Hua Cai

Title(s)Professor, Anesthesiology
SchoolMedicine
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    Title(s)Professor, Medicine


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    Collapse Research Activities and Funding
    Endothelium-driven signaling network in the development of pulmonary hypertension
    NIH R01HL154754Sep 1, 2020 - Jun 30, 2024
    Role: Principal Investigator
    Netrin-1 and Netrin-1 Preconditioned EPCs in Vascular Protection
    NIH R01HL142951Apr 1, 2020 - Jan 31, 2024
    Role: Principal Investigator
    Endothelium-Myocardium Interaction in Netrin-1 Induced Cardioprotection
    NIH R01HL119968Aug 1, 2013 - Jul 31, 2020
    Role: Principal Investigator
    Role of Vascular Oxidative Stress in Obesity
    NIH R01HL108701Feb 24, 2012 - Dec 31, 2017
    Role: Principal Investigator
    Mitochondrial pathways in NO induced cardioprotection
    NIH R01HL101228May 1, 2010 - Feb 28, 2015
    Role: Co-Principal Investigator
    NOXs, eNOS Uncoupling and Diabetic Atherogenesis
    NIH R01HL088975Apr 1, 2007 - Apr 30, 2021
    Role: Principal Investigator
    Endocardial dysfunction in humans with AF
    NIH R21HL081571Jul 1, 2005 - Jun 30, 2008
    Role: Principal Investigator
    Angiotensin II Uncoupling of Enos in Hypertension
    NIH R01HL077440Jul 1, 2004 - Jun 30, 2021
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reversal of Pulmonary Hypertension in a Human-Like Model: Therapeutic Targeting of Endothelial DHFR. Circ Res. 2024 02 16; 134(4):351-370. Murugesan P, Zhang Y, Huang Y, Chenggong Zong N, Youn JY, Chen W, Wang C, Loscalzo J, Cai H. PMID: 38299369; PMCID: PMC10880947.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Sirtuin 2 deficiency aggravates ageing-induced vascular remodelling in humans and mice. Eur Heart J. 2023 08 01; 44(29):2746-2759. Zhang Y, Wang X, Li XK, Lv SJ, Wang HP, Liu Y, Zhou J, Gong H, Chen XF, Ren SC, Zhang H, Dai Y, Cai H, Yan B, Chen HZ, Tang X. PMID: 37377116; PMCID: PMC10393077.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    3. Restoration of coronary microvascular function by OGA overexpression in a high-fat diet with low-dose streptozotocin-induced type 2 diabetic mice. Diab Vasc Dis Res. 2023 May-Jun; 20(3):14791641231173630. Cabrera JT, Si R, Tsuji-Hosokawa A, Cai H, Yuan JX, Dillmann WH, Makino A. PMID: 37186669; PMCID: PMC10196148.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Endothelial damage in young adult e-cigarette users. Redox Biol. 2023 06; 62:102688. Youn JY, Middlekauff HR, Reudiseuli I, Huang K, Cai H. PMID: 37018969; PMCID: PMC10121999.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Longitudinal profiling in patients undergoing cardiac surgery reveals postoperative changes in DNA methylation. Clin Epigenetics. 2022 12 30; 14(1):195. Fischer MA, Chapski DJ, Soehalim E, Montoya DJ, Grogan T, Pellegrini M, Cai H, Shemin RJ, Vondriska TM. PMID: 36585726; PMCID: PMC9805211.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Combination of folic acid with nifedipine is completely effective in attenuating aortic aneurysm formation as a novel oral medication. Redox Biol. 2022 12; 58:102521. Huang K, Wu Y, Zhang Y, Youn JY, Cai H. PMID: 36459715; PMCID: PMC9713368.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    7. Corrigendum to "Diagnostic and predictive values of circulating tetrahydrobiopterin levels as a novel biomarker in patients with thoracic and abdominal aortic aneurysms" [Redox Biol. 56 (2022) 102444]. Redox Biol. 2022 Nov; 57:102516. Zhang Y, Siu KL, Li Q, Howard-Quijano K, Scovotti J, Mahajan A, Cai H. PMID: 36307318; PMCID: PMC9618463.
