David M Underhill

Title(s)Professor-in-Residence, Pathology and Laboratory Medicine
SchoolMedicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Targeting the Mycobiome in Genetically Defined Patients with Crohns Disease
    NIH R01DK125495May 1, 2021 - Feb 28, 2025
    Role: Principal Investigator
    Antifungal immunity in Hirschsprung-Associated Enterocolitis
    NIH R21AI142422Mar 1, 2019 - Feb 28, 2021
    Role: Principal Investigator
    Developing a MRI-guided Disease-Modifying Therapy for Post Infarction Chronic Heart Failure
    NIH R01HL133407Jul 1, 2017 - Jun 30, 2021
    Role: Co-Principal Investigator
    Generating protective immunity to Staphylococcus aureus
    NIH R01AI127406Jun 26, 2017 - May 31, 2022
    Role: Principal Investigator
    Measuring Phagosomal Temperatures
    NIH R21AI103471Feb 1, 2014 - Jan 31, 2016
    Role: Principal Investigator
    Host immunity to commensal gut fungi
    NIH R01DK093426Jul 1, 2012 - May 31, 2022
    Role: Principal Investigator
    Impact of Antibiotics and PBP2a on the Immunopathology of MRSA pneumonia
    NIH R21AI097741Jul 1, 2012 - Jun 30, 2014
    Role: Co-Principal Investigator
    Innate Recognition of Bacterial Sugars
    NIH R01GM085796Apr 1, 2008 - Mar 31, 2021
    Role: Principal Investigator
    Dectin-1 Signaling Mechanisms
    NIH R01AI071116Jul 1, 2006 - May 31, 2024
    Role: Principal Investigator
    TOLL-LIKE RECEPTORS: ACTIVATORS OF INNATE IMMUNITY
    NIH R01GM062995Apr 3, 2001 - Mar 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fungal Microbiota Composition in Inflammatory Bowel Disease Patients: Characterization in Different Phenotypes and Correlation With Clinical Activity and Disease Course. Inflamm Bowel Dis. 2023 Dec 16. Catalán-Serra I, Thorsvik S, Beisvag V, Bruland T, Underhill D, Sandvik AK, Granlund AVB. PMID: 38103028.
      View in: PubMed   Mentions:    Fields:    
    2. Hexokinase dissociation from mitochondria promotes oligomerization of VDAC that facilitates NLRP3 inflammasome assembly and activation. Sci Immunol. 2023 06 23; 8(84):eade7652. Baik SH, Ramanujan VK, Becker C, Fett S, Underhill DM, Wolf AJ. PMID: 37327321; PMCID: PMC10360408.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    3. Mycobiota and diet-derived fungal xenosiderophores promote Salmonella gastrointestinal colonization. Nat Microbiol. 2022 12; 7(12):2025-2038. Santus W, Rana AP, Devlin JR, Kiernan KA, Jacob CC, Tjokrosurjo J, Underhill DM, Behnsen J. PMID: 36411353.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    4. Non-protective immune imprint underlies failure of Staphylococcus aureus IsdB vaccine. Cell Host Microbe. 2022 08 10; 30(8):1163-1172.e6. Tsai CM, Caldera JR, Hajam IA, Chiang AWT, Tsai CH, Li H, Díez ML, Gonzalez C, Trieu D, Martins GA, Underhill DM, Arditi M, Lewis NE, Liu GY. PMID: 35803276; PMCID: PMC9378590.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    5. Pathogen size alters C-type lectin receptor signaling in dendritic cells to influence CD4 Th9 cell differentiation. Cell Rep. 2022 03 29; 38(13):110567. Oh S, Li K, Prince A, Wheeler ML, Hamade H, Nguyen C, Michelsen KS, Underhill DM. PMID: 35354044; PMCID: PMC9052946.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. Fungal microbiome in inflammatory bowel disease: a critical assessment. J Clin Invest. 2022 03 01; 132(5). Underhill DM, Braun J. PMID: 35229726; PMCID: PMC8884899.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    7. Candida-induced asthma steps up to the plate-lets. Immunity. 2021 11 09; 54(11):2442-2444. Lagree K, Underhill DM. PMID: 34758334.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    8. Unsupervised Machine Learning Approaches Reveal Distinct Phenotypes of Perceived Bladder Pain: A Pilot Study. Front Pain Res (Lausanne). 2021 Nov; 2. Mwesigwa PJ, Jackson NJ, Caron AT, Kanji F, Ackerman JE, Webb JR, Scott VCS, Eilber KS, Underhill DM, Anger JT, Ackerman AL. PMID: 35036991; PMCID: PMC8758057.
