Amander Clark, Ph.D.

A Short Biography:

Amander Clark is a stem cell biologist who specializes in reproductive developmental biology.  She has served on the UCLA College of Letters and Science faculty since she joined the Department of Molecular Cell and Developmental Biology (MCDB) in 2006.  She was awarded Associate Professor with tenure in 2012 and Professor in 2015. Since 2013, Dr Clark served as Vice Chair of MCDB, and was promoted to Department Chair in 2017.  Dr. Clark earned her PhD in Anatomy and Cell Biology at the University of Melbourne, she was a postdoctoral fellow at Baylor College  of Medicine, and the University of California, San Francisco where she trained in Mouse Genetics and Stem Cell Biology respectively. Dr Clark's laboratory studies the origins of the human germline with an emphasis on chromatin, epigenetic reprogramming and inheritance. Her lab uses CRISPR/Cas9, next generation sequencing, pluripotent stem cells and mouse models to meet her research goals. The laboratory's long-term research objective is to understand the fundamental principles of human germline cell formation towards the genesis of high quality gametes and the birth of healthy children.


Work Titles
Education:
Degrees:
Ph.D.

Contact Information:

Email Address:

clarka@ucla.edu


Website:

Clark Lab

Work Phone Number:

794 4201

Office Address:

615 Charles E Young Drive South
Box 951606
Los Angeles, CA 90095

BSRB II 451C


Detailed Biography:

Amander Clark PhD is Professor and Chair of the Department of Molecular Cell and Developmental Biology at the University of California Los Angeles. She is a key member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and Co-Director of the Embryonic Stem Cell Derivation laboratory. She is also a member of the Jonsson Comprehensive Cancer Center and the Molecular Biology Institute. Dr Clark's group was the first to map DNA methylation reprogramming in the human germline during prenatal life at single base resolution using next generation sequencing.  This work exposed one of the most vulnerable time windows in human germline development, opening up new areas of investigation into environmental exposures during prenatal life.  Her lab was also the first  to use next generation sequencing to discriminate sex-specific transcriptional differences between male and female human prenatal germline cells, defining the advanced stages of human primordial germ cell development. Dr Clark’'s research is primarily funded by the National Institute of Child Health and Human Development, with previous awards from the California Institute for Regenerative Medicine, Fuller Fundation and the Iris Cantor UCLA Women's Health Center. Dr Clark is a recipient of Young Investigator Award from the Lance Armstrong, a Research and Career Development award from STOP Cancer, a Research award from the Concern Foundation and a Young Investigator Award from the International Society for Stem Cell Research. Dr Clark is a member of the Hinxton Group, an International consortium of scientists, ethicists and policy makers for the use of pluripotent stem cell derived gametes.

Publications:

