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Milan Fiala, M.D.
Contact Information:
Fax Number:
310-825-2042
Work Phone Number:
310-206-6392
310-206-6392
Laboratory Address:
Laboratory Department of Oral Biology and Medicine 10833 Le Conte Westwood, CA 90095 UNITED STATES
Work Address:
Office Department of Oral Biology and Medicine UCLA CHS 73-084 10833 Le Conte Westwood, CA 90095 UNITED STATES
Research Professor,
Orthopaedic Hospital Research Center
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Member,
CTSI
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Detailed Biography:
Role of monocytes and monocyte migration across the blood-brain barrier in neurodegenerative disorders, specifically, the role of chemokines and apoptosis in Alzheimer's disease and AIDS dementia
Research Description: Blood-brain barrier physiology and immunology: immune cell migration and virus penetration; immunomodulation by drugs of abuse: cytokines, lympho- proliferation and virus penetration; Alzheimer's disease: inflammatory pathogenesis.
Publications:
Mizwicki Mathew T, Liu Guanghao, Fiala Milan, Magpantay Larry, Sayre James, Siani Avi, Mahanian Michelle, Weitzman Rachel, Hayden Eric Y, Rosenthal Mark J, Nemere Ilka, Ringman John, Teplow David B
1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between
amyloid-β phagocytosis and inflammation in Alzheimer's disease
patients.
Journal of Alzheimer's disease : JAD,
2013; 34(1):
155-70.
Liu Guanghao, Fiala Milan, Mizwicki Mathew T, Sayre James, Magpantay Larry, Siani Avi, Mahanian Michelle, Chattopadhyay Madhuri, La Cava Antonio, Wiedau-Pazos Martina
Neuronal phagocytosis by inflammatory macrophages in ALS spinal cord:
inhibition of inflammation by resolvin D1.
American journal of neurodegenerative disease,
2012; 1(1):
60-74.
Mizwicki Mathew T, Fiala Milan, Magpantay Larry, Aziz Najib, Sayre James, Liu Guanghao, Siani Avi, Chan Derrick, Martinez-Maza Otoniel, Chattopadhyay Madhuri, La Cava Antonio
Tocilizumab attenuates inflammation in ALS patients through inhibition
of IL6 receptor signaling.
American journal of neurodegenerative disease,
2012; 1(3):
305-15.
Fiala Milan, Chattopadhay Madhuri, La Cava Antonio, Tse Eric, Liu Guanghao, Lourenco Elaine, Eskin Ascia, Liu Philip T, Magpantay Larry, Tse Stephen, Mahanian Michelle, Weitzman Rachel, Tong Jason, Nguyen Caroline, Cho Tiffany, Koo Patrick, Sayre James, Martinez-Maza Otoniel, Rosenthal Mark J, Wiedau-Pazos Martina
IL-17A is increased in the serum and in spinal cord CD8 and mast cells
of ALS patients.
Journal of neuroinflammation,
2010; 7(1):
76.
Avagyan Hripsime, Goldenson Ben, Tse Eric, Masoumi Ava, Porter Verna, Wiedau-Pazos Martina, Sayre James, Ong Reno, Mahanian Michelle, Koo Patrick, Bae Susan, Micic Miodrag, Liu Philip T, Rosenthal Mark J, Fiala Milan
Immune blood biomarkers of Alzheimer disease patients.
Journal of neuroimmunology,
2009; 210(1-2):
67-72.
Masoumi Ava, Goldenson Ben, Ghirmai Senait, Avagyan Hripsime, Zaghi Justin, Abel Ken, Zheng Xueying, Espinosa-Jeffrey Araceli, Mahanian Michelle, Liu Phillip T, Hewison Martin, Mizwickie Matthew, Cashman John, Fiala Milan
1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate
amyloid-beta clearance by macrophages of Alzheimer's disease patients.
Journal of Alzheimer's disease : JAD,
2009; 17(3):
703-17.