      View in: PubMed   Mentions: 1  
    9. Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy. Cancer Cell. 2021 09 13; 39(9):1202-1213.e6. Shiao SL, Kershaw KM, Limon JJ, You S, Yoon J, Ko EY, Guarnerio J, Potdar AA, McGovern DPB, Bose S, Dar TB, Noe P, Lee J, Kubota Y, Maymi VI, Davis MJ, Henson RM, Choi RY, Yang W, Tang J, Gargus M, Prince AD, Zumsteg ZS, Underhill DM. PMID: 34329585; PMCID: PMC8830498.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    10. Debaryomyces is enriched in Crohn's disease intestinal tissue and impairs healing in mice. Science. 2021 03 12; 371(6534):1154-1159. Jain U, Ver Heul AM, Xiong S, Gregory MH, Demers EG, Kern JT, Lai CW, Muegge BD, Barisas DAG, Leal-Ekman JS, Deepak P, Ciorba MA, Liu TC, Hogan DA, Debbas P, Braun J, McGovern DPB, Underhill DM, Stappenbeck TS. PMID: 33707263; PMCID: PMC10114606.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    11. Early Gut Fungal and Bacterial Microbiota and Childhood Growth. Front Pediatr. 2020; 8:572538. Schei K, Simpson MR, Avershina E, Rudi K, Øien T, Júlíusson PB, Underhill D, Salamati S, Ødegård RA. PMID: 33240830; PMCID: PMC7680752.
      View in: PubMed   Mentions: 10  
    12. Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans. Cell. 2020 10 29; 183(3):666-683.e17. Ha CWY, Martin A, Sepich-Poore GD, Shi B, Wang Y, Gouin K, Humphrey G, Sanders K, Ratnayake Y, Chan KSL, Hendrick G, Caldera JR, Arias C, Moskowitz JE, Ho Sui SJ, Yang S, Underhill D, Brady MJ, Knott S, Kaihara K, Steinbaugh MJ, Li H, McGovern DPB, Knight R, Fleshner P, Devkota S. PMID: 32991841; PMCID: PMC7521382.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    13. Malassezia spp. induce inflammatory cytokines and activate NLRP3 inflammasomes in phagocytes. J Leukoc Biol. 2021 01; 109(1):161-172. Wolf AJ, Limon JJ, Nguyen C, Prince A, Castro A, Underhill DM. PMID: 32941658; PMCID: PMC7902306.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    14. Harnessing antifungal immunity in pursuit of a Staphylococcus aureus vaccine strategy. PLoS Pathog. 2020 08; 16(8):e1008733. Paterson MJ, Caldera JR, Nguyen C, Sharma P, Castro AM, Kolar SL, Tsai CM, Limon JJ, Becker CA, Martins GA, Liu GY, Underhill DM. PMID: 32817694; PMCID: PMC7446838.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    15. Frontline Science: Antibiotic treatment routes Mycobacterium avium to phagolysosomes without triggering proinflammatory cytokine production in human Mϕs. J Leukoc Biol. 2021 01; 109(1):23-33. Åsberg SE, Mediaas SD, Marstad A, Ryan L, Louet C, Sporsheim B, Beckwith KS, Underhill DM, Gidon A, Flo TH. PMID: 32531827.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. C-Type Lectin Receptors in Phagocytosis. Curr Top Microbiol Immunol. 2020; 429:1-18. Li K, Underhill DM. PMID: 32060644.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    17. Optimization of DNA extraction from human urinary samples for mycobiome community profiling. PLoS One. 2019; 14(4):e0210306. Ackerman AL, Anger JT, Khalique MU, Ackerman JE, Tang J, Kim J, Underhill DM, Freeman MR, NIH Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP). PMID: 31022216; PMCID: PMC6483181.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    18. Malassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models. Cell Host Microbe. 2019 Mar 13; 25(3):377-388.e6. Limon JJ, Tang J, Li D, Wolf AJ, Michelsen KS, Funari V, Gargus M, Nguyen C, Sharma P, Maymi VI, Iliev ID, Skalski JH, Brown J, Landers C, Borneman J, Braun J, Targan SR, McGovern DPB, Underhill DM. PMID: 30850233; PMCID: PMC6417942.
