Brigitte Kieffer, Ph.D.

Work Titles
UCLA Visiting Professor, Hatos Center for Neuropharmacology
Academic Experience:

Contact Information:

Work Email Address:


Work Phone Number:

33 (0)3 88 65 56 93

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Parc d'innovation
1 rue Laurent Fries BP 10142
Illkirch Cedex 67404,

Detailed Biography:

Dr. Kieffer has been a Full Professor at the Universite Louis Pasteur since 1994. Since 2006, she has been the Research Director at INSERM. Currently, Dr. Kieffer is a Visiting Professor at UCLA as well as the Chairman of the Department for Neurobiology and Genetics and Group Leader at IGBMC (Institute of Genetics and Molecular and Cellular Biology.


Goeldner, Reiss, Wichmann, Kieffer, Ouagazzal   Activation of nociceptin opioid peptide (NOP) receptor impairs contextual fear learning in mice through glutamatergic mechanisms Neurobiology of learning and memory, 2009; .
Kang-Park Maeng-Hee, Kieffer Brigitte L, Roberts Amanda J, Roberto Marisa, Madamba Samuel G, Siggins George Robert, Moore Scott D   Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: lack of ethanol interactions The Journal of pharmacology and experimental therapeutics, 2009; 328(1): 284-93.
Kieffer Brigitte L, Evans Christopher J   Opioid receptors: from binding sites to visible molecules in vivo Neuropharmacology, 2009; 56 Suppl 1(1): 205-12.
Reiss, D. Wichmann, J. Tekeshima, H. Kieffer, B. L. Ouagazzal, A. M.   Effects of nociceptin/orphanin FQ receptor (NOP) agonist, Ro64-6198, on reactivity to acute pain in mice: Comparison to morphine Eur J Pharmacol, 2008; 579(1-3): 141-8.
Benbouzid, M. Gaveriaux-Ruff, C. Yalcin, I. Waltisperger, E. Tessier, L. H. Muller, A. Kieffer, B. L. Freund-Mercier, M. J. Barrot, M.   Delta-Opioid Receptors Are Critical for Tricyclic Antidepressant Treatment of Neuropathic Allodynia Biol Psychiatry, 2007; .
Nagai, J. Kurokawa, M. Takeshima, H. Kieffer, B. L. Ueda, H.   Circadian-dependent learning and memory enhancement in nociceptin receptor-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task J Pharmacol Exp Ther, 2007; 321(1): 195-201.
Papaleo, F. Kieffer, B. L. Tabarin, A. Contarino, A.   Decreased motivation to eat in mu-opioid receptor-deficient mice Eur J Neurosci, 2007; 25(11): 3398-405.
Bigliardi-Qi, M. Gaveriaux-Ruff, C. Pfaltz, K. Bady, P. Baumann, T. Rufli, T. Kieffer, B. L. Bigliardi, P. L.   Deletion of mu- and kappa-opioid receptors in mice changes epidermal hypertrophy, density of peripheral nerve endings, and itch behavior J Invest Dermatol, 2007; 127(6): 1479-88.
Garcia-Fuster, M. J. Ferrer-Alcon, M. Martin, M. Kieffer, B. L. Maldonado, R. Garcia-Sevilla, J. A.   Effects of constitutive deletion of opioid receptors on the basal densities of Fas and Fas-associated protein with death domain (FADD) in the mouse brain: a delta-opioid tone inhibits FADD Eur Neuropsychopharmacol, 2007; 17(5): 366-74.
Contet, C. Dierich, A. Kieffer, B. L.   Knock-in mice reveal nonsense-mediated mRNA decay in the brain Genesis, 2007; 45(1): 38-43.
