The long term aim of Dr. James Byrne�s research is to create and use patient-specific induced pluripotent stem (iPS) cell technology to treat diseases such as Parkinson�s, heart disease and diabetes as well as promote recovery from spinal cord injuries and regenerate human organs, tissues and cells as they age, mutate and die. iPS cell technology is the reprogramming of human somatic cells back into an embryonic-like pluripotent state in order to re-differentiate them into other potentially useful functional cell types. Byrne hopes that by studying the underlying mechanisms of nuclear reprogramming and by developing basic research and clinical applications based on human iPS cells, we will be able to increase both the length and the quality of human life. The iPS cell technology holds much hope for the future of regenerative medicine because it uses the patient�s own cells for treatments, thus avoiding rejection by the patient�s immune system. His research at Stanford and now at UCLA has focused on reprogramming beginning with cells from animals and ultimately in humans. At the University of Cambridge, Byrne investigated both intra- and inter-species epigenetic reprogramming. Byrne also demonstrated that primate embryonic stem cells could be derived through somatic cell nuclear transfer. At Stanford, Byrne focused on extending his reprogramming and isogenic stem cell interests and helped to establish a bank of human patient-specific somatic cells and reprogrammed those cells into patient-specific induced pluripotent stem cells. An assistant professor of molecular and medical pharmacology, Byrne joined the faculty of UCLA in 2010. He earned his doctorate degree at the University of Cambridge. Byrne�s work is funded by the Broad Stem Cell Research Center
Awe Jason P, Crespo Agustin Vega, Li You, Kiledjian Megerditch, Byrne James A BAY11 enhances OCT4 synthetic mRNA expression in adult human skin cells Stem cell research & therapy, 2013; 4(1): 15.
Awe Jason P, Byrne James A Identifying candidate oocyte reprogramming factors using cross-species global transcriptional analysis Cellular reprogramming, 2013; 15(2): 126-33.
Vega Crespo Agustin, Awe Jason P, Reijo Pera Renee, Byrne James A Human skin cells that express stage-specific embryonic antigen 3 associate with dermal tissue regeneration BioResearch open access, 2012; 1(1): 25-33.
Byrne James Global transcriptional analysis of oocyte-based and factor-based nuclear reprogramming in the nonhuman primate Cellular reprogramming, 2011; 13(6): 473-81.
Nguyen Ha Nam, Byers Blake, Cord Branden, Shcheglovitov Aleksandr, Byrne James, Gujar Prachi, Kee Kehkooi, SchÃ¼le Birgitt, Dolmetsch Ricardo E, Langston William, Palmer Theo D, Pera Renee Reijo LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress Cell stem cell, 2011; 8(3): 267-80.
McElroy Sohyun L, Byrne James A, Chavez Shawn L, Behr Barry, Hsueh Aaron J, Westphal Lynn M, Pera Renee A Reijo Parthenogenic blastocysts derived from cumulus-free in vitro matured human oocytes PloS one, 2010; 5(6): e10979.
Byrne James A, Nguyen Ha Nam, Reijo Pera Renee A Enhanced generation of induced pluripotent stem cells from a subpopulation of human fibroblasts PloS one, 2009; 4(9): e7118.
Byrne James A Generation of isogenic pluripotent stem cells Human molecular genetics, 2008; 17(R1): R37-41.
Dighe Vikas, Clepper Lisa, Pedersen Darlene, Byrne James, Ferguson Betsy, Gokhale Sumita, Penedo M Cecilia T, Wolf Don, Mitalipov Shoukhrat Heterozygous embryonic stem cell lines derived from nonhuman primate parthenotes Stem cells (Dayton, Ohio), 2008; 26(3): 756-66.
Sugihara Kazuhiro, Kabir-Salmani Maryam, Byrne James, Wolf Don P, Lessey Bruce, Iwashita Mitsutoshi, Aoki Daisuke, Nakayama Jun, Fukuda Michiko N Induction of trophinin in human endometrial surface epithelia by CGbeta and IL-1beta FEBS letters, 2008; 582(2): 197-202.
Byrne J A, Pedersen D A, Clepper L L, Nelson M, Sanger W G, Gokhale S, Wolf D P, Mitalipov S M Producing primate embryonic stem cells by somatic cell nuclear transfer Nature, 2007; 450(7169): 497-502.
Sugihara Kazuhiro, Sugiyama Daijiro, Byrne James, Wolf Don P, Lowitz Kevin P, Kobayashi Yoichi, Kabir-Salmani Maryam, Nadano Daita, Aoki Daisuke, Nozawa Shiro, Nakayama Jun, Mustelin Tomas, Ruoslahti Erkki, Yamaguchi Naoto, Fukuda Michiko N Trophoblast cell activation by trophinin ligation is implicated in human embryo implantation Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(10): 3799-804.
Byrne James A, Mitalipov Shoukhrat M, Wolf Don P Current progress with primate embryonic stem cells Current stem cell research & therapy, 2006; 1(2): 127-38.
Mitalipov Shoukhrat, Kuo Hung-Chih, Byrne James, Clepper Lisa, Meisner Lorraine, Johnson Julie, Zeier Renee, Wolf Don Isolation and characterization of novel rhesus monkey embryonic stem cell lines Stem cells (Dayton, Ohio), 2006; 24(10): 2177-86.
Byrne James A, Mitalipov Shoukhrat M, Clepper Lisa, Wolf Don P Transcriptional profiling of rhesus monkey embryonic stem cells Biology of reproduction, 2006; 75(6): 908-15.
Byrne James D, Wing Deborah A, Fraser Mhoyra, Fassett Michael J, Goodwin T Murphy, Challis John R G Mifepristone: effect on plasma corticotropin-releasing hormone, adrenocorticotropic hormone, and cortisol in term pregnancy Journal of perinatology : official journal of the California Perinatal Association, 2004; 24(7): 416-20.
Byrne James A, Simonsson Stina, Western Patrick S, Gurdon John B Nuclei of adult mammalian somatic cells are directly reprogrammed to oct-4 stem cell gene expression by amphibian oocytes Current biology : CB, 2003; 13(14): 1206-13.
Byrne James A, Gurdon John B Commentary on human cloning Differentiation; research in biological diversity, 2002; 69(4-5): 154-7.
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