      View in: PubMed   Mentions:    Fields:    
    8. TLR4 activation induces inflammatory vascular permeability via Dock1 targeting and NOX4 upregulation. Biochim Biophys Acta Mol Basis Dis. 2022 12 01; 1868(12):166562. Song JH, Mascarenhas JB, Sammani S, Kempf CL, Cai H, Camp SM, Bermudez T, Zhang DD, Natarajan V, Garcia JGN. PMID: 36179995.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    9. Robust therapeutic effects on COVID-19 of novel small molecules: Alleviation of SARS-CoV-2 S protein induction of ACE2/TMPRSS2, NOX2/ROS, and MCP-1. Front Cardiovasc Med. 2022; 9:957340. Youn JY, Wang J, Li Q, Huang K, Cai H. PMID: 36187008; PMCID: PMC9520320.
      View in: PubMed   Mentions: 1  
    10. Diagnostic and predictive values of circulating tetrahydrobiopterin levels as a novel biomarker in patients with thoracic and abdominal aortic aneurysms. Redox Biol. 2022 10; 56:102444. Zhang Y, Siu KL, Li Q, Howard-Quijano K, Scovotti J, Mahajan A, Cai H. PMID: 36116158; PMCID: PMC9486112.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    11. eNAMPT Neutralization Preserves Lung Fluid Balance and Reduces Acute Renal Injury in Porcine Sepsis/VILI-Induced Inflammatory Lung Injury. Front Physiol. 2022; 13:916159. Sammani S, Bermudez T, Kempf CL, Song JH, Fleming JC, Reyes Hernon V, Hufford M, Tang L, Cai H, Camp SM, Natarajan V, Jacobson JR, Dudek SM, Martin DR, Karmonik C, Sun X, Sun B, Casanova NG, Bime C, Garcia JGN. PMID: 35812318; PMCID: PMC9257134.
      View in: PubMed   Mentions: 7  
    12. Novel and robust treatment of pulmonary hypertension with netrin-1 and netrin-1-derived small peptides. Redox Biol. 2022 Sep; 55:102348. Murugesan P, Zhang Y, Youn JY, Cai H. PMID: 35830752; PMCID: PMC9287481.
      View in: PubMed   Mentions:    Fields:    
    13. Flavored and Nicotine-Containing E-Cigarettes Induce Impaired Angiogenesis and Diabetic Wound Healing via Increased Endothelial Oxidative Stress and Reduced NO Bioavailability. Antioxidants (Basel). 2022 May 05; 11(5). Liu Z, Zhang Y, Youn JY, Zhang Y, Makino A, Yuan JX, Cai H. PMID: 35624768; PMCID: PMC9137638.
      View in: PubMed   Mentions: 5  
    14. eNAMPT Is a Novel Damage-associated Molecular Pattern Protein That Contributes to the Severity of Radiation-induced Lung Fibrosis. Am J Respir Cell Mol Biol. 2022 05; 66(5):497-509. Garcia AN, Casanova NG, Kempf CL, Bermudez T, Valera DG, Song JH, Sun X, Cai H, Moreno-Vinasco L, Gregory T, Oita RC, Hernon VR, Camp SM, Rogers C, Kyubwa EM, Menon N, Axtelle J, Rappaport J, Bime C, Sammani S, Cress AE, Garcia JGN. PMID: 35167418; PMCID: PMC9116358.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    15. Therapeutic application of estrogen for COVID-19: Attenuation of SARS-CoV-2 spike protein and IL-6 stimulated, ACE2-dependent NOX2 activation, ROS production and MCP-1 upregulation in endothelial cells. Redox Biol. 2021 10; 46:102099. Youn JY, Zhang Y, Wu Y, Cannesson M, Cai H. PMID: 34509916; PMCID: PMC8372492.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    16. Targeting MicroRNA-192-5p, a Downstream Effector of NOXs (NADPH Oxidases), Reverses Endothelial DHFR (Dihydrofolate Reductase) Deficiency to Attenuate Abdominal Aortic Aneurysm Formation. Hypertension. 2021 08; 78(2):282-293. Huang K, Narumi T, Zhang Y, Li Q, Murugesan P, Wu Y, Liu NM, Cai H. PMID: 34176283; PMCID: PMC8266749.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    17. Toll-Like Receptor 2 (TLR2) Knockout Abrogates Diabetic and Obese Phenotypes While Restoring Endothelial Function via Inhibition of NOX1. Diabetes. 2021 09; 70(9):2107-2119. Guo Z, Zhang Y, Liu C, Youn JY, Cai H. PMID: 34127487; PMCID: PMC8576422.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    18. More to Explore: Further Definition of Risk Factors for COPD - Differential Gender Difference, Modest Elevation in PM2.5, and e-Cigarette Use. Front Physiol. 2021; 12:669152. Zhang Y, Wang L, Mutlu GM, Cai H. PMID: 34025456; PMCID: PMC8131967.
