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Shaping the Future

Enrique Rozengurt, Ph.D.

Contact Information:

Work Phone Number:

(310) 794-6610

Work Address:

Laboratory
Warren Hall
Westwood , CA 90095
UNITED STATES
Office
Warren Hall
Westwood, CA 90095
UNITED STATES

Work Email Address:

erozengurt@mednet.ucla.edu

Website:

  

Work:

     gastro.ucla.edu


Distinguished Professor, Department of Medicine

Chief of Research, Digestive Diseases/Gastroenterology

Director, CURE: Digestive Diseases Research Center

Member, ACCESS Program: MBI IDP

JCCC Cancer and Stem Cell Biology Program Area

Molecular Biology


A Short Biography:

Dr. Rozengurt discovered that neuro-hormonal signals (e.g., peptides of the bombesin family) which act as molecular messengers in a rich network of information exchange throughout the organism via GPCRs, are potent cellular growth factors for multiple cell types in culture, including intestinal epithelial cells and function as autocrine/paracrine mitogens for human cancer cells. He studies the transmission of the neuro-hormonal signal from surface receptors to the nucleus along a number of transduction pathways, typically protein kinase cascades, that act in a synergistic and combinatorial fashion to promote cellular responses, including migration and proliferation. His work revealed that these extracellular signals trigger a complex set of molecular responses and specific protein kinase cascades including kinase C and A (PKC and PKA), mitogen-activated protein kinases (MAPKs) and p70 S6 ribosomal protein kinase. More recently, he reported on the cloning and expression analysis of a novel protein kinase termed protein kinase D (PKD). PKD is directly activated by phorbol esters and also is part of a novel phosphorylation cascade downstream of protein kinase C. Current research activities in this area include a detailed mutational analysis to define the contribution of different domains of PKD to its regulation, modulation of its expression to determine the role of PKD in cell regulation and development of animal models with over-expression or under-expression of PKD in the epithelial cells of the digestive system. In addition to serine/threonine protein kinase cascades, his studies demonstrated that neuropeptides also stimulate a rapid increase in the tyrosine phosphorylation of multiple substrates including focal adhesion kinase (FAK), paxillin, and Crk-associated substrate (CAS). These proteins localize at focal adhesion plaques and are implicated in cell migration, proliferation, and transformation. The work of Dr. Rozengurt is dissecting the molecular mechanisms by which neuro-hormonal agonists induce these downstream pathways in normal and pancreatic cancer cells and is elucidating the role of these pathways in cell migration, proliferation and cancer.

Detailed Biography:

Signal transduction pathways and growth regulation The elucidation of the mechanism of action of growth factors has emerged as one of the fundamental problems in biological sciences and is proving critical for understanding the causes underlying the unrestrained proliferation of cancer cells. The research activities of this laboratory are focused on the identification of extracellular factors and intracellular signal transduction pathways that stimulate cells to divide. We discovered that neuropeptides (e.g., peptides of the bombesin family) which act as molecular messengers in a rich network of information exchange throughout the organism, are potent cellular growth factors for multiple cell types in culture and function as autocrine/paracrine mitogens for human cancer cells. We study the transmission of the neuropeptide signal from surfacereceptors to the nucleus along a number of transduction pathways, typically protein kinase cascades, that act in a synergistic and combinatorial fashion to promote cell proliferation. Our work revealed that regulatory peptides trigger a complex set of molecular responses and specific protein kinase cascades including kinase C and A, mitogen-activated protein kinases (MAPKs) and p70 S6 ribosomal protein kinase. Recently, we reported on the cloning and expression analysis of a novel protein kinase termed protein kinase D (PKD). PKD is directly activated by phorbol esters and also is part of a novel phosphorylation cascade downstream of protein kinase C. Future research activities in this area include a detailed mutational analysis to define the contribution of different domains of PKD to its regulation and to modulate its expression to determine the role of PKD in cell regulation. In addition to serine/threonine protein kinase cascades, our studies demonstrated that neuropeptides also stimulate a rapid increase in the tyrosine phosphorylation of multiple substrates including focal adhesion kinase (FAK), paxillin, and Crk-associated substrate (CAS). These proteins which localize at focal adhesion plaques, are implicated in cell migration, proliferation, and transformation. Our work is dissecting the molecular mechanisms by which neuropeptides and growth factors induce these downstream pathways and is elucidating the role of these pathways in cell proliferation.

Publications:

