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Shaping the Future

Elizabeth Breen, Ph.D.

Contact Information:

Work Phone Number:

(310) 206-5738
(310) 794-9247

Mailing Address:

UCLA Department of Psychiatry and Biobehavioral Sciences
300 Medical Plaza, Rm 3160 A
Mail Code 696724
Los Angeles, CA 90095
UNITED STATES

Email Address:

ebreen@mednet.ucla.edu

Work Email Address:

ebreen@ucla.edu

Website:

  

Work:

     Work


Member, Cousins Center for Psychoneuroimmunology

Adjunct Associate Professor, Psychiatry and Biobehavioral Sciences


A Short Biography:

Elizabeth Crabb Breen, M.T.(A.S.C.P.), Ph.D., began her career as a Clinical Laboratory Scientist, and transitioned to human immunology research in the Department of Microbiology & Immunology in the UCLA School of Medicine. She was recruited to join the faculty of the Cousins Center to support its program in Psychoneuroimmunology, and to serve as Co-Director of the Inflammatory Biology Core Laboratory, a joint effort of the Cousins Center and the UCLA Claude Pepper Older Americans Independence Center.

Publications:

Vendrame Elena, Hussain Shehnaz K, Breen Elizabeth Crabb, Magpantay Larry I, Widney Daniel P, Jacobson Lisa P, Variakojis Daina, Knowlton Emilee R, Bream Jay H, Ambinder Richard F, Detels Roger, MartĂ­nez-Maza Otoniel   Serum Levels of Cytokines and Biomarkers for Inflammation and Immune Activation, and HIV-Associated Non-Hodgkin B-Cell Lymphoma Risk Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014; .
Ganz Patricia A, Bower J E, Kwan L, Castellon S A, Silverman D H S, Geist C, Breen E C, Irwin M R, Cole S W   Does tumor necrosis factor-alpha (TNF-?) play a role in post-chemotherapy cerebral dysfunction? Brain, behavior, and immunity, 2013; 30 Suppl(5): S99-108.
Moughrabi Samira, Evangelista Lorraine S, Habib Samer I, Kassabian Leo, Breen Elizabeth Crabb, Nyamathi Adeline, Irwin Michael   In Patients With Stable Heart Failure, Soluble TNF-Receptor 2 Is Associated With Increased Risk for Depressive Symptoms Biological research for nursing, 2013; 22(11): .
Hoyt Michael A, Stanton Annette L, Bower Julienne E, Thomas Kamala S, Litwin Mark S, Breen Elizabeth C, Irwin Michael R   Inflammatory Biomarkers and Emotional Approach Coping in Men with Prostate Cancer Brain, behavior, and immunity, 2013; 41(5): .
Hussain Shehnaz K, Hessol Nancy A, Levine Alexandra M, Breen Elizabeth Crabb, Anastos Kathryn, Cohen Mardge, D'Souza Gypsyamber, Gustafson Deborah R, Silver Sylvia, MartĂ­nez-Maza Otoniel   Serum biomarkers of immune activation and subsequent risk of non-hodgkin B-cell lymphoma among HIV-infected women Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2013; 22(11): 2084-93.
Hussain Shehnaz K, Zhu Weiming, Chang Shen-Chih, Breen Elizabeth Crabb, Vendrame Elena, Magpantay Larry, Widney Dan, Conn Daniel, Sehl Mary, Jacobson Lisa P, Bream Jay H, Wolinsky Steven, Rinaldo Charles R, Ambinder Richard F, Detels Roger, Zhang Zuo-Feng, Martínez-Maza Otoniel   Serum levels of the chemokine CXCL13, genetic variation in CXCL13 and its receptor CXCR5, and HIV-associated non-hodgkin B-cell lymphoma risk Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2013; 22(2): 295-307.
Epstein Mara M, Breen Elizabeth Crabb, Magpantay Larry, Detels Roger, Lepone Lauren, Penugonda Sudhir, Bream Jay H, Jacobson Lisa Paula, MartĂ­nez-Maza Otoniel, Birmann Brenda M   Temporal stability of serum concentrations of cytokines and soluble receptors measured across two years in low-risk HIV-seronegative men Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2013; 22(11): 2009-15.
Pirogovsky Eva, Nicoll Diane R, Challener Dillon M, Breen Elizabeth, Gluhm Shea, Corey-Bloom Jody, Gilbert Paul E   The Visual Spatial Learning Test: Differential impairment during the premanifest and manifest stages of Huntington's disease Journal of neuropsychology, 2013; .
