pela, Tseng Han-Ching, Bui Vickie T, Kos Janko, Jewett Anahid   Regulation of split anergy in natural killer cells by inhibition of cathepsins C and H and cystatin F Oncotarget, 2015; 6(26): 22310-27.
Yan-gao Man, Jinlian Wang, Jeffrey Mason, Ciaran Mannion, Sidney Fu, Anahid Jewett, Izhak, Avital, Alexander Stojadinovic   Can current cell sorting methods capture cancer invasion and metastasis-causing stem cells?, New Approaches combating Cancer & Aging, 2014; 1(1): 1-21.
Shurin Michael R, Umansky Viktor, Malyguine Anatoli, Hurwitz Arthur A, Apte Ron N, Whiteside Theresa, Jewett Anahid, Thanavala Yasmin, Murphy William J   Cellular and molecular pathways in the tumor immunoenvironment: 3rd Cancer Immunotherapy and Immunomonitoring (CITIM) meeting, 22-25 April 2013, Krakow, Poland Cancer immunology, immunotherapy : CII, 2014; 63(1): 73-80.
PeriÅ¡ić Nanut Milica, Sabotič Jerica, Jewett Anahid, Kos Janko   Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells Frontiers in immunology, 2014; 5(11): 616.
Song Guohong, Hsiao Hsuan, Wang Jinlian L, Mannion Ciaran, Stojadinovic Alexander, Avital Itzhak, Fu Sidney W, Mason Jeffrey, Chen Wen, Jewett Anahid, Li Huiping, Man Yan-Gao   Differential impact of tumor-infiltrating immune cells on basal and luminal cells: implications for tumor invasion and metastasis Anticancer research, 2014; 34(11): 6363-80.
Jiang B, Avital I, Bilchik A,, Nissan A, Mason J, Chen W, Mannion C, Jewett A, Wang JL, Stojadinovic A, Man YG   Differential lymphatic involvement in primary site of node positive and negative colorectal cancer , New Approaches combating Cancer & Aging , 2014; 1(1): 29-45.
Tseng Han-Ching, Bui Vickie, Man Yan-Gao, Cacalano Nicholas, Jewett Anahid   Induction of Split Anergy Conditions Natural Killer Cells to Promote Differentiation of Stem Cells through Cell-Cell Contact and Secreted Factors Frontiers in immunology, 2014; 5(4): 269.
Jewett Anahid, Man Yan-gao, Cacalano Nicholas, Kos Janko, Tseng Han-Ching   Natural killer cells as effectors of selection and differentiation of stem cells: role in resolution of inflammation Journal of immunotoxicology, 2014; 11(4): 297-307.
Jiang Bin, Mason Jeffrey, Jewett Anahid, Qian Jun, Ding Yijiang, Cho William C S, Zhang Xichen, Man Yan-gao   Cell budding from normal appearing epithelia: a predictor of colorectal cancer metastasis? International journal of biological sciences, 2013; 9(1): 119-33.
Fang Changge, Man Yan-Gao, Cuttitta Frank, Stetler-Stevenson William, Salomon David, Mazar Andrew, Kulesza Piotr, Rosen Steve, Avital Itzhak, Stojadinovic Alexander, Jewett Anahid, Jiang Bin, Mulshine James   Novel Phenotypic Fluorescent Three-Dimensional Co-Culture Platforms for Recapitulating Tumor in vivo Progression and for Personalized Therapy Journal of Cancer, 2013; 4(9): 755-63.
Anahid Jewett and Han-Ching Tseng,   Tumor microenvironment may shape the function and phenotype of NK cells through the induction of split anergy and generation of regulatory NK cells. , Chapter 15 “The Tumor microenvironment” Edited by Drs. Michael R. Shurin, Viktor Umansky and Anatoli Malyguine, 2013; .
Man Yan-Gao, Stojadinovic Alexander, Mason Jeffrey, Avital Itzhak, Bilchik Anton, Bruecher Bjoern, Protic Mladjan, Nissan Aviram, Izadjoo Mina, Zhang Xichen, Jewett Anahid   Tumor-infiltrating immune cells promoting tumor invasion and metastasis: existing theories Journal of Cancer, 2013; 4(1): 84-95.
