Chia Soo, M.D.

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Work Titles
CTSI Member, CTSI
UCLA Professor, Orthopaedic Surgery
Education:
Degrees:
M.D.
Honors and Awards:
1985 National Merit Scholarship
Certifications:
Certification Type:
1989 Graduated Magna Cum Laude
Certification Type:
1993 Alpha Omega Alpha
1989 Phi Beta Kappa
1985 Alpha Lambda Delta

Contact Information:

Work Email Address:

bsoo@ucla.edu


Website:

Web-profile

Work Phone Number:

(310) 713-9978

Office Address:

675 Charles E. Young Dr. South
Room 2641A
Los Angeles, CA 90095


Publications:

A selected list of publications:

Askarinam Asal, James Aaron W, Zara Janette N, Goyal Raghav, Corselli Mirko, Pan Angel, Liang Pei, Chang Le, Rackohn Todd, Stoker David, Zhang Xinli, Ting Kang, Péault Bruno, Soo Chia   Human perivascular stem cells show enhanced osteogenesis and vasculogenesis with nel-like molecule I protein Tissue engineering. Part A, 2013; 19(11-12): 1386-97.
Kwak Jinny, Zara Janette N, Chiang Michael, Ngo Richard, Shen Jia, James Aaron W, Le Khoi M, Moon Crystal, Zhang Xinli, Gou Zhongru, Ting Kang, Soo Chia   NELL-1 injection maintains long-bone quantity and quality in an ovariectomy-induced osteoporotic senile rat model Tissue engineering. Part A, 2013; 19(3-4): 426-36.
Chang Jia, Liu Fei, Lee Min, Wu Benjamin, Ting Kang, Zara Janette N, Soo Chia, Al Hezaimi Khalid, Zou Weiping, Chen Xiaohong, Mooney David J, Wang Cun-Yu   NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation Proceedings of the National Academy of Sciences of the United States of America, 2013; 19(11-12): .
James Aaron W, Pang Shen, Askarinam Asal, Corselli Mirko, Zara Janette N, Goyal Raghav, Chang Le, Pan Angel, Shen Jia, Yuan Wei, Stoker David, Zhang Xinli, Adams John S, Ting Kang, Soo Chia   Additive Effects of Sonic Hedgehog and Nell-1 Signaling in Osteogenic Versus Adipogenic Differentiation of Human Adipose-Derived Stromal Cells Stem cells and development, 2012; 21(5): .
James Aaron W, Zara Janette N, Corselli Mirko, Askarinam Asal, Zhou Ann M, Hourfar Alireza, Nguyen Alan, Megerdichian Silva, Asatrian Greg, Pang Shen, Stoker David, Zhang Xinli, Wu Benjamin, Ting Kang, Péault Bruno, Soo Chia   An abundant perivascular source of stem cells for bone tissue engineering Stem cells translational medicine, 2012; 1(9): 673-84.
Scott Michelle A, Levi Benjamin, Askarinam Asal, Nguyen Alan, Rackohn Todd, Ting Kang, Soo Chia, James Aaron W   Brief review of models of ectopic bone formation Stem cells and development, 2012; 21(5): 655-67.
Zhang Xinli, Ting Kang, Pathmanathan Dharmini, Ko Theodore, Chen Weiwei, Chen Feng, Lee Haofu, James Aaron W, Siu Ronald K, Shen Jia, Culiat Cymbeline T, Soo Chia   Calvarial cleidocraniodysplasia-like defects with ENU-induced Nell-1 deficiency The Journal of craniofacial surgery, 2012; 23(1): 61-6.
Cowan Catherine M, Zhang Xinli, James Aaron W, Mari Kim T, Sun Nichole, Wu Benjamin, Ting Kang, Soo Chia   NELL-1 increases pre-osteoblast mineralization using both phosphate transporter Pit1 and Pit2 Biochemical and biophysical research communications, 2012; 422(3): 351-7.
Siu Ronald K, Zara Janette N, Hou Yaping, James Aaron W, Kwak Jinny, Zhang Xinli, Ting Kang, Wu Benjamin M, Soo Chia, Lee Min   NELL-1 promotes cartilage regeneration in an in vivo rabbit model Tissue engineering. Part A, 2012; 18(3-4): 252-61.
Shen Jia, James Aaron W, Chung Jonguk, Lee Kiho, Zhang James B, Ho Stephanie, Lee Kevin S, Kim Toyong M, Niimi Tomoaki, Kuroda Shun'ichi, Ting Kang, Soo Chia   NELL-1 promotes cell adhesion and differentiation via Integrinβ1 Journal of cellular biochemistry, 2012; 113(12): 3620-8.
Chen Feng, Walder Ben, James Aaron W, Soofer Donnalisa E, Soo Chia, Ting Kang, Zhang Xinli   NELL-1-dependent mineralisation of Saos-2 human osteosarcoma cells is mediated via c-Jun N-terminal kinase pathway activation International orthopaedics, 2012; 36(10): 2181-7.
