Martha Lewis , M.D., Ph.D.

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A Short Biography:

Dr. Lewis has an interest in studying how selective pressure from the immune system and/or drug therapy affects the evolution and pathogenesis of chronic viral infections. She received her combined M.D./Ph.D. from the Tri-Institutional Program at Cornell and Rockefeller Universities in New York City. Her Ph.D. research focused on the origins, evolution and pathogenesis of Human T Lymphotropic Viruses (HTLVs). She then moved to the other coast to complete training in Internal Medicine and Infectious Diseases at UCLA, including post-doctoral research in Dr. Otto Yang's laboratory. Her research aims to study the reciprocal relationship between the immune system and viruses that cause chronic infections. In addition to these research interests, Dr. Lewis also sees patients as part of the Clinical Infectious Diseases consult service.
Work Titles
CTSI Member, CTSI
UCLA Assistant Professor, Medicine Assistant Professor, Assistant Professor In-Residence, Infectious Diseases
Education:
Degrees:
M.D., Cornell University
Ph.D., Rockefeller University
Fellowship:
2004 - 2007 UCLA
Certifications:
Certifications:
2007 - ABIM, Board Certification
2006 - ABIM, Board Certification

Contact Information:

Email Address:

MaLewis@mednet.ucla.edu


Website:

Web-Profile 2
Web-Profile

Work Phone Number:

(310) 825-7225

(310)825-0205

Mailing Address:

10833 LeConte Ave. CHS 37-121
Division of Infectious Diseases
Los Angeles, CA 90095


Detailed Biography:

Dr. Lewis has an interest in studying how selective pressure from the immune system and/or drug therapy affects the evolution and pathogenesis of chronic viral infections. She received her combined M.D./Ph.D. from the Tri-Institutional Program at Cornell and Rockefeller Universities in New York City. Her Ph.D. research focused on the origins, evolution and pathogenesis of Human T Lymphotropic Viruses (HTLVs). She then moved to the other coast to complete training in Internal Medicine and Infectious Diseases at UCLA, including post-doctoral research in Dr. Otto Yang's laboratory. Her research aims to study the reciprocal relationship between the immune system and viruses that cause chronic infections. In addition to these research interests, Dr. Lewis also sees patients as part of the Clinical Infectious Diseases consult service.

Publications:

A selected list of publications:

Bhattacharya Debika, Lewis Martha J, Lassmann Britta, Phan Tina, Knecht Gaby, Bickel Marcus, Yang Otto O   Combination of allele-specific detection techniques to quantify minority resistance variants in hepatitis B infection: A novel approach Journal of virological methods, 2013; 190(1-2): 34-40.
Zuo Jun, Suen Jeffrey, Wong Alanna, Lewis Martha, Ayub Ali, Belzer Marvin, Church Joseph, Yang Otto O, Krogstad Paul   Functional analysis of HIV type 1 Nef gene variants from adolescent and adult survivors of perinatal infection AIDS research and human retroviruses, 2012; 28(5): 486-92.
Lewis Martha J, Lee Patricia, Ng Hwee L, Yang Otto O   Immune selection in vitro reveals human immunodeficiency virus type 1 Nef sequence motifs important for its immune evasion function in vivo Journal of virology, 2012; 86(13): 7126-35.
Lewis Martha J, Dagarag Mirabelle, Khan Basim, Ali Ayub, Yang Otto O   Partial escape of HIV-1 from cytotoxic T lymphocytes during chronic infection Journal of virology, 2012; 86(13): 7459-63.
Yang Otto O, Lewis Martha J, Reed Elaine F, Gjertson David W, Kalilani-Phiri Linda, Mkandawire James, Helleringer Stéphane, Kohler Hans-Peter   Human leukocyte antigen class I haplotypes of human immunodeficiency virus-1-infected persons on Likoma Island, Malawi Human immunology, 2011; 72(10): 877-80.
Maree Cynthia L, Eells Samantha J, Tan Jennifer, Bancroft Elizabeth A, Malek Mark, Harawa Nina T, Lewis Martha J, Santana Elaine, Miller Loren G   Risk factors for infection and colonization with community-associated methicillin-resistant Staphylococcus aureus in the Los Angeles County jail: a case-control study Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2010; 51(11): 1248-57.
Ali Ayub, Realegeno Susan, Yang Otto O, Lewis Martha J   Simultaneous assessment of CD4 and MHC-I downregulation by Nef primary isolates in the context of infection Journal of virological methods, 2009; 161(2): 297-304.
Ali, A. Realegeno, S. Yang, O. O. Lewis, M. J.   Simultaneous assessment of CD4 and MHC-I downregulation by Nef primary isolates in the context of infection J Virol Methods, 2009; volume(number): pages.
Lewis, M. J. Balamurugan, A. Ohno, A. Kilpatrick, S. Ng, H. L. Yang, O. O.   Functional adaptation of Nef to the immune milieu of HIV-1 infection in vivo J Immunol, 2008; 180(6): 4075-81.
Lewis Martha J, Balamurugan Arumugam, Ohno Ayako, Kilpatrick Stephanie, Ng Hwee L, Yang Otto O   Functional adaptation of Nef to the immune milieu of HIV-1 infection in vivo Journal of immunology (Baltimore, Md. : 1950), 2008; 180(6): 4075-81.
Balamurugan, A. Lewis, M. J. Kitchen, C. M. Robertson, M. N. Shiver, J. W. Daar, E. S. Pitt, J. Ali, A. Ng, H. L. Currier, J. S. Yang, O. O.   Primary human immunodeficiency virus type 1 (HIV-1) infection during HIV-1 Gag vaccination J Virol, 2008; 82(6): 2784-91.
Balamurugan Arumugam, Lewis Martha J, Kitchen Christina M R, Robertson Michael N, Shiver John W, Daar Eric S, Pitt Jacqueline, Ali Ayub, Ng Hwee L, Currier Judith S, Yang Otto O   Primary human immunodeficiency virus type 1 (HIV-1) infection during HIV-1 Gag vaccination Journal of virology, 2008; 82(6): 2784-91.
Noviello, C. M. Pond, S. L. Lewis, M. J. Richman, D. D. Pillai, S. K. Yang, O. O. Little, S. J. Smith, D. M. Guatelli, J. C.   Maintenance of Nef-mediated modulation of major histocompatibility complex class I and CD4 after sexual transmission of human immunodeficiency virus type 1 J Virol, 2007; 81(9): 4776-86.
Sheehy, N. Lillis, L. Watters, K. Lewis, M. Gautier, V. Hall, W.   Functional analysis of human T lymphotropic virus type 2 Tax proteins Retrovirology, 2006; 3(number): 20.
Hasegawa, H. Sawa, H. Lewis, M. J. Orba, Y. Sheehy, N. Yamamoto, Y. Ichinohe, T. Tsunetsugu-Yokota, Y. Katano, H. Takahashi, H. Matsuda, J. Sata, T. Kurata, T. Nagashima, K. Hall, W. W.   Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I Nat Med, 2006; 12(4): 466-72.
Hasegawa Hideki, Sawa Hirofumi, Lewis Martha J, Orba Yasuko, Sheehy Noreen, Yamamoto Yoshie, Ichinohe Takeshi, Tsunetsugu-Yokota Yasuko, Katano Harutaka, Takahashi Hidehiro, Matsuda Junichiro, Sata Tetsutaro, Kurata Takeshi, Nagashima Kazuo, Hall William W   Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I Nature medicine, 2006; 12(4): 466-72.
Salemi, M. Fitch, W. M. Ciccozzi, M. Ruiz-Alvarez, M. J. Rezza, G. Lewis, M. J.   Severe acute respiratory syndrome coronavirus sequence characteristics and evolutionary rate estimate from maximum likelihood analysis J Virol, 2004; 78(3): 1602-3.
Salemi Marco, Fitch Walter M, Ciccozzi Massimo, Ruiz-Alvarez Maria Jose, Rezza Giovanni, Lewis Martha J   Severe acute respiratory syndrome coronavirus sequence characteristics and evolutionary rate estimate from maximum likelihood analysis Journal of virology, 2004; 78(3): 1602-3.
Lewis, M. J. Sheehy, N. Salemi, M. VanDamme, A. M. Hall, W. W.   Comparison of CREB- and NF-kappaB-mediated transactivation by human T lymphotropic virus type II (HTLV-II) and type I (HTLV-I) tax proteins Virology, 2002; 295(1): 182-9.
Ishak, R. Vallinoto, A. C. Azevedo, V. N. Lewis, M. Hall, W. W. Guimaraes Ishak, M. O.   Molecular evidence of mother-to-child transmission of HTLV-IIc in the Kararao Village (Kayapo) in the Amazon region of Brazil Rev Soc Bras Med Trop, 2001; 34(6): 519-25.
Lewis, M. J. Novoa, P. Ishak, R. Ishak, M. Salemi, M. Vandamme, A. M. Kaplan, M. H. Hall, W. W.   Isolation, cloning, and complete nucleotide sequence of a phenotypically distinct Brazilian isolate of human T-lymphotropic virus type II (HTLV-II) Virology, 2000; 271(1): 142-54.
Vandamme, A. M. Hall, W. W. Lewis, M. J. Goubau, P. Salemi, M.   Origins of HTLV-1 in South America Nat Med, 2000; 6(3): 232-3.
Lewis, M. J. Gautier, V. W. Wang, X. P. Kaplan, M. H. Hall, W. W.   Spontaneous production of C-C chemokines by individuals infected with human T lymphotropic virus type II (HTLV-II) alone and HTLV-II/HIV-1 coinfected individuals J Immunol, 2000; 165(7): 4127-32.
Salemi, M. Lewis, M. Egan, J. F. Hall, W. W. Desmyter, J. Vandamme, A. M.   Different population dynamics of human T cell lymphotropic virus type II in intravenous drug users compared with endemically infected tribes Proc Natl Acad Sci U S A, 1999; 96(23): 13253-8.
Egan, J. F. O'Leary, B. Lewis, M. J. Mulcahy, F. Sheehy, N. Hasegawa, H. Fitzpatrick, F. O'Connor, J. J. O'Riordan, J. Hall, W. W.   High rate of human T lymphotropic virus type IIa infection in HIV type 1-infected intravenous drug abusers in Ireland AIDS Res Hum Retroviruses, 1999; 15(8): 699-705.
Fukushima, Y. Lewis, M. J. Monken, C. Komuro, K. Kusagawa, S. Sato, H. Takebe, Y. Yamazaki, S. Nguyen, T. H. Hoang, A. Hoang, T. L. Honda, M. Hall, W. W.   Identification and molecular characterization of human T lymphotropic virus type II infections in intravenous drug abusers in the former South Vietnam AIDS Res Hum Retroviruses, 1998; 14(6): 537-40.

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