Jiang Bin, Mason Jeffrey, Jewett Anahid, Liu Min-ling, Chen Wen, Qian Jun, Ding Yijiang, Ding Shuqing, Ni Min, Zhang Xichen, Man Yan-gao   Tumor-infiltrating immune cells: triggers for tumor capsule disruption and tumor progression? International journal of medical sciences, 2013; 10(5): 475-97.
Anahid Jewett*, Hiromi Nakamura, Meiying Wang, Antonia Teruel, Avina Paranjpe and Marcela Romero   Dedifferentiation of Epithelial Tumors Enhances Cytotoxicity, Survival and Expansion of Allogeneic CD8+ T Cells and Natural Killer Cells J Carcinogen Mutagen , 2012; .
Jewett Anahid, Tseng Han-Ching, Arasteh Aida, Saadat Saba, Christensen Russell E, Cacalano Nicholas A   Natural killer cells preferentially target cancer stem cells; role of monocytes in protection against NK cell mediated lysis of cancer stem cells Current drug delivery, 2012; 9(1): 5-16.
Chaudhari Dipak, Sung Eric C, Paranjpe Avina, Jewett Anahid   Novel strategies to enhance survival and growth of pulp cells after dental restorations Journal of the California Dental Association, 2012; 40(5): 409-17.
Krifka Stephanie, Hiller Karl-Anton, Spagnuolo Gianrico, Jewett Anahid, Schmalz Gottfried, Schweikl Helmut   The influence of glutathione on redox regulation by antioxidant proteins and apoptosis in macrophages exposed to 2-hydroxyethyl methacrylate (HEMA) Biomaterials, 2012; 33(21): 5177-86.
Jiang Bin, Mason Jeffrey, Jewett Anahid, Cho William C S, Man Yan-gao   Tube-like structures with co-expression of D2-40 and CD34: newly formed vasculatures? International journal of biological sciences, 2012; 8(8): 1206-16.
Huynh Tri, Kapur Radhika V, Kaplan Chris W, Cacalano Nicholas, Kinder Haake Susan, Shi Wenyuan, Sieling Peter, Jewett Anahid   The role of aggregation in Fusobacterium nucleatum- induced immune cell death Journal of endodontics, 2011; 37(11): 1531-5.
Mussano Federico, Lee Kenneth J, Zuk Patricia, Tran Lisa, Cacalano Nicholas A, Jewett Anahid, Carossa Stefano, Nishimura Ichiro   Differential effect of ionizing radiation exposure on multipotent and differentiation-restricted bone marrow mesenchymal stem cells Journal of cellular biochemistry, 2010; 111(2): 322-32.
Kaplan Christopher W, Ma Xiaoyuan, Paranjpe Avina, Jewett Anahid, Lux Renate, Kinder-Haake Susan, Shi Wenyuan   Fusobacterium nucleatum outer membrane proteins Fap2 and RadD induce cell death in human lymphocytes Infection and immunity, 2010; 78(11): 4773-8.
JOHN A. YAGIELA AND ANAHID JEWETT   Immunotherapy, Pharmacology, 2010; Chapter 41.
Tseng Han-Ching, Arasteh Aida, Paranjpe Avina, Teruel Antonia, Yang Wendy, Behel Armin, Alva Jackelyn A, Walter Gina, Head Christian, Ishikawa Tomo-o, Herschman Harvey R, Cacalano Nicholas, Pyle April D, Park No-Hee, Jewett Anahid   Increased lysis of stem cells but not their differentiated cells by natural killer cells; de-differentiation or reprogramming activates NK cells PloS one, 2010; 5(7): e11590.
Jewett Anahid, Arasteh Aida, Tseng Han-Ching, Behel Armin, Arasteh Hobie, Yang Wendy, Cacalano Nicholas A, Paranjpe Avina   Strategies to rescue mesenchymal stem cells (MSCs) and dental pulp stem cells (DPSCs) from NK cell mediated cytotoxicity PloS one, 2010; 5(3): e9874.
Tsukimura Naoki, Yamada Masahiro, Aita Hideki, Hori Norio, Yoshino Fumihiko, Chang-Il Lee Masaichi, Kimoto Katsuhiko, Jewett Anahid, Ogawa Takahiro   N-acetyl cysteine (NAC)-mediated detoxification and functionalization of poly(methyl methacrylate) bone cement Biomaterials, 2009; 30(20): 3378-89.
