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Shaping the Future

Hong Zhou, Ph.D.

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570 Westwood Plaza


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615 Charles E. Young Dr. South
Los Angeles, CA 90095
570 Westwood Plaza
Los Angeles, CA

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6350B CNSI
570 Westwood Plaza
Los Angeles, CA 90095

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     Electron Imaging Center for NanoMachines

Director, Electron Imaging Center for NanoMachines (EICN)

Professor, Microbiology, Immunology & Molecular Genetics

Member, ACCESS Program: Dept. of Microbiology, Immunology, & Molecular Genetics

Access Biochemistry, Biophysics, Structural Biology Home Area

ACCESS Program

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California NanoSystems Institute

Faculty, Biomedical Engineering IDP

A Short Biography:

Prof. Hong Zhou has a PhD degree in biochemistry from Baylor College of Medicine (1995) and MS and BS degrees in physics from University of Science and Technology of China (USTC). He also received advanced training in computational sciences and mathematics. Dr. Zhou is a leader in the field of cryo-electron microscopy and the founding director of the UCLA cryoEM facility - the Electron Imaging Center for NanoMachines, based in the California NanoSystems Institute (CNSI). His research focuses on the structural and functional studies of large molecular complexes, viruses and cellular michineries using cryo-electron microscopy and related biophysical means as the primary tools.

Awards and Honors:

K H Kuo Educational Foundation K H Kuo Award of Distinguished Scientist
American Microscopy Society Burton Award
American Heart Association Established Investigator Award
March of Dimes Foundation Basil O'Connor Scholar Award
Pew Scholar in the Biomedical Sciences Pew Scholar in the Biomedical Sciences

Detailed Biography:

Z. Hong Zhou, Ph. D. Professor Hong Zhou is a Professor in UCLA's Microbiology, Immunology, and Molecular Genetics department. Dr. Zhou's research centers on studying the assembly and structures of macromolecular complexes, viruses and cellular machineries using cryo-electron microscopy (cryoEM) and cryo-electron tomography (cryoET). He also developed cryoEM and computational methods for structure determination at atomic resolution. To this end, he combines expertise in structural biology, virology, microbiology, computational biology, and bioinformatics. Dr. Zhou was a Pew Scholar in the Biomedical Sciences, received numerous awards, including the Basil O'Connor Scholar Award, the Established Investigator Award of American Heart Association, the Burton award, and the KH Kuo Award of Distinguished Scientist.