Black David S, Cole Steve W, Irwin Michael R, Breen Elizabeth, St Cyr Natalie M, Nazarian Nora, Khalsa Dharma S, Lavretsky Helen   Yogic meditation reverses NF-ÎşB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial Psychoneuroendocrinology, 2013; 38(3): 348-55.
Creswell J David, Irwin Michael R, Burklund Lisa J, Lieberman Matthew D, Arevalo Jesusa M G, Ma Jeffrey, Breen Elizabeth Crabb, Cole Steven W   Mindfulness-Based Stress Reduction training reduces loneliness and pro-inflammatory gene expression in older adults: a small randomized controlled trial Brain, behavior, and immunity, 2012; 26(7): 1095-101.
Becker Nikolaus, Falster Michael O, Vajdic Claire M, de Sanjose Silvia, Martínez-Maza Otoniel, Bracci Paige M, Melbye Mads, Smedby Karin Ekström, Engels Eric A, Turner Jennifer, Vineis Paolo, Costantini Adele Seniori, Holly Elizabeth A, Spinelli John J, La Vecchia Carlo, Zheng Tongzhang, Chiu Brian C-H, Montella Maurizio, Cocco Pierluigi, Maynadié Marc, Foretova Lenka, Staines Anthony, Brennan Paul, Davis Scott, Severson Richard, Cerhan James R, Breen Elizabeth C, Birmann Brenda, Cozen Wendy, Grulich Andrew E, Newton Robert   Self-reported history of infections and the risk of non-Hodgkin lymphoma: an InterLymph pooled analysis International journal of cancer. Journal international du cancer, 2012; 131(10): 2342-8.
Schultze-Florey Christian R, Martínez-Maza Otoniel, Magpantay Larry, Breen Elizabeth Crabb, Irwin Michael R, Gündel Harald, O'Connor Mary-Frances   When grief makes you sick: bereavement induced systemic inflammation is a question of genotype Brain, behavior, and immunity, 2012; 26(7): 1066-71.
Breen Elizabeth Crabb, Hussain Shehnaz K, Magpantay Larry, Jacobson Lisa P, Detels Roger, Rabkin Charles S, Kaslow Richard A, Variakojis Daina, Bream Jay H, Rinaldo Charles R, Ambinder Richard F, Martinez-Maza Otoniel   B-cell stimulatory cytokines and markers of immune activation are elevated several years prior to the diagnosis of systemic AIDS-associated non-Hodgkin B-cell lymphoma Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011; 20(7): 1303-14.
Regidor Deborah L, Detels Roger, Breen Elizabeth C, Widney Daniel P, Jacobson Lisa P, Palella Frank, Rinaldo Charles R, Bream Jay H, MartĂ­nez-Maza Otoniel   Effect of highly active antiretroviral therapy on biomarkers of B-lymphocyte activation and inflammation AIDS (London, England), 2011; 25(3): 303-14.
Bower Julienne E, Ganz Patricia A, Irwin Michael R, Kwan Lorna, Breen Elizabeth C, Cole Steve W   Inflammation and behavioral symptoms after breast cancer treatment: do fatigue, depression, and sleep disturbance share a common underlying mechanism? Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011; 29(26): 3517-22.
Beachler Daniel C, Gellert Lan L, Jacobson Lisa P, Ambinder Richard F, Breen Elizabeth C, Martínez-Maza Otoniel, Rabkin Charles S, Rabkin Charles C, Kaslow Richard A, D'Souza Gypsyamber   Kaposi sarcoma-associated herpesvirus serum DNA and antibodies not associated with subsequent non-Hodgkin lymphoma risk Journal of acquired immune deficiency syndromes (1999), 2011; 56(2): 188-92.
Breen Elizabeth Crabb, Reynolds Sandra M, Cox Christopher, Jacobson Lisa P, Magpantay Larry, Mulder Candice B, Dibben Oliver, Margolick Joseph B, Bream Jay H, Sambrano Elise, Martínez-Maza Otoniel, Sinclair Elizabeth, Borrow Persephone, Landay Alan L, Rinaldo Charles R, Norris Philip J   Multisite comparison of high-sensitivity multiplex cytokine assays Clinical and vaccine immunology : CVI, 2011; 18(8): 1229-42.