Paranjpe Avina, Cacalano Nicholas A, Hume Wyatt R, Jewett Anahid   N-acetyl cysteine mediates protection from 2-hydroxyethyl methacrylate induced apoptosis via nuclear factor kappa B-dependent and independent pathways: potential involvement of JNK Toxicological sciences : an official journal of the Society of Toxicology, 2009; 108(2): 356-66.
Paranjpe Avina, Cacalano Nicholas A, Hume Wyatt R, Jewett Anahid   Mechanisms of N-acetyl cysteine-mediated protection from 2-hydroxyethyl methacrylate-induced apoptosis Journal of endodontics, 2008; 34(10): 1191-7.
Yamada M, Kojima N, Paranjpe A, Att W, Aita H, Jewett A, Ogawa T   N-acetyl cysteine (NAC)-assisted detoxification of PMMA resin Journal of dental research, 2008; 87(4): 372-7.
Paranjpe A, Sung E C, Cacalano N A, Hume W R, Jewett A   N-acetyl cysteine protects pulp cells from resin toxins in vivo Journal of dental research, 2008; 87(6): 537-41.
Teruel Antonia, Romero Marcela, Cacalano Nicholas A, Head Christian, Jewett Anahid   Potential contribution of naïve immune effectors to oral tumor resistance: role in synergistic induction of VEGF, IL-6, and IL-8 secretion Cancer immunology, immunotherapy : CII, 2008; 57(3): 359-66.
Jewett Anahid, Teruel Antonia, Romero Marcela, Head Christian, Cacalano Nicholas   Rapid and potent induction of cell death and loss of NK cell cytotoxicity against oral tumors by F(ab')2 fragment of anti-CD16 antibody Cancer immunology, immunotherapy : CII, 2008; 57(7): 1053-66.
Cacalano Nicholas A, Le David, Paranjpe Avina, Wang Mei-Ying, Fernandez Augustine, Evazyan Tandik, Park No-Hee, Jewett Anahid   Regulation of IGFBP6 gene and protein is mediated by the inverse expression and function of c-jun N-terminal kinase (JNK) and NFkappaB in a model of oral tumor cells Apoptosis : an international journal on programmed cell death, 2008; 13(12): 1439-49.
Kojima N, Yamada M, Paranjpe A, Tsukimura N, Kubo K, Jewett A, Ogawa T   Restored viability and function of dental pulp cells on poly-methylmethacrylate (PMMA)-based dental resin supplemented with N-acetyl cysteine (NAC) Dental materials : official publication of the Academy of Dental Materials, 2008; 24(12): 1686-93.
Sitko John C, Yeh Brian, Kim Moonhong, Zhou Hong, Takaesu Giichi, Yoshimura Akihiko, McBride William H, Jewett Anahid, Jamieson Christina A M, Cacalano Nicholas A   SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage Cellular signalling, 2008; 20(12): 2221-30.
Wang Chiachien Jake, Iida Keisuke, Egusa Hiroshi, Hokugo Akishige, Jewett Anahid, Nishimura Ichiro   Trabecular bone deterioration in col9a1+/- mice associated with enlarged osteoclasts adhered to collagen IX-deficient bone Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2008; 23(6): 837-49.
Paranjpe Avina, Cacalano Nicholas A, Hume Wyatt R, Jewett Anahid   N-acetylcysteine protects dental pulp stromal cells from HEMA-induced apoptosis by inducing differentiation of the cells Free radical biology & medicine, 2007; 43(10): 1394-408.
Romero-Reyes Marcela, Head Christian, Cacalano Nicholas A, Jewett Anahid   Potent induction of TNF-alpha during interaction of immune effectors with oral tumors as a potential mechanism for the loss of NK cell viability and function Apoptosis : an international journal on programmed cell death, 2007; 12(11): 2063-75.
Jewett Anahid, Cacalano Nicholas A, Head Christian, Teruel Antonia   Coengagement of CD16 and CD94 receptors mediates secretion of chemokines and induces apoptotic death of naive natural killer cells Clinical cancer research : an official journal of the American Association for Cancer Research, 2006; 12(7 Pt 1): 1994-2003.
Jewett A, Head C, Cacalano N A   Emerging mechanisms of immunosuppression in oral cancers Journal of dental research, 2006; 85(12): 1061-73.