      View in: PubMed   Mentions: 172     Fields:    Translation:Animals
    19. Mucosal immune responses to fungi and the implications for inflammatory bowel disease. Curr Opin Gastroenterol. 2018 11; 34(6):398-403. Limon JJ, Kershaw KM, Underhill DM. PMID: 30299290.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    20. Expansion of commensal fungus Wallemia mellicola in the gastrointestinal mycobiota enhances the severity of allergic airway disease in mice. PLoS Pathog. 2018 09; 14(9):e1007260. Skalski JH, Limon JJ, Sharma P, Gargus MD, Nguyen C, Tang J, Coelho AL, Hogaboam CM, Crother TR, Underhill DM. PMID: 30235351; PMCID: PMC6147580.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsPHPublic Health
    21. Cryptococcal meningitis in a daily cannabis smoker without evidence of immunodeficiency. BMJ Case Rep. 2018 Jan 26; 2018. Shapiro BB, Hedrick R, Vanle BC, Becker CA, Nguyen C, Underhill DM, Morgan MA, Kopple JD, Danovitch I, IsHak WW. PMID: 29374632; PMCID: PMC5787011.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    22. Peptidoglycan recognition by the innate immune system. Nat Rev Immunol. 2018 04; 18(4):243-254. Wolf AJ, Underhill DM. PMID: 29292393.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    23. Host-microbe interactions: commensal fungi in the gut. Curr Opin Microbiol. 2017 Dec; 40:131-137. Paterson MJ, Oh S, Underhill DM. PMID: 29175338; PMCID: PMC5733715.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    24. O-Acetylation of Peptidoglycan Limits Helper T Cell Priming and Permits Staphylococcus aureus Reinfection. Cell Host Microbe. 2017 Oct 11; 22(4):543-551.e4. Sanchez M, Kolar SL, Müller S, Reyes CN, Wolf AJ, Ogawa C, Singhania R, De Carvalho DD, Arditi M, Underhill DM, Martins GA, Liu GY. PMID: 28943328; PMCID: PMC5679255.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    25. Commensal Fungi in Health and Disease. Cell Host Microbe. 2017 Aug 09; 22(2):156-165. Limon JJ, Skalski JH, Underhill DM. PMID: 28799901; PMCID: PMC5573128.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    26. Direct Antimicrobial Activity of IFN-β. J Immunol. 2017 05 15; 198(10):4036-4045. Kaplan A, Lee MW, Wolf AJ, Limon JJ, Becker CA, Ding M, Murali R, Lee EY, Liu GY, Wong GCL, Underhill DM. PMID: 28411186; PMCID: PMC5469413.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    27. Myeloid ATG16L1 Facilitates Host-Bacteria Interactions in Maintaining Intestinal Homeostasis. J Immunol. 2017 03 01; 198(5):2133-2146. Zhang H, Zheng L, McGovern DP, Hamill AM, Ichikawa R, Kanazawa Y, Luu J, Kumagai K, Cilluffo M, Fukata M, Targan SR, Underhill DM, Zhang X, Shih DQ. PMID: 28130498; PMCID: PMC5322190.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    28. The mycobiome of the human urinary tract: potential roles for fungi in urology. Ann Transl Med. 2017 Jan; 5(2):31. Ackerman AL, Underhill DM. PMID: 28217696; PMCID: PMC5300854.