      View in: PubMed   Mentions: 1  
    19. Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms. Pharmacol Ther. 2021 09; 225:107843. Huang K, Zhang P, Zhang Z, Youn JY, Wang C, Zhang H, Cai H. PMID: 33811957; PMCID: PMC8011334.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansCells
    20. Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics. Redox Biol. 2021 01; 38:101757. Huang K, Wang Y, Siu KL, Zhang Y, Cai H. PMID: 33126053; PMCID: PMC7585948.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    21. More to Add to E-Cigarette Regulations: Unified Approaches. Chest. 2020 04; 157(4):771-773. Cai H, Garcia JGN, Wang C. PMID: 32252929.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. Sex difference and smoking predisposition in patients with COVID-19. Lancet Respir Med. 2020 04; 8(4):e20. Cai H. PMID: 32171067; PMCID: PMC7103991.
      View in: PubMed   Mentions: 293     Fields:    Translation:HumansCellsPHPublic Health
    23. Knockout of dihydrofolate reductase in mice induces hypertension and abdominal aortic aneurysm via mitochondrial dysfunction. Redox Biol. 2019 06; 24:101185. Li Q, Youn JY, Siu KL, Murugesan P, Zhang Y, Cai H. PMID: 30954686; PMCID: PMC6451172.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    24. Novel Treatment of Hypertension by Specifically Targeting E2F for Restoration of Endothelial Dihydrofolate Reductase and eNOS Function Under Oxidative Stress. Hypertension. 2019 01; 73(1):179-189. Li H, Li Q, Zhang Y, Liu W, Gu B, Narumi T, Siu KL, Youn JY, Liu P, Yang X, Cai H. PMID: 30571557; PMCID: PMC6310047.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    25. KDM4B protects against obesity and metabolic dysfunction. Proc Natl Acad Sci U S A. 2018 06 12; 115(24):E5566-E5575. Cheng Y, Yuan Q, Vergnes L, Rong X, Youn JY, Li J, Yu Y, Liu W, Cai H, Lin JD, Tontonoz P, Hong C, Reue K, Wang CY. PMID: 29844188; PMCID: PMC6004484.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    26. Surviving With Smog and Smoke: Precision Interventions? Chest. 2017 11; 152(5):925-929. Cai H, Wang C. PMID: 28694198; PMCID: PMC5812760.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    27. Graphical review: The redox dark side of e-cigarettes; exposure to oxidants and public health concerns. Redox Biol. 2017 10; 13:402-406. Cai H, Wang C. PMID: 28667909; PMCID: PMC5493817.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsPHPublic Health
    28. Editorial commentary: Endothelial-to-mesenchymal transition: When the good one goes bad. Trends Cardiovasc Med. 2017 08; 27(6):394-396. Zhang Y, Cai H. PMID: 28583438; PMCID: PMC6529939.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    29. Endothelial cell calpain as a critical modulator of angiogenesis. Biochim Biophys Acta Mol Basis Dis. 2017 06; 1863(6):1326-1335. Zhang Y, Liu NM, Wang Y, Youn JY, Cai H. PMID: 28366876; PMCID: PMC6511073.