Jewett Anahid, Cacalano Nicholas A, Teruel Antonia, Romero Marcela, Rashedi Marjan, Wang Meiying, Nakamura Hiromi   Inhibition of nuclear factor kappa B (NFkappaB) activity in oral tumor cells prevents depletion of NK cells and increases their functional activation Cancer immunology, immunotherapy : CII, 2006; 55(9): 1052-63.
Kaplan CW, Lux R, Huynh T, Jewett A, Shi W, Haake SK   Fusobacterium nucleatum Apoptosis-inducing Outer Membrane Protein Journal of dental research. , 2005; 84(8): 700-4.
Egusa H, Nikawa H, Makihira S, Jewett A, Yatani H, Hamada T   Intercellular adhesion molecule 1-dependent activation of interleukin 8 expression in Candida albicans-infected human gingival epithelial cells Infection and immunity. , 2005; 73(1): 622-6.
Paranjpe A, Bordador L C F, Wang M-Y, Hume W R, Jewett A   Resin monomer 2-hydroxyethyl methacrylate (HEMA) is a potent inducer of apoptotic cell death in human and mouse cells Journal of dental research, 2005; 84(2): 172-7.
David Han, G. Huang. Anahid Jewett   Expression of HLA-Class II, CD70, CD80, CD86 and proinflammatory cytokines is differentially regulated in oral epithelial cells following bacterial challenge, Oral Microbiology and Immunology, 2003; 18: 1-9.
Han DC, Huang GT, Lin LM, Warner NA, Gim JS, Jewett A   Expression of MHC Class II, CD70, CD80, CD86 and pro-inflammatory cytokines is differentially regulated in oral epithelial cells following bacterial challenge Oral microbiology and immunology. , 2003; 18(6): 350-8.
Reichl F X, Durner J, Hickel R, Kunzelmann K H, Jewett A, Wang M Y, Spahl W, Kreppel H, Moes G W, Kehe K, Walther U, Forth W, Hume W R   Distribution and excretion of TEGDMA in guinea pigs and mice Journal of dental research, 2001; 80(5): 1412-5.
Messadi D V, Le A, Berg S, Jewett A, Wen Z, Kelly P, Bertolami C N   Expression of apoptosis-associated genes by human dermal scar fibroblasts Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2000; 7(6): 511-7.
Jewett A, Hume W R, Le H, Huynh T N, Han Y W, Cheng G, Shi W   Induction of apoptotic cell death in peripheral blood mononuclear and polymorphonuclear cells by an oral bacterium, Fusobacterium nucleatum Infection and immunity, 2000; 68(4): 1893-8.
Cavalcanti M, Jewett A, Bonavida B   Irreversible cancer cell-induced functional anergy and apoptosis in resting and activated NK cells International journal of oncology, 1999; 14(2): 361-6.
Mori S, Jewett A, Cavalcanti M, Murakami-Mori K, Nakamura S, Bonavida B   Differential regulation of human NK cell-associated gene expression following activation by IL-2, IFN-alpha and PMA/ionomycin International journal of oncology, 1998; 12(5): 1165-70.
Messadi, D., Jewett, A., Le, A., Berg, S., Wen, Z., Bertolami, C   The role of apoptosis in Keloid Formation, International Journal of Oral Biology, 1998; 31-35.
Jewett A, Cavalcanti M, Giorgi J, Bonavida B   Concomitant killing in vitro of both gp120-coated CD4+ peripheral T lymphocytes and natural killer cells in the antibody-dependent cellular cytotoxicity (ADCC) system Journal of immunology (Baltimore, Md. : 1950), 1997; 158(11): 5492-500.
Jewett, A., Cavalcanti, M., and Bonavida, B   Expression of CD16 and KIR in NK cells signaled for apoptosis, Leukocyte Typing VI: Proceedings of the 6th International Workshop/Conference, 1997; 298-300.
Jewett A, Cavalcanti M, Bonavida B   Pivotal role of endogenous TNF-alpha in the induction of functional inactivation and apoptosis in NK cells Journal of immunology (Baltimore, Md. : 1950), 1997; 159(10): 4815-22.
Mori S, Jewett A, Murakami-Mori K, Cavalcanti M, Bonavida B   The participation of the Fas-mediated cytotoxic pathway by natural killer cells is tumor-cell-dependent Cancer immunology, immunotherapy : CII, 1997; 44(5): 282-90.
