Timothy Deming, Ph.D.

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A Short Biography:

Timothy Deming received his B.S. in Chemistry fom the University of California, Irvine in 1989, and his Ph.D. in Chemistry from the University of California, Berkeley, in 1993. After a NIH postdoctoral fellowship at the University of Massachusetts, Amherst, he joined the faculty in the Materials Department at the University of California, Santa Barbara in 1995. Here he held a joint appointment in the Materials and Chemistry Departments where he was promoted to Associate Professor in 1999 and Full Professor in 2003. In 2004 he moved to UCLA where he is now as Professor and Chair of the Bioengineering Department and Professor of Chemistry and Biochemistry.
Work Titles
CTSI Co-Leader, Pilot and Collaborative Translational Clinical Studies Program
California NanoSystems Institute Member, California NanoSystems Institute
UCLA Chair, Professor, Bioengineering Professor, Chemistry and Biochemistry Professor, Organic Chemistry Member, JCCC Signal Transduction and Therapeutics Program Area Researcher, Nanoscience and Materials Researcher, Organic Researcher, Synthesis
Education:
Degrees:
Ph.D., University of California, Berkeley, 1993
B.S., University of California, Irvine, 1989
Fellowship:
2002 Institut Curie, Rothschild and Mayent Foundation Fellow
1998 Alfred P. Sloan Research Fellow
Academic Experience:
1993 - 1995 University of Massachusetts, Amherst, MA, Polymer Science
Honors and Awards:
Unilever Award for Outstanding Graduate Research in Polymer Chemistry
2004 World Polymer Congress, IUPAC Macromolecular Division, Samsung-IUPAC Young Scientist Award
2003 Materials Research Society, Young Investigator Award
2000 Camille Dreyfus Teacher-Scholar Award
1999 3M, Non-Tenured Faculty Award
1998 Beckman Young Investigator Award
1997 NSF, CAREER Award
1996 UC Regents, Junior Faculty Fellow
1996 Office of Naval Research Young Investigator
Professional Societies:
American Chemical Society
Certifications:
Certification Type:
1993 NIH, National Research Service Award Postdoctoral Fellow

Contact Information:

Work Email Address:

demingt@seas.ucla.edu


Website:

Deming SEAS Web-Page

Lab Number:

(310) 204-5956

Work Phone Number:

(310) 207-4450

Office Address:

UCLA Bioengineering/Biomedical Engineering
410 Westwood Plaza
BOX 951600, 5121 Engineering V
Los Angeles, CA 90095


Detailed Biography:

Timothy J. Deming received a B.S. in Chemistry fom the University of California, Irvine in 1989, and graduated with a Ph.D. in Chemistry from the University of California, Berkeley, under Bruce Novak in 1993. After a NIH postdoctoral fellowship at the University of Massachusetts, Amherst with David Tirrell, he joined the faculty in the Materials Department at the University of California, Santa Barbara in 1995. Here he held a joint appointment in the Materials and Chemistry Departments where he was promoted to Associate Professor in 1999 and Full Professor in 2003. His appointment is now as the Chair of the Bioengineering Department at the University of California, Los Angeles. Current research interests include polypeptide synthesis, self-assembly of block copolypeptides, and biological activity of polypeptides, for which he has received young investigator awards from the National Science Foundation, the Office of Naval Research, The Arnold and Mabel Beckman Foundation, the Alfred P. Sloan Foundation, the Camille and Henry Dreyfus Foundation, the Materials Research Society, and the IUPAC Macromolecular Division.

Publications:

A selected list of publications:

Choe Uh-Joo, Rodriguez April R, Lee Brian S, Knowles Scott M, Wu Anna M, Deming Timothy J, Kamei Daniel T   Endocytosis and intracellular trafficking properties of transferrin-conjugated block copolypeptide vesicles Biomacromolecules, 2013; 14(5): 1458-64.
Jiang Ziyue Karen, Koh Sok Boon S, Sato Makoto, Atanasov Ivo C, Johnson Mai, Zhou Z Hong, Deming Timothy J, Wu Lily   Engineering polypeptide coatings to augment gene transduction and in vivo stability of adenoviruses Journal of controlled release : official journal of the Controlled Release Society, 2013; 166(1): 75-85.
Kramer Jessica R, Deming Timothy J   Reversible chemoselective tagging and functionalization of methionine containing peptides Chemical communications (Cambridge, England), 2013; 49(45): 5144-6.
Kuroiwa Keita, Masaki Yoshitaka, Koga Yuko, Deming Timothy J   Self-Assembly of Discrete Metal Complexes in Aqueous Solution via Block Copolypeptide Amphiphiles International journal of molecular sciences, 2013; 14(1): 2022-35.
Sun Victor Z, Choe Uh-Joo, Rodriguez April R, Dai Howard, Deming Timothy J, Kamei Daniel T   Transfection of Mammalian Cells Using Block Copolypeptide Vesicles Macromolecular bioscience, 2013; 49(45): .
Rodriguez April R, Choe Uh-Joo, Kamei Daniel T, Deming Timothy J   Fine Tuning of Vesicle Assembly and Properties Using Dual Hydrophilic Triblock Copolypeptides Macromolecular bioscience, 2012; .
Kramer Jessica R, Deming Timothy J   Glycopolypeptides with a redox-triggered helix-to-coil transition Journal of the American Chemical Society, 2012; 134(9): 4112-5.
Kramer Jessica R, Deming Timothy J   Preparation of Multifunctional and Multireactive Polypeptides via Methionine Alkylation Biomacromolecules, 2012; .
Song Bingbing, Song Jinsuk, Zhang Shanshan, Anderson Mark A, Ao Yan, Yang Chu-Ya, Deming Timothy J, Sofroniew Michael V   Sustained local delivery of bioactive nerve growth factor in the central nervous system via tunable diblock copolypeptide hydrogel depots Biomaterials, 2012; 33(35): 9105-16.
Cheng Jianjun, Deming Timothy J   Synthesis of polypeptides by ring-opening polymerization of α-amino acid N-carboxyanhydrides Topics in current chemistry, 2012; 310: 1-26.
Rhodes Allison J, Deming Timothy J   Tandem catalysis for the preparation of cylindrical polypeptide brushes Journal of the American Chemical Society, 2012; 134(47): 19463-7.
Sun Victor Z, Li Zhibo, Deming Timothy J, Kamei Daniel T   Intracellular fates of cell-penetrating block copolypeptide vesicles Biomacromolecules, 2011; 12(1): 10-3.
Mishra Abhijit, Lai Ghee Hwee, Schmidt Nathan W, Sun Victor Z, Rodriguez April R, Tong Rong, Tang Li, Cheng Jianjun, Deming Timothy J, Kamei Daniel T, Wong Gerard C L   Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(41): 16883-8.
Kramer Jessica R, Deming Timothy J   General method for purification of α-amino acid-n-carboxyanhydrides using flash chromatography Biomacromolecules, 2010; 11(12): 3668-72.
Kramer Jessica R, Deming Timothy J   Glycopolypeptides via living polymerization of glycosylated-L-lysine N-carboxyanhydrides Journal of the American Chemical Society, 2010; 132(42): 15068-71.
Hanson Jarrod A, Li Zhibo, Deming Timothy J   Nonionic Block Copolypeptide Micelles Containing a Hydrophobic racemic-Leucine Core Macromolecules, 2010; 43(15): 6268-6269.
Deming Timothy J   Regenerative medicine: Noodle gels for cells Nature materials, 2010; 9(7): 535-6.
Holowka Eric P, Deming Timothy J   Synthesis and crosslinking of L-DOPA containing polypeptide vesicles Macromolecular bioscience, 2010; 10(5): 496-502.