Grulich Andrew E, Vajdic Claire M, Falster Michael O, Kane Eleanor, Smedby Karin Ekstrom, Bracci Paige M, de Sanjose Silvia, Becker Nikolaus, Turner Jenny, Martinez-Maza Otoniel, Melbye Mads, Engels Eric A, Vineis Paolo, Costantini Adele Seniori, Holly Elizabeth A, Spinelli John J, La Vecchia Carlo, Zheng Tongzhang, Chiu Brian C H, Franceschi Silvia, Cocco Pierluigi, MaynadiĂ© Marc, Foretova Lenka, Staines Anthony, Brennan Paul, Davis Scott, Severson Richard K, Cerhan James R, Breen Elizabeth C, Birmann Brenda, Cozen Wendy   Birth order and risk of non-hodgkin lymphoma--true association or bias? American journal of epidemiology, 2010; 172(6): 621-30.
Wong Hui-Lee, Breen Elizabeth C, Pfeiffer Ruth M, Aissani Brahim, Martinson Jeremy J, Margolick Joseph B, Kaslow Richard A, Jacobson Lisa P, Ambinder Richard F, Chanock Stephen, MartĂ­nez-Maza Otoniel, Rabkin Charles S   Cytokine signaling pathway polymorphisms and AIDS-related non-Hodgkin lymphoma risk in the multicenter AIDS cohort study AIDS (London, England), 2010; 24(7): 1025-33.
Widney Daniel P, Gui Dorina, Popoviciu Laura M, Said Jonathan W, Breen Elizabeth C, Huang Xin, Kitchen Christina M R, Alcantar Juan M, Smith Jeffrey B, Detels Roger, MartĂ­nez-Maza Otoniel   Expression and Function of the Chemokine, CXCL13, and Its Receptor, CXCR5, in Aids-Associated Non-Hodgkin's Lymphoma AIDS research and treatment, 2010; 2010(7): 164586.
Irwin Michael R, Olmstead Richard, Valladares Edwin M, Breen Elizabeth Crabb, Ehlers Cindy L   In response to: Etanercept for sleep in patients with Alcohol use disorder - mechanisms need to be elucidated Biological psychiatry, 2010; 67(1): e3.
Breen E C, Walsh J J   Tubulin-targeting agents in hybrid drugs Current medicinal chemistry, 2010; 17(7): 609-39.
Vajdic Claire M, Falster Michael O, de Sanjose Silvia, Martínez-Maza Otoniel, Becker Nikolaus, Bracci Paige M, Melbye Mads, Smedby Karin Ekström, Engels Eric A, Turner Jennifer, Vineis Paolo, Costantini Adele Seniori, Holly Elizabeth A, Kane Eleanor, Spinelli John J, La Vecchia Carlo, Zheng Tongzhang, Chiu Brian C-H, Dal Maso Luigino, Cocco Pierluigi, Maynadié Marc, Foretova Lenka, Staines Anthony, Brennan Paul, Davis Scott, Severson Richard, Cerhan James R, Breen Elizabeth C, Birmann Brenda, Cozen Wendy, Grulich Andrew E   Atopic disease and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis Cancer research, 2009; 69(16): 6482-9.
Birmann Brenda M, Breen Elizabeth C, Stuver Sherri, Cranston Beverly, Martínez-Maza Otoniel, Falk Kerstin I, Okayama Akihiko, Hanchard Barrie, Mueller Nancy, Hisada Michie   Population differences in immune marker profiles associated with human T-lymphotropic virus type I infection in Japan and Jamaica International journal of cancer. Journal international du cancer, 2009; 124(3): 614-21.
Souter Irene, Huang Andy, Martinez-Maza Otoniel, Breen Elizabeth Crabb, Decherney Alan H, Chaudhuri Gautam, Nathan Lauren   Serum levels of soluble vascular cell adhesion molecule-1, tumor necrosis factor-alpha, and interleukin-6 in in vitro fertilization cycles Fertility and sterility, 2009; 91(5 Suppl): 2012-9.
Aissani Andrew E, Ogwaro Andrew E, Shrestha Andrew E, Tang Andrew E, Breen Andrew E, Wong Andrew E, Jacobson Andrew E, Rabkin Andrew E, Ambinder Andrew E, Martinez-Maza Andrew E, Kaslow Andrew E   The Major Histocompatibility Complex Conserved Extended Haplotype 8.1 in AIDS-Related Non-Hodgkin Lymphoma Journal of acquired immune deficiency syndromes (1999), 2009; 69(16): .
Irwin Michael R, Olmstead Richard, Valladares Edwin M, Breen Elizabeth Crabb, Ehlers Cindy L   Tumor necrosis factor antagonism normalizes rapid eye movement sleep in alcohol dependence Biological psychiatry, 2009; 66(2): 191-5.
Ekström Smedby Karin, Vajdic Claire M, Falster Michael, Engels Eric A, Martínez-Maza Otoniel, Turner Jennifer, Hjalgrim Henrik, Vineis Paolo, Seniori Costantini Adele, Bracci Paige M, Holly Elizabeth A, Willett Eleanor, Spinelli John J, La Vecchia Carlo, Zheng Tongzhang, Becker Nikolaus, De Sanjosé Silvia, Chiu Brian C-H, Dal Maso Luigino, Cocco Pierluigi, Maynadié Marc, Foretova Lenka, Staines Anthony, Brennan Paul, Davis Scott, Severson Richard, Cerhan James R, Breen Elizabeth C, Birmann Brenda, Grulich Andrew E, Cozen Wendy   Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium Blood, 2008; 111(8): 4029-38.