Soares Heloisa P, Ni Yang, Kisfalvi Krisztina, Sinnett-Smith James, Rozengurt Enrique   Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells PloS one, 2013; 8(2): e57289.
Giovinazzo Francesco, Malpeli Giorgio, Zanini Sara, Parenti Marco, Piemonti Lorenzo, Colombatti Marco, Valenti Maria Teresa, Dalle Carbonare Luca, Scarpa Aldo, Sinnett-Smith James, Rozengurt Enrique, Bassi Claudio, Innamorati Giulio   Ectopic expression of the heterotrimeric G15 protein in pancreatic carcinoma and its potential in cancer signal transduction Cellular signalling, 2013; 25(3): 651-9.
Young, S. H.; Rey, O.; Sinnett-Smith, J.; Rozengurt, E.   Intracellular Ca2+ oscillations generated via the Ca2-sensing receptor are mediated by negative feedback by PKCalpha at Thr888, Am J Physiol Cell Physiol, 2013; .
Young Steven H, Rey Osvaldo, Sinnett-Smith James, Rozengurt Enrique   Intracellular Ca2+ oscillations generated via the Ca2-sensing receptor are mediated by negative feedback by PKCα at Thr888 American journal of physiology. Cell physiology, 2013; .
Sinnett-Smith James, Kisfalvi Krisztina, Kui Robert, Rozengurt Enrique   Metformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: dependence on glucose concentration and role of AMPK Biochemical and biophysical research communications, 2013; 430(1): 352-7.
Kisfalvi Krisztina, Moro Aune, Sinnett-Smith James, Eibl Guido, Rozengurt Enrique   Metformin inhibits the growth of human pancreatic cancer xenografts Pancreas, 2013; 42(5): 781-5.
Ni Yang, Sinnett-Smith James, Young Steven H, Rozengurt Enrique   PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors PloS one, 2013; 8(9): e73149.
Yoo James, Perez Citlali Ekaterina, Nie Wenxian, Sinnett-Smith James, Rozengurt Enrique   TNF-alpha and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR BMC gastroenterology, 2013; 13(1): 90.
Waldron Richard T, Innamorati Giulio, Torres-Marquez M Eugenia, Sinnett-Smith James, Rozengurt Enrique   Differential PKC-dependent and -independent PKD activation by G protein α subunits of the Gq family: selective stimulation of PKD Ser⁷⁴⁸ autophosphorylation by Gαq Cellular signalling, 2012; 24(4): 914-21.
Ziegler Mary E, Jin Yi-Ping, Young Steven H, Rozengurt Enrique, Reed Elaine F   HLA class I-mediated stress fiber formation requires ERK1/2 activation in the absence of an increase in intracellular Ca2+ in human aortic endothelial cells American journal of physiology. Cell physiology, 2012; 303(8): C872-82.
Rey Osvaldo, Chang Wenhan, Bikle Daniel, Rozengurt Nora, Young Steven H, Rozengurt Enrique   Negative cross-talk between calcium-sensing receptor and β-catenin signaling systems in colonic epithelium The Journal of biological chemistry, 2012; 287(2): 1158-67.
Young Steven H, Rozengurt Nora, Sinnett-Smith James, Rozengurt Enrique   Rapid protein kinase D1 signaling promotes migration of intestinal epithelial cells American journal of physiology. Gastrointestinal and liver physiology, 2012; 303(3): G356-66.
Yoo James, Rodriguez Perez Citlali Ekaterina, Nie Wenxian, Edwards Robert A, Sinnett-Smith James, Rozengurt Enrique   TNF-α induces upregulation of EGFR expression and signaling in human colonic myofibroblasts American journal of physiology. Gastrointestinal and liver physiology, 2012; 302(8): G805-14.
Rozengurt Enrique   Protein kinase D signaling: multiple biological functions in health and disease Physiology (Bethesda, Md.), 2011; 26(1): 23-33.
Sinnett-Smith James, Rozengurt Nora, Kui Robert, Huang Carlos, Rozengurt Enrique   Protein kinase D1 mediates stimulation of DNA synthesis and proliferation in intestinal epithelial IEC-18 cells and in mouse intestinal crypts The Journal of biological chemistry, 2011; 286(1): 511-20.
Yoo James, Rodriguez Perez Citlali Ekaterina, Nie Wenxian, Sinnett-Smith James, Rozengurt Enrique   Protein kinase D1 mediates synergistic MMP-3 expression induced by TNF-α and bradykinin in human colonic myofibroblasts Biochemical and biophysical research communications, 2011; 413(1): 30-5.
Ochi Nobuo, Tanasanvimon Suebpong, Matsuo Yoichi, Tong Zhimin, Sung Bokyung, Aggarwal Bharat B, Sinnett-Smith James, Rozengurt Enrique, Guha Sushovan   Protein kinase D1 promotes anchorage-independent growth, invasion, and angiogenesis by human pancreatic cancer cells Journal of cellular physiology, 2011; 226(4): 1074-81.
Rodriguez Perez Citlali Ekaterina, Nie Wenxian, Sinnett-Smith James, Rozengurt Enrique, Yoo James   TNF-α potentiates lysophosphatidic acid-induced COX-2 expression via PKD in human colonic myofibroblasts American journal of physiology. Gastrointestinal and liver physiology, 2011; 300(4): G637-46.
Harikumar Kuzhuvelil B, Kunnumakkara Ajaikumar B, Ochi Nobuo, Tong Zhimin, Deorukhkar Amit, Sung Bokyung, Kelland Lloyd, Jamieson Stephen, Sutherland Rachel, Raynham Tony, Charles Mark, Bagherzadeh Azadeh, Bagherazadeh Azadeh, Foxton Caroline, Boakes Alexandra, Farooq Muddasar, Maru Dipen, Diagaradjane Parmeswaran, Matsuo Yoichi, Sinnett-Smith James, Gelovani Juri, Krishnan Sunil, Aggarwal Bharat B, Rozengurt Enrique, Ireson Christopher R, Guha Sushovan   A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo Molecular cancer therapeutics, 2010; 9(5): 1136-46.
