Bogdan Pasaniuc, Ph.D.


Work Titles
UCLA Assistant Professor, Pathology and Laboratory Medicine
Education:
Degrees:
Ph.D.

Contact Information:

Work Email Address:

pasaniuc@ucla.edu


Website:



Work Phone Number:

310-825-3291

Work Address:

Department of Pathology & Laboratory Medicine
Geffen School of Medicine at UCLA
10833 Le Conte Ave, CHS 33-365
Los Angeles, CA 90095


Detailed Biography:

Bogdan is primarily interested in statistical and computational methods for understanding genetic risk factors for common diseases with a particular focus in the study of admixed populations.

Before joining UCLA, Bogdan was a Postdoctoral Research Fellow in the Program of Molecular and Genetic Epidemiology at the Departments of Epidemiology at Harvard School of Public Health in the group of Alkes Price . Prior to that, Bogdan completed a postdoctoral fellowship in the group of Eran Halperin at the International Computer Science Institute (Algorithms research group) in Berkeley CA. Bogdan obtained his Ph.D. in Computer Science from the University of Connecticut working in the lab of Ion Mandoiu.

Publications:

Han Ying, Rand Kristin A, Hazelett Dennis J, Ingles Sue A, Kittles Rick A, Strom Sara S, Rybicki Benjamin A, Nemesure Barbara, Isaacs William B, Stanford Janet L, Zheng Wei, Schumacher Fredrick R, Berndt Sonja I, Wang Zhaoming, Xu Jianfeng, Rohland Nadin, Reich David, Tandon Arti, Pasaniuc Bogdan, Allen Alex, Quinque Dominique, Mallick Swapan, Notani Dimple, Rosenfeld Michael G, Jayani Ranveer Singh, Kolb Suzanne, Gapstur Susan M, Stevens Victoria L, Pettaway Curtis A, Yeboah Edward D, Tettey Yao, Biritwum Richard B, Adjei Andrew A, Tay Evelyn, Truelove Ann, Niwa Shelley, Chokkalingam Anand P, John Esther M, Murphy Adam B, Signorello Lisa B, Carpten John, Leske M Cristina, Wu Suh-Yuh, Hennis Anslem J M, Neslund-Dudas Christine, Hsing Ann W, Chu Lisa, Goodman Phyllis J, Klein Eric A, Zheng S Lilly, Witte John S, Casey Graham, Lubwama Alex, Pooler Loreall C, Sheng Xin, Coetzee Gerhard A, Cook Michael B, Chanock Stephen J, Stram Daniel O, Watya Stephen, Blot William J, Conti David V, Henderson Brian E, Haiman Christopher A   Prostate Cancer Susceptibility in Men of African Ancestry at 8q24 Journal of the National Cancer Institute, 2016; 108(7): .
Gusev Alexander, Ko Arthur, Shi Huwenbo, Bhatia Gaurav, Chung Wonil, Penninx Brenda W J H, Jansen Rick, de Geus Eco J C, Boomsma Dorret I, Wright Fred A, Sullivan Patrick F, Nikkola Elina, Alvarez Marcus, Civelek Mete, Lusis Aldons J, Lehtimäki Terho, Raitoharju Emma, Kähönen Mika, Seppälä Ilkka, Raitakari Olli T, Kuusisto Johanna, Laakso Markku, Price Alkes L, Pajukanta Päivi, Pasaniuc Bogdan   Integrative approaches for large-scale transcriptome-wide association studies Nature genetics, 2016; 48(3): 245-52.
Brown Robert, Lee Hane, Eskin Ascia, Kichaev Gleb, Lohmueller Kirk E, Reversade Bruno, Nelson Stanley F, Pasaniuc Bogdan   Leveraging ancestry to improve causal variant identification in exome sequencing for monogenic disorders European journal of human genetics : EJHG, 2016; 24(1): 113-9.
Mancuso Nicholas, Rohland Nadin, Rand Kristin A, Tandon Arti, Allen Alexander, Quinque Dominique, Mallick Swapan, Li Heng, Stram Alex, Sheng Xin, Kote-Jarai Zsofia, Easton Douglas F, Eeles Rosalind A, Eeles Rosalind A, Le Marchand Loic, Lubwama Alex, Stram Daniel, Watya Stephen, Conti David V, Henderson Brian, Haiman Christopher A, Pasaniuc Bogdan, Reich David   The contribution of rare variation to prostate cancer heritability Nature genetics, 2016; 48(1): 30-5.
