Alan Grinnell, Ph.D.

Distinguished Professor, Integrative Biology and Physiology
Professor, Physiology
Associate Dean, Life Sciences
Member, Brain Research Institute, Cell & Developmental Biology GPB Home Area, Center for Duchenne Muscular Dystrophy, Molecular, Cellular & Integrative Physiology GPB Home Area

Contact Information:

Email Address:

adg@ucla.edu

Lab Number:

(310) 825-7870

Office Phone Number:

310-825-4468

Work Address:

Laboratory
CHS
Los Angeles, CA 90095
Office
Dept. of Physiology,
David Geffen School of Medicine at UCLA
Los Angeles, CA 90095

Detailed Biography:

Dr. Grinnell received his B.A. in 1958 and his PhD in 1962, both from Harvard. He did postdoctoral training in the laboratory of Prof. Bernard Katz, University College London (1962-64) and with Prof. T. H. Bullock, UCLA, (1964-65). He was appointed an Assitant Prof. of Biology at UCLA in 1964, Assoc. Prof. in 1966, and Full Prof. in 1971. Since 1972 he has been a Prof. in the Dept. of Physiology. In 1977 he was named Head of the Ahmanson Laboratory of Neurobiology in the BRI, and from 1978-2002 was Director of the Jerry Lewis Neuromuscular Research Center. IN 1997 he joined the Dept. of Physiological Science and chaired that department until 2001. Since 1990, he has been a Researtch Associate of the Fowler Museum of Cultural History.

Publications:

Yazejian Bruce, Yazejian Rita M, Einarsson Rachel, Grinnell Alan D   Simultaneous pre- and post-synaptic electrophysiological recording from Xenopus nerve-muscle co-cultures Journal of visualized experiments : JoVE, 2013; (73): e50253.
Kim Michelle H, Kay Danielle I, Rudra Renuka T, Chen Bo Ming, Hsu Nigel, Izumiya Yasuhiro, Martinez Leonel, Spencer Melissa J, Walsh Kenneth, Grinnell Alan D, Crosbie Rachelle H   Myogenic Akt signaling attenuates muscular degeneration, promotes myofiber regeneration and improves muscle function in dystrophin-deficient mdx mice Human molecular genetics, 2011; 20(7): 1324-38.
Sun Xiao-Ping, Chen Bo-Ming, Sand Olav, Kidokoro Yoshi, Grinnell Alan D   Depolarization-induced Ca2+ entry preferentially evokes release of large quanta in the developing Xenopus neuromuscular junction Journal of neurophysiology, 2010; 104(5): 2730-40.
Grinnell, A.D.   Echolocation I: Behavior, New Encyclopedia of Neuroscience, ed. L. R. Squire, in press,, 2007; .
Grinnell, A.D.   How Muscle Stretch In fluences Neuromuscular Transmission, ed. L. R. Squire, in press, New Encyclopedia of Neuroscience, 2007; .
Sun, X-P, Yazejian, B. and Grinnell, A.D.   Electrophysiological properties of BK channels in Xenopus motor nerve terminals, J. Physiol, 2004; 557: 207-228.
Sun, XP Yazejian, B Grinnell, AD   Electrophysiological properties of BK channels in Xenopus motor nerve terminals The Journal of physiology. , 2004; 557(Pt 1): 207-28.
Sun Xiao-Ping, Yazejian Bruce, Grinnell Alan D   Electrophysiological properties of BK channels in Xenopus motor nerve terminals The Journal of physiology, 2004; 557(Pt 1): 207-28.
Grinnell Alan D, Chen Bo-Ming, Kashani Amir, Lin Jennifer, Suzuki Kazuhiro, Kidokoro Yoshiaki   The role of integrins in the modulation of neurotransmitter release from motor nerve terminals by stretch and hypertonicity Journal of neurocytology, 2004; 32(5-8): 489-503.
Grinnell, A.D., Chen, B.-M., Kashani, A., Lin, J., Suzuki, K., and Kidokoro, Y.   The role of integrins in the modulation of neurotransmitter release from motor nerve terminals by stretch and hypertonicity, J. Neurocytol, 2003; 32: 489-503.
Suzuki, K Grinnell, AD Kidokoro, Y   Hypertonicity-induced transmitter release at Drosophila neuromuscular junctions is partly mediated by integrins and cAMP/protein kinase A The Journal of physiology. , 2002; 538(Pt 1): 103-19.
Sand, O Chen, BM Grinnell, AD   Contribution of L-type Ca(2+) channels to evoked transmitter release in cultured Xenopus nerve-muscle synapses The Journal of physiology. , 2001; 536(Pt 1): 21-33.
Kashani, A., Chen, B.-M., and Grinnell   Osmotic modulation of transmitter release from frog motor nerve terminals: Ca++-independence and role of integrins, J. Physiol, 2001; 530: 243-252.
Yazejian, B, Sun, X.-P, and Grinnell, A.D.   Tracking presynaptic Ca++ dynamics during neurotransmitter release with Ca-activated K+ channels, Nature Neuroscience, 2000; 3: 566-571.
Kalko, E.K.V., Schnitzler, H.-U., Kaipf, I & Grinnell, A.D.   Hunting and echolocation behavior in Noctilio albiventris: the evolution of piscivory, Behavioral Ecology and Sociobiology, 1998; 45: 305-319.
Chen, B.M and Grinnell, A.D.   Kinetics, Ca++ dependence, and biophysical properties of integrin-mediated mechanical modulation of transmitter release from frog motor nerve terminals, J. Neuroscience, 1997; 17: 904-916.
Yazejian, B DiGregorio, DA Vergara, JL Poage, RE Meriney, SD Grinnell, AD   Direct measurements of presynaptic calcium and calcium-activated potassium currents regulating neurotransmitter release at cultured Xenopus nerve-muscle synapses The Journal of neuroscience : the official journal of the Society for Neuroscience. , 1997; 17(9): 2990-3001.
Harada, Y Grinnell, AD   Regeneration of specific innervation in Xenopus pectoralis muscle Journal of neurobiology. , 1996; 31(4): 433-48.
Grinnell, AD Harada, Y   Specificity and development of innervation pattern of Xenopus pectoralis muscle Journal of neurobiology. , 1996; 31(4): 415-32.
Grinnell, AD   Dynamics of nerve-muscle interaction in developing and mature neuromuscular junctions Physiological reviews. , 1995; 75(4): 789-834.
Chen, B.M. and Grinnell, A.D.   Integrins help mediate the stretch-induced modulation of transmitter release from frog motor nerve terminals, Science, 1995; 269: 1578-1580.

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