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    30. Attenuation of neointimal formation with netrin-1 and netrin-1 preconditioned endothelial progenitor cells. J Mol Med (Berl). 2017 03; 95(3):335-348. Liu NM, Siu KL, Youn JY, Cai H. PMID: 28004124; PMCID: PMC5976243.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    31. Protein Phosphotyrosine Phosphatase 1B (PTP1B) in Calpain-dependent Feedback Regulation of Vascular Endothelial Growth Factor Receptor (VEGFR2) in Endothelial Cells: IMPLICATIONS IN VEGF-DEPENDENT ANGIOGENESIS AND DIABETIC WOUND HEALING. J Biol Chem. 2017 Jan 13; 292(2):407-416. Zhang Y, Li Q, Youn JY, Cai H. PMID: 27872190; PMCID: PMC5241720.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    32. NOX isoforms in the development of abdominal aortic aneurysm. Redox Biol. 2017 04; 11:118-125. Siu KL, Li Q, Zhang Y, Guo J, Youn JY, Du J, Cai H. PMID: 27912196; PMCID: PMC5133668.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    33. Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. Circulation. 2016 May 24; 133(21):2038-49. Sun H, Olson KC, Gao C, Prosdocimo DA, Zhou M, Wang Z, Jeyaraj D, Youn JY, Ren S, Liu Y, Rau CD, Shah S, Ilkayeva O, Gui WJ, William NS, Wynn RM, Newgard CB, Cai H, Xiao X, Chuang DT, Schulze PC, Lynch C, Jain MK, Wang Y. PMID: 27059949; PMCID: PMC4879058.
      View in: PubMed   Mentions: 217     Fields:    Translation:HumansAnimalsCells
    34. Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress. J Biol Chem. 2016 Apr 15; 291(16):8653-62. Siu KL, Gao L, Cai H. PMID: 26826128; PMCID: PMC4861435.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    35. Reply: To PMID 25882860. J Hypertens. 2015 Nov; 33(11):2368-70. Li Q, Youn JY, Li S, Cai H. PMID: 26372324; PMCID: PMC4819245.
      View in: PubMed   Mentions:    Fields:    
    36. Nifedipine attenuation of abdominal aortic aneurysm in hypertensive and non-hypertensive mice: Mechanisms and implications. J Mol Cell Cardiol. 2015 Oct; 87:152-9. Miao XN, Siu KL, Cai H. PMID: 26254182; PMCID: PMC4637219.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    37. Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative. Circ Res. 2015 Jul 17; 117(3):234-8. Ping P, Gustafsson ÅB, Bers DM, Blatter LA, Cai H, Jahangir A, Kelly D, Muoio D, O'Rourke B, Rabinovitch P, Trayanova N, Van Eyk J, Weiss JN, Wong R, Schwartz Longacre L. PMID: 26185209; PMCID: PMC4535701.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    38. Bone Morphogenic Protein 4 Mediates NOX1-Dependent eNOS Uncoupling, Endothelial Dysfunction, and COX2 Induction in Type 2 Diabetes Mellitus. Mol Endocrinol. 2015 Aug; 29(8):1123-33. Youn JY, Zhou J, Cai H. PMID: 26121233; PMCID: PMC4518001.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    39. Mechanisms and consequences of endothelial nitric oxide synthase dysfunction in hypertension. J Hypertens. 2015 Jun; 33(6):1128-36. Li Q, Youn JY, Cai H. PMID: 25882860; PMCID: PMC4816601.