Rand Kristin A, Rohland Nadin, Tandon Arti, Stram Alex, Sheng Xin, Do Ron, Pasaniuc Bogdan, Allen Alex, Quinque Dominique, Mallick Swapan, Le Marchand Loic, Kaggwa Sam, Lubwama Alex, Lubwama Alex, Lubwama Alex, Stram Daniel O, Watya Stephen, Henderson Brian E, Conti David V, Reich David, Haiman Christopher A   Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk Human molecular genetics, 2016; 25(2): 371-81.
Shi Huwenbo, Pasaniuc Bogdan, Lange Kenneth L   A multivariate Bernoulli model to predict DNaseI hypersensitivity status from haplotype data Bioinformatics (Oxford, England), 2015; 31(21): 3514-21.
Aschard Hugues, Gusev Alexander, Brown Robert, Pasaniuc Bogdan   Leveraging local ancestry to detect gene-gene interactions in genome-wide data BMC genetics, 2015; 16(21): 124.
Vilhjálmsson Bjarni J, Yang Jian, Finucane Hilary K, Gusev Alexander, Lindström Sara, Ripke Stephan, Genovese Giulio, Loh Po-Ru, Bhatia Gaurav, Do Ron, Hayeck Tristan, Won Hong-Hee, Won Hong-Hee, Kathiresan Sekar, Pato Michele, Pato Carlos, Tamimi Rulla, Stahl Eli, Zaitlen Noah, Pasaniuc Bogdan, Belbin Gillian, Kenny Eimear E, Schierup Mikkel H, De Jager Philip, Patsopoulos Nikolaos A, McCarroll Steve, Daly Mark, Purcell Shaun, Chasman Daniel, Neale Benjamin, Goddard Michael, Visscher Peter M, Kraft Peter, Patterson Nick, Price Alkes L   Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores American journal of human genetics, 2015; 97(4): 576-92.
Kichaev Gleb, Pasaniuc Bogdan   Leveraging Functional-Annotation Data in Trans-ethnic Fine-Mapping Studies American journal of human genetics, 2015; 97(2): 260-71.
Hormozdiari Farhad, Kichaev Gleb, Yang Wen-Yun, Pasaniuc Bogdan, Eskin Eleazar   Identification of causal genes for complex traits Bioinformatics (Oxford, England), 2015; 31(12): i206-13.
Yang Wen-Yun, Hormozdiari Farhad, Eskin Eleazar, Pasaniuc Bogdan   A spatial haplotype copying model with applications to genotype imputation Journal of computational biology : a journal of computational molecular cell biology, 2015; 22(5): 451-62.
Zaitlen Noah, Pasaniuc Bogdan, Sankararaman Sriram, Bhatia Gaurav, Zhang Jianqi, Gusev Alexander, Young Taylor, Tandon Arti, Pollack Samuela, Vilhjálmsson Bjarni J, Assimes Themistocles L, Berndt Sonja I, Blot William J, Chanock Stephen, Franceschini Nora, Goodman Phyllis G, He Jing, Hennis Anselm J M, Hsing Ann, Ingles Sue A, Isaacs William, Kittles Rick A, Klein Eric A, Lange Leslie A, Nemesure Barbara, Patterson Nick, Reich David, Rybicki Benjamin A, Stanford Janet L, Stevens Victoria L, Strom Sara S, Whitsel Eric A, Witte John S, Xu Jianfeng, Haiman Christopher, Wilson James G, Kooperberg Charles, Stram Daniel, Reiner Alex P, Tang Hua, Price Alkes L   Leveraging population admixture to characterize the heritability of complex traits Nature genetics, 2014; 46(12): 1356-62.
Yang Wen-Yun, Platt Alexander, Chiang Charleston Wen-Kai, Eskin Eleazar, Novembre John, Pasaniuc Bogdan   Spatial localization of recent ancestors for admixed individuals G3 (Bethesda, Md.), 2014; 4(12): 2505-18.
Gusev Alexander, Lee S Hong, Trynka Gosia, Finucane Hilary, Vilhjálmsson Bjarni J, Xu Han, Zang Chongzhi, Ripke Stephan, Bulik-Sullivan Brendan, Stahl Eli, Stahl Eli, Stahl Eli, Kähler Anna K, Hultman Christina M, Purcell Shaun M, McCarroll Steven A, Daly Mark, Pasaniuc Bogdan, Sullivan Patrick F, Neale Benjamin M, Wray Naomi R, Raychaudhuri Soumya, Price Alkes L, Price Alkes L, Price Alkes L   Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases American journal of human genetics, 2014; 95(5): 535-52.