Li ZB, Deming TJ   Tunable hydrogel morphology via self-assembly of amphiphilic pentablock copolypeptides SOFT MATTER , 2010; 6(11): 2546-2551.
Yang Chu-Ya, Song Bingbing, Ao Yan, Nowak Andrew P, Abelowitz Ryan B, Korsak Rose A, Havton Leif A, Deming Timothy J, Sofroniew Michael V   Biocompatibility of amphiphilic diblock copolypeptide hydrogels in the central nervous system Biomaterials, 2009; 30(15): 2881-98.
Yan-Yan Hu, Yusuf Yusufoglu, Mathumai Kanapathipillai, Chu-Ya Yang, YaQiao Wu, Papannan Thiyagarajan, Timothy Deming, Mufit Akinc, Klaus Schmidt-Rohr and Surya Mallapragada   Self-assembled calcium phosphate nanocomposites using block copolypeptide templates SOFT MATTER, 2009; 5(21): 4311-4320.
Hanson Jarrod A, Chang Connie B, Graves Sara M, Li Zhibo, Mason Thomas G, Deming Timothy J   Nanoscale double emulsions stabilized by single-component block copolypeptides Nature, 2008; 455(7209): 85-8.
Auguste Debra T, Furman Kay, Wong Andrew, Fuller Jason, Armes Steven P, Deming Timothy J, Langer Robert   Triggered release of siRNA from poly(ethylene glycol)-protected, pH-dependent liposomes Journal of controlled release : official journal of the Controlled Release Society, 2008; 130(3): 266-74.
Klok, H.A., Deming, T.J.; Gnanou, Y., Matyjaszewski, K., Leibler, L.   Macromolecular Engineering of Polypeptides using the Ring Opening Polymerization of Alpha-Amino Acid N Carboxy Anhydrides Macromolecular Engineering, 2007; 1: 519-540.
Holowka Eric P, Sun Victor Z, Kamei Daniel T, Deming Timothy J   Polyarginine segments in block copolypeptides drive both vesicular assembly and intracellular delivery Nature materials, 2007; 6(1): 52-7.
Nowak, A.P., Sato. J., Breedveld, V., Deming, T.J.   Hydrogel Formation in Amphiphilic Triblock Copolypeptides Supramolecular Chemistry, 2006; (18): 429-427.
Bellomo Enrico G, Deming Timothy J   Monoliths of aligned silica-polypeptide hexagonal platelets Journal of the American Chemical Society, 2006; 128(7): 2276-9.
Deming, T.J.   Polypeptide abd Polypeptide Hybrid Copolymer Synthesis via NCA Polymerization Adv. Polym. Sci, 2006; (202): 1-8.
Schaefer, K.E., Keller, P., Deming, T.J.   Thermotropic Polypeptides Bearing Side-On Mesogens Macromolecules, 2006; (39): 19-22.
Auguste Debra T, Armes Steven P, Brzezinska Krystyna R, Deming Timothy J, Kohn Joachim, Prud'homme Robert K   pH triggered release of protective poly(ethylene glycol)-b-polycation copolymers from liposomes Biomaterials, 2006; 27(12): 2599-608.
Cui, H.; Krikorian, V.; Thompson, J.; Nowak, A. P.; Deming, T. J.; Pochan, D. J.   "Preparation and Characterization of Synthetic Polypeptide Single Crystals with Controlled Thickness" Macromolecules , 2005; 38: 7371-7377.
Holowka Eric P, Pochan Darrin J, Deming Timothy J   Charged polypeptide vesicles with controllable diameter Journal of the American Chemical Society, 2005; 127(35): 12423-8.
Deming, T. J.   Polypeptide Hydrogels via a Unique Assembly Mechanism Soft Matter, 2005; (1): 28-35.
Tomczak Melanie M, Glawe Diana D, Drummy Lawrence F, Lawrence Charles G, Stone Morley O, Perry Carole C, Pochan Darrin J, Deming Timothy J, Naik Rajesh R   Polypeptide-templated synthesis of hexagonal silica platelets Journal of the American Chemical Society, 2005; 127(36): 12577-82.
Bellomo Enrico G, Davidson Patrick, Impéror-Clerc Marianne, Deming Timothy J   Aqueous cholesteric liquid crystals using uncharged rodlike polypeptides Journal of the American Chemical Society, 2004; 126(29): 9101-5.
Euliss Larken E, Trnka Tina M, Deming Timothy J, Stucky Galen D   Design of a doubly-hydrophilic block copolypeptide that directs the formation of calcium carbonate microspheres Chemical communications (Cambridge, England), 2004; 43(15): 1736-7.