Kang-Park, M. H. Kieffer, B. L. Roberts, A. J. Siggins, G. R. Moore, S. D.   Presynaptic delta opioid receptors regulate ethanol actions in central amygdala J Pharmacol Exp Ther, 2007; 320(2): 917-25.
Marquez, P. Baliram, R. Kieffer, B. L. Lutfy, K.   The mu opioid receptor is involved in buprenorphine-induced locomotor stimulation and conditioned place preference Neuropharmacology, 2007; 52(6): 1336-41.
Chakass, D. Philippe, D. Erdual, E. Dharancy, S. Malapel, M. Dubuquoy, C. Thuru, X. Gay, J. Gaveriaux-Ruff, C. Dubus, P. Mathurin, P. Kieffer, B. L. Desreumaux, P. Chamaillard, M.   micro-Opioid receptor activation prevents acute hepatic inflammation and cell death Gut, 2007; 56(7): 974-81.
Ghate, A. Befort, K. Becker, J. A. Filliol, D. Bole-Feysot, C. Demebele, D. Jost, B. Koch, M. Kieffer, B. L.   Identification of novel striatal genes by expression profiling in adult mouse brain Neuroscience, 2007; 146(3): 1182-92.
Walwyn, W. M. Wei, W. Xie, C. W. Chiu, K. Kieffer, B. L. Evans, C. J. Maidment, N. T.   Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons Neuroscience, 2006; 142(2): 493-503.
Scherrer, G. Tryoen-Toth, P. Filliol, D. Matifas, A. Laustriat, D. Cao, Y. Q. Basbaum, A. I. Dierich, A. Vonesh, J. L. Gaveriaux-Ruff, C. Kieffer, B. L.   Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo Proc Natl Acad Sci U S A, 2006; 103(25): 9691-6.
Merg, F. Filliol, D. Usynin, I. Bazov, I. Bark, N. Hurd, Y. L. Yakovleva, T. Kieffer, B. L. Bakalkin, G.   Big dynorphin as a putative endogenous ligand for the kappa-opioid receptor J Neurochem, 2006; 97(1): 292-301.
Bigliardi-Qi, M. Gaveriaux-Ruff, C. Zhou, H. Hell, C. Bady, P. Rufli, T. Kieffer, B. Bigliardi, P.   Deletion of delta-opioid receptor in mice alters skin differentiation and delays wound healing Differentiation, 2006; 74(4): 174-85.
Contet, C. Gaveriaux-Ruff, C. Matifas, A. Caradec, C. Champy, M. F. Kieffer, B. L.   Dissociation of analgesic and hormonal responses to forced swim stress using opioid receptor knockout mice Neuropsychopharmacology, 2006; 31(8): 1733-44.
Snook, L. A. Milligan, G. Kieffer, B. L. Massotte, D.   Mu-delta opioid receptor functional interaction: Insight using receptor-G protein fusions J Pharmacol Exp Ther, 2006; 318(2): 683-90.
Galeote, L. Kieffer, B. L. Maldonado, R. Berrendero, F.   Mu-opioid receptors are involved in the tolerance to nicotine antinociception J Neurochem, 2006; 97(2): 416-23.
Nadal, X. Banos, J. E. Kieffer, B. L. Maldonado, R.   Neuropathic pain is enhanced in delta-opioid receptor knockout mice Eur J Neurosci, 2006; 23(3): 830-4.
Simonin, F. Schmitt, M. Laulin, J. P. Laboureyras, E. Jhamandas, J. H. MacTavish, D. Matifas, A. Mollereau, C. Laurent, P. Parmentier, M. Kieffer, B. L. Bourguignon, J. J. Simonnet, G.   RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia Proc Natl Acad Sci U S A, 2006; 103(2): 466-71.
Kovacs, K. M. Szakall, I. O'Brien, D. Wang, R. Vinod, K. Y. Saito, M. Simonin, F. Kieffer, B. L. Vadasz, C.   Decreased oral self-administration of alcohol in kappa-opioid receptor knock-out mice Alcohol Clin Exp Res, 2005; 29(5): 730-8.
Sanders, M. J. Kieffer, B. L. Fanselow, M. S.   Deletion of the mu opioid receptor results in impaired acquisition of Pavlovian context fear Neurobiol Learn Mem, 2005; 84(1): 33-41.
