Timothy Hales, Ph.D.


Work Titles and Affiliation
UCLA Visiting Associate Professor, Hatos Center for Neuropharmacology
Education:
Degrees:
Ph.D., Dundee University, Scotland
B.Sc., King's College, London University

Contact Information:

Email Address:

phmtgh@gwumc.edu

Work Email Address:

phmtgh@gwumc.edu


Website:

Laboratory

Work Phone Number:

202-994-3541

Mailing Address:

George Washington University Medical Center
2300 Eyes St. NW
Washington, DC 20037

Detailed Biography:

Dr. Tim Hales is a professor in the Department of Pharmacology and Physiology at the George Washington University. He earned his doctorate degree in pharmacology at the University of Dundee in Scotland, UK studying the mechanisms of the intravenous anesthetic agent propofol. During postdoctoral studies at UCLA Dr. Hales became interested in opioid receptor signaling. He became an Assistant Professor in Residence within the Department of Anesthesiology at UCLA in 1994. In 1997, Dr. Hales joined the faculty of the Department of Pharmacology at GWU and in 2006 became a Professor of Pharmacology and Physiology with a joint appointment in the Department of Anesthesiology and Critical Care Medicine. Dr. Hales' research is funded by grants from National Institute of General Medical Sciences, National Institute on Drug abuse, and the National Science Foundation. MENTORSHIPS Dr. Hales directs the Neuroscience Track of the Molecular Medicine PhD degree course within the Institute for Biomedical Sciences at GWU. He has mentored numerous anesthesiologists (residents and faculty), postdoctoral fellows, PhD students, and undergraduate students. His lab currently includes an Assistant Professor of Anesthesiology, two postdoctoral fellows, three graduate students and two undergraduate students.

Publications:

Bollan, K. A. Baur, R. Hales, T. G. Sigel, E. Connolly, C. N.   The promiscuous role of the epsilon subunit in GABAA receptor biogenesis Mol Cell Neurosci, 2008; 37(3): 610-21.
McCartney, M. R. Deeb, T. Z. Henderson, T. N. Hales, T. G.   Tonically active GABAA receptors in hippocampal pyramidal neurons exhibit constitutive GABA-independent gating Mol Pharmacol, 2007; 71(2): 539-48.
Deeb, T. Z. Carland, J. E. Cooper, M. A. Livesey, M. R. Lambert, J. J. Peters, J. A. Hales, T. G.   Dynamic modification of a mutant cytoplasmic cysteine residue modulates the conductance of the human 5-HT3A receptor J Biol Chem, 2007; 282(9): 6172-82.
Hales, T. G. Deeb, T. Z. Tang, H. Bollan, K. A. King, D. P. Johnson, S. J. Connolly, C. N.   An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunits J Biol Chem, 2006; 281(25): 17034-43.
Hales, T. G. Dunlop, J. I. Deeb, T. Z. Carland, J. E. Kelley, S. P. Lambert, J. J. Peters, J. A.   Common determinants of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and alpha4beta2 nicotinic acetylcholine receptors J Biol Chem, 2006; 281(12): 8062-71.
Wagner, D. A. Goldschen-Ohm, M. P. Hales, T. G. Jones, M. V.   Kinetics and spontaneous open probability conferred by the epsilon subunit of the GABAA receptor J Neurosci, 2005; 25(45): 10462-8.
Walwyn, W. Maidment, N. T. Sanders, M. Evans, C. J. Kieffer, B. L. Hales, T. G.   Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons Mol Pharmacol, 2005; 68(6): 1688-98.