O'Brien Carmel M, Chy Hun S, Zhou Qi, Blumenfeld Shiri, Lambshead Jack W, Liu Xiaodong, Kie Joshua, Capaldo Bianca D, Chung Tung-Liang, Adams Timothy E, Phan Tram, Bentley John D, McKinstry William J, Oliva Karen, McMurrick Paul J, Wang Yu-Chieh, Rossello Fernando J, Lindeman Geoffrey J, Chen Di, Jarde Thierry, Clark Amander T, Abud Helen E, Visvader Jane E, Nefzger Christian M, Polo Jose M, Loring Jeanne F, Laslett Andrew L   New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells Stem cells (Dayton, Ohio), 2017; 35(3): 626-640.
Patel Sanjeet, Bonora Giancarlo, Sahakyan Anna, Kim Rachel, Chronis Constantinos, Langerman Justin, Fitz-Gibbon Sorel, Rubbi Liudmilla, Skelton Rhys J P, Ardehali Reza, Pellegrini Matteo, Lowry William E, Clark Amander T, Plath Kathrin   Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation Cell reports, 2017; 18(1): 54-67.
Sahakyan Anna, Kim Rachel, Chronis Constantinos, Sabri Shan, Bonora Giancarlo, Theunissen Thorold W, Kuoy Edward, Langerman Justin, Clark Amander T, Jaenisch Rudolf, Plath Kathrin   Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation Cell stem cell, 2017; 20(1): 87-101.
Nagaraj Raghavendra, Sharpley Mark S, Chi Fangtao, Braas Daniel, Zhou Yonggang, Kim Rachel, Clark Amander T, Banerjee Utpal   Nuclear Localization of Mitochondrial TCA Cycle Enzymes as a Critical Step in Mammalian Zygotic Genome Activation Cell, 2017; 168(1-2): 210-223.e11.
Masaeli Mahdokht, Gupta Dewal, O'Byrne Sean, Tse Henry T K, Gossett Daniel R, Tseng Peter, Utada Andrew S, Jung Hea-Jin, Young Stephen, Clark Amander T, Di Carlo Dino   Multiparameter mechanical and morphometric screening of cells Scientific reports, 2016; 6(1): 37863.
Hargan-Calvopina Joseph, Taylor Sara, Cook Helene, Hu Zhongxun, Lee Serena A, Yen Ming-Ren, Chiang Yih-Shien, Chen Pao-Yang, Clark Amander T   Stage-Specific Demethylation in Primordial Germ Cells Safeguards against Precocious Differentiation Developmental cell, 2016; 39(1): 75-86.
Sosa Enrique, Kim Rachel, Rojas Ernesto J, Hosohama Linzi, Hennebold Jon D, Orwig Kyle E, Clark Amander T   An integration-free, virus-free rhesus macaque induced pluripotent stem cell line (riPSC89) from embryonic fibroblasts Stem cell research, 2016; 17(2): 444-447.
Li Sisi, Yen Linda, Pastor William A, Johnston Jonathan B, Du Jiamu, Shew Colin J, Liu Wanlu, Ho Jamie, Stender Bryan, Clark Amander T, Burlingame Alma L, Daxinger Lucia, Patel Dinshaw J, Jacobsen Steven E   Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin Proceedings of the National Academy of Sciences of the United States of America, 2016; 113(35): E5108-16.
Pastor William A, Chen Di, Liu Wanlu, Kim Rachel, Sahakyan Anna, Lukianchikov Anastasia, Plath Kathrin, Jacobsen Steven E, Clark Amander T   Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory Cell stem cell, 2016; 18(3): 323-9.
Clark Amander T   DNA methylation remodeling in vitro and in vivo Current opinion in genetics & development, 2015; 34(34): 82-7.
Clark Amander T, Zwaka Thomas P   Editorial overview: Cell reprogramming, regeneration and repair: Reprogramming: the eternal circle Current opinion in genetics & development, 2015; 34(34): v-vi.
Oliveros-Etter Marisabel, Li Ziwei, Nee Kevin, Hosohama Linzi, Hargan-Calvopina Joseph, Lee Serena A, Joti Prakash, Yu Juehua, Clark Amander T   PGC Reversion to Pluripotency Involves Erasure of DNA Methylation from Imprinting Control Centers followed by Locus-Specific Re-methylation Stem cell reports, 2015; 5(3): 337-49.