      View in: PubMed   Mentions: 88     Fields:    Translation:Humans
    40. Induction of cardioprotection by small netrin-1-derived peptides. Am J Physiol Cell Physiol. 2015 Jul 15; 309(2):C100-6. Li Q, Cai H. PMID: 25924621; PMCID: PMC4504940.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    41. ANO1 taking center stage: blood pressure regulation in SHRs. J Mol Cell Cardiol. 2015 May; 82:216-7. Li Q, Cai H. PMID: 25817885; PMCID: PMC4819994.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    42. Fueling up skeletal muscle to reduce obesity: A TrkB story. Chem Biol. 2015 Mar 19; 22(3):311-2. Youn JY, Cai H. PMID: 25794433; PMCID: PMC4817994.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    43. Central role of SIAH inhibition in DCC-dependent cardioprotection provoked by netrin-1/NO. Proc Natl Acad Sci U S A. 2015 Jan 20; 112(3):899-904. Li Q, Wang P, Ye K, Cai H. PMID: 25561546; PMCID: PMC4311801.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    44. Circulating tetrahydrobiopterin as a novel biomarker for abdominal aortic aneurysm. Am J Physiol Heart Circ Physiol. 2014 Dec 01; 307(11):H1559-64. Siu KL, Cai H. PMID: 25260610; PMCID: PMC4255016.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    45. Netrin-1 abrogates ischemia/reperfusion-induced cardiac mitochondrial dysfunction via nitric oxide-dependent attenuation of NOX4 activation and recoupling of NOS. J Mol Cell Cardiol. 2015 Jan; 78:174-85. Siu KL, Lotz C, Ping P, Cai H. PMID: 25066694; PMCID: PMC4268247.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    46. NADPH oxidase 4 induces cardiac arrhythmic phenotype in zebrafish. J Biol Chem. 2014 Aug 15; 289(33):23200-23208. Zhang Y, Shimizu H, Siu KL, Mahajan A, Chen JN, Cai H. PMID: 24962575; PMCID: PMC4132817.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    47. Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial integrity, while attenuating autophagy. Biochim Biophys Acta. 2015 Feb; 1852(2):277-89. Bouhidel JO, Wang P, Siu KL, Li H, Youn JY, Cai H. PMID: 24928309; PMCID: PMC4262720.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    48. Recoupling of eNOS with folic acid prevents abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E null mice. PLoS One. 2014; 9(2):e88899. Siu KL, Miao XN, Cai H. PMID: 24558445; PMCID: PMC3928303.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    49. Role of vascular oxidative stress in obesity and metabolic syndrome. Diabetes. 2014 Jul; 63(7):2344-55. Youn JY, Siu KL, Lob HE, Itani H, Harrison DG, Cai H. PMID: 24550188; PMCID: PMC4066332.
      View in: PubMed   Mentions: 64     Fields:    Translation:Animals
    50. Pharmacological postconditioning treatment of myocardial infarction with netrin-1. Front Biosci (Landmark Ed). 2014 01 01; 19(3):566-70. Bouhidel JO, Wang P, Li Q, Cai H. PMID: 24389204; PMCID: PMC4053198.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    51. Oxidative stress in atrial fibrillation: an emerging role of NADPH oxidase. J Mol Cell Cardiol. 2013 Sep; 62:72-9. Youn JY, Zhang J, Zhang Y, Chen H, Liu D, Ping P, Weiss JN, Cai H. PMID: 23643589; PMCID: PMC3735724.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimals
    52. Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis. Clin Sci (Lond). 2012 Oct; 123(8):509-18. Youn JY, Nguyen A, Cai H. PMID: 22568671; PMCID: PMC3675905.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    53. Intralipid, a clinically safe compound, protects the heart against ischemia-reperfusion injury more efficiently than cyclosporine-A. Anesthesiology. 2012 Oct; 117(4):836-46. Li J, Iorga A, Sharma S, Youn JY, Partow-Navid R, Umar S, Cai H, Rahman S, Eghbali M. PMID: 22814384; PMCID: PMC3769111.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    54. NOX4-Dependent Hydrogen Peroxide Overproduction in Human Atrial Fibrillation and HL-1 Atrial Cells: Relationship to Hypertension. Front Physiol. 2012; 3:140. Zhang J, Youn JY, Kim AY, Ramirez RJ, Gao L, Ngo D, Chen P, Scovotti J, Mahajan A, Cai H. PMID: 22679437; PMCID: PMC3367314.