Young Steven H, Rey Osvaldo, Sternini Catia, Rozengurt Enrique   Amino acid sensing by enteroendocrine STC-1 cells: role of the Na+-coupled neutral amino acid transporter 2 American journal of physiology. Cell physiology, 2010; 298(6): C1401-13.
Torres-Marquez Eugenia, Sinnett-Smith James, Guha Sushovan, Kui Robert, Waldron Richard T, Rey Osvaldo, Rozengurt Enrique   CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway Biochemical and biophysical research communications, 2010; 391(1): 63-8.
Young Steven H, Rozengurt Enrique   Crosstalk between insulin receptor and G protein-coupled receptor signaling systems leads to Ca²+ oscillations in pancreatic cancer PANC-1 cells Biochemical and biophysical research communications, 2010; 401(1): 154-8.
Rozengurt Enrique, Sinnett-Smith James, Kisfalvi Krisztina   Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancer Clinical cancer research : an official journal of the American Association for Cancer Research, 2010; 16(9): 2505-11.
Rey Osvaldo, Young Steven H, Jacamo Rodrigo, Moyer Mary P, Rozengurt Enrique   Extracellular calcium sensing receptor stimulation in human colonic epithelial cells induces intracellular calcium oscillations and proliferation inhibition Journal of cellular physiology, 2010; 225(1): 73-83.
Zhang Xiaohai, Rozengurt Enrique, Reed Elaine F   HLA class I molecules partner with integrin β4 to stimulate endothelial cell proliferation and migration Science signaling, 2010; 3(149): ra85.
Kisfalvi Krisztina, Hurd Cliff, Guha Sushovan, Rozengurt Enrique   Induced overexpression of protein kinase D1 stimulates mitogenic signaling in human pancreatic carcinoma PANC-1 cells Journal of cellular physiology, 2010; 223(2): 309-16.
Guha Sushovan, Tanasanvimon Suebpong, Sinnett-Smith James, Rozengurt Enrique   Role of protein kinase D signaling in pancreatic cancer Biochemical pharmacology, 2010; 80(12): 1946-54.
Jiang Xiaohua, Sinnett-Smith James, Rozengurt Enrique   Carbachol induces p70S6K1 activation through an ERK-dependent but Akt-independent pathway in human colonic epithelial cells Biochemical and biophysical research communications, 2009; 387(3): 521-4.
Kisfalvi Krisztina, Eibl Guido, Sinnett-Smith James, Rozengurt Enrique   Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth Cancer research, 2009; 69(16): 6539-45.
Amadesi Silvia, Grant Andrew D, Cottrell Graeme S, Vaksman Natalya, Poole Daniel P, Rozengurt Enrique, Bunnett Nigel W   Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2 The Journal of comparative neurology, 2009; 516(2): 141-56.
Sinnett-Smith James, Jacamo Rodrigo, Kui Robert, Wang Yunzu M, Young Steven H, Rey Osvaldo, Waldron Richard T, Rozengurt Enrique   Protein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylation The Journal of biological chemistry, 2009; 284(20): 13434-45.
Yoo James, Chung Christine, Slice Lee, Sinnett-Smith James, Rozengurt Enrique   Protein kinase D mediates synergistic expression of COX-2 induced by TNF-{alpha} and bradykinin in human colonic myofibroblasts American journal of physiology. Cell physiology, 2009; 297(6): C1576-87.
Sternini Catia, Anselmi Laura, Rozengurt Enrique   Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing Current opinion in endocrinology, diabetes, and obesity, 2008; 15(1): 73-8.
Jindra Peter T, Jin Yi-Ping, Jacamo Rodrigo, Rozengurt Enrique, Reed Elaine F   MHC class I and integrin ligation induce ERK activation via an mTORC2-dependent pathway Biochemical and biophysical research communications, 2008; 369(2): 781-7.
Yuan Jingzhen, Rozengurt Enrique   PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells Journal of cellular biochemistry, 2008; 103(2): 648-62.
Papazyan Romeo, Doche Michael, Waldron Richard T, Rozengurt Enrique, Moyer Mary Pat, Rey Osvaldo   Protein kinase D isozymes activation and localization during mitosis Experimental cell research, 2008; 314(16): 3057-68.
Yuan Jingzhen, Lugea Aurelia, Zheng Ling, Gukovsky Ilya, Edderkaoui Mouad, Rozengurt Enrique, Pandol Stephen J   Protein kinase D1 mediates NF-kappaB activation induced by cholecystokinin and cholinergic signaling in pancreatic acinar cells American journal of physiology. Gastrointestinal and liver physiology, 2008; 295(6): G1190-201.
Jacamo Rodrigo, Sinnett-Smith James, Rey Osvaldo, Waldron Richard T, Rozengurt Enrique   Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation The Journal of biological chemistry, 2008; 283(19): 12877-87.
Jiang Xiaohua, Sinnett-Smith James, Rozengurt Enrique   Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells Cellular signalling, 2007; 19(5): 1000-10.