Calvopina Joseph Hargan, Cook Helene, Vincent John J, Nee Kevin, Clark Amander T   The Aorta-Gonad-Mesonephros Organ Culture Recapitulates 5hmC Reorganization and Replication-Dependent and Independent Loss of DNA Methylation in the Germline Stem cells and development, 2015; 24(13): 1536-45.
Gkountela Sofia, Zhang Kelvin X, Shafiq Tiasha A, Liao Wen-Wei, Hargan-Calvopiña Joseph, Chen Pao-Yang, Clark Amander T   DNA Demethylation Dynamics in the Human Prenatal Germline Cell, 2015; 161(6): 1425-36.
Chen Di, Clark Amander T   Human germline differentiation charts a new course The EMBO journal, 2015; 34(8): 975-7.
Morselli Marco, Pastor William A, Montanini Barbara, Nee Kevin, Ferrari Roberto, Fu Kai, Bonora Giancarlo, Rubbi Liudmilla, Clark Amander T, Ottonello Simone, Jacobsen Steven E, Pellegrini Matteo   In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse eLife, 2015; 4(8): e06205.
Li Ziwei, Yu Juehua, Hosohama Linzi, Nee Kevin, Gkountela Sofia, Chaudhari Sonal, Cass Ashley A, Xiao Xinshu, Clark Amander T   The Sm protein methyltransferase PRMT5 is not required for primordial germ cell specification in mice The EMBO journal, 2015; 34(6): 748-58.
Gkountela Sofia, Clark Amander T   A big surprise in the little zygote: the curious business of losing methylated cytosines Cell stem cell, 2014; 15(4): 393-4.
Ben-David Uri, Arad Gal, Weissbein Uri, Mandefro Berhan, Maimon Adva, Golan-Lev Tamar, Narwani Kavita, Clark Amander T, Andrews Peter W, Benvenisty Nissim, Carlos Biancotti Juan   Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells Nature communications, 2014; 5(13): 4825.
Durruthy-Durruthy Jens, Briggs Sharon F, Awe Jason, Ramathal Cyril Y, Karumbayaram Saravanan, Lee Patrick C, Heidmann Julia D, Clark Amander, Karakikes Ioannis, Loh Kyle M, Wu Joseph C, Hoffman Andrew R, Byrne James, Reijo Pera Renee A, Sebastiano Vittorio   Rapid and efficient conversion of integration-free human induced pluripotent stem cells to GMP-grade culture conditions PloS one, 2014; 9(4): e94231.
Gkountela Sofia, Li Ziwei, Chin Chee Jia, Lee Serena A, Clark Amander T   PRMT5 is required for human embryonic stem cell proliferation but not pluripotency Stem cell reviews, 2014; 10(2): 230-9.
Pastor William A, Stroud Hume, Nee Kevin, Liu Wanlu, Pezic Dubravka, Manakov Sergei, Lee Serena A, Moissiard Guillaume, Zamudio Natasha, Bourc'his Déborah, Aravin Alexei A, Clark Amander T, Jacobsen Steven E   MORC1 represses transposable elements in the mouse male germline Nature communications, 2014; 5(6): 5795.
Valli Hanna, Phillips Bart T, Shetty Gunapala, Byrne James A, Clark Amander T, Meistrich Marvin L, Orwig Kyle E   Germline stem cells: toward the regeneration of spermatogenesis Fertility and sterility, 2014; 101(1): 3-13.
Feng You, Maity Ranjan, Whitelegge Julian P, Hadjikyriacou Andrea, Li Ziwei, Zurita-Lopez Cecilia, Al-Hadid Qais, Clark Amander T, Bedford Mark T, Masson Jean-Yves, Clarke Steven G   Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions The Journal of biological chemistry, 2013; 288(52): 37010-25.
Awe Jason P, Lee Patrick C, Ramathal Cyril, Vega-Crespo Agustin, Durruthy-Durruthy Jens, Cooper Aaron, Karumbayaram Saravanan, Lowry William E, Clark Amander T, Zack Jerome A, Sebastiano Vittorio, Kohn Donald B, Pyle April D, Martin Martin G, Lipshutz Gerald S, Phelps Patricia E, Pera Renee A Reijo, Byrne James A   Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status Stem cell research & therapy, 2013; 4(4): 87.
Gkountela Sofia, Clark Amander T   RNA-Seq Library Generation from Rare Human Cells Isolated by FACS Bio-protocol, 2013; 3(12): 87.