Grillet, N. Pattyn, A. Contet, C. Kieffer, B. L. Goridis, C. Brunet, J. F.   Generation and characterization of Rgs4 mutant mice Mol Cell Biol, 2005; 25(10): 4221-8.
Walwyn, W. Maidment, N. T. Sanders, M. Evans, C. J. Kieffer, B. L. Hales, T. G.   Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons Mol Pharmacol, 2005; 68(6): 1688-98.
Tryoen-Toth, P. Decaillot, F. M. Filliol, D. Befort, K. Lazarus, L. H. Schiller, P. W. Schmidhammer, H. Kieffer, B. L.   Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors J Pharmacol Exp Ther, 2005; 313(1): 410-21.
Ghozland, S. Chu, K. Kieffer, B. L. Roberts, A. J.   Lack of stimulant and anxiolytic-like effects of ethanol and accelerated development of ethanol dependence in mu-opioid receptor knockout mice Neuropharmacology, 2005; 49(4): 493-501.
Nieto, M. M. Guen, S. L. Kieffer, B. L. Roques, B. P. Noble, F.   Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors Neuroscience, 2005; 135(2): 305-13.
Tabarin, A. Diz-Chaves, Y. Carmona Mdel, C. Catargi, B. Zorrilla, E. P. Roberts, A. J. Coscina, D. V. Rousset, S. Redonnet, A. Parker, G. C. Inoue, K. Ricquier, D. Penicaud, L. Kieffer, B. L. Koob, G. F.   Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene" Diabetes, 2005; 54(12): 3510-6.
Moles, A. Kieffer, B. L. D'Amato, F. R.   Deficit in attachment behavior in mice lacking the mu-opioid receptor gene Science, 2004; 304(5679): 1983-6.
Gaveriaux-Ruff, C. Simonin, F. Filliol, D. Kieffer, B.   Antibody response and allogeneic mixed lymphocyte reaction in mu-, delta-, and kappa-opioid receptor knockout mice J Neuroimmunol, 2004; 147(1-2): 121-2.
Wang, D. Raehal, K. M. Lin, E. T. Lowery, J. J. Kieffer, B. L. Bilsky, E. J. Sadee, W.   Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence J Pharmacol Exp Ther, 2004; 308(2): 512-20.
Chefer, V. I. Kieffer, B. L. Shippenberg, T. S.   Contrasting effects of mu opioid receptor and delta opioid receptor deletion upon the behavioral and neurochemical effects of cocaine Neuroscience, 2004; 127(2): 497-503.
Walwyn, W. M. Keith, D. E., Jr. Wei, W. Tan, A. M. Xie, C. W. Evans, C. J. Kieffer, B. L. Maidment, N. T.   Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice Neuroscience, 2004; 123(1): 111-21.
Simonin, F. Karcher, P. Boeuf, J. J. Matifas, A. Kieffer, B. L.   Identification of a novel family of G protein-coupled receptor associated sorting proteins J Neurochem, 2004; 89(3): 766-75.
Morinville, A. Cahill, C. M. Kieffer, B. Collier, B. Beaudet, A.   Mu-opioid receptor knockout prevents changes in delta-opioid receptor trafficking induced by chronic inflammatory pain Pain, 2004; 109(3): 266-73.
Garcia-Sevilla, J. A. Ferrer-Alcon, M. Martin, M. Kieffer, B. L. Maldonado, R.   Neurofilament proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid receptor gene knock-out mice: effects of chronic morphine administration Neuropharmacology, 2004; 46(4): 519-30.
Robledo, P. Mendizabal, V. Ortuno, J. de la Torre, R. Kieffer, B. L. Maldonado, R.   The rewarding properties of MDMA are preserved in mice lacking mu-opioid receptors Eur J Neurosci, 2004; 20(3): 853-8.
