Work Phone Number:
1 (310) 206-4747
1 (310) 206-7481
Paul Boyer Hall 659
Paul Boyer Hall 655
Chemistry and Biochemistry
Biochemistry, Molecular Biology
UCLA-DOE Institute for Genomics & Proteomics
Molecular Biology Institute
Macromolecular Crystallization Core Facility (DOE)
A Short Biography:
B.A. Carleton College 1981; Ph.D. MIT 1989; Life Sciences Research Council Postdoctoral Fellow, 1989-92; American Cancer Society Postdoctoral Fellow, 1992-3; Assistant Professor, Chemistry and Biochemistry, UCLA, 1993-2000, Associate Professor, Chemistry and Biochemistry, UCLA, 2000-04, Professor, Chemistry and Biochemistry, 2004-present. Protein Society Executive Council (2006-), Editorial Board of Journal of Molecular Biology (2006-), Biochemistry (2006-), Protein Science (2000-) and Proteins (1997-2005), Advisory Board Swedish Biomembrane Center (2005-), Co-chair FASEB summer conference on Mol. Biophys. Cell. Membranes (2006&08). Co-chair Gordon Conference on Proteins (2010&12), Member NIH BBM study section (2006-) Temporary Member NIH BBCB (2001), NIH Biochemistry(2000, 2002) and NIH BBM (2005) Study Sections
Click here for information about the Biochemistry and Molecular Biology (BMB) Graduate Program.
Awards and Honors:
2001 Leukemia & Lymphoma Society
1998 McCoy Award
National Young Investigator
Life Science Research Foundation Postdoctoral Fellowship
American Cancer Society Postdoctoral Fellowship
Bowie got hooked on proteins at an early age and never looked back. The obsession began as a high school student when he did a research project on blood clotting enzymes with Kenneth G. Mann at the Mayo Clinic in his hometown of Rochester, MN. The research project won him a trip to the International Science and Engineering fair and a Westinghouse Award, experiences that further stimulated his interest in science. He went on to Carleton College, where he got a B. A. degree in Chemistry with Distinction. He did research in carbohydrate chemistry with Gary R. Gray at the University of Minnesota before entering graduate school at M.I.T. There he returned to proteins in the laboratory of Robert T. Sauer, using experimental and computational methods to probe and predict protein structure. After completing his Ph.D. work, he did postdoctoral work with David Eisenberg at UCLA, continuing work on structure prediction and structure determination by x-ray crystallography. He joined the UCLA faculty in 1993 and is now a full professor.
Stafford Ryan L, Hinde Elizabeth, Knight Mary Jane, Pennella Mario A, Ear Jason, Digman Michelle A, Gratton Enrico, Bowie James U
Tandem SAM domain structure of human Caskin1: a presynaptic,
self-assembling scaffold for CASK.
Structure (London, England : 1993),
Ryan Christopher M, Souda Puneet, Bassilian Sara, Ujwal Rachna, Zhang Jun, Abramson Jeff, Ping Peipei, Durazo Armando, Bowie James U, Hasan S Saif, Baniulis Danas, Cramer William A, Faull Kym F, Whitelegge Julian P
Post-translational modifications of integral membrane proteins
resolved by top-down Fourier transform mass spectrometry with
collisionally activated dissociation.
Molecular & cellular proteomics : MCP,
Qiao Feng, Bowie James U
The many faces of SAM.
Science's STKE : signal transduction knowledge environment,
Edwards Michelle D, Li Yuezhou, Kim Sanguk, Miller Samantha, Bartlett Wendy, Black Susan, Dennison Sally, Iscla Irene, Blount Paul, Bowie James U, Booth Ian R
Pivotal role of the glycine-rich TM3 helix in gating the MscS
Nature structural & molecular biology,