Daniel C. Buehler, Daniel B. Toso, Valerie A. Kickhoefer, Z. Hong Zhou, Leonard H. Rome   Vaults Engineered for Hydrophobic Drug Delivery Small, 2011; Epub ahead of print: .
Zhang X, Jin L, Fang Q, Hui WH, Zhou ZH.   3.3 A Cryo-EM Structure of a Nonenveloped Virus Reveals a Priming Mechanism for Cell Entry Cell, 2010; 141(3): 472-82.
Ming Yan, Juanjuan Du, Zhen Gu, Min Liang, Yufang Hu, Wenjun Zhang, Saul Priceman, Lily Wu, Z. Hong Zhou, Zheng Liu, Tatiana Segura, Yi Tang, Yunfeng Lu   A novel intracellular protein delivery platform based on single-protein nanocapsules Nature Nanotechnology, 2010; 5: 48 - 53 .
Hongrong Liu, Lei Jin, Sok Boon S. Koh, Ivo Atanasov, Stan Schein, Lily Wu, Z. Hong Zhou   Atomic Structure of Human Adenovirus by Cryo-EM Reveals Interactions Among Protein Networks Science, 2010; 329(5995): 1038-1043.
Zhang X, Boyce M, Bhattacharya B, Zhang X, Schein S, Roy P, Zhou ZH   Bluetongue virus coat protein VP2 contains sialic acid-binding domains, and VP5 resembles enveloped virus fusion proteins PNAS, 2010; 107(14): 6292-7.
Liu J, Howell JK, Bradley SD, Zheng Y, Zhou ZH, Norris SJ   Cellular architecture of Treponema pallidum: novel flagellum, periplasmic cone, and cell envelope as revealed by cryo electron tomography J Mol Biol, 2010; 403(4): 546-61.
Leong PA, Yu X, Zhou ZH, Jensen GJ   Correcting for the ewald sphere in high-resolution single-particle reconstructions Methods Enzymol, 2010; 482: 369-80.
Ge, P., Tsao, J., Schein, S., Green, T.J., Luo, M., Zhou, Z.H.   Cryo-EM Model of the Bullet-Shaped Vesicular Stomatitis Virus Science, 2010; 327(5966): 689-93.
Huang CS, Sadre-Bazzaz K, Shen Y, Deng B, Zhou ZH, Tong L   Crystal structure of the alpha(6)beta(6) holoenzyme of propionyl-coenzyme A carboxylase Nature, 2010; 466(7309): 1001-5.
Faller M, Toso D, Matsunaga M, Atanasov I, Senturia R, Chen Y, Zhou ZH, Guo F   DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures RNA, 2010; 16(8): 1570-83.
Jin L, Pan C, Qi Z, Zhou ZH, Jiang S   Fab crystallization and preliminary X-ray analysis of NC-1, an anti-HIV-1 antibody that recognizes the six-helix bundle core of gp41 Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010; 66(7): 854-7.
Liu S, He J, Shih C, Li K, Dai A, Zhou ZH, Zhang J   Structural comparisons of hepatitis B core antigen particles with different C-terminal lengths Virus Res, 2010; 149(2): 241-4.
Dai W, Hodes A, Hui WH, Gingery M, Miller JF, Zhou ZH   Three-dimensional structure of tropism-switching Bordetella bacteriophage PNAS, 2010; 107(9): 4347-52.
Peng, L Ryazantsev, S Sun, R Zhou, Z. H.   Three-dimensional visualization of gammaherpesvirus life cycle in host cells by electron tomography Structure, 2010; 18(1): 47-58.
Zhu Jiang, Cheng Lingpeng, Fang Qin, Zhou Z Hong, Honig Barry   Building and Refining Protein Models within Cryoelectron Microscopy Density Maps Based on Homology Modeling and Multiscale Structure Refinement Journal of Molecular Biology, 2010; 327(5966): .
Cheng Lingpeng, Zhu Jiang, Hui Wong Hoi, Zhang Xiaokang, Honig Barry, Fang Qin, Zhou Z Hong   Backbone Model of an Aquareovirus Virion by Cryo-Electron Microscopy and Bioinformatics Journal of molecular biology, 2009; 5(1): .
Guo Haitao, Wang Lili, Peng Li, Zhou Z Hong, Deng Hongyu   Open reading frame 33 of a gammaherpesvirus encodes a tegument protein essential for virion morphogenesis and egress Journal of virology, 2009; 83(20): 10582-95.
Nayak Debi P, Balogun Rilwan A, Yamada Hiroshi, Zhou Z Hong, Barman Subrata   Influenza virus morphogenesis and budding Virus research, 2009; 143(2): 147-61.
Li Feng, Ge Peng, Hui Wong H, Atanasov Ivo, Rogers Kestrel, Guo Qiang, Osato Daren, Falick Arnold M, Zhou Z Hong, Simpson Larry   Structure of the core editing complex (L-complex) involved in uridine insertion/deletion RNA editing in trypanosomatid mitochondria Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(30): 12306-10.
Pan, D. X. Wang Zhou, Z. H. W. Chen C. Xu Lu, Y   Synthesis of quaternary semiconductor nanocrystals with tunable band gaps Chemistry of Materials, 2009; 21(12): 2489-2493.
Song Changyong, Jiang Huaidong, Mancuso Adrian, Amirbekian Bagrat, Peng Li, Sun Ren, Shah Sanket S, Zhou Z Hong, Ishikawa Tetsuya, Miao Jianwei   Quantitative imaging of single, unstained viruses with coherent x rays Physical review letters, 2008; 101(15): 158101.
Cheng, L. Fang, Q. Shah, S. Atanasov, I. C. Zhou, Z. H.   Subnanometer-resolution structures of the grass carp reovirus core and virion J Mol Biol, 2008; 382(1): 213-22.
Jiang, J., Zhang, X., Chen, Y., Wu, Y., Zhou, Z.H., Chang, Z. and Sui, S.F.   Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins PNAS, 2008; 33(105): 11939-44.
Xuekui Yu, Lei Jin, & Z. Hong Zhou   3.88 A structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy Nature, 2008; 453: 415-419.
Deng, B., O'Connor, C.M., Kedes, D.H. and Zhou, Z.H.   Cryo-electron tomography of Kaposi's sarcoma-associated herpesvirus capsids reveals dynamic scaffolding structures essential to capsid assembly and maturation Journal of Structural Biology, 2008; 161(3): 419-427.
