Research Interest:

BioMEMS, Single-cell biology, and oncology

The Wei Lab moved to the Insitute for Systems Biology at Seattle in August 2018. Please visit (http://www.wei-lab.net) for more details. My research resides in a highly cross-disciplinary field of BioMEMS,single-cell biology and oncology. Currently focusing on: 1) Single-cell multi-omics tools and associated multivariate computational approaches for interrogating the heterogeneous tumor cells and immune cells at multiple bimolecular levels; 2) Epigenetic remodeling and signaling network dynamics associated with cell state transition and resistance development in epigenetically plastic tumors; 3)Liquid biopsy-based rare cell analysis for cancer metastasis and immunotherapy.

Detailed Biography:

Dr. Wei Wei is an Assistant Professor in Department of Molecular & Medical Pharmacology at UCLA School of Medicine. He received his B.S. in Fundamental Sciences (Mathematics and Physics) at Tsinghua University (Beijing) and M.S. in Materials Science and Engineering at UC San Diego. He received his Ph.D. in Materials Science at California Institute of Technology under the supervision of Dr. James R. Heath, but with very cross-disciplinary training that include the physical and biological sciences. Wei's research interests include developing and employing a unique suite of single cell tools to cultivate new understanding and address significant questions in cancer research. Specifically, 1) Develop multi-omics single cell tools for interrogating the heterogeneous tumor cells and immune cells at multiple bimolecular levels. 2) Information theoretical and computational approaches for dissecting the high-dimensional single cell data with a particular focus on resolving tumor heterogeneity and dynamics of the signal transduction network for anticipating therapy resistance and identifying effective combination therapies. 3) Isolation, molecular characterization, and neoantigen identification of rare tumor cells in body fluids for cancer diagnosis and immunotherapy.