      View in: PubMed   Mentions: 48  
    29. Immunity to Commensal Fungi: Detente and Disease. Annu Rev Pathol. 2017 Jan 24; 12:359-385. Wheeler ML, Limon JJ, Underhill DM. PMID: 28068483; PMCID: PMC6573037.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimals
    30. Autocrine Type I IFN Signaling in Dendritic Cells Stimulated with Fungal β-Glucans or Lipopolysaccharide Promotes CD8 T Cell Activation. J Immunol. 2017 01 01; 198(1):375-382. Hassanzadeh-Kiabi N, Yáñez A, Dang I, Martins GA, Underhill DM, Goodridge HS. PMID: 27872213; PMCID: PMC5173402.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    31. Persistent Microvascular Obstruction After Myocardial Infarction Culminates in the Confluence of Ferric Iron Oxide Crystals, Proinflammatory Burden, and Adverse Remodeling. Circ Cardiovasc Imaging. 2016 Nov; 9(11). Kali A, Cokic I, Tang R, Dohnalkova A, Kovarik L, Yang HJ, Kumar A, Prato FS, Wood JC, Underhill D, Marbán E, Dharmakumar R. PMID: 27903536; PMCID: PMC5703213.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    32. Inflammatory properties of antibiotic-treated bacteria. J Leukoc Biol. 2017 01; 101(1):127-134. Wolf AJ, Liu GY, Underhill DM. PMID: 27576461; PMCID: PMC5166437.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    33. Élie Metchnikoff (1845-1916): celebrating 100 years of cellular immunology and beyond. Nat Rev Immunol. 2016 10; 16(10):651-6. Underhill DM, Gordon S, Imhof BA, Núñez G, Bousso P. PMID: 27477126.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    34. Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan. Cell. 2016 Jul 28; 166(3):624-636. Wolf AJ, Reyes CN, Liang W, Becker C, Shimada K, Wheeler ML, Cho HC, Popescu NI, Coggeshall KM, Arditi M, Underhill DM. PMID: 27374331; PMCID: PMC5534359.
      View in: PubMed   Mentions: 256     Fields:    Translation:HumansAnimalsCells
    35. Immunological Consequences of Intestinal Fungal Dysbiosis. Cell Host Microbe. 2016 Jun 08; 19(6):865-73. Wheeler ML, Limon JJ, Bar AS, Leal CA, Gargus M, Tang J, Brown J, Funari VA, Wang HL, Crother TR, Arditi M, Underhill DM, Iliev ID. PMID: 27237365; PMCID: PMC4900921.
      View in: PubMed   Mentions: 201     Fields:    Translation:AnimalsCells
    36. Group B Streptococcus Evades Host Immunity by Degrading Hyaluronan. Cell Host Microbe. 2015 Dec 09; 18(6):694-704. Kolar SL, Kyme P, Tseng CW, Soliman A, Kaplan A, Liang J, Nizet V, Jiang D, Murali R, Arditi M, Underhill DM, Liu GY. PMID: 26651945; PMCID: PMC4683412.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    37. Immune Interactions with Pathogenic and Commensal Fungi: A Two-Way Street. Immunity. 2015 Nov 17; 43(5):845-58. Underhill DM, Pearlman E. PMID: 26588778; PMCID: PMC4865256.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimals
    38. Poorly Cross-Linked Peptidoglycan in MRSA Due to mecA Induction Activates the Inflammasome and Exacerbates Immunopathology. Cell Host Microbe. 2015 Nov 11; 18(5):604-12. Müller S, Wolf AJ, Iliev ID, Berg BL, Underhill DM, Liu GY. PMID: 26567511; PMCID: PMC4648675.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    39. Characterization of Bacterial and Fungal Microbiome in Children with Hirschsprung Disease with and without a History of Enterocolitis: A Multicenter Study. PLoS One. 2015; 10(4):e0124172. Frykman PK, Nordenskjöld A, Kawaguchi A, Hui TT, Granström AL, Cheng Z, Tang J, Underhill DM, Iliev I, Funari VA, Wester T, HAEC Collaborative Research Group (HCRG). PMID: 25909773; PMCID: PMC4409062.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    40. Mycobiome: Approaches to analysis of intestinal fungi. J Immunol Methods. 2015 Jun; 421:112-121. Tang J, Iliev ID, Brown J, Underhill DM, Funari VA. PMID: 25891793; PMCID: PMC4451377.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    41. Time to cast a larger net. Nat Immunol. 2014 Nov; 15(11):1000-1. Wheeler ML, Underhill DM. PMID: 25329179.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    42. Batf3 deficiency is not critical for the generation of CD8α⁺ dendritic cells. Immunobiology. 2015 Apr; 220(4):518-24. Mott KR, Maazi H, Allen SJ, Zandian M, Matundan H, Ghiasi YN, Sharifi BG, Underhill D, Akbari O, Ghiasi H. PMID: 25468565; PMCID: PMC4355210.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    43. The mycobiota: interactions between commensal fungi and the host immune system. Nat Rev Immunol. 2014 Jun; 14(6):405-16. Underhill DM, Iliev ID. PMID: 24854590; PMCID: PMC4332855.