Vincent John J, Huang Yun, Chen Pao-Yang, Feng Suhua, Calvopiña Joseph H, Nee Kevin, Lee Serena A, Le Thuc, Yoon Alexander J, Faull Kym, Fan Guoping, Rao Anjana, Jacobsen Steven E, Pellegrini Matteo, Clark Amander T   Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells Cell stem cell, 2013; 12(4): 470-8.
Gkountela Sofia, Li Ziwei, Vincent John J, Zhang Kelvin X, Chen Angela, Pellegrini Matteo, Clark Amander T   The ontogeny of cKIT+ human primordial germ cells proves to be a resource for human germ line reprogramming, imprint erasure and in vitro differentiation Nature cell biology, 2013; 15(1): 113-22.
Clark Amander T   Pluripotency Takes Off without Blimp1 Cell stem cell, 2012; 11(1): 1-2.
Deshpande Amit M, Khalid Omar, Kim Jeffrey J, Kim Yong, Lindgren Anne, Clark Amander T, Wong David T W   Cdk2ap2 Is a Novel Regulator for Self-Renewal of Murine Embryonic Stem Cells Stem cells and development, 2012; 11(1): .
Gossett Daniel R, Tse Henry T K, Lee Serena A, Ying Yong, Lindgren Anne G, Yang Otto O, Rao Jianyu, Clark Amander T, Di Carlo Dino   Hydrodynamic stretching of single cells for large population mechanical phenotyping Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(20): 7630-5.
Diaz Perez Silvia V, Kim Rachel, Li Ziwei, Marquez Victor E, Patel Sanjeet, Plath Kathrin, Clark Amander T   Derivation of new human embryonic stem cell lines reveals rapid epigenetic progression in vitro that can be prevented by chemical modification of chromatin Human molecular genetics, 2012; 21(4): 751-64.
Karumbayaram Saravanan, Lee Peiyee, Azghadi Soheila F, Cooper Aaron R, Patterson Michaela, Kohn Donald B, Pyle April, Clark Amander, Byrne James, Zack Jerome A, Plath Kathrin, Lowry William E   From skin biopsy to neurons through a pluripotent intermediate under Good Manufacturing Practice protocols Stem cells translational medicine, 2012; 1(1): 36-43.
Clark Amander T, Phillips Bart T, Orwig Kyle E   Fruitful progress to fertility: male fertility in the test tube Nature medicine, 2011; 17(12): 1564-5.
Azghadi Soheila, Clark Amander T   Epigenetically reprogramming of human embryonic stem cells by 3-deazaneplanocin a and sodium butyrate International journal of preventive medicine, 2011; 2(2): 73-8.
Lindgren Anne G, Natsuhara Kyle, Tian E, Vincent John J, Li Xinmin, Jiao Jing, Wu Hong, Banerjee Utpal, Clark Amander T   Loss of Pten causes tumor initiation following differentiation of murine pluripotent stem cells due to failed repression of Nanog PloS one, 2011; 6(1): e16478.
Vincent John J, Li Ziwei, Lee Serena A, Liu Xian, Etter Marisabel O, Diaz-Perez Silvia V, Taylor Sara K, Gkountela Sofia, Lindgren Anne G, Clark Amander T   Single cell analysis facilitates staging of Blimp1-dependent primordial germ cells derived from mouse embryonic stem cells PloS one, 2011; 6(12): e28960.
Mandal Sudip, Lindgren Anne G, Srivastava Anand S, Clark Amander T, Banerjee Utpal   Mitochondrial Function Controls Proliferation and Early Differentiation Potential of Embryonic Stem Cells Stem cells (Dayton, Ohio), 2010; .
Mayshar Yoav, Ben-David Uri, Lavon Neta, Biancotti Juan-Carlos, Yakir Benjamin, Clark Amander T, Plath Kathrin, Lowry William E, Benvenisty Nissim   Identification and classification of chromosomal aberrations in human induced pluripotent stem cells Cell stem cell, 2010; 7(4): 521-31.
Tchieu Jason, Kuoy Edward, Chin Mark H, Trinh Hung, Patterson Michaela, Sherman Sean P, Aimiuwu Otaren, Lindgren Anne, Hakimian Shahrad, Zack Jerome A, Clark Amander T, Pyle April D, Lowry William E, Plath Kathrin   Female human iPSCs retain an inactive X chromosome Cell stem cell, 2010; 7(3): 329-42.