Jacamo Rodrigo, Jiang Xiaohua, Lunn J Adrian, Rozengurt Enrique   FAK phosphorylation at Ser-843 inhibits Tyr-397 phosphorylation, cell spreading and migration Journal of cellular physiology, 2007; 210(2): 436-44.
Waldron Richard T, Whitelegge Julian P, Faull Kym F, Rozengurt Enrique   Identification of a novel phosphorylation site in c-jun directly targeted in vitro by protein kinase D Biochemical and biophysical research communications, 2007; 356(2): 361-7.
Kisfalvi Krisztina, Rey Osvaldo, Young Steven H, Sinnett-Smith James, Rozengurt Enrique   Insulin potentiates Ca2+ signaling and phosphatidylinositol 4,5-bisphosphate hydrolysis induced by Gq protein-coupled receptor agonists through an mTOR-dependent pathway Endocrinology, 2007; 148(7): 3246-57.
Rozengurt Enrique   Mitogenic signaling pathways induced by G protein-coupled receptors Journal of cellular physiology, 2007; 213(3): 589-602.
Lunn J Adrian, Jacamo Rodrigo, Rozengurt Enrique   Preferential phosphorylation of focal adhesion kinase tyrosine 861 is critical for mediating an anti-apoptotic response to hyperosmotic stress The Journal of biological chemistry, 2007; 282(14): 10370-9.
Santiskulvong Chintda, Rozengurt Enrique   Protein kinase Calpha mediates feedback inhibition of EGF receptor transactivation induced by Gq-coupled receptor agonists Cellular signalling, 2007; 19(6): 1348-57.
Chiu Terence T, Leung Wai Yin, Moyer Mary Pat, Strieter Robert M, Rozengurt Enrique   Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB American journal of physiology. Cell physiology, 2007; 292(2): C767-77.
Sinnett-Smith James, Zhukova Elena, Rey Osvaldo, Rozengurt Enrique   Protein kinase D2 potentiates MEK/ERK/RSK signaling, c-Fos accumulation and DNA synthesis induced by bombesin in Swiss 3T3 cells Journal of cellular physiology, 2007; 211(3): 781-90.
Jin Yi-Ping, Korin Yael, Zhang Xiaohai, Jindra Peter T, Rozengurt Enrique, Reed Elaine F   RNA interference elucidates the role of focal adhesion kinase in HLA class I-mediated focal adhesion complex formation and proliferation in human endothelial cells Journal of immunology (Baltimore, Md. : 1950), 2007; 178(12): 7911-22.
Rozengurt Enrique, Sternini Catia   Taste receptor signaling in the mammalian gut Current opinion in pharmacology, 2007; 7(6): 557-62.
Lu Yu-Chun, Rozengurt Enrique, Zhukova Elena   Transgenic insulin released from G cells preferentially signals in the liver Biochemical and biophysical research communications, 2007; 355(1): 23-7.
Yuan Jingzhen, Rey Osvaldo, Rozengurt Enrique   Activation of protein kinase D3 by signaling through Rac and the alpha subunits of the heterotrimeric G proteins G12 and G13 Cellular signalling, 2006; 18(7): 1051-62.
Chen Monica C, Wu S Vincent, Reeve Joseph R, Rozengurt Enrique   Bitter stimuli induce Ca2+ signaling and CCK release in enteroendocrine STC-1 cells: role of L-type voltage-sensitive Ca2+ channels American journal of physiology. Cell physiology, 2006; 291(4): C726-39.
Rozengurt Nora, Wu S Vincent, Chen Monica C, Huang Carlos, Sternini Catia, Rozengurt Enrique   Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon American journal of physiology. Gastrointestinal and liver physiology, 2006; 291(5): G792-802.
Wu Steven S, Jácamo Rodrigo O, Vong Sheung K, Rozengurt Enrique   Differential regulation of Pyk2 phosphorylation at Tyr-402 and Tyr-580 in intestinal epithelial cells: roles of calcium, Src, Rho kinase, and the cytoskeleton Cellular signalling, 2006; 18(11): 1932-40.
Young Steven H, Rozengurt Enrique   Qdot nanocrystal conjugates conjugated to bombesin or ANG II label the cognate G protein-coupled receptor in living cells American journal of physiology. Cell physiology, 2006; 290(3): C728-32.
Jiang Xiaohua, Jacamo Rodrigo, Zhukova Elena, Sinnett-Smith James, Rozengurt Enrique   RNA interference reveals a differential role of FAK and Pyk2 in cell migration, leading edge formation and increase in focal adhesions induced by LPA in intestinal epithelial cells Journal of cellular physiology, 2006; 207(3): 816-28.
Rey Osvaldo, Young Steven H, Papazyan Romeo, Shapiro Mark S, Rozengurt Enrique   Requirement of the TRPC1 cation channel in the generation of transient Ca2+ oscillations by the calcium-sensing receptor The Journal of biological chemistry, 2006; 281(50): 38730-7.
Rozengurt Enrique   Taste receptors in the gastrointestinal tract. I. Bitter taste receptors and alpha-gustducin in the mammalian gut American journal of physiology. Gastrointestinal and liver physiology, 2006; 291(2): G171-7.
Papazyan Romeo, Rozengurt Enrique, Rey Osvaldo   The C-terminal tail of protein kinase D2 and protein kinase D3 regulates their intracellular distribution Biochemical and biophysical research communications, 2006; 342(3): 685-9.
Keire David A, Kumar Mohanraja, Hu Weidong, Sinnett-Smith James, Rozengurt Enrique   The lipid-associated 3D structure of SPA, a broad-spectrum neuropeptide antagonist with anticancer properties Biophysical journal, 2006; 91(12): 4478-89.