James Aaron W, Zara Janette N, Zhang Xinli, Askarinam Asal, Goyal Raghav, Chiang Michael, Yuan Wei, Chang Le, Corselli Mirko, Shen Jia, Pang Shen, Stoker David, Wu Ben, Ting Kang, Péault Bruno, Soo Chia   Perivascular stem cells: a prospectively purified mesenchymal stem cell population for bone tissue engineering Stem cells translational medicine, 2012; 1(6): 510-9.
Zheng Zhong, Jian Jia, Zhang Xinli, Zara Janette N, Yin Wei, Chiang Michael, Liu Yi, Wang Joyce, Pang Shen, Ting Kang, Soo Chia   Reprogramming of human fibroblasts into multipotent cells with a single ECM proteoglycan, fibromodulin Biomaterials, 2012; 33(24): 5821-31.
Liu Yi, Zheng Zhong, Zara Janette N, Hsu Chingyun, Soofer Donnalisa E, Lee Kevin S, Siu Ronald K, Miller Lloyd S, Zhang Xinli, Carpenter Doug, Wang Chunling, Ting Kang, Soo Chia   The antimicrobial and osteoinductive properties of silver nanoparticle/poly (DL-lactic-co-glycolic acid)-coated stainless steel Biomaterials, 2012; 33(34): 8745-56.
James Aaron W, Zara Janette N, Corselli Mirko, Chiang Michael, Yuan Wei, Nguyen Virginia, Askarinam Asal, Goyal Raghav, Siu Ronald K, Scott Victoria, Lee Min, Ting Kang, Péault Bruno, Soo Chia   Use of human perivascular stem cells for bone regeneration Journal of visualized experiments : JoVE, 2012; 422(63): .
James Aaron W, Pan Angel, Chiang Michael, Zara Janette N, Zhang Xinli, Ting Kang, Soo Chia   A new function of Nell-1 protein in repressing adipogenic differentiation Biochemical and biophysical research communications, 2011; 411(1): 126-31.
Khorasani Hooman, Zheng Zhong, Nguyen Calvin, Zara Janette, Zhang Xinli, Wang Joyce, Ting Kang, Soo Chia   A quantitative approach to scar analysis The American journal of pathology, 2011; 178(2): 621-8.
Zheng Zhong, Nguyen Calvin, Zhang Xinli, Khorasani Hooman, Wang Joyce Z, Zara Janette N, Chu Franklin, Yin Wei, Pang Shen, Le Anh, Ting Kang, Soo Chia   Delayed wound closure in fibromodulin-deficient mice is associated with increased TGF-β3 signaling The Journal of investigative dermatology, 2011; 131(3): 769-78.
Zara Janette N, Siu Ronald K, Zhang Xinli, Shen Jia, Ngo Richard, Lee Min, Li Weiming, Chiang Michael, Chung Jonguk, Kwak Jinny, Wu Benjamin M, Ting Kang, Soo Chia   High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo Tissue engineering. Part A, 2011; 17(9-10): 1389-99.
Sun Shan, Wang Qiuwei, Giang An, Cheng Cong, Soo Chia, Wang Cun-Yu, Liau Linda M, Chiu Robert   Knockdown of CypA inhibits interleukin-8 (IL-8) and IL-8-mediated proliferation and tumor growth of glioblastoma cells through down-regulated NF-κB Journal of neuro-oncology, 2011; 101(1): 1-14.
Zou Xuan, Shen Jia, Chen Feng, Ting Kang, Zheng Zhong, Pang Shen, Zara Janette N, Adams John S, Soo Chia, Zhang Xinli   NELL-1 binds to APR3 affecting human osteoblast proliferation and differentiation FEBS letters, 2011; 585(15): 2410-8.
Chen Feng, Zhang Xinli, Sun Shan, Zara Janette N, Zou Xuan, Chiu Robert, Culiat Cymbelin T, Ting Kang, Soo Chia   NELL-1, an osteoinductive factor, is a direct transcriptional target of Osterix PloS one, 2011; 6(9): e24638.
Li Weiming, Zara Janette N, Siu Ronald K, Lee Min, Aghaloo Tara, Zhang Xinli, Wu Benjamin M, Gertzman Arthur A, Ting Kang, Soo Chia   Nell-1 enhances bone regeneration in a rat critical-sized femoral segmental defect model Plastic and reconstructive surgery, 2011; 127(2): 580-7.
Siu Ronald K, Lu Steven S, Li Weiming, Whang Julie, McNeill Gabriel, Zhang Xinli, Wu Benjamin M, Turner A Simon, Seim Howard B, Hoang Paul, Wang Jeffrey C, Gertzman Arthur A, Ting Kang, Soo Chia   Nell-1 protein promotes bone formation in a sheep spinal fusion model Tissue engineering. Part A, 2011; 17(7-8): 1123-35.