Irwin Michael R, Wang Minge, Ribeiro Denise, Cho Hyong Jin, Olmstead Richard, Breen Elizabeth Crabb, Martinez-Maza Otoniel, Cole Steve   Sleep loss activates cellular inflammatory signaling Biological psychiatry, 2008; 64(6): 538-40.
Epeldegui Marta, Breen Elizabeth Crabb, Hung Yee Ping, Boscardin W John, Detels Roger, Martínez-Maza Otoniel   Elevated expression of activation induced cytidine deaminase in peripheral blood mononuclear cells precedes AIDS-NHL diagnosis AIDS (London, England), 2007; 21(17): 2265-70.
Breen Elizabeth Crabb, Fatahi Sepi, Epeldegui Marta, Boscardin W John, Detels Roger, Martínez-Maza Otoniel   Elevated serum soluble CD30 precedes the development of AIDS-associated non-Hodgkin's B cell lymphoma Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2006; 27(4): 187-94.
Breen Elizabeth, Irani Jennifer L, Mello Michelle M, Whang Edward E, Zinner Michael J, Ashley Stanley W   The future of surgery: today's residents speak Current surgery, 2006; 62(5): 543-6.
Breen Elizabeth Crabb, Epeldegui Marta, Boscardin W John, Widney Daniel P, Detels Roger, Martínez-Maza Otoniel   Elevated levels of soluble CD44 precede the development of AIDS-associated non-Hodgkin's B-cell lymphoma AIDS (London, England), 2005; 19(15): 1711-2.
Souter Irene, Janzen Carla, Martinez-Maza Otoniel, Breen Elizabeth Crabb, Stanczyk Frank, Chaudhuri Gautam, Nathan Lauren   Serum levels of soluble vascular cell adhesion molecule-1 are decreased in women receiving oral contraceptives compared with normally menstruating women: implications in atherosclerosis Fertility and sterility, 2005; 83(5): 1480-8.
Widney Daniel P, Breen Elizabeth C, Boscardin W John, Kitchen Scott G, Alcantar Juan M, Smith Jeffrey B, Zack Jerome A, Detels Roger, Martínez-Maza Otoniel   Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2005; 25(11): 702-6.
Breen Elizabeth Crabb, Boscardin W John, Detels Roger, Jacobson Lisa P, Smith Michael W, O'Brien Stephen J, Chmiel Joan S, Rinaldo Charles R, Lai Shenghan, Martínez-Maza Otoniel   Non-Hodgkin's B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the IL10 promoter -592 C/C genotype Clinical immunology (Orlando, Fla.), 2003; 109(2): 119-29.
Martínez-Maza Otoniel, Breen Elizabeth Crabb   B-cell activation and lymphoma in patients with HIV Current opinion in oncology, 2002; 14(5): 528-32.
Breen Elizabeth Crabb   Pro- and anti-inflammatory cytokines in human immunodeficiency virus infection and acquired immunodeficiency syndrome Pharmacology & therapeutics, 2002; 95(3): 295-304.
Olfert I M, Breen E C, Mathieu-Costello O, Wagner P D   Chronic hypoxia attenuates resting and exercise-induced VEGF, flt-1, and flk-1 mRNA levels in skeletal muscle Journal of applied physiology (Bethesda, Md. : 1985), 2001; 90(4): 1532-8.
Siafakas N M, Jordan M, Wagner H, Breen E C, Benoit H, Wagner P D   Diaphragmatic angiogenic growth factor mRNA responses to increased ventilation caused by hypoxia and hypercapnia The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, 2001; 17(4): 681-7.
Olfert I M, Breen E C, Mathieu-Costello O, Wagner P D   Skeletal muscle capillarity and angiogenic mRNA levels after exercise training in normoxia and chronic hypoxia Journal of applied physiology (Bethesda, Md. : 1985), 2001; 91(3): 1176-84.
Breen E C, Gage J R, Guo B, Magpantay L, Narazaki M, Kishimoto T, Miles S, Martínez-Maza O   Viral interleukin 6 stimulates human peripheral blood B cells that are unresponsive to human interleukin 6 Cellular immunology, 2001; 212(2): 118-25.