Pakstis Lisa M, Ozbas Bulent, Hales Kelly D, Nowak Andrew P, Deming Timothy J, Pochan Darrin   Effect of chemistry and morphology on the biofunctionality of self-assembling diblock copolypeptide hydrogels Biomacromolecules, 2004; 5(2): 312-8.
McKenna Brandon J, Birkedal Henrik, Bartl Michael H, Deming Timothy J, Stucky Galen D   Micrometer-sized spherical assemblies of polypeptides and small molecules by acid-base chemistry Angewandte Chemie (International ed. in English), 2004; 43(42): 5652-5.
Breedveld, V.; Nowak, A. P.; Sato, J.; Deming, T. J.; Pine, D. J.   Rheology of Block Copolypeptide Solutions: Hydrogels with Tunable Properties Macromolecules, 2004; 37: 3943-3953.
Minich, E. A.; Nowak, A. P.; Deming, T. J.; Pochan, D. J.   Rod–rod and rod–coil self-assembly and phase behavior of polypeptide diblock copolymers Polymer, 2004; 45(6): 1951-1957.
Bellomo Enrico G, Wyrsta Michael D, Pakstis Lisa, Pochan Darrin J, Deming Timothy J   Stimuli-responsive polypeptide vesicles by conformation-specific assembly Nature materials, 2004; 3(4): 244-8.
Brzezinska Krystyna R, Deming Timothy J   Synthesis of AB diblock copolymers by atom-transfer radical polymerization (ATRP) and living polymerization of alpha-amino acid-N-carboxyanhydrides Macromolecular bioscience, 2004; 4(6): 566-9.
Cha, J. N.; Bartl, M. H.; Wong, M. S.; Popitsch, A.; Deming, T. J.; Stucky, G. D.   Microcavity Lasing from Block Peptide Hierarchically Assembled Quantum Dot Spherical Resonators Nano Lett, 2003; 3: 907-911.
Cha Jennifer N, Birkedal Henrik, Euliss Larken E, Bartl Michael H, Wong Michael S, Deming Timothy J, Stucky Galen D   Spontaneous formation of nanoparticle vesicles from homopolymer polyelectrolytes Journal of the American Chemical Society, 2003; 125(27): 8285-9.
Nowak Andrew P, Breedveld Victor, Pine David J, Deming Timothy J   Unusual salt stability in highly charged diblock co-polypeptide hydrogels Journal of the American Chemical Society, 2003; 125(50): 15666-70.
Seidel, S. W.; Deming, T. J.   Use of Chiral Ruthenium and Iridium Amido-Sulfonamidate Complexes for Controlled, Enantioselective Polypeptide Synthesis Macromolecules , 2003; 36(4): 969-972.
Wong, M. S.; Cha, J. N.; Choi, K-S.; Deming, T. J.; Stucky, G. D.   Assembly of Nanoparticles into Hollow Spheres Using Block Copolypeptides” Nano Letters, 2002; 2(6): 583-587.
Deming Timothy J   Methodologies for preparation of synthetic block copolypeptides: materials with future promise in drug delivery Advanced drug delivery reviews, 2002; 54(8): 1145-55.
Brzezinska, K. R.; Curtin, S. A.; Deming, T. J.   Polypeptide End-capping Using Functionalized Isocyanates: Preparation of Pentablock Copolymers Macromolecules, 2002; 35(8): 2970-2976.
Krikorian, V.; Kurian, M.; Galvin, M. E.; Nowak, A. P.; Deming, T. J.; Pochan, D. J.   Polypeptide-based Nanocomposite: Structure and Properties of Poly(L-lysine)/Na+-montmorillonite Polymer Sci. Polym. Phys, 2002; 40: 2579-2586.
Nowak Andrew P, Breedveld Victor, Pakstis Lisa, Ozbas Bulent, Pine David J, Pochan Darrin, Deming Timothy J   Rapidly recovering hydrogel scaffolds from self-assembling diblock copolypeptide amphiphiles Nature, 2002; 417(6887): 424-8.
Pochan, D. J.; Pakstis, L.; Ozbas, B.; Nowak, A. P.; Deming, T. J.   SANS and Cryo-TEM Study of Self-Assembled Diblock Copolypeptide Hydrogels with Rich Nano- through Microscale Morphology Macromolecules, 2002; 35(14): 5358-5360.

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