Jewett A, Gan X H, Lebow L T, Bonavida B   Differential secretion of TNF-alpha and IFN-gamma by human peripheral blood-derived NK subsets and association with functional maturation Journal of clinical immunology, 1996; 16(1): 46-54.
Stewart S A, Feuer G, Jewett A, Lee F V, Bonavida B, Chen I S   HTLV-1 gene expression in adult T-cell leukemia cells elicits an NK cell response in vitro and correlates with cell rejection in SCID mice Virology, 1996; 226(2): 167-75.
Bonavida, B. and Jewett, A.   Natural killer cells in HIV infection, Chapter 17, Immunology of HIV infections, S. Gupta, ed. Plenum Press, New York, , 1996; 353-364.
Mori S, Murakami-Mori K, Jewett A, Nakamura S, Bonavida B   Resistance of AIDS-associated Kaposi's sarcoma cells to Fas-mediated apoptosis Cancer research, 1996; 56(8): 1874-9.
Jewett A, Bonavida B   Target-induced inactivation and cell death by apoptosis in a subset of human NK cells Journal of immunology (Baltimore, Md. : 1950), 1996; 156(3): 907-15.
Hober D, Jewett A, Bonavida B   Lysis of uninfected HIV-1 gp120-coated peripheral blood-derived T lymphocytes by monocyte-mediated antibody-dependent cellular cytotoxicity FEMS immunology and medical microbiology, 1995; 10(2): 83-91.
Hu P F, Hultin L E, Hultin P, Hausner M A, Hirji K, Jewett A, Bonavida B, Detels R, Giorgi J V   Natural killer cell immunodeficiency in HIV disease is manifest by profoundly decreased numbers of CD16+CD56+ cells and expansion of a population of CD16dimCD56- cells with low lytic activity Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1995; 10(3): 331-40.
Bonavida, B. and Jewett, A.   Maturation, differentiation, and inactivation of human peripheral blood NK cells. In "L'Immuno-Intervention", S. Chouaib and J.M. Mencia-Huerta, eds., Media Science, 1994; 181-1888.
Bonavida B, Braquet M, Lebow L T, Jewett A   Qualitative and quantitative analysis of subpopulations of cytotoxic effector cells by flow cytometry Journal of lipid mediators and cell signalling, 1994; 9(1): 19-25.
Lebow L T, Jewett A, Bonavida B   Killer cell recruitment and renewal capacity of purified cytolytic and noncytolytic human peripheral blood natural killer cell subsets Journal of immunology (Baltimore, Md. : 1950), 1993; 150(1): 320-9.
Bonavida B, Lebow L T, Jewett A   Natural killer cell subsets: maturation, differentiation and regulation Natural immunity, 1993; 12(4-5): 194-208.
Lebow, L.T., Gan, X.-H., Jewett, A., and Bonavida, B.   Induction and secretion of TNF-* during the maturation and differentiation of human natural killer cells, In "Tumor necrosis factor: Structure function relationship and clinical application," T. Osawa and B. Bonavida, eds., Karger Press, Basel,, 1992; 144-151.
Jewett A, Giorgi J V, Bonavida B   Antibody-dependent cellular cytotoxicity against HIV-coated target cells by peripheral blood monocytes from HIV seropositive asymptomatic patients Journal of immunology (Baltimore, Md. : 1950), 1990; 145(12): 4065-71.
Jewett A, Bonavida B   Peripheral blood monocytes derived from HIV+ individuals mediate antibody-dependent cellular cytotoxicity (ADCC) Clinical immunology and immunopathology, 1990; 54(2): 192-9.
Bonavida, B., Jewett, A., and Mencia-Huerta, J.M.   Biology of Platelet Activating Factor (PAF) Interaction with Human Peripheral Blood Monocytes and induction of Tumor Necrosis Factor (TNF) Secretion. , "The Ginkgolides Vol 2", Chemistry, Biology, Pharmacology and Clinical Perspectives, P. Braquet, ed., J. R. Proc. science Publishers, 1989; 2:685-696.
Wright S C, Jewett A, Mitsuyasu R, Bonavida B   Spontaneous cytotoxicity and tumor necrosis factor production by peripheral blood monocytes from AIDS patients Journal of immunology (Baltimore, Md. : 1950), 1988; 141(1): 99-104.

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