Simon W Beaven

Title(s)HS Clinical Professor, Medicine
SchoolMedicine
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    The Role of Liver X Receptors (LXRs) in the Pathogenesis of Hepatic Fibrosis
    NIH K08DK088998Jul 1, 2010 - Jun 30, 2015
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reducing diagnostic delays in Acute Hepatic Porphyria using electronic health records data and machine learning: a multicenter development and validation study. medRxiv. 2023 Aug 31. Bhasuran B, Schmolly K, Kapoor Y, Jayakumar NL, Doan R, Amin J, Meninger S, Cheng N, Deering R, Anderson K, Beaven SW, Wang B, Rudrapatna VA. PMID: 37693437; PMCID: PMC10491361.
      View in: PubMed   Mentions:
    2. Evidence-based consensus guidelines for the diagnosis and management of protoporphyria-related liver dysfunction in erythropoietic protoporphyria and X-linked protoporphyria. Hepatology. 2024 Mar 01; 79(3):731-743. Levy C, Dickey AK, Wang B, Thapar M, Naik H, Keel SB, Saberi B, Beaven SW, Rudnick SR, Elmariah SB, Erwin AL, Goddu RJ, Hedstrom K, Leaf RK, Kazamel M, Mazepa M, Philpotts LL, Quigley J, Raef H, Ungar J, Anderson KE, Balwani M, Porphyrias Consortium of the Rare Diseases Clinical Network. PMID: 37505211; PMCID: PMC10818013.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Evidence-based consensus guidelines for the diagnosis and management of erythropoietic protoporphyria and X-linked protoporphyria. J Am Acad Dermatol. 2023 12; 89(6):1227-1237. Dickey AK, Naik H, Keel SB, Levy C, Beaven SW, Elmariah SB, Erwin AL, Goddu RJ, Hedstrom K, Leaf RK, Kazamel M, Mazepa M, Philpotts LL, Quigley J, Raef H, Rudnick SR, Saberi B, Thapar M, Ungar J, Wang B, Balwani M, Porphyrias Consortium of the Rare Diseases Clinical Research Network. PMID: 36041558; PMCID: PMC9968824.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    4. Yield of Post-Acute Diverticulitis Colonoscopy for Ruling Out Colorectal Cancer. Tech Innov Gastrointest Endosc. 2022; 24(3):254-261. Azizian JM, Trieu H, Kovacs TO, Turkiewicz J, Hilder R, Palmer S, Roux ML, Dong T, Berry R, Beaven SW, Tabibian JH. PMID: 36540108; PMCID: PMC9762736.
      View in: PubMed   Mentions:
    5. Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis. Liver Res. 2021 Dec; 5(4):224-231. Dalai C, Azizian J, Trieu H, Rajan A, Chen F, Dong T, Beaven S, Tabibian JH. PMID: 35186364; PMCID: PMC8855981.
      View in: PubMed   Mentions:
    6. Predictive Modeling of Colonoscopic Findings in a Fecal Immunochemical Test-Based Colorectal Cancer Screening Program. Dig Dis Sci. 2022 07; 67(7):2842-2848. Law J, Rajan A, Trieu H, Azizian J, Berry R, Beaven SW, Tabibian JH. PMID: 34350518; PMCID: PMC9237000.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    7. The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice. Cell Mol Gastroenterol Hepatol. 2021; 11(1):199-220. Tuominen I, Fuqua BK, Pan C, Renaud N, Wroblewski K, Civelek M, Clerkin K, Asaryan A, Haroutunian SG, Loureiro J, Borawski J, Roma G, Knehr J, Carbone W, French S, Parks BW, Hui ST, Mehrabian M, Magyar C, Cantor RM, Ukomadu C, Lusis AJ, Beaven SW. PMID: 32866618; PMCID: PMC7674618.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    8. Reactivation of Hepatitis B Virus: A Review of Clinical Guidelines. Clin Liver Dis (Hoboken). 2020 Apr; 15(4):162-167. Myint A, Tong MJ, Beaven SW. PMID: 32395244; PMCID: PMC7206320.