Hales, T. G. Tang, H. Bollan, K. A. Johnson, S. J. King, D. P. McDonald, N. A. Cheng, A. Connolly, C. N.   The epilepsy mutation, gamma2(R43Q) disrupts a highly conserved inter-subunit contact site, perturbing the biogenesis of GABAA receptors Mol Cell Neurosci, 2005; 29(1): 120-7.
Charles, A. C. Mostovskaya, N. Asas, K. Evans, C. J. Dankovich, M. L. Hales, T. G.   Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory Mol Pharmacol, 2003; 63(1): 89-95.
Stewart, A. Davies, P. A. Kirkness, E. F. Safa, P. Hales, T. G.   Introduction of the 5-HT3B subunit alters the functional properties of 5-HT3 receptors native to neuroblastoma cells Neuropharmacology, 2003; 44(2): 214-23.
Davies, P. A. Wang, W. Hales, T. G. Kirkness, E. F.   A novel class of ligand-gated ion channel is activated by Zn2+ J Biol Chem, 2003; 278(2): 712-7.
Davies, P. A. McCartney, M. R. Wang, W. Hales, T. G. Kirkness, E. F.   Alternative transcripts of the GABA(A) receptor epsilon subunit in human and rat Neuropharmacology, 2002; 43(4): 467-75.
Irnaten, M. Walwyn, W. M. Wang, J. Venkatesan, P. Evans, C. Chang, K. S. Andresen, M. C. Hales, T. G. Mendelowitz, D.   Pentobarbital enhances GABAergic neurotransmission to cardiac parasympathetic neurons, which is prevented by expression of GABA(A) epsilon subunit Anesthesiology, 2002; 97(3): 717-24.
Davies, P. A. Kirkness, E. F. Hales, T. G.   Evidence for the formation of functionally distinct alphabetagammaepsilon GABA(A) receptors J Physiol, 2001; 537(Pt 1): 101-13.
Piros, E. T. Charles, R. C. Song, L. Evans, C. J. Hales, T. G.   Cloned delta-opioid receptors in GH(3) cells inhibit spontaneous Ca(2+) oscillations and prolactin release through K(IR) channel activation J Neurophysiol, 2000; 83(5): 2691-8.
Hanna, M. C. Davies, P. A. Hales, T. G. Kirkness, E. F.   Evidence for expression of heteromeric serotonin 5-HT(3) receptors in rodents J Neurochem, 2000; 75(1): 240-7.
Prather, P. L. Song, L. Piros, E. T. Law, P. Y. Hales, T. G.   delta-Opioid receptors are more efficiently coupled to adenylyl cyclase than to L-type Ca(2+) channels in transfected rat pituitary cells J Pharmacol Exp Ther, 2000; 295(2): 552-62.
Davies, P. A. Hoffmann, E. B. Carlisle, H. J. Tyndale, R. F. Hales, T. G.   The influence of an endogenous beta3 subunit on recombinant GABA(A) receptor assembly and pharmacology in WSS-1 cells and transiently transfected HEK293 cells Neuropharmacology, 2000; 39(4): 611-20.
Tian, J. Chau, C. Hales, T. G. Kaufman, D. L.   GABA(A) receptors mediate inhibition of T cell responses J Neuroimmunol, 1999; 96(1): 21-8.
Davies, P. A. Pistis, M. Hanna, M. C. Peters, J. A. Lambert, J. J. Hales, T. G. Kirkness, E. F.   The 5-HT3B subunit is a major determinant of serotonin-receptor function Nature, 1999; 397(6717): 359-63.
Bronstein, J. M. Hales, T. G. Tyndale, R. F. Charles, A. C.   A conditionally immortalized glial cell line that expresses mature myelin proteins and functional GABA(A) receptors J Neurochem, 1998; 70(2): 483-91.
Davies, P. A. Hanna, M. C. Hales, T. G. Kirkness, E. F.   Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit Nature, 1997; 385(6619): 820-3.