Rey Osvaldo, Papazyan Romeo, Waldron Richard T, Young Steven H, Lippincott-Schwartz Jennifer, Jacamo Rodrigo, Rozengurt Enrique   The nuclear import of protein kinase D3 requires its catalytic activity The Journal of biological chemistry, 2006; 281(8): 5149-57.
Jácamo Rodrigo O, Rozengurt Enrique   A truncated FAK lacking the FERM domain displays high catalytic activity but retains responsiveness to adhesion-mediated signals Biochemical and biophysical research communications, 2005; 334(4): 1299-304.
Slice Lee W, Chiu Terence, Rozengurt Enrique   Angiotensin II and epidermal growth factor induce cyclooxygenase-2 expression in intestinal epithelial cells through small GTPases using distinct signaling pathways The Journal of biological chemistry, 2005; 280(2): 1582-93.
Guha Sushovan, Eibl Guido, Kisfalvi Krisztina, Fan Robert S, Burdick Marie, Reber Howard, Hines Oscar J, Strieter Robert, Rozengurt Enrique   Broad-spectrum G protein-coupled receptor antagonist, [D-Arg1,D-Trp5,7,9,Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer Cancer research, 2005; 65(7): 2738-45.
Chiu Terence, Santiskulvong Chintda, Rozengurt Enrique   EGF receptor transactivation mediates ANG II-stimulated mitogenesis in intestinal epithelial cells through the PI3-kinase/Akt/mTOR/p70S6K1 signaling pathway American journal of physiology. Gastrointestinal and liver physiology, 2005; 288(2): G182-94.
Chiu T, Santiskulvong C, Rozengurt E   EGF receptor transactivation mediates ANG II-stimulated mitogenesis in intestinal epithelial cells through the PI3-kinase/Akt/mTOR/p70S6K1 signaling pathway American journal of physiology. Gastrointestinal and liver physiology. , 2005; 288(2): G182-94.
Fan Robert S, Jácamo Rodrigo O, Jiang Xiaohua, Sinnett-Smith James, Rozengurt Enrique   G protein-coupled receptor activation rapidly stimulates focal adhesion kinase phosphorylation at Ser-843. Mediation by Ca2+, calmodulin, and Ca2+/calmodulin-dependent kinase II The Journal of biological chemistry, 2005; 280(25): 24212-20.
Wu S Vincent, Chen Monica C, Rozengurt Enrique   Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat Physiological genomics, 2005; 22(2): 139-49.
Kisfalvi Krisztina, Guha Sushovan, Rozengurt Enrique   Neurotensin and EGF induce synergistic stimulation of DNA synthesis by increasing the duration of ERK signaling in ductal pancreatic cancer cells Journal of cellular physiology, 2005; 202(3): 880-90.
Krysan Kostyantyn, Reckamp Karen L, Dalwadi Harnisha, Sharma Sherven, Rozengurt Enrique, Dohadwala Mariam, Dubinett Steven M   Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner Cancer research, 2005; 65(14): 6275-81.
Rozengurt E, Rey O, Waldron RT   Protein kinase D signaling J Biol Chem, 2005; .
Rozengurt Enrique, Rey Osvaldo, Waldron Richard T   Protein kinase D signaling The Journal of biological chemistry, 2005; 280(14): 13205-8.
Yuan Jingzhen, Rey Osvaldo, Rozengurt Enrique   Protein kinase D3 activation and phosphorylation by signaling through G alpha q Biochemical and biophysical research communications, 2005; 335(2): 270-6.
Lu Yu-Chun, Sternini Catia, Rozengurt Enrique, Zhukova Elena   Release of transgenic human insulin from gastric g cells: a novel approach for the amelioration of diabetes Endocrinology, 2005; 146(6): 2610-9.
Rey O, Reeve JR, Zhukova E, Sinnett-Smith J, Rozengurt E   G protein-coupled receptor-mediated phosphorylation of the activation loop of protein kinase D: dependence on plasma membrane translocation and protein kinase Cepsilon The Journal of biological chemistry. , 2004; 279(33): 34361-72.
Zhang L, Keane MP, Zhu LX, Sharma S, Rozengurt E, Strieter RM, Dubinett SM, Huang M.   IL-7 and TGF-beta play counter-regulatory roles in PKC-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis Journal of Biological Chemistry, 2004; 279: 28315-28319.
Santiskulvong C, Sinnett-Smith J, Rozengurt E   Insulin reduces the requirement for EGFR transactivation in bombesin-induced DNA synthesis Biochemical and biophysical research communications. , 2004; 318(4): 826-32.
Waldron RT, Rey O, Zhukova E, Rozengurt E   Oxidative stress induces protein kinase C-mediated activation loop phosphorylation and nuclear redistribution of protein kinase D The Journal of biological chemistry. , 2004; 279(26): 27482-93.
Hunger-Glaser I, Fan RS, Perez-Salazar E, Rozengurt E   PDGF and FGF induce focal adhesion kinase (FAK) phosphorylation at Ser-910: dissociation from Tyr-397 phosphorylation and requirement for ERK activation Journal of cellular physiology. , 2004; 200(2): 213-22.
Sinnett-Smith J, Zhukova E, Hsieh N, Jiang X, Rozengurt E   Protein kinase D potentiates DNA synthesis induced by Gq-coupled receptors by increasing the duration of ERK signaling in swiss 3T3 cells The Journal of biological chemistry. , 2004; 279(16): 16883-93.