Ambartsumyan Gayane, Gill Rajbir K, Perez Silvia Diaz, Conway Deirdre, Vincent John, Dalal Yamini, Clark Amander T   Centromere protein A dynamics in human pluripotent stem cell self-renewal, differentiation and DNA damage Human molecular genetics, 2010; 7(3): .
Biancotti Juan-Carlos, Narwani Kavita, Buehler Nicole, Mandefro Berhan, Golan-Lev Tamar, Yanuka Ofra, Clark Amander T, Hill David, Benvenisty Nissim, Lavon Neta   Human Embryonic Stem Cells as Models for Aneuploid Chromosomal Syndromes Stem cells (Dayton, Ohio), 2010; 7(3): .
Chodavarapu Ramakrishna K, Feng Suhua, Bernatavichute Yana V, Chen Pao-Yang, Stroud Hume, Yu Yanchun, Hetzel Jonathan A, Kuo Frank, Kim Jin, Cokus Shawn J, Casero David, Bernal Maria, Huijser Peter, Clark Amander T, Krämer Ute, Merchant Sabeeha S, Zhang Xiaoyu, Jacobsen Steven E, Pellegrini Matteo   Relationship between nucleosome positioning and DNA methylation Nature, 2010; 466(7304): 388-92.
Kamei Ken-ichiro, Ohashi Minori, Gschweng Eric, Ho Quinn, Suh Jane, Tang Jinghua, For Yu Zeta Tak, Clark Amander T, Pyle April D, Teitell Michael A, Lee Ki-Bum, Witte Owen N, Tseng Hsian-Rong   Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions Lab on a chip, 2010; 10(9): 1113-9.
Clark Amander T   Egg-citing advances in generating primordial germ cells in the laboratory Biology of reproduction, 2010; 82(2): 233-4.
Kim Yong, Deshpande Amit, Dai Yanshan, Kim Jeffrey J, Lindgren Anne, Conway Anne, Clark Amander T, Wong David T   Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation The Journal of biological chemistry, 2009; 284(35): 23405-14.
Chin Mark H, Mason Mike J, Xie Wei, Volinia Stefano, Singer Mike, Peterson Cory, Ambartsumyan Gayane, Aimiuwu Otaren, Richter Laura, Zhang Jin, Khvorostov Ivan, Ott Vanessa, Grunstein Michael, Lavon Neta, Benvenisty Nissim, Croce Carlo M, Clark Amander T, Baxter Tim, Pyle April D, Teitell Mike A, Pelegrini Matteo, Plath Kathrin, Lowry William E   Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures Cell stem cell, 2009; 5(1): 111-23.
Wei Xie, Chunying Song, Nicolas L. Young, Adam S. Sperling, Feng Xu, Rupa Sridharan, Anne E. Conway, Benjamin A. Garcia, Kathrin Plath, Amander T. Clark, Michael Grunstein   Histone H3 Lysine 56 Acetylation Is Linked to the Core Transcriptional Network in Human Embryonic Stem Cells, Molecular Cell, 2009; 33(4): 417.
Park Tae Sub, Galic Zoran, Conway Anne E, Lindgren Anne, van Handel Benjamin J, Magnusson Mattias, Richter Laura, Teitell Michael A, Mikkola Hanna K A, Lowry William E, Plath Kathrin, Clark Amander T   Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells Stem cells (Dayton, Ohio), 2009; 27(4): 783-95.
Karumbayaram Saravanan, Novitch Bennett G, Patterson Michaela, Umbach Joy A, Richter Laura, Lindgren Anne, Conway Anne E, Clark Amander T, Goldman Steve A, Plath Kathrin, Wiedau-Pazos Martina, Kornblum Harley I, Lowry William E   Directed differentiation of human-induced pluripotent stem cells generates active motor neurons Stem cells (Dayton, Ohio), 2009; 27(4): 806-11.
Xie Wei, Song Chunying, Young Nicolas L, Sperling Adam S, Xu Feng, Sridharan Rupa, Conway Anne E, Garcia Benjamin A, Plath Kathrin, Clark Amander T, Grunstein Michael   Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells Molecular cell, 2009; 33(4): 417-27.
Conway Anne E, Lindgren Anne, Galic Zoran, Pyle April D, Wu Hong, Zack Jerome A, Pelligrini Matteo, Teitell Michael A, Clark Amander T   A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors Stem cells (Dayton, Ohio), 2009; 27(1): 18-28.
Lowry, WE., Richter, L,. Yachechko, R., Pyle, AD., Tshieu, J., Sridharan, R., Clark, AT., Plath, K   Generation of human induced pluripotent stem cells from dermal fibroblasts, Proceedings of the National Academy of Sciences, 2008; 105(8): 2883-2888.
