Dr. Tim Hales is a professor in the Department of Pharmacology and Physiology at the George Washington University. He earned his doctorate degree in pharmacology at the University of Dundee in Scotland, UK studying the mechanisms of the intravenous anesthetic agent propofol. During postdoctoral studies at UCLA Dr. Hales became interested in opioid receptor signaling. He became an Assistant Professor in Residence within the Department of Anesthesiology at UCLA in 1994. In 1997, Dr. Hales joined the faculty of the Department of Pharmacology at GWU and in 2006 became a Professor of Pharmacology and Physiology with a joint appointment in the Department of Anesthesiology and Critical Care Medicine. Dr. Hales' research is funded by grants from National Institute of General Medical Sciences, National Institute on Drug abuse, and the National Science Foundation. MENTORSHIPS Dr. Hales directs the Neuroscience Track of the Molecular Medicine PhD degree course within the Institute for Biomedical Sciences at GWU. He has mentored numerous anesthesiologists (residents and faculty), postdoctoral fellows, PhD students, and undergraduate students. His lab currently includes an Assistant Professor of Anesthesiology, two postdoctoral fellows, three graduate students and two undergraduate students.
Bollan, K. A. Baur, R. Hales, T. G. Sigel, E. Connolly, C. N. The promiscuous role of the epsilon subunit in GABAA receptor biogenesis Mol Cell Neurosci, 2008; 37(3): 610-21.
McCartney, M. R. Deeb, T. Z. Henderson, T. N. Hales, T. G. Tonically active GABAA receptors in hippocampal pyramidal neurons exhibit constitutive GABA-independent gating Mol Pharmacol, 2007; 71(2): 539-48.
Walwyn, W. Evans, C. J. Hales, T. G. Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons J Neurosci, 2007; 27(19): 5092-104.
Deeb, T. Z. Carland, J. E. Cooper, M. A. Livesey, M. R. Lambert, J. J. Peters, J. A. Hales, T. G. Dynamic modification of a mutant cytoplasmic cysteine residue modulates the conductance of the human 5-HT3A receptor J Biol Chem, 2007; 282(9): 6172-82.
Hales, T. G. Deeb, T. Z. Tang, H. Bollan, K. A. King, D. P. Johnson, S. J. Connolly, C. N. An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunits J Biol Chem, 2006; 281(25): 17034-43.
Hales, T. G. Dunlop, J. I. Deeb, T. Z. Carland, J. E. Kelley, S. P. Lambert, J. J. Peters, J. A. Common determinants of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and alpha4beta2 nicotinic acetylcholine receptors J Biol Chem, 2006; 281(12): 8062-71.
Wagner, D. A. Goldschen-Ohm, M. P. Hales, T. G. Jones, M. V. Kinetics and spontaneous open probability conferred by the epsilon subunit of the GABAA receptor J Neurosci, 2005; 25(45): 10462-8.
Walwyn, W. Maidment, N. T. Sanders, M. Evans, C. J. Kieffer, B. L. Hales, T. G. Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons Mol Pharmacol, 2005; 68(6): 1688-98.
Hales, T. G. Tang, H. Bollan, K. A. Johnson, S. J. King, D. P. McDonald, N. A. Cheng, A. Connolly, C. N. The epilepsy mutation, gamma2(R43Q) disrupts a highly conserved inter-subunit contact site, perturbing the biogenesis of GABAA receptors Mol Cell Neurosci, 2005; 29(1): 120-7.
Charles, A. C. Mostovskaya, N. Asas, K. Evans, C. J. Dankovich, M. L. Hales, T. G. Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory Mol Pharmacol, 2003; 63(1): 89-95.
Stewart, A. Davies, P. A. Kirkness, E. F. Safa, P. Hales, T. G. Introduction of the 5-HT3B subunit alters the functional properties of 5-HT3 receptors native to neuroblastoma cells Neuropharmacology, 2003; 44(2): 214-23.