      View in: PubMed   Mentions: 284     Fields:    Translation:HumansAnimalsCells
    44. Cutting edge: FYCO1 recruitment to dectin-1 phagosomes is accelerated by light chain 3 protein and regulates phagosome maturation and reactive oxygen production. J Immunol. 2014 Feb 15; 192(4):1356-60. Ma J, Becker C, Reyes C, Underhill DM. PMID: 24442442; PMCID: PMC3966112.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    45. Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce. Eur J Immunol. 2013 Aug; 43(8):2114-25. Yáñez A, Hassanzadeh-Kiabi N, Ng MY, Megías J, Subramanian A, Liu GY, Underhill DM, Gil ML, Goodridge HS. PMID: 23661549; PMCID: PMC3783206.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    46. β-Glucan signaling connects phagocytosis to autophagy. Glycobiology. 2013 Sep; 23(9):1047-51. Ma J, Underhill DM. PMID: 23749474; PMCID: PMC3858030.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    47. Striking a balance: fungal commensalism versus pathogenesis. Curr Opin Microbiol. 2013 Jun; 16(3):366-73. Iliev ID, Underhill DM. PMID: 23756050; PMCID: PMC3742553.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    48. Vacuum assisted vegetation extraction for the management of large lead vegetations. J Card Surg. 2013 May; 28(3):321-4. Patel N, Azemi T, Zaeem F, Underhill D, Gallagher R, Hagberg R, Sadiq I. PMID: 23445461.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    49. Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence. J Immunol. 2012 Dec 15; 189(12):5903-11. Nakayama M, Kurokawa K, Nakamura K, Lee BL, Sekimizu K, Kubagawa H, Hiramatsu K, Yagita H, Okumura K, Takai T, Underhill DM, Aderem A, Ogasawara K. PMID: 23152562.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    50. Failure to induce IFN-β production during Staphylococcus aureus infection contributes to pathogenicity. J Immunol. 2012 Nov 01; 189(9):4537-45. Kaplan A, Ma J, Kyme P, Wolf AJ, Becker CA, Tseng CW, Liu GY, Underhill DM. PMID: 23008447; PMCID: PMC3478442.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    51. Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens. J Biol Chem. 2012 Oct 05; 287(41):34149-56. Ma J, Becker C, Lowell CA, Underhill DM. PMID: 22902620; PMCID: PMC3464523.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    52. Mechanisms of Fc receptor and dectin-1 activation for phagocytosis. Traffic. 2012 Aug; 13(8):1062-71. Goodridge HS, Underhill DM, Touret N. PMID: 22624959.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    53. Information processing during phagocytosis. Nat Rev Immunol. 2012 Jun 15; 12(7):492-502. Underhill DM, Goodridge HS. PMID: 22699831; PMCID: PMC5570470.
      View in: PubMed   Mentions: 231     Fields:    Translation:HumansAnimalsCells
    54. Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science. 2012 Jun 08; 336(6086):1314-7. Iliev ID, Funari VA, Taylor KD, Nguyen Q, Reyes CN, Strom SP, Brown J, Becker CA, Fleshner PR, Dubinsky M, Rotter JI, Wang HL, McGovern DP, Brown GD, Underhill DM. PMID: 22674328; PMCID: PMC3432565.