Ko Arthur, Cantor Rita M, Weissglas-Volkov Daphna, Nikkola Elina, Reddy Prasad M V Linga, Sinsheimer Janet S, Pasaniuc Bogdan, Brown Robert, Alvarez Marcus, Rodriguez Alejandra, Rodriguez-Guillen Rosario, Bautista Ivette C, Arellano-Campos Olimpia, Muñoz-Hernández Linda L, Salomaa Veikko, Kaprio Jaakko, Jula Antti, Jauhiainen Matti, Heliövaara Markku, Raitakari Olli, Lehtimäki Terho, Eriksson Johan G, Perola Markus, Lohmueller Kirk E, Matikainen Niina, Taskinen Marja-Riitta, Rodriguez-Torres Maribel, Riba Laura, Tusie-Luna Teresa, Aguilar-Salinas Carlos A, Pajukanta Päivi   Amerindian-specific regions under positive selection harbour new lipid variants in Latinos Nature communications, 2014; 5(10): 3983.
Pasaniuc Bogdan, Zaitlen Noah, Shi Huwenbo, Bhatia Gaurav, Gusev Alexander, Pickrell Joseph, Hirschhorn Joel, Strachan David P, Patterson Nick, Price Alkes L   Fast and accurate imputation of summary statistics enhances evidence of functional enrichment Bioinformatics (Oxford, England), 2014; 30(20): 2906-14.
Hormozdiari Farhad, Kostem Emrah, Kang Eun Yong, Pasaniuc Bogdan, Eskin Eleazar   Identifying causal variants at loci with multiple signals of association Genetics, 2014; 198(2): 497-508.
Kichaev Gleb, Yang Wen-Yun, Lindstrom Sara, Hormozdiari Farhad, Eskin Eleazar, Price Alkes L, Kraft Peter, Pasaniuc Bogdan   Integrating functional data to prioritize causal variants in statistical fine-mapping studies PLoS genetics, 2014; 10(10): e1004722.
Brown Robert, Pasaniuc Bogdan   Enhanced methods for local ancestry assignment in sequenced admixed individuals PLoS computational biology, 2014; 10(4): e1003555.
Kaser Arthur, Pasaniuc Bogdan   IBD genetics: focus on (dys) regulation in immune cells and the epithelium Gastroenterology, 2014; 146(4): 896-9.
Yang Wen-Yun, Hormozdiari Farhad, Wang Zhanyong, He Dan, Pasaniuc Bogdan, Eskin Eleazar   Leveraging reads that span multiple single nucleotide polymorphisms for haplotype inference from sequencing data Bioinformatics (Oxford, England), 2013; 29(18): 2245-52.
Pasaniuc Bogdan, Sankararaman Sriram, Torgerson Dara G, Gignoux Christopher, Zaitlen Noah, Eng Celeste, Rodriguez-Cintron William, Chapela Rocio, Ford Jean G, Avila Pedro C, Rodriguez-Santana Jose, Chen Gary K, Le Marchand Loic, Henderson Brian, Reich David, Haiman Christopher A, Gonzàlez Burchard Esteban, Halperin Eran   Analysis of Latino populations from GALA and MEC studies reveals genomic loci with biased local ancestry estimation Bioinformatics (Oxford, England), 2013; 29(11): 1407-15.
Baran Yael, Quintela Inés, Carracedo Angel, Pasaniuc Bogdan, Halperin Eran   Enhanced localization of genetic samples through linkage-disequilibrium correction American journal of human genetics, 2013; 92(6): 882-94.
Zaitlen Noah, Kraft Peter, Patterson Nick, Pasaniuc Bogdan, Bhatia Gaurav, Pollack Samuela, Price Alkes L   Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits PLoS genetics, 2013; 9(5): e1003520.
Gusev Alexander, Bhatia Gaurav, Zaitlen Noah, Vilhjalmsson Bjarni J, Diogo Dorothée, Stahl Eli A, Gregersen Peter K, Worthington Jane, Klareskog Lars, Raychaudhuri Soumya, Plenge Robert M, Pasaniuc Bogdan, Price Alkes L   Quantifying missing heritability at known GWAS loci PLoS genetics, 2013; 9(12): e1003993.