      View in: PubMed   Mentions: 25  
    55. Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial proteome design: from molecular identity to pathophysiological regulation. J Gen Physiol. 2012 Jun; 139(6):395-406. Zhang J, Lin A, Powers J, Lam MP, Lotz C, Liem D, Lau E, Wang D, Deng N, Korge P, Zong NC, Cai H, Weiss J, Ping P. PMID: 22641634; PMCID: PMC3362520.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    56. Cardiac vulnerability to ischemia/reperfusion injury drastically increases in late pregnancy. Basic Res Cardiol. 2012 Jul; 107(4):271. Li J, Umar S, Iorga A, Youn JY, Wang Y, Regitz-Zagrosek V, Cai H, Eghbali M. PMID: 22648276; PMCID: PMC3769136.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    57. Endothelium-specific sepiapterin reductase deficiency in DOCA-salt hypertension. Am J Physiol Heart Circ Physiol. 2012 Jun 01; 302(11):H2243-9. Youn JY, Wang T, Blair J, Laude KM, Oak JH, McCann LA, Harrison DG, Cai H. PMID: 22467312; PMCID: PMC3378300.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    58. Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: treatment with folic acid. Hypertension. 2012 Jan; 59(1):158-66. Gao L, Siu KL, Chalupsky K, Nguyen A, Chen P, Weintraub NL, Galis Z, Cai H. PMID: 22083158; PMCID: PMC3668799.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    59. Netrin-1 prevents ischemia/reperfusion-induced myocardial infarction via a DCC/ERK1/2/eNOS s1177/NO/DCC feed-forward mechanism. J Mol Cell Cardiol. 2010 Jun; 48(6):1060-70. Zhang J, Cai H. PMID: 20004665; PMCID: PMC2866819.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    60. Aminoguanidine inhibits aortic hydrogen peroxide production, VSMC NOX activity and hypercontractility in diabetic mice. Cardiovasc Diabetol. 2009 Dec 30; 8:65. Oak JH, Youn JY, Cai H. PMID: 20040119; PMCID: PMC2811700.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    61. Mechanistic insights into folic acid-dependent vascular protection: dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: a novel HPLC-based fluorescent assay for DHFR activity. J Mol Cell Cardiol. 2009 Dec; 47(6):752-60. Gao L, Chalupsky K, Stefani E, Cai H. PMID: 19660467; PMCID: PMC2784291.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    62. Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. J Clin Invest. 2009 Jun; 119(6):1678-87. Lu G, Sun H, She P, Youn JY, Warburton S, Ping P, Vondriska TM, Cai H, Lynch CJ, Wang Y. PMID: 19411760; PMCID: PMC2689111.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    63. Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability. Am J Physiol Heart Circ Physiol. 2009 Jul; 297(1):H331-9. Gao L, Pung YF, Zhang J, Chen P, Wang T, Li M, Meza M, Toro L, Cai H. PMID: 19429835; PMCID: PMC2711718.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    64. An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production. Circ Res. 2009 Jan 02; 104(1):50-9. Youn JY, Wang T, Cai H. PMID: 19038867; PMCID: PMC2720268.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    65. Mitochondrial pathophysiology, reactive oxygen species, and cardiovascular diseases. Vet Clin North Am Small Anim Pract. 2008 Jan; 38(1):137-55, vi. Gao L, Laude K, Cai H. PMID: 18249246; PMCID: PMC2700041.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    66. CaM Kinase II-dependent pathophysiological signalling in endothelial cells. Cardiovasc Res. 2008 Jan; 77(1):30-4. Cai H, Liu D, Garcia JG. PMID: 18006482.
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    67. Targeted cardiac overexpression of A20 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction. Circulation. 2007 Apr 10; 115(14):1885-94. Li HL, Zhuo ML, Wang D, Wang AB, Cai H, Sun LH, Yang Q, Huang Y, Wei YS, Liu PP, Liu DP, Liang CC. PMID: 17389268.
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    68. Detection of reactive oxygen species and nitric oxide in vascular cells and tissues: comparison of sensitivity and specificity. Methods Mol Med. 2007; 139:293-311. Cai H, Dikalov S, Griendling KK, Harrison DG. PMID: 18287681.
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    69. Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice. Diabetes. 2007 Jan; 56(1):118-26. Oak JH, Cai H. PMID: 17192473.
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    70. Autocrine/paracrine pattern of superoxide production through NAD(P)H oxidase in coronary arterial myocytes. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H483-95. Zhang G, Zhang F, Muh R, Yi F, Chalupsky K, Cai H, Li PL. PMID: 16963617.