Davies, P. A. Wang, W. Hales, T. G. Kirkness, E. F. A novel class of ligand-gated ion channel is activated by Zn2+ J Biol Chem, 2003; 278(2): 712-7.
Davies, P. A. McCartney, M. R. Wang, W. Hales, T. G. Kirkness, E. F. Alternative transcripts of the GABA(A) receptor epsilon subunit in human and rat Neuropharmacology, 2002; 43(4): 467-75.
Irnaten, M. Walwyn, W. M. Wang, J. Venkatesan, P. Evans, C. Chang, K. S. Andresen, M. C. Hales, T. G. Mendelowitz, D. Pentobarbital enhances GABAergic neurotransmission to cardiac parasympathetic neurons, which is prevented by expression of GABA(A) epsilon subunit Anesthesiology, 2002; 97(3): 717-24.
Davies, P. A. Kirkness, E. F. Hales, T. G. Evidence for the formation of functionally distinct alphabetagammaepsilon GABA(A) receptors J Physiol, 2001; 537(Pt 1): 101-13.
Safa, P. Boulter, J. Hales, T. G. Functional properties of Cav1.3 (alpha1D) L-type Ca2+ channel splice variants expressed by rat brain and neuroendocrine GH3 cells J Biol Chem, 2001; 276(42): 38727-37.
Piros, E. T. Charles, R. C. Song, L. Evans, C. J. Hales, T. G. Cloned delta-opioid receptors in GH(3) cells inhibit spontaneous Ca(2+) oscillations and prolactin release through K(IR) channel activation J Neurophysiol, 2000; 83(5): 2691-8.
Hanna, M. C. Davies, P. A. Hales, T. G. Kirkness, E. F. Evidence for expression of heteromeric serotonin 5-HT(3) receptors in rodents J Neurochem, 2000; 75(1): 240-7.
Prather, P. L. Song, L. Piros, E. T. Law, P. Y. Hales, T. G. delta-Opioid receptors are more efficiently coupled to adenylyl cyclase than to L-type Ca(2+) channels in transfected rat pituitary cells J Pharmacol Exp Ther, 2000; 295(2): 552-62.
Davies, P. A. Hoffmann, E. B. Carlisle, H. J. Tyndale, R. F. Hales, T. G. The influence of an endogenous beta3 subunit on recombinant GABA(A) receptor assembly and pharmacology in WSS-1 cells and transiently transfected HEK293 cells Neuropharmacology, 2000; 39(4): 611-20.
Tian, J. Chau, C. Hales, T. G. Kaufman, D. L. GABA(A) receptors mediate inhibition of T cell responses J Neuroimmunol, 1999; 96(1): 21-8.
Charles, A. C. Piros, E. T. Evans, C. J. Hales, T. G. L-type Ca2+ channels and K+ channels specifically modulate the frequency and amplitude of spontaneous Ca2+ oscillations and have distinct roles in prolactin release in GH3 cells J Biol Chem, 1999; 274(11): 7508-15.
Davies, P. A. Pistis, M. Hanna, M. C. Peters, J. A. Lambert, J. J. Hales, T. G. Kirkness, E. F. The 5-HT3B subunit is a major determinant of serotonin-receptor function Nature, 1999; 397(6717): 359-63.
Bronstein, J. M. Hales, T. G. Tyndale, R. F. Charles, A. C. A conditionally immortalized glial cell line that expresses mature myelin proteins and functional GABA(A) receptors J Neurochem, 1998; 70(2): 483-91.
Davies, P. A. Kirkness, E. F. Hales, T. G. Modulation by general anaesthetics of rat GABAA receptors comprised of alpha 1 beta 3 and beta 3 subunits expressed in human embryonic kidney 293 cells Br J Pharmacol, 1997; 120(5): 899-909.
Davies, P. A. Hanna, M. C. Hales, T. G. Kirkness, E. F. Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit Nature, 1997; 385(6619): 820-3.
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