Hailiang Hu, Ph.D.

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Work Titles
UCLA Assistant Professor, Pathology and Laboratory Medicine Member, JCCC Cancer and Stem Cell Biology Program Area
Education:
Degrees:
Ph.D.

Contact Information:

Email Address:

hhu@mednet.ucla.edu

Work Email Address:

hhu@mednet.ucla.edu


Lab Number:

310-825-7200

Work Phone Number:

310-825-6105

Laboratory Address:

MRL 4-609
UCLA School of Medicine
Los Angeles, CA 90095


Work Address:

CHS1P-433
UCLA School of Medicine
Los Angeles, CA 90095


Detailed Biography:

Dr. HuÂ’s research interest is to investigate the role of microRNAs in the DNA damage response for cancer. Of particularly, his laboratory focuses on the functions of ATM-related microRNAs in cell cycle checkpoints, DNA repair and DNA damage-induced apoptosis. Furthermore, they will use breast cancer stem/initiating cells as a model to study the role of these microRNAs in radio/chemo-sensitivity, which might provide new therapeutic targets for radioresistant/chemoresistant cancers. In addition, they are also interested in developing small molecule readthrough compounds with Ataxia Telangiectasia iPSCs as models for treating human genetic diseases such as Ataxia-Telangiectasia.

Publications:

A selected list of publications:

Du Liutao, Kayali Refik, Bertoni Carmen, Fike Francesca, Hu Hailiang, Iversen Patrick L, Gatti Richard A   Arginine-rich cell-penetrating peptide dramatically enhances AMO-mediated ATM aberrant splicing correction and enables delivery to brain and cerebellum Human molecular genetics, 2011; 20(16): 3151-60.
Hu Hailiang, Gatti Richard A   MicroRNAs: new players in the DNA damage response Journal of molecular cell biology, 2011; 3(3): 151-8.
Hu Hailiang, Du Liutao, Nagabayashi Gindy, Seeger Robert C, Gatti Richard A   ATM is down-regulated by N-Myc-regulated microRNA-421 Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(4): 1506-11.
Du Liutao, Damoiseaux Robert, Nahas Shareef, Gao Kun, Hu Hailiang, Pollard Julianne M, Goldstine Jimena, Jung Michael E, Henning Susanne M, Bertoni Carmen, Gatti Richard A   Nonaminoglycoside compounds induce readthrough of nonsense mutations The Journal of experimental medicine, 2009; 206(10): 2285-97.
Hu Hailiang, Gatti Richard A   New approaches to treatment of primary immunodeficiencies: fixing mutations with chemicals Current opinion in allergy and clinical immunology, 2008; 8(6): 540-6.
Hu Hailiang, Milstein Marc, Bliss Joanne M, Thai Minh, Malhotra Gautam, Huynh Lucia C, Colicelli John   Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration Molecular and cellular biology, 2008; 28(5): 1573-83.
Milstein Marc, Mooser Chelsea K, Hu Hailiang, Fejzo Marlena, Slamon Dennis, Goodglick Lee, Dry Sarah, Colicelli John   RIN1 is a breast tumor suppressor gene Cancer research, 2007; 67(24): 11510-6.
Hu Hailiang, Bliss Joanne M, Wang Ying, Colicelli John   RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration Current biology : CB, 2005; 15(9): 815-23.
Dhaka Ajay, Costa Rui M, Hu Hailiang, Irvin Dwain K, Patel Apoor, Kornblum Harley I, Silva Alcino J, O'Dell Thomas J, Colicelli John   The RAS effector RIN1 modulates the formation of aversive memories The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003; 23(3): 748-57.

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