Breen E C, McDonald M, Fan J, Boscardin J, Fahey J L   Cytokine gene expression occurs more rapidly in stimulated peripheral blood mononuclear cells from human immunodeficiency virus-infected persons Clinical and diagnostic laboratory immunology, 2000; 7(5): 769-73.
Gavin T P, Spector D A, Wagner H, Breen E C, Wagner P D   Effect of captopril on skeletal muscle angiogenic growth factor responses to exercise Journal of applied physiology (Bethesda, Md. : 1985), 2000; 88(5): 1690-7.
Breen E C   Mechanical strain increases type I collagen expression in pulmonary fibroblasts in vitro Journal of applied physiology (Bethesda, Md. : 1985), 2000; 88(1): 203-9.
Gavin T P, Spector D A, Wagner H, Breen E C, Wagner P D   Nitric oxide synthase inhibition attenuates the skeletal muscle VEGF mRNA response to exercise Journal of applied physiology (Bethesda, Md. : 1985), 2000; 88(4): 1192-8.
Breen E C, Fu Z, Normand H   Calcyclin gene expression is increased by mechanical strain in fibroblasts and lung American journal of respiratory cell and molecular biology, 1999; 21(6): 746-52.
Gage J R, Breen E C, Echeverri A, Magpantay L, Kishimoto T, Miles S, Martínez-Maza O   Human herpesvirus 8-encoded interleukin 6 activates HIV-1 in the U1 monocytic cell line AIDS (London, England), 1999; 13(14): 1851-5.
Schroeder J R, Saah A J, Hoover D R, Margolick J B, Ambinder R F, Martinez-Maza O, Breen E C, Jacobson L P, Variakojis D, Rowe D T, Armenian H K   Serum soluble CD23 level correlates with subsequent development of AIDS-related non-Hodgkin's lymphoma Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1999; 8(11): 979-84.
Breen E C, van der Meijden M, Cumberland W, Kishimoto T, Detels R, Martínez-Maza O   The development of AIDS-associated Burkitt's/small noncleaved cell lymphoma is preceded by elevated serum levels of interleukin 6 Clinical immunology (Orlando, Fla.), 1999; 92(3): 293-9.
Fan J, Nishanian P, Breen E C, McDonald M, Fahey J L   Cytokine gene expression in normal human lymphocytes in response to stimulation Clinical and diagnostic laboratory immunology, 1998; 5(3): 335-40.
van der Meijden M, Gage J, Breen E C, Taga T, Kishimoto T, Martínez-Maza O   IL-6 receptor (CD126'IL-6R') expression is increased on monocytes and B lymphocytes in HIV infection Cellular immunology, 1998; 190(2): 156-66.
Martínez-Maza O, Widney D, van der Meijden M, Knox R, Echeverri A, Breen E C, Magpantay L, Miles S A   Immune dysfunction and the pathogenesis of AIDS-associated non-Hodgkin's lymphoma Memórias do Instituto Oswaldo Cruz, 1998; 93(3): 373-81.
Shen L P, Sheridan P, Cao W W, Dailey P J, Salazar-Gonzalez J F, Breen E C, Fahey J L, Urdea M S, Kolberg J A   Quantification of cytokine mRNA in peripheral blood mononuclear cells using branched DNA (bDNA) technology Journal of immunological methods, 1998; 215(1-2): 123-34.
Breen E C, Salazar-Gonzalez J F, Shen L P, Kolberg J A, Urdea M S, Martinéz-Maza O, Fahey J L   Circulating CD8 T cells show increased interferon-gamma mRNA expression in HIV infection Cellular immunology, 1997; 178(1): 91-8.
Takeshita S, Breen E C, Ivashchenko M, Nishanian P G, Kishimoto T, Vredevoe D L, Martinez-Maza O   Induction of IL-6 and IL-10 production by recombinant HIV-1 envelope glycoprotein 41 (gp41) in the THP-1 human monocytic cell line Cellular immunology, 1995; 165(2): 234-42.
Breen E C, Rezai A R, Nakajima K, Beall G N, Mitsuyasu R T, Hirano T, Kishimoto T, Martinez-Maza O   Infection with HIV is associated with elevated IL-6 levels and production Journal of immunology (Baltimore, Md. : 1950), 1990; 144(2): 480-4.
Nakajima K, Martínez-Maza O, Hirano T, Breen E C, Nishanian P G, Salazar-Gonzalez J F, Fahey J L, Kishimoto T   Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV Journal of immunology (Baltimore, Md. : 1950), 1989; 142(2): 531-6.
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