Zaghi Justin, Goldenson Ben, Inayathullah Mohammed, Lossinsky Albert S, Masoumi Ava, Avagyan Hripsime, Mahanian Michelle, Bernas Michael, Weinand Martin, Rosenthal Mark J, Espinosa-Jeffrey Araceli, de Vellis Jean, Teplow David B, Fiala Milan
Alzheimer disease macrophages shuttle amyloid-beta from neurons to
vessels, contributing to amyloid angiopathy.
Acta neuropathologica,
2009; 117(2):
111-24.
Fiala Milan, Singer Elyse J, Commins Deborah, Mirzapoiazova Tamara, Verin Alexander, Espinosa Araceli, Ugen Kenneth, Bernas Michael, Witte Marlys, Weinand Martin, Lossinsky Albert S
HIV-1 Antigens in Neurons of Cocaine-Abusing Patients.
The open virology journal,
2008; 2(3):
24-31.
Fiala Milan, Liu Philip T, Espinosa-Jeffrey Araceli, Rosenthal Mark J, Bernard George, Ringman John M, Sayre James, Zhang Laura, Zaghi Justin, Dejbakhsh Sheila, Chiang Ben, Hui James, Mahanian Michelle, Baghaee Anita, Hong Pamela, Cashman John
Innate immunity and transcription of MGAT-III and Toll-like receptors
in Alzheimer's disease patients are improved by bisdemethoxycurcumin.
Proceedings of the National Academy of Sciences of the United States of America,
2007; 104(31):
12849-54.
Zhang Laura, Fiala Milan, Cashman John, Sayre James, Espinosa Araceli, Mahanian Michelle, Zaghi Justin, Badmaev Vladimir, Graves Michael C, Bernard George, Rosenthal Mark
Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's
disease patients.
Journal of Alzheimer's disease : JAD,
2006; 10(1):
1-7.
Fiala Milan, Lin Justin, Ringman John, Kermani-Arab Vali, Tsao George, Patel Amish, Lossinsky Albert S, Graves Michael C, Gustavson Andrew, Sayre James, Sofroni Emanuela, Suarez Tatiana, Chiappelli Francesco, Bernard George
Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's
disease patients.
Journal of Alzheimer's disease : JAD,
2005; 7(3):
221-32; discussion 255-62.
Graves Michael C, Fiala Milan, Dinglasan Lu Anne V, Liu Nancy Q, Sayre James, Chiappelli Francesco, van Kooten Cees, Vinters Harry V
Inflammation in amyotrophic lateral sclerosis spinal cord and brain is
mediated by activated macrophages, mast cells and T cells.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases,
2004; 5(4):
213-9.
Fiala Milan, Popik Waldemar, Qiao Jian-Hua, Lossinsky Albert S, Alce Timothy, Tran Kenix, Yang Wendy, Roos Kenneth P, Arthos James
HIV-1 induces cardiomyopathyby cardiomyocyte invasion and gp120, Tat,
and cytokine apoptotic signaling.
Cardiovascular toxicology,
2004; 4(2):
97-107.
Twu Cheryl, Liu Nancy Q, Popik Waldemar, Bukrinsky Michael, Sayre James, Roberts Jaclyn, Rania Shammas, Bramhandam Vishnu, Roos Kenneth P, MacLellan W Robb, Fiala Milan
Cardiomyocytes undergo apoptosis in human immunodeficiency virus
cardiomyopathy through mitochondrion- and death receptor-controlled
pathways.
Proceedings of the National Academy of Sciences of the United States of America,
2002; 99(22):
14386-91.
Liu Nancy Q, Lossinsky Albert S, Popik Waldemar, Li Xia, Gujuluva Chandrasekhar, Kriederman Benjamin, Roberts Jaclyn, Pushkarsky Tatania, Bukrinsky Michael, Witte Marlys, Weinand Martin, Fiala Milan
Human immunodeficiency virus type 1 enters brain microvascular
endothelia by macropinocytosis dependent on lipid rafts and the
mitogen-activated protein kinase signaling pathway.
Journal of virology,
2002; 76(13):
6689-700.
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