Dai, W., Jia, Q., Bortz, E., Shah, S., Liu, J., Atanasov, I., Li, X., Taylor, D.A., Sun, R. and Zhou, Z.H.   Unique stuctures of a tumor herpesvirus revealed by cryo-electron tomography and microscopy Journal of Structural Biology, 2008; 161: 428-438.
Yu, X., Hiromasa, Y., Tsen, H., Stoops, J.K., Roche, T.E., Zhou, Z.H.   Structures of the Human Pyruvate Dehydrogenase Complex Cores: a Highly Conserved Catalytic Center with Flexible N-terminal Domains Structure, 2008; 16(1): 104-114.
Liu, H., Cheng,L., Zeng, S., Cai, C., Zhou,Z.H., Yang, Q.   Symmetry-adapted spherical harmonics method for high-resolution 3D single-particle reconstructions Journal of Structural Biology, 2008; 161(1): 64-73.
Yu, X Qiao, M Atanasov, I Hu, Z Kato, T Liang, TJ Zhou, ZH   Cryo-electron microscopy and three-dimensional reconstructions of hepatitis C virus particles Virology, 2007; 367(1): 126-134.
Zhou, Z. H.   Cypovirus, In Structure and Molecular Biology of Segmented Double-Stranded RNA Viruses, P.J.T. and M. L. Nibert eds, Horizon Scientific Press, 2007; .
Deng, B O'Connor, CM Kedes, DH Zhou, ZH   Direct visualization of the putative portal in the Kaposi's sarcoma-associated herpesvirus capsid by cryoelectron tomography Journal of virology, 2007; 81(7): 3640-4.
Liu, F. and Zhou, Z.H.   Comparative virion structures of human herpesviruses. In Human Herpesviruses: Biology, Therapy and Immunoprophylaxis, Arvin, A., Campadelli-Fiume, G., Moore, P., Mocarski, E., Roizman, B., Whitley, R., & Yamanishi, K., eds, Cambridge University Press, 2006; 27-43.
Zhou, Z. H.*, Stoops, JK, Krueger   Ultrastructure and Assembly of Human Herpesvirus-6 (HHV-6), In Human Herpesvirus-6, Krueger/Alashi (eds.), Elsevier Science Publishers, 2006; 11-21.
Yu, X Trang, P Shah, S Atanasov, I Kim, YH Bai, Y Zhou, ZH Liu, F   Dissecting human cytomegalovirus gene function and capsid maturation by ribozyme targeting and electron cryomicroscopy Proceedings of the National Academy of Sciences of the United States of America, 2005; 102(20): 7103-8.
Yu, X Shah, S Atanasov, I Lo, P Liu, F Britt, WJ Zhou, ZH   Three-dimensional localization of the smallest capsid protein in the human cytomegalovirus capsid Journal of Virology, 2005; 79(2): 1327-32.
Wan, Y., Chiu, W., Zhou, Z.H.   Full contrast transfer function correction in 3D cryo-EM reconstruction IEEE Proceedings of ICCCAS, 2004; 960-964.
Baker, ML Jiang, W Bowman, BR Zhou, ZH Quiocho, FA Rixon, FJ Chiu, W   Architecture of the herpes simplex virus major capsid protein derived from structural bioinformatics Journal of molecular biology, 2003; 331(2): 447-56.
Kong, Y., Ming, D., Wu, Y., Stoops, J.S., Zhou, Z.H., Ma, J.   Conformational flexibility of pyruvate dehydrogenase complexes J. Mol. Biol, 2003; 330(1): 129-135.
Bortz, E. Whitelegge, J. P. Jia, Q. Zhou, Z. H. Stewart, J. P. Wu, T. T. Sun, R.   Identification of proteins associated with murine gammaherpesvirus 68 virions J Virol, 2003; 77(24): 13425-32.
Zhou, Z.H.*, Stoops, J.K. and Reed, L.J.   Structural and functional organization of pyruvate dehydrogenase complexes. In: Thiamine, Jordan F. & Patel M.S. (eds), Jordan F. & Patel M.S. (Eds), 2003; 309-330.
Xia, Q., Jakana, J., Zhang, J.-Q., Zhou, Z.H.   Structural comparisons of empty and full CPV: protein-RNA interactions and implications for endogenous RNA transcription mechanisms J. Biol. Chem, 2003; 278: 1094-1100.
Zhou, Z.H.* and Chiu, W.   Structural determination of icosahedral viruses by electron cryomicroscopy at subnanometer resolution Advances in Protein Chemistry, 2003; 64: 93-124.
Lo, P., Yu, X., Atanasov, I., Chandran, B., Zhou, Z.H.   Three-dimensional localization of pORF65 in Kaposi's sarcoma-associated herpesvirus capsid J. Virol, 2003; 77: 4221-4230.
Yu, X.K., O'Connor, C.M., Atanasov, I., Damania, B., Kedes, D.H., Zhou, Z.H.   Three-dimensional structures of the A, B, and C capsids of Rhesus monkey Rhadinovirus J. Virol, 2003; 77: 13182-13193.
Dai, W Liang, Y Zhou, ZH   Web portal to an image database for high-resolution three-dimensional reconstruction Journal of structural biology, 2003; 144(1-2): 238-45.
Zhou, Z. H., Zhang, H., Jakana, J., Lu, X.Y., Zhang, J.Q.   Cytoplasmic Polyhedrosis Virus Structure at 8 A by Electron ryomicoscopy: Structural Basis of Capsid Stability and mRNA Processing Regulation Structure, 2003; 11(6): 651-663.
Lu, BY Atanasov, I Zhou, ZH Chang, JY   Reversible aggregation of mouse prion protein derivatives with PrPSC-like structural properties Journal of protein chemistry, 2003; 22(2): 115-26.
Zhang, H Yu, XK Lu, XY Zhang, JQ Zhou, ZH   Molecular interactions and viral stability revealed by structural analyses of chemically treated cypovirus capsids Virology, 2002; 298(1): 45-52.
Chiu, W., Baker, M.L., Jiang, W., Zhou, Z.H.   Deriving folds of macromolecular complexes through electron cryomicroscopy and bioinformatics Curr. Opin. Struct. Biol, 2002; 12(2): 263-269.
Liang, Y., Ke, E.Y., Zhou, Z.H.   IMIRS: a high-resolution 3D reconstruction package integrated with a relational image database J. Struct. Biol, 2002; 137: 292-304.
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