Zhang Xinli, Ting Kang, Bessette Catherine M, Culiat Cymbeline T, Sung Sang Jin, Lee Haofu, Chen Feng, Shen Jia, Wang James J, Kuroda Shun'ichi, Soo Chia   Nell-1, a key functional mediator of Runx2, partially rescues calvarial defects in Runx2(+/-) mice Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011; 26(4): 777-91.
Chen Weiwei, Zhang Xinli, Siu Ronald K, Chen Feng, Shen Jia, Zara Janette N, Culiat Cymbeline T, Tetradis Sotirios, Ting Kang, Soo Chia   Nfatc2 is a primary response gene of Nell-1 regulating chondrogenesis in ATDC5 cells Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011; 26(6): 1230-41.
Zhang Xinli, Péault Bruno, Chen Weiwei, Li Weiming, Corselli Mirko, James Aaron W, Lee Min, Siu Ronald K, Shen Pang, Zheng Zhong, Shen Jia, Kwak Jinny, Zara Janette N, Chen Feng, Zhang Hong, Yin Zack, Wu Ben, Ting Kang, Soo Chia   The Nell-1 growth factor stimulates bone formation by purified human perivascular cells Tissue engineering. Part A, 2011; 17(19-20): 2497-509.
Li Weiming, Lee Min, Whang Julie, Siu Ronald K, Zhang Xinli, Liu Chen, Wu Benjamin M, Wang Jeffrey C, Ting Kang, Soo Chia   Delivery of lyophilized Nell-1 in a rat spinal fusion model Tissue engineering. Part A, 2010; 16(9): 2861-70.
Aghaloo Tara, Cowan Catherine M, Zhang Xinli, Freymiller Earl, Soo Chia, Wu Benjamin, Ting Kang, Zhang Zhiyuan   The effect of NELL1 and bone morphogenetic protein-2 on calvarial bone regeneration Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2010; 68(2): 300-8.
Zheng Zhong, Yin Wei, Zara Janette N, Li Weiming, Kwak Jinny, Mamidi Rachna, Lee Min, Siu Ronald K, Ngo Richard, Wang Joyce, Carpenter Doug, Zhang Xinli, Wu Benjamin, Ting Kang, Soo Chia   The use of BMP-2 coupled - Nanosilver-PLGA composite grafts to induce bone repair in grossly infected segmental defects Biomaterials, 2010; 31(35): 9293-300.
Lee Min, Li Weiming, Siu Ronald K, Whang Julie, Zhang Xinli, Soo Chia, Ting Kang, Wu Benjamin M   Biomimetic apatite-coated alginate/chitosan microparticles as osteogenic protein carriers Biomaterials, 2009; 30(30): 6094-101.
Aghaloo Tara, Jiang Xinquan, Soo Chia, Zhang Zhiyuan, Zhang Xiuli, Hu Jingzhou, Pan Hongya, Hsu Tiffany, Wu Benjamin, Ting Kang, Zhang Xinli   A study of the role of nell-1 gene modified goat bone marrow stromal cells in promoting new bone formation Molecular therapy : the journal of the American Society of Gene Therapy, 2007; 15(10): 1872-80.
Truong Thien, Zhang Xinli, Pathmanathan Dharmini, Soo Chia, Ting Kang   Craniosynostosis-associated gene nell-1 is regulated by runx2 Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2007; 22(1): 7-18.
Cowan Catherine M, Aghaloo Tara, Chou Yu-Fen, Walder Benjamin, Zhang Xinli, Soo Chia, Ting Kang, Wu Benjamin   MicroCT evaluation of three-dimensional mineralization in response to BMP-2 doses in vitro and in critical sized rat calvarial defects Tissue engineering, 2007; 13(3): 501-12.
Cowan Catherine M, Jiang Xinquan, Hsu Tiffany, Soo Chia, Zhang Beiji, Wang Joyce Z, Kuroda Shun'ichi, Wu Benjamin, Zhang Zhiyuan, Zhang Xinli, Ting Kang   Synergistic effects of Nell-1 and BMP-2 on the osteogenic differentiation of myoblasts Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2007; 22(6): 918-30.
Lu Steven S, Zhang Xinli, Soo Chia, Hsu Tiffany, Napoli Antonia, Aghaloo Tara, Wu Benjamin M, Tsou Paul, Ting Kang, Wang Jeffrey C   The osteoinductive properties of Nell-1 in a rat spinal fusion model The spine journal : official journal of the North American Spine Society, 2007; 7(1): 50-60.
Zhang Qunzhou, Oh Chad K, Messadi Diana V, Duong Hai S, Kelly A Paul, Soo Chia, Wang Lina, Le Anh D   Hypoxia-induced HIF-1 alpha accumulation is augmented in a co-culture of keloid fibroblasts and human mast cells: involvement of ERK1/2 and PI-3K/Akt Experimental cell research, 2006; 312(2): 145-55.