      View in: PubMed   Mentions: 506     Fields:    Translation:HumansAnimals
    55. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. 2012 Mar 23; 36(3):401-14. Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, Rentsendorj A, Vargas M, Guerrero C, Wang Y, Fitzgerald KA, Underhill DM, Town T, Arditi M. PMID: 22342844; PMCID: PMC3312986.
      View in: PubMed   Mentions: 949     Fields:    Translation:AnimalsCells
    56. Phagosomal degradation increases TLR access to bacterial ligands and enhances macrophage sensitivity to bacteria. J Immunol. 2011 Dec 01; 187(11):6002-10. Wolf AJ, Arruda A, Reyes CN, Kaplan AT, Shimada T, Shimada K, Arditi M, Liu G, Underhill DM. PMID: 22031762; PMCID: PMC3221871.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    57. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature. 2011 Apr 28; 472(7344):471-5. Goodridge HS, Reyes CN, Becker CA, Katsumoto TR, Ma J, Wolf AJ, Bose N, Chan AS, Magee AS, Danielson ME, Weiss A, Vasilakos JP, Underhill DM. PMID: 21525931; PMCID: PMC3084546.
      View in: PubMed   Mentions: 334     Fields:    Translation:HumansAnimalsCells
    58. Adaptor protein Lnk inhibits c-Fms-mediated macrophage function. J Leukoc Biol. 2010 Oct; 88(4):699-706. Gueller S, Goodridge HS, Niebuhr B, Xing H, Koren-Michowitz M, Serve H, Underhill DM, Brandts CH, Koeffler HP. PMID: 20571037; PMCID: PMC3218676.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    59. Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling. J Immunol. 2010 Jun 01; 184(11):6359-66. Gray P, Michelsen KS, Sirois CM, Lowe E, Shimada K, Crother TR, Chen S, Brikos C, Bulut Y, Latz E, Underhill D, Arditi M. PMID: 20435923; PMCID: PMC3057206.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    60. Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion. Cell Host Microbe. 2010 Jan 21; 7(1):38-49. Shimada T, Park BG, Wolf AJ, Brikos C, Goodridge HS, Becker CA, Reyes CN, Miao EA, Aderem A, Götz F, Liu GY, Underhill DM. PMID: 20114027; PMCID: PMC2818986.
      View in: PubMed   Mentions: 141     Fields:    Translation:AnimalsCells
    61. Beta-glucan recognition by the innate immune system. Immunol Rev. 2009 Jul; 230(1):38-50. Goodridge HS, Wolf AJ, Underhill DM. PMID: 19594628; PMCID: PMC6618291.
      View in: PubMed   Mentions: 204     Fields:    Translation:HumansAnimalsCells
    62. A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages. Virol J. 2009 May 13; 6:56. Mott KR, Underhill D, Wechsler SL, Town T, Ghiasi H. PMID: 19439086; PMCID: PMC2686698.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    63. The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. PLoS Pathog. 2009 Apr; 5(4):e1000379. Shimada K, Chen S, Dempsey PW, Sorrentino R, Alsabeh R, Slepenkin AV, Peterson E, Doherty TM, Underhill D, Crother TR, Arditi M. PMID: 19360122; PMCID: PMC2660273.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    64. Differential use of CARD9 by dectin-1 in macrophages and dendritic cells. J Immunol. 2009 Jan 15; 182(2):1146-54. Goodridge HS, Shimada T, Wolf AJ, Hsu YM, Becker CA, Lin X, Underhill DM. PMID: 19124758; PMCID: PMC2718573.
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    65. Current understanding of fungal microflora in inflammatory bowel disease pathogenesis. Inflamm Bowel Dis. 2008 Aug; 14(8):1147-53. Underhill D, Braun J. PMID: 18286647; PMCID: PMC3752988.
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    66. Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latency. J Virol. 2008 Oct; 82(20):9870-9. Mott KR, Underhill D, Wechsler SL, Ghiasi H. PMID: 18667491; PMCID: PMC2566288.