Wu Hao, Kim Kevin J, Mehta Kshama, Paxia Salvatore, Sundstrom Andrew, Anantharaman Thomas, Kuraishy Ali I, Doan Tri, Ghosh Jayati, Pyle April D, Clark Amander, Lowry William, Fan Guoping, Baxter Tim, Mishra Bud, Sun Yi, Teitell Michael A   Copy number variant analysis of human embryonic stem cells Stem cells (Dayton, Ohio), 2008; 26(6): 1484-9.
Ambartsumyan Gayane, Clark Amander T   Aneuploidy and early human embryo development Human molecular genetics, 2008; 17(R1): R10-5.
Bostick Magnolia, Kim Jong Kyong, Estève Pierre-Olivier, Clark Amander, Pradhan Sriharsa, Jacobsen Steven E   UHRF1 plays a role in maintaining DNA methylation in mammalian cells Science (New York, N.Y.), 2007; 317(5845): 1760-4.
Clark Amander T   Establishment and differentiation of human embryonic stem cell derived germ cells Society of Reproduction and Fertility supplement, 2007; 63(2): 77-86.
Fox Mark S, Clark Amander T, El Majdoubi Mohammed, Vigne Jean-Louis, Urano Jun, Hostetler Chris E, Griswold Michael D, Weiner Richard I, Reijo Pera Renee A   Intermolecular interactions of homologs of germ plasm components in mammalian germ cells Developmental biology, 2007; 301(2): 417-31.
Clark Amander T   The stem cell identity of testicular cancer Stem cell reviews, 2007; 3(1): 49-59.
Kee Kehkooi, Gonsalves Joanna M, Clark Amander T, Pera Renee A Reijo   Bone morphogenetic proteins induce germ cell differentiation from human embryonic stem cells Stem cells and development, 2006; 15(6): 831-7.
Clark Amander T, Reijo Pera Renee A   Modeling human germ cell development with embryonic stem cells Regenerative medicine, 2006; 1(1): 85-93.
Ezeh Uche I, Turek Paul J, Reijo Renee A, Clark Amander T   Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma Cancer, 2005; 104(10): 2255-65.
Clark Amander T, Goldowitz Daniel, Takahashi Joseph S, Vitaterna Martha Hotz, Siepka Sandra M, Peters Luanne L, Frankel Wayne N, Carlson George A, Rossant Janet, Nadeau Joseph H, Justice Monica J   Implementing large-scale ENU mutagenesis screens in North America Genetica, 2004; 122(1): 51-64.
Clark Amander T, Bodnar Megan S, Fox Mark, Rodriquez Ryan T, Abeyta Michael J, Firpo Meri T, Pera Renee A Reijo   Spontaneous differentiation of germ cells from human embryonic stem cells in vitro Human molecular genetics, 2004; 13(7): 727-39.
Clark Amander T, Rodriguez Ryan T, Bodnar Megan S, Abeyta Michael J, Cedars Marcelle I, Turek Paul J, Firpo Meri T, Reijo Pera Renee A   Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma Stem cells (Dayton, Ohio), 2004; 22(2): 169-79.
Abeyta Michael J, Clark Amander T, Rodriguez Ryan T, Bodnar Megan S, Pera Renee A Reijo, Firpo Meri T   Unique gene expression signatures of independently-derived human embryonic stem cell lines Human molecular genetics, 2004; 13(6): 601-8.
Kile Benjamin T, Hentges Kathryn E, Clark Amander T, Nakamura Hisashi, Salinger Andrew P, Liu Bin, Box Neil, Stockton David W, Johnson Randy L, Behringer Richard R, Bradley Allan, Justice Monica J   Functional genetic analysis of mouse chromosome 11 Nature, 2003; 425(6953): 81-6.
Joyce, I. M. Clark, A. T. Pendola, F. L. Eppig, J. J.   Comparison of recombinant growth differentiation factor-9 and oocyte regulation of KIT ligand messenger ribonucleic acid expression in mouse ovarian follicles, Biol Reprod, 2000; 63(6): 1669-75.
Elvin, J. A. Clark, A. T. Wang, P. Wolfman, N. M. Matzuk, M. M.   Paracrine actions of growth differentiation factor-9 in the mammalian ovary Mol Endocrinol, 1999; 13(6): 1035-48.

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