Contet, C. Matifas, A. Kieffer, B. L.   No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse Eur J Pharmacol, 2004; 492(2-3): 131-6.
Lena, I. Matthes, H. Kieffer, B. Kitchen, I.   Quantitative autoradiography of dopamine receptors in the brains of micro-opioid receptor knockout mice Neurosci Lett, 2004; 356(3): 220-4.
Lutfy, K. Eitan, S. Bryant, C. D. Yang, Y. C. Saliminejad, N. Walwyn, W. Kieffer, B. L. Takeshima, H. Carroll, F. I. Maidment, N. T. Evans, C. J.   Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors J Neurosci, 2003; 23(32): 10331-7.
Martin, M. Matifas, A. Maldonado, R. Kieffer, B. L.   Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones Eur J Neurosci, 2003; 17(4): 701-8.
Philippe, D. Dubuquoy, L. Groux, H. Brun, V. Chuoi-Mariot, M. T. Gaveriaux-Ruff, C. Colombel, J. F. Kieffer, B. L. Desreumaux, P.   Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation J Clin Invest, 2003; 111(9): 1329-38.
Chefer, V. I. Kieffer, B. L. Shippenberg, T. S.   Basal and morphine-evoked dopaminergic neurotransmission in the nucleus accumbens of MOR- and DOR-knockout mice Eur J Neurosci, 2003; 18(7): 1915-22.
Berrendero, F. Mendizabal, V. Murtra, P. Kieffer, B. L. Maldonado, R.   Cannabinoid receptor and WIN 55 212-2-stimulated [35S]-GTPgammaS binding in the brain of mu-, delta- and kappa-opioid receptor knockout mice Eur J Neurosci, 2003; 18(8): 2197-202.
Castane, A. Robledo, P. Matifas, A. Kieffer, B. L. Maldonado, R.   Cannabinoid withdrawal syndrome is reduced in double mu and delta opioid receptor knockout mice Eur J Neurosci, 2003; 17(1): 155-9.
Romberg, R. Sarton, E. Teppema, L. Matthes, H. W. Kieffer, B. L. Dahan, A.   Comparison of morphine-6-glucuronide and morphine on respiratory depressant and antinociceptive responses in wild type and mu-opioid receptor deficient mice Br J Anaesth, 2003; 91(6): 862-70.
Jamot, L. Matthes, H. W. Simonin, F. Kieffer, B. L. Roder, J. C.   Differential involvement of the mu and kappa opioid receptors in spatial learning Genes Brain Behav, 2003; 2(2): 80-92.
Gaveriaux-Ruff, C. Simonin, F. Filliol, D. Kieffer, B. L.   Enhanced humoral response in kappa-opioid receptor knockout mice J Neuroimmunol, 2003; 134(1-2): 72-81.
Li, Y. Eitan, S. Wu, J. Evans, C. J. Kieffer, B. Sun, X. Polakiewicz, R. D.   Morphine induces desensitization of insulin receptor signaling Mol Cell Biol, 2003; 23(17): 6255-66.
Decaillot, F. M. Befort, K. Filliol, D. Yue, S. Walker, P. Kieffer, B. L.   Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation Nat Struct Biol, 2003; 10(8): 629-36.
Morinville, A. Cahill, C. M. Esdaile, M. J. Aibak, H. Collier, B. Kieffer, B. L. Beaudet, A.   Regulation of delta-opioid receptor trafficking via mu-opioid receptor stimulation: evidence from mu-opioid receptor knock-out mice J Neurosci, 2003; 23(12): 4888-98.
Oakley, S. M. Toth, G. Borsodi, A. Kieffer, B. L. Kitchen, I.   G-protein coupling of delta-opioid receptors in brains of mu-opioid receptor knockout mice Eur J Pharmacol, 2003; 466(1-2): 91-8.

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