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    71. Netrin-1 induces angiogenesis via a DCC-dependent ERK1/2-eNOS feed-forward mechanism. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6530-5. Nguyen A, Cai H. PMID: 16611730; PMCID: PMC1458918.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    72. Urokinase plasminogen activator stimulates vascular smooth muscle cell proliferation via redox-dependent pathways. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):801-7. Menshikov M, Plekhanova O, Cai H, Chalupsky K, Parfyonova Y, Bashtrikov P, Tkachuk V, Berk BC. PMID: 16456094.
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    73. Hydrogen peroxide regulation of endothelial function: origins, mechanisms, and consequences. Cardiovasc Res. 2005 Oct 01; 68(1):26-36. Cai H. PMID: 16009356.
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    74. Ion-trap tandem mass spectrometric analysis of Amadori-glycated phosphatidylethanolamine in human plasma with or without diabetes. J Lipid Res. 2005 Nov; 46(11):2514-24. Nakagawa K, Oak JH, Higuchi O, Tsuzuki T, Oikawa S, Otani H, Mune M, Cai H, Miyazawa T. PMID: 16150834.
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    75. Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 2005 Jun 21; 102(25):9056-61. Chalupsky K, Cai H. PMID: 15941833; PMCID: PMC1157015.
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    76. Regulation of xanthine oxidoreductase protein expression by hydrogen peroxide and calcium. Arterioscler Thromb Vasc Biol. 2005 Aug; 25(8):1623-8. McNally JS, Saxena A, Cai H, Dikalov S, Harrison DG. PMID: 15905466.
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    77. NAD(P)H oxidase-dependent self-propagation of hydrogen peroxide and vascular disease. Circ Res. 2005 Apr 29; 96(8):818-22. Cai H. PMID: 15860762.
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    78. Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice. Am J Physiol Heart Circ Physiol. 2005 Jan; 288(1):H7-12. Laude K, Cai H, Fink B, Hoch N, Weber DS, McCann L, Kojda G, Fukai T, Schmidt HH, Dikalov S, Ramasamy S, Gamez G, Griendling KK, Harrison DG. PMID: 15471976.
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    79. Role of CaMKII in hydrogen peroxide activation of ERK1/2, p38 MAPK, HSP27 and actin reorganization in endothelial cells. FEBS Lett. 2004 Aug 13; 572(1-3):307-13. Nguyen A, Chen P, Cai H. PMID: 15304367.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    80. Actin cytoskeleton organization and posttranscriptional regulation of endothelial nitric oxide synthase during cell growth. Circ Res. 2004 Sep 03; 95(5):488-95. Searles CD, Ide L, Davis ME, Cai H, Weber M. PMID: 15256481.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    81. Oscillatory shear stress upregulation of endothelial nitric oxide synthase requires intracellular hydrogen peroxide and CaMKII. J Mol Cell Cardiol. 2004 Jul; 37(1):121-5. Cai H, McNally JS, Weber M, Harrison DG. PMID: 15242742.
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    82. The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases. Trends Pharmacol Sci. 2003 Sep; 24(9):471-8. Cai H, Griendling KK, Harrison DG. PMID: 12967772.
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    83. Endothelial control of vasomotion and nitric oxide production. Cardiol Clin. 2003 Aug; 21(3):289-302. Harrison DG, Cai H. PMID: 14621446.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    84. Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease. J Renin Angiotensin Aldosterone Syst. 2003 Jun; 4(2):51-61. Harrison DG, Cai H, Landmesser U, Griendling KK. PMID: 12806586.
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    85. Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide. Mol Pharmacol. 2003 Feb; 63(2):325-31. Cai H, Li Z, Davis ME, Kanner W, Harrison DG, Dudley SC. PMID: 12527803.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    86. Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training. Am J Physiol Heart Circ Physiol. 2003 Apr; 284(4):H1449-53. Davis ME, Cai H, McCann L, Fukai T, Harrison DG. PMID: 12595302.