Chiu T, Santiskulvong C, Rozengurt E   ANG II stimulates PKC-dependent ERK activation, DNA synthesis, and cell division in intestinal epithelial cells American journal of physiology. Gastrointestinal and liver physiology. , 2003; 285(1): G1-11.
Hunger-Glaser I, Salazar EP, Sinnett-Smith J, Rozengurt E   Bombesin, lysophosphatidic acid, and epidermal growth factor rapidly stimulate focal adhesion kinase phosphorylation at Ser-910: requirement for ERK activation The Journal of biological chemistry. , 2003; 278(25): 22631-43.
Yuan J, Slice LW, Gu J, Rozengurt E   Cooperation of Gq, Gi, and G12/13 in protein kinase D activation and phosphorylation induced by lysophosphatidic acid The Journal of biological chemistry. , 2003; 278(7): 4882-91.
Guha S, Lunn JA, Santiskulvong C, Rozengurt E   Neurotensin stimulates protein kinase C-dependent mitogenic signaling in human pancreatic carcinoma cell line PANC-1 Cancer research. , 2003; 63(10): 2379-87.
Hurd C, Rozengurt E   Uncoupling of protein kinase D from suppression of EGF-dependent c-Jun phosphorylation in cancer cells Biochemical and biophysical research communications. , 2003; 302(4): 800-4.
Rey O, Zhukova E, Sinnett-Smith J, Rozengurt E   Vasopressin-induced intracellular redistribution of protein kinase D in intestinal epithelial cells Journal of cellular physiology. , 2003; 196(3): 483-92.
Wu SS, Chiu T, Rozengurt E   ANG II and LPA induce Pyk2 tyrosine phosphorylation in intestinal epithelial cells: role of Ca2+, PKC, and Rho kinase American journal of physiology. Cell physiology. , 2002; 282(6): C1432-44.
Young S, Rozengurt E.   Amino Acids and Ca 2+ Stimulate Different Patterns of Ca 2+ Oscillations through the Ca 2+-sensing Receptor American Journal of Physiology: Cell Physiology, 2002; 282: C1414-C1422.
Young SH, Wu SV, Rozengurt E   Ca2+-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor require negative feedback by protein kinase C The Journal of biological chemistry. , 2002; 277(49): 46871-6.
Wu SV, Rozengurt N, Yang M, Young SH, Sinnett-Smith J, Rozengurt E   Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells Proceedings of the National Academy of Sciences of the United States of America. , 2002; 99(4): 2392-7.
Waldron RT, Rey O, Iglesias T, Tugal T, Cantrell D, Rozengurt E   Activation loop Ser744 and Ser748 in protein kinase D are transphosphorylated in vivo The Journal of biological chemistry. , 2001; 276(35): 32606-15.
Yuan J, Slice LW, and Rozengurt E.   Activation of protein kinase D (PKD) by signaling through Rho and the alpha subunit of the heterotrimeric G protein G {sub 13} Journal of Biological Chemistry, 2001; 276: 38619-38627.
Ryder NM, Guha S, Hines OJ, Reber HA, Rozengurt E   G Protein-Coupled Receptor Signaling in Human Ductal Pancreatic Cancer Cells: Neurotensin Responsiveness and Mitogenic Stimulation N Journal of Cellular Physiology, 2001; 186: 53-64.
Chiu T, Rozengurt E   PKD in intestinal epithelial cells: rapid activation by phorbol esters, LPA, and angiotensin through PKC American journal of physiology. Cell physiology. , 2001; 280(4): C929-42.
Hurd C, Rozengurt E   Protein kinase D is sufficient to suppress EGF-induced c-Jun Ser 63 phosphorylation Biochemical and biophysical research communications. , 2001; 282(2): 404-8.
Zhukova E, Sinnett-Smith J, Rozengurt E   Protein kinase D potentiates DNA synthesis and cell proliferation induced by bombesin, vasopressin, or phorbol esters in Swiss 3T3 cells The Journal of biological chemistry. , 2001; 276(43): 40298-305.
Rey O, Young SH, Cantrell D, and Rozengurt E.   Rapid Protein Kinase D Translocation in Response to G Protein-coupled Receptor Activation: Dependence on Protein Kinase C Journal of Biological Chemistry, 2001; 276: 32616-32626.
Rey O, Sinnett-Smith J, Zhukova E, and Rozengurt E.   Regulated nucleocytoplasmic transport of protein kinase D in response to G protein-coupled receptor activation Journal of Biological Chemistry, 2001; 276, 52: 49228-49235.
Yuan J, Slice L, Walsh JH, Rozengurt E   Activation of protein kinase D by signaling through the alpha subunit of the heterotrimeric G protein G(q) The Journal of biological chemistry. , 2000; 275(3): 2157-64.
Iglesias T, Cabrera-Poch N, Mitchell MP, Naven TJ, Rozengurt E, Schiavo G   Identification and cloning of Kidins220, a novel neuronal substrate of protein kinase D The Journal of biological chemistry. , 2000; 275(51): 40048-56.
Paolucci L, Sinnett-Smith J, Rozengurt E   Lysophosphatidic acid rapidly induces protein kinase D activation through a pertussis toxin-sensitive pathway American journal of physiology. Cell physiology. , 2000; 278(1): C33-9.
Waldron RT, Rozengurt E   Oxidative stress induces protein kinase D activation in intact cells. Involvement of Src and dependence on protein kinase C The Journal of biological chemistry. , 2000; 275(22): 17114-21.
Matthews SA, Rozengurt E, Cantrell D   Protein kinase D. A selective target for antigen receptors and a downstream target for protein kinase C in lymphocytes The Journal of experimental medicine. , 2000; 191(12): 2075-82.