Genovese Giulio, Handsaker Robert E, Li Heng, Altemose Nicolas, Lindgren Amelia M, Chambert Kimberly, Pasaniuc Bogdan, Price Alkes L, Reich David, Morton Cynthia C, Pollak Martin R, Wilson James G, McCarroll Steven A   Using population admixture to help complete maps of the human genome Nature genetics, 2013; 45(4): 406-14, 414e1-2.
Zaitlen Noah, Pasaniuc Bogdan, Patterson Nick, Pollack Samuela, Voight Benjamin, Groop Leif, Altshuler David, Henderson Brian E, Kolonel Laurence N, Le Marchand Loic, Waters Kevin, Haiman Christopher A, Stranger Barbara E, Dermitzakis Emmanouil T, Kraft Peter, Price Alkes L   Analysis of case-control association studies with known risk variants Bioinformatics (Oxford, England), 2012; 28(13): 1729-37.
Pasaniuc Bogdan, Rohland Nadin, McLaren Paul J, Garimella Kiran, Zaitlen Noah, Li Heng, Gupta Namrata, Neale Benjamin M, Daly Mark J, Sklar Pamela, Sullivan Patrick F, Bergen Sarah, Moran Jennifer L, Hultman Christina M, Lichtenstein Paul, Magnusson Patrik, Purcell Shaun M, Haas David W, Liang Liming, Sunyaev Shamil, Patterson Nick, de Bakker Paul I W, Reich David, Price Alkes L   Extremely low-coverage sequencing and imputation increases power for genome-wide association studies Nature genetics, 2012; 44(6): 631-5.
Baran Yael, Pasaniuc Bogdan, Sankararaman Sriram, Torgerson Dara G, Gignoux Christopher, Eng Celeste, Rodriguez-Cintron William, Chapela Rocio, Ford Jean G, Avila Pedro C, Rodriguez-Santana Jose, Burchard Esteban Gonzàlez, Halperin Eran   Fast and accurate inference of local ancestry in Latino populations Bioinformatics (Oxford, England), 2012; 28(10): 1359-67.
Fejerman Laura, Chen Gary K, Eng Celeste, Huntsman Scott, Hu Donglei, Williams Amy, Pasaniuc Bogdan, John Esther M, Via Marc, Gignoux Christopher, Ingles Sue, Monroe Kristine R, Kolonel Laurence N, Torres-Mejía Gabriela, Pérez-Stable Eliseo J, Burchard Esteban González, Henderson Brian E, Haiman Christopher A, Ziv Elad   Admixture mapping identifies a locus on 6q25 associated with breast cancer risk in US Latinas Human molecular genetics, 2012; 21(8): 1907-17.
Zaitlen Noah, Lindström Sara, Pasaniuc Bogdan, Cornelis Marilyn, Genovese Giulio, Pollack Samuela, Barton Anne, Bickeböller Heike, Bowden Donald W, Eyre Steve, Freedman Barry I, Friedman David J, Field John K, Groop Leif, Haugen Aage, Heinrich Joachim, Henderson Brian E, Hicks Pamela J, Hocking Lynne J, Kolonel Laurence N, Landi Maria Teresa, Langefeld Carl D, Le Marchand Loic, Meister Michael, Morgan Ann W, Raji Olaide Y, Risch Angela, Rosenberger Albert, Scherf David, Steer Sophia, Walshaw Martin, Waters Kevin M, Wilson Anthony G, Wordsworth Paul, Zienolddiny Shanbeh, Tchetgen Eric Tchetgen, Haiman Christopher, Hunter David J, Plenge Robert M, Worthington Jane, Christiani David C, Schaumberg Debra A, Chasman Daniel I, Altshuler David, Voight Benjamin, Kraft Peter, Patterson Nick, Price Alkes L   Informed conditioning on clinical covariates increases power in case-control association studies PLoS genetics, 2012; 8(11): e1003032.
Bhatia Gaurav, Patterson Nick, Pasaniuc Bogdan, Zaitlen Noah, Genovese Giulio, Pollack Samuela, Mallick Swapan, Myers Simon, Tandon Arti, Spencer Chris, Palmer Cameron D, Adeyemo Adebowale A, Akylbekova Ermeg L, Cupples L Adrienne, Divers Jasmin, Fornage Myriam, Kao W H Linda, Lange Leslie, Li Mingyao, Musani Solomon, Mychaleckyj Josyf C, Ogunniyi Adesola, Papanicolaou George, Rotimi Charles N, Rotter Jerome I, Ruczinski Ingo, Salako Babatunde, Siscovick David S, Tayo Bamidele O, Yang Qiong, McCarroll Steve, Sabeti Pardis, Lettre Guillaume, De Jager Phil, Hirschhorn Joel, Zhu Xiaofeng, Cooper Richard, Reich David, Wilson James G, Price Alkes L   Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection American journal of human genetics, 2011; 89(3): 368-81.
