Dr. Gustavo Miranda-Carboni's reasearch interests are on modeling human breast cancer using mouse models of the Wnt/beta-catenin signaling pathway. His translation model is for a subset of human breast cancers known as Triple-Negative which afflicts African-American women three times higher than other ethnic groups. This type of breast cancer is highly aggressive, lacks any known therapeutics and afflicts pre-menopausal women at ~33 percent of the time upon diagnosis.
Work Titles
UCLAAssistant Professor,Obstetrics and GynecologyMember,JCCC Signal Transduction and Therapeutics Program Area
Garcia Alejandro J, Tom Colton, Guemes Miriam, Polanco Gloria, Mayorga Maria E, Wend Korinna, Miranda-Carboni Gustavo A, Krum Susan A
ER? signaling regulates MMP3 expression to induce FasL cleavage and
osteoclast apoptosis
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
2013; 28(2):
283-90.