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Information from U.S. National Library of Medicine.

5-Lipoxygenase-Activating Protein Inhibitors 5-Lipoxygenase-Activating Proteins Actin Capping Proteins Agouti Signaling Protein Amino Acid Sequence Androgen-Binding Protein Anesthetics Anesthetics, Intravenous Animals Arginine Bicuculline Brain CASP8 and FADD-Like Apoptosis Regulating Protein CCAAT-Enhancer-Binding Protein-alpha CCAAT-Enhancer-Binding Protein-beta CCAAT-Enhancer-Binding Protein-delta CCAAT-Enhancer-Binding Proteins CCN Intercellular Signaling Proteins COS Cells CREB-Binding Protein Calcium Calcium Channels, L-Type Calcium-Binding Protein, Vitamin D-Dependent Calcium-Binding Proteins Calmodulin-Binding Proteins CapZ Actin Capping Protein Cell Division Cell Line Cell Line, Transformed Cell Membrane Cells, Cultured Cercopithecus aethiops Chlorophyll Binding Proteins Cloning, Molecular Complement C4b-Binding Protein Cyclic AMP Response Element-Binding Protein Cyclic AMP Response Element-Binding Protein A Cysteine Cytoplasm DNA, Complementary DNA-Binding Proteins Dopamine Dose-Response Relationship, Drug Drug Interactions Egg Proteins Egg Proteins, Dietary Electric Conductivity Electric Stimulation Electrophysiology Epilepsy Fanconi Anemia Complementation Group G Protein Fatty Acid-Binding Proteins Flunitrazepam G Protein-Coupled Inwardly-Rectifying Potassium Channels GA-Binding Protein Transcription Factor GABA Antagonists GABA Modulators GTP-Binding Protein Regulators GTP-Binding Protein alpha Subunit, Gi2 GTP-Binding Protein alpha Subunits GTP-Binding Protein alpha Subunits, G12-G13 GTP-Binding Protein alpha Subunits, Gi-Go GTP-Binding Protein alpha Subunits, Gq-G11 GTP-Binding Protein alpha Subunits, Gs GTP-Binding Protein beta Subunits GTP-Binding Protein gamma Subunits GTP-Binding Proteins GTPase-Activating Proteins Gene Expression Guanylate Cyclase-Activating Proteins Hedgehog Proteins Heterotrimeric GTP-Binding Proteins Hippocampus Humans Immunoglobulin J Recombination Signal Sequence-Binding Protein In Situ Hybridization Insulin-Like Growth Factor Binding Protein 1 Insulin-Like Growth Factor Binding Protein 2 Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor Binding Protein 4 Insulin-Like Growth Factor Binding Protein 5 Insulin-Like Growth Factor Binding Protein 6 Insulin-Like Growth Factor Binding Proteins Intracellular Calcium-Sensing Proteins Ion Channel Gating Ion Channels Iron-Binding Proteins Kinetics Kv Channel-Interacting Proteins Latent TGF-beta Binding Proteins Ligands Light-Harvesting Protein Complexes MARVEL Domain-Containing Proteins Macromolecular Substances Maltose-Binding Proteins Mannose-Binding Protein-Associated Serine Proteases Matrix Attachment Region Binding Proteins Membrane Potentials Methyl-CpG-Binding Protein 2 Mice Microdialysis Molecular Sequence Data Monomeric GTP-Binding Proteins Muscimol MutS DNA Mismatch-Binding Protein Mutation Neural Conduction Neurons Neuropharmacology Nuclear Cap-Binding Protein Complex Patch-Clamp Techniques Penicillin-Binding Proteins Pentobarbital Periplasmic Binding Proteins Pharmacokinetics Phosphate-Binding Proteins Phosphatidylethanolamine Binding Protein Picrotoxin Poly(A)-Binding Protein I Poly(A)-Binding Protein II Poly(A)-Binding Proteins Polymerase Chain Reaction Polypyrimidine Tract-Binding Protein Pregnanolone Prolactin Propofol Protein Structure, Tertiary Protein Subunits RNA Cap-Binding Proteins RNA, Messenger RNA-Binding Protein EWS RNA-Binding Protein FUS RNA-Binding Proteins Rats Receptor Activity-Modifying Protein 1 Receptor Activity-Modifying Protein 2 Receptor Activity-Modifying Protein 3 Receptor Activity-Modifying Proteins Receptor-Interacting Protein Serine-Threonine Kinase 2 Receptor-Interacting Protein Serine-Threonine Kinases Receptors, GABA-A Receptors, Serotonin Receptors, Serotonin, 5-HT3 Recombinant Fusion Proteins Recombinant Proteins Retinoblastoma Binding Proteins Retinoblastoma-Binding Protein 1 Retinoblastoma-Binding Protein 2 Retinoblastoma-Binding Protein 4 Retinoblastoma-Binding Protein 7 Retinol-Binding Proteins Retinol-Binding Proteins, Cellular Retinol-Binding Proteins, Plasma Reverse Transcriptase Polymerase Chain Reaction Ribosome Inactivating Proteins Ribosome Inactivating Proteins, Type 1 Ribosome Inactivating Proteins, Type 2 SH2 Domain-Containing Protein Tyrosine Phosphatases Selenium-Binding Proteins Sequence Homology, Amino Acid Serotonin Sterol Regulatory Element Binding Protein 1 Sterol Regulatory Element Binding Protein 2 Sterol Regulatory Element Binding Proteins Structure-Activity Relationship Suppressor of Cytokine Signaling Proteins TATA Box Binding Protein-Like Proteins TATA-Binding Protein Associated Factors TATA-Box Binding Protein Tacrolimus Binding Protein 1A Tacrolimus Binding Proteins Telomere-Binding Proteins Telomeric Repeat Binding Protein 1 Telomeric Repeat Binding Protein 2 Thyroxine-Binding Proteins Time Factors Transfection Transferrin-Binding Protein A Transferrin-Binding Protein B Transferrin-Binding Proteins Vacuolar Sorting Protein VPS15 Vitamin D-Binding Protein Y-Box-Binding Protein 1 beta-Transducin Repeat-Containing Proteins cdc42 GTP-Binding Protein cdc42 GTP-Binding Protein, Saccharomyces cerevisiae gamma-Aminobutyric Acid p120 GTPase Activating Protein rab GTP-Binding Proteins rab1 GTP-Binding Proteins rab2 GTP-Binding Protein rab3 GTP-Binding Proteins rab3A GTP-Binding Protein rab4 GTP-Binding Proteins rab5 GTP-Binding Proteins rac GTP-Binding Proteins rac1 GTP-Binding Protein ral GTP-Binding Proteins ran GTP-Binding Protein rap GTP-Binding Proteins rap1 GTP-Binding Proteins ras GTPase-Activating Proteins rho GTP-Binding Proteins rhoA GTP-Binding Protein rhoB GTP-Binding Protein

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