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    87. Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke. Circulation. 2002 Nov 26; 106(22):2854-8. Cai H, Li Z, Goette A, Mera F, Honeycutt C, Feterik K, Wilcox JN, Dudley SC, Harrison DG, Langberg JJ. PMID: 12451014.
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    88. NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production in response to angiotensin II. J Biol Chem. 2002 Dec 13; 277(50):48311-7. Cai H, Li Z, Dikalov S, Holland SM, Hwang J, Jo H, Dudley SC, Harrison DG. PMID: 12377764.
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    89. Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II. Hypertension. 2002 Oct; 40(4):511-5. Landmesser U, Cai H, Dikalov S, McCann L, Hwang J, Jo H, Holland SM, Harrison DG. PMID: 12364355; PMCID: PMC4734745.
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    90. Shear stress regulates endothelial nitric oxide synthase expression through c-Src by divergent signaling pathways. Circ Res. 2001 Nov 23; 89(11):1073-80. Davis ME, Cai H, Drummond GR, Harrison DG. PMID: 11717166.
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    91. Induction of endothelial NO synthase by hydrogen peroxide via a Ca(2+)/calmodulin-dependent protein kinase II/janus kinase 2-dependent pathway. Arterioscler Thromb Vasc Biol. 2001 Oct; 21(10):1571-6. Cai H, Davis ME, Drummond GR, Harrison DG. PMID: 11597928.
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    92. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res. 2000 Nov 10; 87(10):840-4. Cai H, Harrison DG. PMID: 11073878.
      View in: PubMed   Mentions: 1052     Fields:    Translation:HumansAnimals
    93. The alpha-synuclein gene and Parkinson disease in a Chinese population. Arch Neurol. 2000 Apr; 57(4):501-3. Chan DK, Mellick G, Cai H, Wang XL, Ng PW, Pang CP, Woo J, Kay R. PMID: 10768624.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    94. Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. Circ Res. 2000 Feb 18; 86(3):347-54. Drummond GR, Cai H, Davis ME, Ramasamy S, Harrison DG. PMID: 10679488.
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    95. Genetic polymorphism of heparan sulfate proteoglycan (perlecan, HSPG2), lipid profiles and coronary artery disease in the Australian population. Atherosclerosis. 2000 Jan; 148(1):125-9. Cai H, Wang XL, Wilcken DE. PMID: 10580178.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    96. NADH/NADPH oxidase p22 phox C242T polymorphism and coronary artery disease in the Australian population. Eur J Clin Invest. 1999 Sep; 29(9):744-8. Cai H, Duarte N, Wilcken DE, Wang XL. PMID: 10469162.
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    97. Relationship between total plasma homocysteine, polymorphisms of homocysteine metabolism related enzymes, risk factors and coronary artery disease in the Australian hospital-based population. Atherosclerosis. 1999 Sep; 146(1):133-40. Wang XL, Duarte N, Cai H, Adachi T, Sim AS, Cranney G, Wilcken DE. PMID: 10487496.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansPHPublic Health
    98. The Glu-298-->Asp (894G-->T) mutation at exon 7 of the endothelial nitric oxide synthase gene and coronary artery disease. J Mol Med (Berl). 1999 Jun; 77(6):511-4. Cai H, Wilcken DE, Wang XL. PMID: 10475066.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    99. A common Glu298-->Asp (894G-->T) mutation at exon 7 of the endothelial nitric oxide synthase gene and vascular complications in type 2 diabetes. Diabetes Care. 1998 Dec; 21(12):2195-6. Cai H, Wang X, Colagiuri S, Wilcken DE. PMID: 9839121.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    100. Methionine synthase D919G mutation in type 2 diabetes and its relation to vascular events. Diabetes Care. 1998 Oct; 21(10):1774-5. Cai H, Wang X, Colagiuri S, Wilcken DE. PMID: 9773747.
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    101. The frequency of a common mutation of the methionine synthase gene in the Australian population and its relation to smoking and coronary artery disease. J Cardiovasc Risk. 1998 Oct-Dec; 5(5-6):289-95. Wang XL, Cai H, Cranney G, Wilcken DE. PMID: 9919998.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
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