Cowan Catherine M, Cheng Samson, Ting Kang, Soo Chia, Walder Benjamin, Wu Benjamin, Kuroda Shun'ichi, Zhang Xinli   Nell-1 induced bone formation within the distracted intermaxillary suture Bone, 2006; 38(1): 48-58.
Zhang Xinli, Cowan Catherine M, Jiang Xinquan, Soo Chia, Miao Steve, Carpenter Dale, Wu Benjamin, Kuroda Shun'ichi, Ting Kang   Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development Laboratory investigation; a journal of technical methods and pathology, 2006; 86(7): 633-44.
Aghaloo Tara, Cowan Catherine M, Chou Yu-Fen, Zhang Xinli, Lee Haofu, Miao Steve, Hong Nichole, Kuroda Shun'ichi, Wu Benjamin, Ting Kang, Soo Chia   Nell-1-induced bone regeneration in calvarial defects The American journal of pathology, 2006; 169(3): 903-15.
Cowan Catherine M, Soo Chia, Ting Kang, Wu Benjamin   Evolving concepts in bone tissue engineering Current topics in developmental biology, 2005; 66(1): 239-85.
Colwell Amy S, Beanes Steven R, Soo Chia, Dang Catherine, Ting Kang, Longaker Michael T, Atkinson James B, Lorenz H Peter   Increased angiogenesis and expression of vascular endothelial growth factor during scarless repair Plastic and reconstructive surgery, 2005; 115(1): 204-12.
Dang Catherine M, Beanes Steven R, Soo Chia, Ting Kang, Benhaim Prosper, Hedrick Marc H, Lorenz H Peter   Decreased expression of fibroblast and keratinocyte growth factor isoforms and receptors during scarless repair Plastic and reconstructive surgery, 2003; 111(6): 1969-79.
Dang Catherine, Ting Kang, Soo Chia, Longaker Michael T, Lorenz H Peter   Fetal wound healing current perspectives Clinics in plastic surgery, 2003; 30(1): 13-23.
Soo Chia, Beanes Steven R, Hu Fei-Ya, Zhang Xinli, Dang Catherine, Chang Grace, Wang Yubert, Nishimura Ichiro, Freymiller Earl, Longaker Michael T, Lorenz H Peter, Ting Kang   Ontogenetic transition in fetal wound transforming growth factor-beta regulation correlates with collagen organization The American journal of pathology, 2003; 163(6): 2459-76.
Zhang Xinli, Carpenter Dale, Bokui Nobuyuki, Soo Chia, Miao Steve, Truong Thien, Wu Benjamin, Chen Ingrid, Vastardis Heleni, Tanizawa Katsuyuki, Kuroda Shun'ichi, Ting Kang   Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2003; 18(12): 2126-34.
Dang Catherine M, Beanes Steven R, Lee Haofu, Zhang Xinli, Soo Chia, Ting Kang   Scarless fetal wounds are associated with an increased matrix metalloproteinase-to-tissue-derived inhibitor of metalloproteinase ratio Plastic and reconstructive surgery, 2003; 111(7): 2273-85.
Beanes Steven R, Dang Catherine, Soo Chia, Ting Kang   Skin repair and scar formation: the central role of TGF-beta Expert reviews in molecular medicine, 2003; 5(8): 1-22.
Beanes Steven R, Hu Fei-Ya, Soo Chia, Dang Catherine M H, Urata Mark, Ting Kang, Atkinson James B, Benhaim Prosper, Hedrick Marc H, Lorenz H Peter   Confocal microscopic analysis of scarless repair in the fetal rat: defining the transition Plastic and reconstructive surgery, 2002; 109(1): 160-70.
Zhang Xinli, Kuroda Shun'ichi, Carpenter Dale, Nishimura Ichiro, Soo Chia, Moats Rex, Iida Keisuke, Wisner Eric, Hu Fei-Ya, Miao Steve, Beanes Steve, Dang Catherine, Vastardis Heleni, Longaker Michael, Tanizawa Katsuyuki, Kanayama Norihiro, Saito Naoaki, Ting Kang   Craniosynostosis in transgenic mice overexpressing Nell-1 The Journal of clinical investigation, 2002; 110(6): 861-70.
Soo Chia, Sayah David N, Zhang Xinli, Beanes Steven R, Nishimura Ichiro, Dang Catherine, Freymiller Earl, Ting Kang   The identification of novel wound-healing genes through differential display Plastic and reconstructive surgery, 2002; 110(3): 787-97; discussion 798-800.

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