Wang Jianrong, Geesman Glenn J, Hostikka Sirkka Liisa, Atallah Michelle, Blackwell Benjamin, Lee Elbert, Cook Peter J, Pasaniuc Bogdan, Shariat Goli, Halperin Eran, Dobke Marek, Rosenfeld Michael G, Jordan I King, Lunyak Victoria V   Inhibition of activated pericentromeric SINE/Alu repeat transcription in senescent human adult stem cells reinstates self-renewal Cell cycle (Georgetown, Tex.), 2011; 10(17): 3016-30.
Seldin Michael F, Pasaniuc Bogdan, Price Alkes L   New approaches to disease mapping in admixed populations Nature reviews. Genetics, 2011; 12(8): 523-8.
Aschard Hugues, Qiu Weiliang, Pasaniuc Bogdan, Zaitlen Noah, Cho Michael H, Carey Vincent   Combining effects from rare and common genetic variants in an exome-wide association study of sequence data BMC proceedings, 2011; 5 Suppl 9(11): S44.
Pasaniuc Bogdan, Zaitlen Noah, Lettre Guillaume, Chen Gary K, Tandon Arti, Kao W H Linda, Ruczinski Ingo, Fornage Myriam, Siscovick David S, Zhu Xiaofeng, Larkin Emma, Lange Leslie A, Cupples L Adrienne, Yang Qiong, Akylbekova Ermeg L, Musani Solomon K, Divers Jasmin, Mychaleckyj Joe, Li Mingyao, Papanicolaou George J, Millikan Robert C, Ambrosone Christine B, John Esther M, Bernstein Leslie, Zheng Wei, Hu Jennifer J, Ziegler Regina G, Nyante Sarah J, Bandera Elisa V, Ingles Sue A, Press Michael F, Chanock Stephen J, Deming Sandra L, Rodriguez-Gil Jorge L, Palmer Cameron D, Buxbaum Sarah, Ekunwe Lynette, Hirschhorn Joel N, Henderson Brian E, Myers Simon, Haiman Christopher A, Reich David, Patterson Nick, Wilson James G, Price Alkes L   Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium PLoS genetics, 2011; 7(4): e1001371.
Paşaniuc Bogdan, Zaitlen Noah, Halperin Eran   Accurate estimation of expression levels of homologous genes in RNA-seq experiments Journal of computational biology : a journal of computational molecular cell biology, 2011; 18(3): 459-68.
He Dan, Zaitlen Noah, Pasaniuc Bogdan, Eskin Eleazar, Halperin Eran   Genotyping common and rare variation using overlapping pool sequencing BMC bioinformatics, 2011; 12 Suppl 6(3): S2.
Paşaniuc Bogdan, Avinery Ram, Gur Tom, Skibola Christine F, Bracci Paige M, Halperin Eran   A generic coalescent-based framework for the selection of a reference panel for imputation Genetic epidemiology, 2010; 34(8): 773-82.
Zaitlen Noah, Paşaniuc Bogdan, Gur Tom, Ziv Elad, Halperin Eran   Leveraging genetic variability across populations for the identification of causal variants American journal of human genetics, 2010; 86(1): 23-33.
Pasaniuc Bogdan, Sankararaman Sriram, Kimmel Gad, Halperin Eran   Inference of locus-specific ancestry in closely related populations Bioinformatics (Oxford, England), 2009; 25(12): i213-21.
Kennedy Justin, Măndoiu Ion, Paşaniuc Bogdan   Genotype error detection using Hidden Markov Models of haplotype diversity Journal of computational biology : a journal of computational molecular cell biology, 2008; 15(9): 1155-71.
Gusev Alexander, Măndoiu Ion I, Paşaniuc Bogdan   Highly scalable genotype phasing by entropy minimization IEEE/ACM transactions on computational biology and bioinformatics / IEEE, ACM, 2008; 5(2): 252-61.
Pasaniuc Bogdan, Mandoiu Ion   Highly scalable genotype phasing by entropy minimization Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2006; 1(2): 3482-6.

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