Matthews SA, Iglesias T, Rozengurt E, Cantrell D   Spatial and temporal regulation of protein kinase D (PKD) The EMBO journal. , 2000; 19(12): 2935-45.
Sinnett-Smith J, Santiskulvong C, Dugue J, Rozengurt E.   [D-Arg1,D-Trp5,7,9,Leu11] Substance P inhibits bombesin-induced mitogenic signal transduction mediated by both Gq and G12 in Swiss 3T3 cells Journal of Biological Chemistry, 2000; 275: 30644-30652.
Salazar EP, Rozengurt E   Bombesin and platelet-derived growth factor induce association of endogenous focal adhesion kinase with Src in intact Swiss 3T3 cells The Journal of biological chemistry. , 1999; 274(40): 28371-8.
Matthews SA, Rozengurt E, Cantrell D   Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/Protein kinase Cmu The Journal of biological chemistry. , 1999; 274(37): 26543-9.
Slice LW, Walsh JH, Rozengurt E.   Ga13 stimulates Rho-dependent activation of the cyclooxygenase-2 promoter Journal of Biological Chemistry, 1999; 274: 27562-27566.
Waldron RT, Iglesias T, Rozengurt E   The pleckstrin homology domain of protein kinase D interacts preferentially with the eta isoform of protein kinase C The Journal of biological chemistry. , 1999; 274(14): 9224-30.
Rodriguez-Fernandez JL, Rozengurt E.   Bombesin, vasopressin, lysophosphatidic acid and sphingosylphosphorylcholine induce focal adhesion kinase activation in intact Swiss 3T3 cells Journal of Biological Chemistry, 1998; 273: 19321-19328.
Iglesias T, Waldron RT, Rozengurt E   Identification of in vivo phosphorylation sites required for protein kinase D activation The Journal of biological chemistry. , 1998; 273(42): 27662-7.
Iglesias T, Rozengurt E   Protein kinase D activation by mutations within its pleckstrin homology domain The Journal of biological chemistry. , 1998; 273(1): 410-6.
Zugaza JL, Waldron RT, Sinnett-Smith J, Rozengurt E   Bombesin, vasopressin, endothelin, bradykinin, and platelet-derived growth factor rapidly activate protein kinase D through a protein kinase C-dependent signal transduction pathway The Journal of biological chemistry. , 1997; 272(38): 23952-60.
Matthews SA, Pettit GR, Rozengurt E   Bryostatin 1 induces biphasic activation of protein kinase D in intact cells The Journal of biological chemistry. , 1997; 272(32): 20245-50.
Mann DJ, Higgins T, Jones NC, Rozengurt E   Differential control of cyclins D1 and D3 and the cdk inhibitor p27Kip1 by diverse signalling pathways in Swiss 3T3 cells Oncogene. , 1997; 14(15): 1759-66.
Withers DJ, Seufferlein T, Mann D, Garcia B, Jones N, Rozengurt E.   Rapamycin dissociates p70s6k activation from DNA synthesis stimulated by bombesin and insulin in Swiss 3T3 cells, Journal of Biological Chemistry, 1997; 272: 2509-2514.
Zugaza JL, Sinnett-Smith J, Van Lint J, Rozengurt E   Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway The EMBO journal. , 1996; 15(22): 6220-30.
Seufferlein T, Withers DJ, Rozengurt E.   Reduced requirement of MAPK activity for entry into the S phase of the cell cycle in Swiss 3T3 fibroblasts by bombesin and insulin Journal of Biological Chemistry, 1996; 271: 21471-21477.
Rankin S, Hooshmand-Rad R, Claesson-Welsh L, Rozengurt E   Requirement for phosphatidylinositol 3'-kinase activity in platelet-derived growth factor-stimulated tyrosine phosphorylation of p125 focal adhesion kinase and paxillin The Journal of biological chemistry. , 1996; 271(13): 7829-34.
Withers DJ, Bloom SR, Rozengurt E   Dissociation of cAMP-stimulated mitogenesis from activation of the mitogen-activated protein kinase cascade in Swiss 3T3 cells The Journal of biological chemistry. , 1995; 270(36): 21411-9.
Van Lint JV, Sinnett-Smith J, Rozengurt E   Expression and characterization of PKD, a phorbol ester and diacylglycerol-stimulated serine protein kinase The Journal of biological chemistry. , 1995; 270(3): 1455-61.
Seckl MJ, Morii N, Narumiya S, Rozengurt E   Guanosine 5'-3-O-(thio)triphosphate stimulates tyrosine phosphorylation of p125FAK and paxillin in permeabilized Swiss 3T3 cells. Role of p21rho The Journal of biological chemistry. , 1995; 270(12): 6984-90.
Lach EB, Broad S, Rozengurt E.   Mitogenic signalling by transfected neuromedin B receptors in Rat-1 cells, Cell Growth and Differentiation, 1995; 6: 1427-1435.
Seufferlein T, Withers DJ, Broad S, Herget T, Walsh JH, Rozengurt E.   The human CCKB/Gastrin receptor transfected into rat1 fibroblasts mediates activation of MAP kinase, p74raf-1 kinase, and mitogenesis, Cell Growth and Differentiation, 1995; 6: 383-393.
Rankin S, Morii N, Narumiya S, Rozengurt E   Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of p125FAK and paxillin induced by bombesin and endothelin FEBS letters. , 1994; 354(3): 315-9.
Valverde AM, Sinnett-Smith J, Van Lint J, Rozengurt E.   Molecular cloning and characterization of protein kinase D (PKD): a novel target for diacylglycerol and phorbol esters with a unique catalytic domain Proceedings of the National Academy of Science, USA, 1994; 91: 8572-8576.