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    67. Host-microbe interactions: fungi. Curr Opin Microbiol. 2008 Aug; 11(4):303-4. Underhill DM. PMID: 18625338.
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    68. Fungal Recognition by TLR2 and Dectin-1. Handb Exp Pharmacol. 2008; (183):87-109. Goodridge HS, Underhill DM. PMID: 18071656.
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    69. Collaboration between the innate immune receptors dectin-1, TLRs, and Nods. Immunol Rev. 2007 Oct; 219:75-87. Underhill DM. PMID: 17850483.
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    70. Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine production. J Immunol. 2007 Apr 01; 178(7):4250-9. Nakayama M, Underhill DM, Petersen TW, Li B, Kitamura T, Takai T, Aderem A. PMID: 17371981.
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    71. Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells. J Immunol. 2007 Mar 01; 178(5):3107-15. Goodridge HS, Simmons RM, Underhill DM. PMID: 17312158.
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    72. A pair of 9s: it's in the CARDs. Nat Immunol. 2007 Feb; 8(2):122-4. Underhill DM, Shimada T. PMID: 17242682.
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    73. The many faces of ITAMs. Trends Immunol. 2007 Feb; 28(2):66-73. Underhill DM, Goodridge HS. PMID: 17197236.
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    74. Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses. J Biol Chem. 2006 Dec 15; 281(50):38854-66. Sato K, Yang XL, Yudate T, Chung JS, Wu J, Luby-Phelps K, Kimberly RP, Underhill D, Cruz PD, Ariizumi K. PMID: 17050534.
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    75. IFN-gamma enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2. J Immunol. 2006 Apr 15; 176(8):4804-10. Tötemeyer S, Sheppard M, Lloyd A, Roper D, Dowson C, Underhill D, Murray P, Maskell D, Bryant C. PMID: 16585574.
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    76. Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states. J Immunol. 2006 Mar 15; 176(6):3717-24. Gersuk GM, Underhill DM, Zhu L, Marr KA. PMID: 16517740.
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    77. Phagosome maturation: steady as she goes. Immunity. 2005 Oct; 23(4):343-4. Underhill DM. PMID: 16226498.
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    78. Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood. 2005 Oct 01; 106(7):2543-50. Underhill DM, Rossnagle E, Lowell CA, Simmons RM. PMID: 15956283; PMCID: PMC1895265.
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    79. Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. EMBO J. 2005 Mar 23; 24(6):1277-86. Gantner BN, Simmons RM, Underhill DM. PMID: 15729357; PMCID: PMC556398.
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    80. Integration of Toll-like receptor and phagocytic signaling for tailored immunity. Microbes Infect. 2004 Dec; 6(15):1368-73. Underhill DM, Gantner B. PMID: 15596122.
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    81. Toll-like receptors and microbes take aim at each other. Curr Opin Immunol. 2004 Aug; 16(4):483-7. Underhill DM. PMID: 15245743.
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    82. Toll gets tied in a knot. Nat Immunol. 2003 Aug; 4(8):723-4. Underhill D. PMID: 12888789.
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    83. Toll-like receptors: networking for success. Eur J Immunol. 2003 Jul; 33(7):1767-75. Underhill DM. PMID: 12811836.
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    85. Macrophage recognition of zymosan particles. J Endotoxin Res. 2003; 9(3):176-80. Underhill DM. PMID: 12831459.
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    86. Toll-like receptors: key mediators of microbe detection. Curr Opin Immunol. 2002 Feb; 14(1):103-10. Underhill DM, Ozinsky A. PMID: 11790539.
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    87. Generation of diversity in the innate immune system: macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes. J Immunol. 2002 Jan 01; 168(1):44-50. Ravasi T, Wells C, Forest A, Underhill DM, Wainwright BJ, Aderem A, Grimmond S, Hume DA. PMID: 11751944.
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    88. Phagocytosis of microbes: complexity in action. Annu Rev Immunol. 2002; 20:825-52. Underhill DM, Ozinsky A. PMID: 11861619.
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