Sarosh Motivala, Ph.D.
Work Phone Number:
300 UCLA Medical Plaza
Mail Code 707624
Los Angeles, CA 90095
Assistant Professor In-Residence,
Psychiatry and Biobehavioral Sciences
Semel Institute for Neuroscience and Human Behavior
Dr. Motivala?s work focuses on sleep disturbance, stress and health outcomes and the underlying physiological pathways that link these phenomena together. Poor sleep impacts the immune system in ways that are just beginning to be identified. Immune processes, specifically the expression of signaling molecules called cytokines, can impact sleep. This bidirectional relationship is important for overall health because the very same cytokines involved in sleep regulation, including interleukins 1 and 6 and tumor necrosis factor also play a role in chronic low grade inflammatory processes and a number of autoimmune disorders.
Dr. Motivala was recently awarded a five-year clinical scientist grant from the National Institutes of Health to study the effects of behavioral treatment of chronic insomnia on markers of energy balance and metabolism in older adults. There is growing evidence that sleep disturbance is associated with changes energy balance that promote weight gain and this will be the first study to examine sleep and energy balance in older adults with chronic insomnia.
Irwin Michael R, Olmos Luis, Wang Minge, Valladares Edwin M, Motivala Sarosh J, Fong Tim, Newton Tom, Butch Anthony, Olmstead Richard, Cole Steve W
Cocaine dependence and acute cocaine induce decreases of monocyte
proinflammatory cytokine expression across the diurnal period:
The Journal of pharmacology and experimental therapeutics,