Domin J, Higgins T, Rozengurt E   Preferential inhibition of platelet-derived growth factor-stimulated DNA synthesis and protein tyrosine phosphorylation by nordihydroguaiaretic acid The Journal of biological chemistry. , 1994; 269(11): 8260-7.
Seufferlein T, Rozengurt E   Sphingosine induces p125FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cells The Journal of biological chemistry. , 1994; 269(44): 27610-7.
Sinnett-Smith J, Zachary I, Valverde AM, Rozengurt E   Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton The Journal of biological chemistry. , 1993; 268(19): 14261-8.
Zachary I, Sinnett-Smith J, Turner CE, Rozengurt E   Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation of the focal adhesion-associated protein paxillin in Swiss 3T3 cells The Journal of biological chemistry. , 1993; 268(29): 22060-5.
Sethi T, Herget T, Wu SV, Walsh JH, Rozengurt E.   CCKA and CCKB receptors are expressed in small lung cancer lines and mediate Ca+2 mobilization and clonal growth Cancer Research, 1993; 53: 5208-5213.
Seckl M, Rozengurt E   Tyrphostin inhibits bombesin stimulation of tyrosine phosphorylation, c-fos expression, and DNA synthesis in Swiss 3T3 cells The Journal of biological chemistry. , 1993; 268(13): 9548-54.
Langdon S, Sethi T, Ritchie A, Muir M, Smyth J, Rozengurt E   Broad spectrum neuropeptide antagonists inhibit the growth of small cell lung cancer in vivo Cancer research. , 1992; 52(16): 4554-7.
Sethi T, Rozengurt E   Gastrin stimulates Ca2+ mobilization and clonal growth in small cell lung cancer cells Cancer research. , 1992; 52(21): 6031-5.
Domin J, Rozengurt E   Heterologous desensitization of platelet-derived growth factor-mediated arachidonic acid release and prostaglandin synthesis The Journal of biological chemistry. , 1992; 267(21): 15217-23.
Staddon JM, Bouzyk MM, Rozengurt E.   Interconversion of GRP78/BiP: a novel event in the action of Pasteurella multocida toxin, bombesin and platelet-derived growth factor Journal of Biological Chemistry, 1992; 267: 25239-25245.
Higgins TE, Murphy AC, Staddon JM, Lax AJ, Rozengurt E   Pasteurella multocida toxin is a potent inducer of anchorage-independent cell growth Proceedings of the National Academy of Sciences of the United States of America. , 1992; 89(10): 4240-4.
Albert DA, Rozengurt E   Synergistic and coordinate expression of the genes encoding ribonucleotide reductase subunits in Swiss 3T3 cells: effect of multiple signal-transduction pathways Proceedings of the National Academy of Sciences of the United States of America. , 1992; 89(5): 1597-601.
Staddon JM, Bouzyk MM, Rozengurt E   A novel approach to detect toxin-catalyzed ADP-ribosylation in intact cells: its use to study the action of Pasteurella multocida toxin The Journal of cell biology. , 1991; 115(4): 949-58.
Zachary I, Gil J, Lehmann W, Sinnett-Smith J, Rozengurt E   Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation in intact Swiss 3T3 cells Proceedings of the National Academy of Sciences of the United States of America. , 1991; 88(11): 4577-81.
Erusalimsky JD, Brooks SF, Herget T, Morris C, Rozengurt E.   Molecular cloning and charaterization of the acidic 80-kDa protein kinase C substrate from rat brain Journal of Biological Chemistry, 1991; 266: 7073-7080.
Staddon JM, Barker CJ, Murphy AC, Chanter N, Lax AJ, Michell RH, Rozengurt E.   Pasteurella multocida toxin, a potent mitogen, increases inositol 1,4,5-triphosphate and mobilizes Ca+2 in Swiss 3T3 cells Journal of Biological Chemistry, 1991; 266: 4840-4847.
Brooks SF, Herget T, Erusalimsky JD, Rozengurt E   Protein kinase C activation potently down-regulates the expression of its major substrate, 80K, in Swiss 3T3 cells The EMBO journal. , 1991; 10(9): 2497-505.
Woll PJ, Rozengurt E   A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro Cancer research. , 1990; 50(13): 3968-73.
Millar JBA, Rozengurt E.   Arachidonic acid release by bombesin: a novel post-receptor target for heterologous mitogenic desensitization Journal of Biological Chemistry, 1990; 265: 19973-19979.
Issandou M, Rozengurt E   Bradykinin transiently activates protein kinase C in Swiss 3T3 cells. Distinction from activation by bombesin and vasopressin The Journal of biological chemistry. , 1990; 265(20): 11890-6.
Staddon JM, Chanter N, Lax AJ, Higgins TE, Rozengurt E   Pasteurella multocida toxin, a potent mitogen, stimulates protein kinase C-dependent and -independent protein phosphorylation in Swiss 3T3 cells The Journal of biological chemistry. , 1990; 265(20): 11841-8.
Rozengurt E, Higgins T, Chanter N, Lax AJ, Staddon JM.   Pasteurella multocida toxin: A novel potent mitogen for cultured fibroblasts Proceedings of the National Academy of Sciences of the USA, 1990; 87: 123-127.
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