      View in: PubMed   Mentions: 20  
    9. Hymenolepis nana Causing Chronic Diarrhea in an Immunosuppressed Patient. Clin Gastroenterol Hepatol. 2021 05; 19(5):e45. Dalai C, Beaven SW. PMID: 32147596.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    10. Diesel Exhaust Induces Mitochondrial Dysfunction, Hyperlipidemia, and Liver Steatosis. Arterioscler Thromb Vasc Biol. 2019 09; 39(9):1776-1786. Yin F, Gupta R, Vergnes L, Driscoll WS, Ricks J, Ramanathan G, Stewart JA, Shih DM, Faull KF, Beaven SW, Lusis AJ, Reue K, Rosenfeld ME, Araujo JA. PMID: 31340670; PMCID: PMC6703953.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    11. The Genetic Architecture of Diet-Induced Hepatic Fibrosis in Mice. Hepatology. 2018 12; 68(6):2182-2196. Hui ST, Kurt Z, Tuominen I, Norheim F, C Davis R, Pan C, Dirks DL, Magyar CE, French SW, Chella Krishnan K, Sabir S, Campos-Pérez F, Méndez-Sánchez N, Macías-Kauffer L, León-Mimila P, Canizales-Quinteros S, Yang X, Beaven SW, Huertas-Vazquez A, Lusis AJ. PMID: 29907965; PMCID: PMC6269199.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    12. Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med. 2016 Apr 13; 8(334):334ra54. Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. PMID: 27075628; PMCID: PMC4934679.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    13. A Phase I Dose Escalation Study Demonstrates Quercetin Safety and Explores Potential for Bioflavonoid Antivirals in Patients with Chronic Hepatitis C. Phytother Res. 2016 Jan; 30(1):160-8. Lu NT, Crespi CM, Liu NM, Vu JQ, Ahmadieh Y, Wu S, Lin S, McClune A, Durazo F, Saab S, Han S, Neiman DC, Beaven S, French SW. PMID: 26621580; PMCID: PMC5590840.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCellsCTClinical Trials
    14. Intestinal farnesoid X receptor puts a fresh coat of wax on fatty liver. Hepatology. 2015 Aug; 62(2):646-8. Tuominen I, Beaven SW. PMID: 25998695; PMCID: PMC4523235.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    15. Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein. Hepatology. 2015 Aug; 62(2):615-26. O'Mahony F, Wroblewski K, O'Byrne SM, Jiang H, Clerkin K, Benhammou J, Blaner WS, Beaven SW. PMID: 25482505; PMCID: PMC4458237.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    16. La mort de la lipogenèse: RNF20 lashes ubiquitin to SREBP-1c. Hepatology. 2014 Sep; 60(3):776-8. Beaven SW. PMID: 24604429; PMCID: PMC4607314.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    17. Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):E2866-74. Clark PM, Flores G, Evdokimov NM, McCracken MN, Chai T, Nair-Gill E, O'Mahony F, Beaven SW, Faull KF, Phelps ME, Jung ME, Witte ON. PMID: 24982199; PMCID: PMC4104878.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    18. Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance. Cell Metab. 2013 Jul 02; 18(1):106-17. Beaven SW, Matveyenko A, Wroblewski K, Chao L, Wilpitz D, Hsu TW, Lentz J, Drew B, Hevener AL, Tontonoz P. PMID: 23823481; PMCID: PMC4089509.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    19. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome. 2012 Oct; 23(9-10):680-92. Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov VA, Laughlin RE, Martin LJ, Ohmen JD, Parks BW, Pellegrini M, Reue K, Smith DJ, Tetradis S, Wang J, Wang Y, Weiss JN, Kirchgessner T, Gargalovic PS, Eskin E, Lusis AJ, LeBoeuf RC. PMID: 22892838; PMCID: PMC3586763.
      View in: PubMed   Mentions: 90     Fields:    Translation:Animals
    20. The number of x chromosomes causes sex differences in adiposity in mice. PLoS Genet. 2012; 8(5):e1002709. Chen X, McClusky R, Chen J, Beaven SW, Tontonoz P, Arnold AP, Reue K. PMID: 22589744; PMCID: PMC3349739.
      View in: PubMed   Mentions: 162     Fields:    Translation:AnimalsCells
    21. Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. J Clin Invest. 2012 Jan; 122(1):337-47. Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ. PMID: 22156197; PMCID: PMC3248291.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    22. Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. Gastroenterology. 2011 Mar; 140(3):1052-62. Beaven SW, Wroblewski K, Wang J, Hong C, Bensinger S, Tsukamoto H, Tontonoz P. PMID: 21134374; PMCID: PMC3049833.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    23. Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice. Am J Physiol Endocrinol Metab. 2010 Feb; 298(2):E304-19. Ribas V, Nguyen MT, Henstridge DC, Nguyen AK, Beaven SW, Watt MJ, Hevener AL. PMID: 19920214; PMCID: PMC2822483.
      View in: PubMed   Mentions: 162     Fields:    Translation:AnimalsCells
    24. Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt. Cell Metab. 2009 Jun; 9(6):525-36. Dean JT, Tran L, Beaven S, Tontonoz P, Reue K, Dipple KM, Liao JC. PMID: 19490907; PMCID: PMC4277884.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    25. Scott L. Friedman, 59th President, AASLD. Hepatology. 2008 Nov; 48(5):1357-8. Bansal MB, Beaven SW, Rockey DC. PMID: 18972438.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. KLF6 degradation after apoptotic DNA damage. FEBS Lett. 2006 Dec 22; 580(30):6981-6. Banck MS, Beaven SW, Narla G, Walsh MJ, Friedman SL, Beutler AS. PMID: 17113081.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    27. Phosphorylation of the liver X receptors. FEBS Lett. 2006 Sep 04; 580(20):4835-41. Chen M, Bradley MN, Beaven SW, Tontonoz P. PMID: 16904112.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    28. Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. Annu Rev Med. 2006; 57:313-29. Beaven SW, Tontonoz P. PMID: 16409152.
      View in: PubMed   Mentions: 104     Fields:    Translation:Humans
    29. Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha. J Lipid Res. 2005 Dec; 46(12):2570-9. Chen M, Beaven S, Tontonoz P. PMID: 16170053.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    30. Tales from the crypt: beta-catenin in the development of juvenile polyps: commentary on the article by Iwamoto et al. on page 4. Pediatr Res. 2005 Jan; 57(1):1-3. Beaven SW, Martín MG. PMID: 15557110.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    31. Biomarkers in inflammatory bowel disease. Curr Opin Gastroenterol. 2004 Jul; 20(4):318-27. Beaven SW, Abreu MT. PMID: 15703659.
      View in: PubMed   Mentions: 18     Fields:    
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